Opioid system is necessary but not sufficient for antidepressive actions of ketamine in rodents

Association of Combined Naltrexone and Ketamine With Depressive Symptoms in a Case series of Patients With Depression and Alcohol Use Disorder

(2019) Gihyun Yoon et al.   JAMA Psychiatry

Concurrent Use of Buprenorphine, Methadone, or Naltrexone Does Not Inhibit Ketamine’s Antidepressant Activity

(2019) Tobias Marton et al.   BIOLOGICAL PSYCHIATRY

Caution Against Overinterpreting Opiate Receptor Stimulation as Mediating Antidepressant Effects of Ketamine

(2019) Gerard Sanacora   AMERICAN JOURNAL OF PSYCHIATRY

Mu opioid receptors in the medial habenula contribute to naloxone aversion

(2019) L. J. Boulos et al.   NEUROPSYCHOPHARMACOLOGY

Prognosis and improved outcomes in major depression: a review

(2019) Christoph Kraus et al.   Translational Psychiatry

Stress transforms lateral habenula reward responses into punishment signals

(2019) Steven J. Shabel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Attenuation of antidepressant and antisuicidal effects of ketamine by opioid receptor antagonism

(2019) Nolan R. Williams et al.   MOLECULAR PSYCHIATRY

Ketamine and Ketamine Metabolite Pharmacology: Insights into Therapeutic Mechanisms

(2018) Panos Zanos et al.   PHARMACOLOGICAL REVIEWS

A neural pathway controlling motivation to exert effort

(2018) Christophe D. Proulx et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Attenuation of Antidepressant Effects of Ketamine by Opioid Receptor Antagonism

(2018) Nolan R. Williams et al.   AMERICAN JOURNAL OF PSYCHIATRY

Is There Really Nothing New Under the Sun? Is Low-Dose Ketamine a Fast-Acting Antidepressant Simply Because It Is An Opioid?

(2018) Mark S. George   AMERICAN JOURNAL OF PSYCHIATRY

Ketamine blocks bursting in the lateral habenula to rapidly relieve depression

(2018) Yan Yang et al.   NATURE

Lack of Opioid System in the Antidepressant Actions of Ketamine

(2018) Kai Zhang et al.   BIOLOGICAL PSYCHIATRY

Opioid system modulation with buprenorphine/samidorphan combination for major depressive disorder: two randomized controlled studies

(2018) Maurizio Fava et al.   MOLECULAR PSYCHIATRY

Limiting habenular hyperactivity ameliorates maternal separation-driven depressive-like symptoms

(2017) Anna Tchenio et al.   Nature Communications

The pharmacology of effort-related choice behavior: Dopamine, depression, and individual differences

(2016) John D. Salamone et al.   BEHAVIOURAL PROCESSES

Kappa-Opioid Antagonists for Psychiatric Disorders: From Bench to Clinical Trials

(2016) William A. Carlezon et al.   DEPRESSION AND ANXIETY

Deletion of the mu opioid receptor gene in mice reshapes the reward–aversion connectome

(2016) Anna E. Mechling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mu Opioid Receptor Actions in the Lateral Habenula

(2016) Elyssa B. Margolis et al.   PLoS One

Ketamine and other N-methyl-D-aspartate receptor antagonists in the treatment of depression: a perspective review

(2015) Nicolas D. Iadarola et al.   Therapeutic Advances in Chronic Disease

A Randomized Controlled Trial of Intranasal Ketamine in Major Depressive Disorder

(2014) Kyle A.B. Lapidus et al.   BIOLOGICAL PSYCHIATRY

Central antinociception induced by ketamine is mediated by endogenous opioids and μ- and δ-opioid receptors

(2014) Daniela da Fonseca Pacheco et al.   BRAIN RESEARCH

The lateral habenula in addiction and depression: an anatomical, synaptic and behavioral overview

(2014) Salvatore Lecca et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Reward processing by the lateral habenula in normal and depressive behaviors

(2014) Christophe D Proulx et al.   NATURE NEUROSCIENCE

Neural Correlates of Rapid Antidepressant Response to Ketamine in Treatment-Resistant Unipolar Depression: A Preliminary Positron Emission Tomography Study

(2013) Paul J. Carlson et al.   BIOLOGICAL PSYCHIATRY

The plasticity of the association between mu-opioid receptor and glutamate ionotropic receptor N in opioid analgesic tolerance and neuropathic pain

(2013) Pilar Sánchez-Blázquez et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The Ketamine Analogue Methoxetamine and 3- and 4-Methoxy Analogues of Phencyclidine Are High Affinity and Selective Ligands for the Glutamate NMDA Receptor

(2013) Bryan L. Roth et al.   PLoS One

Reward Signals, Attempted Suicide, and Impulsivity in Late-Life Depression

(2013) Alexandre Y. Dombrovski et al.   JAMA Psychiatry

A prefrontal cortex–brainstem neuronal projection that controls response to behavioural challenge

(2012) Melissa R. Warden et al.   NATURE

Dopamine neurons modulate neural encoding and expression of depression-related behaviour

(2012) Kay M. Tye et al.   NATURE

Opioid receptors: distinct roles in mood disorders

(2012) Pierre-Eric Lutz et al.   TRENDS IN NEUROSCIENCES

Potentiation of μ-opioid receptor-mediated signaling by ketamine

(2011) Achla Gupta et al.   JOURNAL OF NEUROCHEMISTRY

Synaptic potentiation onto habenula neurons in the learned helplessness model of depression

(2011) Bo Li et al.   NATURE

NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses

(2011) Anita E. Autry et al.   NATURE

The Mu-Opioid Receptor and the NMDA Receptor Associate in PAG Neurons: Implications in Pain Control

(2011) María Rodríguez-Muñoz et al.   NEUROPSYCHOPHARMACOLOGY

Pharmacological inhibition of the lateral habenula improves depressive-like behavior in an animal model of treatment resistant depression

(2010) C. Winter et al.   BEHAVIOURAL BRAIN RESEARCH

The histidine triad nucleotide-binding protein 1 supports mu-opioid receptor–glutamate NMDA receptor cross-regulation

(2010) María Rodríguez-Muñoz et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Dopamine in Motivational Control: Rewarding, Aversive, and Alerting

(2010) Ethan S. Bromberg-Martin et al.   NEURON

Electrical stimulation of the lateral habenula produces an inhibitory effect on sucrose self-administration

(2010) Alexander Friedman et al.   NEUROPHARMACOLOGY

Remission of Major Depression Under Deep Brain Stimulation of the Lateral Habenula in a Therapy-Refractory Patient

(2009) Alexander Sartorius et al.   BIOLOGICAL PSYCHIATRY

Cognitive aspects of congenital learned helplessness and its reversal by the monoamine oxidase (MAO)-B inhibitor deprenyl

(2009) Daniela Schulz et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Ultrastructural relationship between N-methyl-d-aspartate-NR1 receptor subunit and mu-opioid receptor in the mouse central nucleus of the amygdala

(2009) M.J. Glass et al.   NEUROSCIENCE