Ketamine and its metabolites: Potential as novel treatments for depression

Ketamine: anesthetic, psychotomimetic, antidepressant, or anthelmintic?

(2022) Kenji Hashimoto   MOLECULAR PSYCHIATRY

Ketamine activates adult-born immature granule neurons to rapidly alleviate depression-like behaviors in mice

(2022) Radhika Rawat et al.   Nature Communications

Dual action of ketamine confines addiction liability

(2022) Linda D. Simmler et al.   NATURE

(R)-ketamine as prophylactic and therapeutic drug for neurological disorders: Beyond depression

(2022) Xingming Wang et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Arketamine, a new rapid-acting antidepressant: A historical review and future directions

(2022) Ji-chun Zhang et al.   NEUROPHARMACOLOGY

Ketamine and the Future of Rapid-Acting Antidepressants

(2021) Lace M. Riggs et al.   Annual Review of Clinical Psychology

Antidepressant drugs act by directly binding to TRKB neurotrophin receptors

(2021) Plinio C. Casarotto et al.   CELL

Stereoselective ketamine effect on cardiac output: a population pharmacokinetic/pharmacodynamic modelling study in healthy volunteers

(2021) Jasper Kamp et al.   BRITISH JOURNAL OF ANAESTHESIA

Molecular mechanisms underlying the antidepressant actions of arketamine: beyond the NMDA receptor

(2021) Yan Wei et al.   MOLECULAR PSYCHIATRY

Pharmacological and behavioral divergence of ketamine enantiomers: implications for abuse liability

(2021) Jordi Bonaventura et al.   MOLECULAR PSYCHIATRY

Intranasal administration of transforming growth factor-β1 elicits rapid-acting antidepressant-like effects in a chronic social defeat stress model: A role of TrkB signaling

(2021) Yan Wei et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Structural basis of ketamine action on human NMDA receptors

(2021) Youyi Zhang et al.   NATURE

Ventral pallidum DRD3 potentiates a pallido-habenular circuit driving accumbal dopamine release and cocaine seeking

(2021) Horia Pribiag et al.   NEURON

Rodent models of ketamine‐induced cystitis

(2021) Saki Sultana et al.   NEUROUROLOGY AND URODYNAMICS

Microglial ERK-NRBP1-CREB-BDNF signaling in sustained antidepressant actions of (R)-ketamine

(2021) Wei Yao et al.   MOLECULAR PSYCHIATRY

Ketamine as a Treatment for Anorexia Nervosa: A Narrative Review

(2021) Johanna Louise Keeler et al.   Nutrients

Intravenous arketamine for treatment-resistant depression: open-label pilot study

(2020) Gustavo C. Leal et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

Modulation of the antidepressant effects of ketamine by the mTORC1 inhibitor rapamycin

(2020) Chadi G. Abdallah et al.   NEUROPSYCHOPHARMACOLOGY

A historical review of antidepressant effects of ketamine and its enantiomers

(2020) Yan Wei et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Opioid system is necessary but not sufficient for antidepressive actions of ketamine in rodents

(2020) Matthew E. Klein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Essential role of microglial transforming growth factor-β1 in antidepressant actions of (R)-ketamine and the novel antidepressant TGF-β1

(2020) Kai Zhang et al.   Translational Psychiatry

Reviewing the Potential of Psychedelics for the Treatment of PTSD

(2020) Erwin Krediet et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Ketamine metabolites, clinical response, and gamma power in a randomized, placebo-controlled, crossover trial for treatment-resistant major depression

(2020) Cristan A. Farmer et al.   NEUROPSYCHOPHARMACOLOGY

Are NMDA and opioid receptors involved in the antidepressant actions of ketamine?

(2020) Kenji Hashimoto   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular mechanisms of the rapid-acting and long-lasting antidepressant actions of (R)-ketamine

(2020) Kenji Hashimoto   BIOCHEMICAL PHARMACOLOGY

The role of dissociation in ketamine’s antidepressant effects

(2020) Elizabeth D. Ballard et al.   Nature Communications

Altered Connectivity in Depression: GABA and Glutamate Neurotransmitter Deficits and Reversal by Novel Treatments

(2019) Ronald S. Duman et al.   NEURON

Comparison of antidepressant and side effects in mice after intranasal administration of (R,S)-ketamine, (R)-ketamine, and (S)-ketamine

(2019) Lijia Chang et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Rapid‐acting antidepressant ketamine, its metabolites and other candidates: A historical overview and future perspective

(2019) Kenji Hashimoto   PSYCHIATRY AND CLINICAL NEUROSCIENCES

Long-lasting effects of repeated ketamine administration in adult and adolescent rats

(2019) M.L. Shawn Bates et al.   BEHAVIOURAL BRAIN RESEARCH

Attenuation of antidepressant and antisuicidal effects of ketamine by opioid receptor antagonism

(2019) Nolan R. Williams et al.   MOLECULAR PSYCHIATRY

MPTP-induced dopaminergic neurotoxicity in mouse brain is attenuated after subsequent intranasal administration of (R)-ketamine: a role of TrkB signaling

(2019) Atsuhiro Fujita et al.   PSYCHOPHARMACOLOGY

Ketamine for suicidal ideation in adults with psychiatric disorders: A systematic review and meta-analysis of treatment trials

(2019) Katrina Witt et al.   AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY

TGF-β Signaling in Cellular Senescence and Aging-Related Pathology

(2019) Kana Tominaga et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ketamine metabolite pilot study in a suicidal depression trial

(2019) Michael F. Grunebaum et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Potential link between antidepressant-like effects of ketamine and promotion of adult neurogenesis in the ventral hippocampus of mice

(2019) Jun Yamada et al.   NEUROPHARMACOLOGY

Splenic NKG2D confers resilience versus susceptibility in mice after chronic social defeat stress: beneficial effects of (R)-ketamine

(2019) Kai Zhang et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

Phencyclidine-induced cognitive deficits in mice are ameliorated by subsequent repeated intermittent administration of (R)-ketamine, but not (S)-ketamine: Role of BDNF-TrkB signaling

(2019) Yunfei Tan et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

The Effect of a Single Dose of Intravenous Ketamine on Suicidal Ideation: A Systematic Review and Individual Participant Data Meta-Analysis

(2018) Samuel T. Wilkinson et al.   AMERICAN JOURNAL OF PSYCHIATRY

Mechanistic Target of Rapamycin–Independent Antidepressant Effects of ( R )-Ketamine in a Social Defeat Stress Model

(2018) Chun Yang et al.   BIOLOGICAL PSYCHIATRY

AMPA Receptor Activation–Independent Antidepressant Actions of Ketamine Metabolite ( S )-Norketamine

(2018) Chun Yang et al.   BIOLOGICAL PSYCHIATRY

Features of dissociation differentially predict antidepressant response to ketamine in treatment-resistant depression

(2018) Mark J. Niciu et al.   JOURNAL OF AFFECTIVE DISORDERS

A rapid and sensitive chiral LC–MS/MS method for the determination of ketamine and norketamine in mouse plasma, brain and cerebrospinal fluid applicable to the stereoselective pharmacokinetic study of ketamine

(2018) Hidetoh Toki et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Glutamatergic Signaling in the Central Nervous System: Ionotropic and Metabotropic Receptors in Concert

(2018) Andreas Reiner et al.   NEURON

(2R,6R)-Hydroxynorketamine is not essential for the antidepressant actions of (R)-ketamine in mice

(2018) Jun-ichi Yamaguchi et al.   NEUROPSYCHOPHARMACOLOGY

Ketamine-induced neurotoxicity blocked by N -Methyl- d -aspartate is mediated through activation of PKC/ERK pathway in developing hippocampal neurons

(2018) Sufang Jiang et al.   NEUROSCIENCE LETTERS

Neurobiological links between depression and AD: The role of TGF-β1 signaling as a new pharmacological target

(2018) Filippo Caraci et al.   PHARMACOLOGICAL RESEARCH

Ketamine and Ketamine Metabolite Pharmacology: Insights into Therapeutic Mechanisms

(2018) Panos Zanos et al.   PHARMACOLOGICAL REVIEWS

Expression of heat shock protein HSP-70 in the retrosplenial cortex of rat brain after administration of ( R,S )-ketamine and ( S )-ketamine, but not ( R )-ketamine

(2018) Zheng Tian et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Lack of metabolism in (R)-ketamine’s antidepressant actions in a chronic social defeat stress model

(2018) Kai Zhang et al.   Scientific Reports

Attenuation of Antidepressant Effects of Ketamine by Opioid Receptor Antagonism

(2018) Nolan R. Williams et al.   AMERICAN JOURNAL OF PSYCHIATRY

Lack of deuterium isotope effects in the antidepressant effects of (R)-ketamine in a chronic social defeat stress model

(2018) Kai Zhang et al.   PSYCHOPHARMACOLOGY

Lack of Opioid System in the Antidepressant Actions of Ketamine

(2018) Kai Zhang et al.   BIOLOGICAL PSYCHIATRY

Essential roles of neuropeptide VGF regulated TrkB/mTOR/BICC1 signaling and phosphorylation of AMPA receptor subunit GluA1 in the rapid antidepressant-like actions of ketamine in mice

(2018) Mengxin Shen et al.   BRAIN RESEARCH BULLETIN

An update on ketamine and its two enantiomers as rapid-acting antidepressants

(2018) Kai Zhang et al.   Expert Review of Neurotherapeutics

Lack of Antidepressant Effects of (2R,6R)-Hydroxynorketamine in a Rat Learned Helplessness Model: Comparison with (R)-Ketamine

(2017) Yukihiko Shirayama et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Ketamine for Depression, 4: In What Dose, at What Rate, by What Route, for How Long, and at What Frequency?

(2017) Chittaranjan Andrade   JOURNAL OF CLINICAL PSYCHIATRY

Antidepressant Potential of ( R )-Ketamine in Rodent Models: Comparison with ( S )-Ketamine

(2017) Kenichi Fukumoto et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Effects of ketamine administration on mTOR and reticulum stress signaling pathways in the brain after the infusion of rapamycin into prefrontal cortex

(2017) Helena M. Abelaira et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Neuronal plasticity and neurotrophic factors in drug responses

(2017) E Castrén et al.   MOLECULAR PSYCHIATRY

Comparison of (R)-ketamine and lanicemine on depression-like phenotype and abnormal composition of gut microbiota in a social defeat stress model

(2017) Youge Qu et al.   Scientific Reports

Placebo-controlled pilot trial testing dose titration and intravenous, intramuscular and subcutaneous routes for ketamine in depression

(2016) C. K. Loo et al.   ACTA PSYCHIATRICA SCANDINAVICA

Role of Cytochrome P4502B6 Polymorphisms in Ketamine Metabolism and Clearance

(2016) Lesley K. Rao et al.   ANESTHESIOLOGY

Intravenous Esketamine in Adult Treatment-Resistant Depression: A Double-Blind, Double-Randomization, Placebo-Controlled Study

(2016) Jaskaran B. Singh et al.   BIOLOGICAL PSYCHIATRY

Brain-derived Neurotrophic Factor (BDNF)-TrkB Signaling in Inflammation-related Depression and Potential Therapeutic Targets

(2016) Ji-chun Zhang et al.   Current Neuropharmacology

Effects of a single bilateral infusion of R-ketamine in the rat brain regions of a learned helplessness model of depression

(2016) Yukihiko Shirayama et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

Reduction of dopamine D2/3 receptor binding in the striatum after a single administration of esketamine, but not R-ketamine: a PET study in conscious monkeys

(2016) Kenji Hashimoto et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

Antidepressant Effects of (+)-MK-801 and (-)-MK-801 in the Social Defeat Stress Model

(2016) Bangkun Yang et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Ketamine: NMDA Receptors and Beyond

(2016) C. F. Zorumski et al.   JOURNAL OF NEUROSCIENCE

Antidepressant action of ketamine via mTOR is mediated by inhibition of nitrergic Rheb degradation

(2016) M M Harraz et al.   MOLECULAR PSYCHIATRY

NMDAR inhibition-independent antidepressant actions of ketamine metabolites

(2016) Panos Zanos et al.   NATURE

Adjunctive Lanicemine (AZD6765) in Patients with Major Depressive Disorder and History of Inadequate Response to Antidepressants: A Randomized, Placebo-Controlled Study

(2016) Gerard Sanacora et al.   NEUROPSYCHOPHARMACOLOGY

NMDA receptor subunits and associated signaling molecules mediating antidepressant-related effects of NMDA-GluN2B antagonism

(2015) Carly Kiselycznyk et al.   BEHAVIOURAL BRAIN RESEARCH

Alterations in Cortical Network Oscillations and Parvalbumin Neurons in Schizophrenia

(2015) Guillermo Gonzalez-Burgos et al.   BIOLOGICAL PSYCHIATRY

R-ketamine: a rapid-onset and sustained antidepressant without psychotomimetic side effects

(2015) C Yang et al.   Translational Psychiatry

Enhancing ketamine translational pharmacology via receptor occupancy normalization

(2014) Christopher L. Shaffer et al.   NEUROPHARMACOLOGY

The Role of GluN2A and GluN2B Subunits on the Effects of NMDA Receptor Antagonists in Modeling Schizophrenia and Treating Refractory Depression

(2014) Laura Jiménez-Sánchez et al.   NEUROPSYCHOPHARMACOLOGY

Acute Suppression of Spontaneous Neurotransmission Drives Synaptic Potentiation

(2013) E. Nosyreva et al.   JOURNAL OF NEUROSCIENCE

NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease

(2013) Pierre Paoletti et al.   NATURE REVIEWS NEUROSCIENCE

R (−)-ketamine shows greater potency and longer lasting antidepressant effects than S (+)-ketamine

(2013) Ji-chun Zhang et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

The prevalence and natural history of urinary symptoms among recreational ketamine users

(2012) Adam R. Winstock et al.   BJU INTERNATIONAL

Simultaneous population pharmacokinetic modelling of ketamine and three major metabolites in patients with treatment-resistant bipolar depression

(2012) Xiaochen Zhao et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Sub-anesthetic concentrations of (R,S)-ketamine metabolites inhibit acetylcholine-evoked currents in α7 nicotinic acetylcholine receptors

(2012) Ruin Moaddel et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Decreased expression of synapse-related genes and loss of synapses in major depressive disorder

(2012) Hyo Jung Kang et al.   NATURE MEDICINE

Opioid receptors: distinct roles in mood disorders

(2012) Pierre-Eric Lutz et al.   TRENDS IN NEUROSCIENCES

Glutamate N-methyl-D-aspartate Receptor Antagonists Rapidly Reverse Behavioral and Synaptic Deficits Caused by Chronic Stress Exposure

(2011) Nanxin Li et al.   BIOLOGICAL PSYCHIATRY

Ketamine effects on the urogenital system-changes in the urinary bladder and sperm motility

(2011) Sijie Tan et al.   MICROSCOPY RESEARCH AND TECHNIQUE

NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses

(2011) Anita E. Autry et al.   NATURE

Taming the Ketamine Tiger

(2010) Edward F. Domino   ANESTHESIOLOGY

Enantioselective capillary electrophoresis for identification and characterization of human cytochrome P450 enzymes which metabolize ketamine and norketamine in vitro

(2010) Simone Portmann et al.   JOURNAL OF CHROMATOGRAPHY A

Rapid Resolution of Suicidal Ideation After a Single Infusion of anN-Methyl-D-Aspartate Antagonist in Patients With Treatment-Resistant Major Depressive Disorder

(2010) Nancy DiazGranados et al.   JOURNAL OF CLINICAL PSYCHIATRY

Glutamate Receptor Ion Channels: Structure, Regulation, and Function

(2010) S. F. Traynelis et al.   PHARMACOLOGICAL REVIEWS

mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

(2010) N. Li et al.   SCIENCE

Consequences of chronic ketamine self-administration upon neurocognitive function and psychological wellbeing: a 1-year longitudinal study

(2009) Celia J. A. Morgan et al.   ADDICTION

Potency, voltage-dependency, agonist concentration-dependency, blocking kinetics and partial untrapping of the uncompetitive N-methyl-d-aspartate (NMDA) channel blocker memantine at human NMDA (GluN1/GluN2A) receptors

(2009) Kate E. Gilling et al.   NEUROPHARMACOLOGY

mTOR signaling: At the crossroads of plasticity, memory and disease

(2009) Charles A. Hoeffer et al.   TRENDS IN NEUROSCIENCES

The destruction of the lower urinary tract by ketamine abuse: a new syndrome?

(2008) Peggy Sau-Kwan Chu et al.   BJU INTERNATIONAL

The Antidepressant Fluoxetine Restores Plasticity in the Adult Visual Cortex

(2008) J. F. M. Vetencourt et al.   SCIENCE

Cellular Mechanisms Underlying the Antidepressant Effects of Ketamine: Role of α-Amino-3-Hydroxy-5-Methylisoxazole-4-Propionic Acid Receptors

(2007) Sungho Maeng et al.   BIOLOGICAL PSYCHIATRY