Subunit composition, molecular environment, and activation of native TRPC channels encoded by their interactomes

Contribution of TRPC Channels in Neuronal Excitotoxicity Associated With Neurodegenerative Disease and Ischemic Stroke

(2021) Jaepyo Jeon et al.   Frontiers in Cell and Developmental Biology

Structural basis for human TRPC5 channel inhibition by two distinct inhibitors

(2021) Kangcheng Song et al.   eLife

Transient Receptor Potential Canonical Channels in Health and Disease: A 2020 Update

(2021) Priya R. Kirtley et al.   Cells

Structural basis of gating modulation of Kv4 channel complexes

(2021) Yoshiaki Kise et al.   NATURE

Molecular structure of an open human KATP channel

(2021) Chen Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CNNM proteins selectively bind to the TRPM7 channel to stimulate divalent cation entry into cells

(2021) Zhiyong Bai et al.   PLOS BIOLOGY

The molecular appearance of native TRPM7 channel complexes identified by high-resolution proteomics

(2021) Astrid Kollewe et al.   eLife

TRPC channels: Structure, function, regulation and recent advances in small molecular probes

(2020) Hongbo Wang et al.   PHARMACOLOGY & THERAPEUTICS

A Family of Auxiliary Subunits of the TRP Cation Channel Encoded by the Complex inaF Locus

(2020) Zijing Chen et al.   GENETICS

Structural basis for pharmacological modulation of the TRPC6 channel

(2020) Yonghong Bai et al.   eLife

Structural basis of TRPC4 regulation by calmodulin and pharmacological agents

(2020) Deivanayagabarathy Vinayagam et al.   eLife

Human TRPC5 structures reveal interaction of a xanthine-based TRPC1/4/5 inhibitor with a conserved lipid binding site

(2020) David J. Wright et al.   Communications Biology

Differential PI(4,5)P2 sensitivities of TRPC4, C5 homomeric and TRPC1/4, C1/5 heteromeric channels

(2019) Juyeon Ko et al.   Scientific Reports

Complex formation of APP with GABAB receptors links axonal trafficking to amyloidogenic processing

(2019) Margarita C. Dinamarca et al.   Nature Communications

Structural basis for KCTD-mediated rapid desensitization of GABAB signalling

(2019) Sanduo Zheng et al.   NATURE

Mechanism of pharmacochaperoning in a mammalian KATP channel revealed by cryo-EM

(2019) Gregory M Martin et al.   eLife

Cryo-EM structure of TRPC5 at 2.8-Å resolution reveals unique and conserved structural elements essential for channel function

(2019) Jingjing Duan et al.   Science Advances

TRPC channels regulate Ca2+-signaling and short-term plasticity of fast glutamatergic synapses

(2019) Yvonne Schwarz et al.   PLOS BIOLOGY

An ER Assembly Line of AMPA-Receptors Controls Excitatory Neurotransmission and Its Plasticity

(2019) Jochen Schwenk et al.   NEURON

Structure of the receptor-activated human TRPC6 and TRPC3 ion channels

(2018) Qinglin Tang et al.   CELL RESEARCH

Electron cryo-microscopy structure of the canonical TRPC4 ion channel

(2018) Deivanayagabarathy Vinayagam et al.   eLife

Structure–function analyses of the ion channel TRPC3 reveal that its cytoplasmic domain allosterically modulates channel gating

(2018) Francisco Sierra-Valdez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of the mouse TRPC4 ion channel

(2018) Jingjing Duan et al.   Nature Communications

Calcium permeability of transient receptor potential canonical (TRPC) 4 channels measured by TRPC4-GCaMP6s

(2017) Juyeon Ko et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Neuroplastin and Basigin Are Essential Auxiliary Subunits of Plasma Membrane Ca 2+ -ATPases and Key Regulators of Ca 2+ Clearance

(2017) Nadine Schmidt et al.   NEURON

AMPA-receptor specific biogenesis complexes control synaptic transmission and intellectual ability

(2017) Aline Brechet et al.   Nature Communications

A complex of Neuroplastin and Plasma Membrane Ca2+ ATPase controls T cell activation

(2017) Mark Korthals et al.   Scientific Reports

The interaction domains of transient receptor potential canonical (TRPC)1/4 and TRPC1/5 heteromultimeric channels

(2016) Jongyun Myeong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

TRPC3/6/7 Knockdown Protects the Brain from Cerebral Ischemia Injury via Astrocyte Apoptosis Inhibition and Effects on NF-кB Translocation

(2016) Xiaoyun Chen et al.   MOLECULAR NEUROBIOLOGY

A background Ca2+entry pathway mediated by TRPC1/TRPC4 is critical for development of pathological cardiac remodelling

(2015) Juan E. Camacho Londoño et al.   EUROPEAN HEART JOURNAL

Modular composition and dynamics of native GABAB receptors identified by high-resolution proteomics

(2015) Jochen Schwenk et al.   NATURE NEUROSCIENCE

Molecular Determinants Mediating Gating of Transient Receptor Potential Canonical (TRPC) Channels by Stromal Interaction Molecule 1 (STIM1)

(2014) Kyu Pil Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Do mutations in the murine ataxia geneTRPC3cause cerebellar ataxia in humans?

(2014) Brent L. Fogel et al.   MOVEMENT DISORDERS

Cornichon2 Dictates the Time Course of Excitatory Transmission at Individual Hippocampal Synapses

(2014) Sami Boudkkazi et al.   NEURON

Auxiliary GABAB Receptor Subunits Uncouple G Protein βγ Subunits from Effector Channels to Induce Desensitization

(2014) Rostislav Turecek et al.   NEURON

The Role of Canonical Transient Receptor Potential Channels in Seizure and Excitotoxicity

(2014) Fang Zheng et al.   Cells

Ligand-Gating by Ca2+ Is Rate Limiting for Physiological Operation of BKCa Channels

(2013) H. Berkefeld et al.   JOURNAL OF NEUROSCIENCE

Isoform- and receptor-specific channel property of canonical transient receptor potential (TRPC)1/4 channels

(2013) Jinsung Kim et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

TRPC Channels and their Implications for Neurological Diseases

(2012) Senthil Selvaraj et al.   CNS & Neurological Disorders-Drug Targets

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

High-Resolution Proteomics Unravel Architecture and Molecular Diversity of Native AMPA Receptor Complexes

(2012) Jochen Schwenk et al.   NEURON

Genetic Identification of GnRH Receptor Neurons: A New Model for Studying Neural Circuits Underlying Reproductive Physiology in the Mouse Brain

(2011) Shuping Wen et al.   ENDOCRINOLOGY

Intrinsic phototransduction persists in melanopsin-expressing ganglion cells lacking diacylglycerol-sensitive TRPC subunits

(2011) Claudio E. Perez-Leighton et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Transient Receptor Potential Channel 1 (TRPC1) Reduces Calcium Permeability in Heteromeric Channel Complexes

(2011) Ursula Storch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of ML204, a Novel Potent Antagonist That Selectively Modulates Native TRPC4/C5 Ion Channels

(2011) Melissa Miller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabotropic glutamate receptors regulate hippocampal CA1 pyramidal neuron excitability via Ca2+wave-dependent activation of SK and TRPC channels

(2011) Lynda El-Hassar et al.   JOURNAL OF PHYSIOLOGY-LONDON

Extending the Dynamic Range of Label-free Mass Spectrometric Quantification of Affinity Purifications

(2011) Wolfgang Bildl et al.   MOLECULAR & CELLULAR PROTEOMICS

Melanopsin signalling in mammalian iris and retina

(2011) T. Xue et al.   NATURE

Proteomic analyses of native brain KV4.2 channel complexes

(2010) Céline Marionneau et al.   Channels

TRPC channels as STIM1-regulated SOCs

(2010) Joseph P. Yuan et al.   Channels

STIM1-dependent and STIM1-independent Function of Transient Receptor Potential Canonical (TRPC) Channels Tunes Their Store-operated Mode

(2010) Kyu Pil Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Native GABAB receptors are heteromultimers with a family of auxiliary subunits

(2010) Jochen Schwenk et al.   NATURE

Quantitative proteomics of the Cav2 channel nano-environments in the mammalian brain

(2010) C. S. Muller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deletion of TRPC4 and TRPC6 in Mice Impairs Smooth Muscle Contraction and Intestinal Motility In Vivo

(2009) Volodymyr V. Tsvilovskyy et al.   GASTROENTEROLOGY

TRPC5 Is a Ca2+-activated Channel Functionally Coupled to Ca2+-selective Ion Channels

(2009) Stefan Alfred Gross et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intracellular calcium strongly potentiates agonist-activated TRPC5 channels

(2009) Nathaniel T. Blair et al.   JOURNAL OF GENERAL PHYSIOLOGY

Group I mGluR Activation Enhances Ca2+-Dependent Nonselective Cation Currents and Rhythmic Bursting in Main Olfactory Bulb External Tufted Cells

(2009) H.-W. Dong et al.   JOURNAL OF NEUROSCIENCE

Functional Proteomics Identify Cornichon Proteins as Auxiliary Subunits of AMPA Receptors

(2009) J. Schwenk et al.   SCIENCE

TRP channels entering the structural era

(2008) Rachelle Gaudet   JOURNAL OF PHYSIOLOGY-LONDON

Control of KCa Channels by Calcium Nano/Microdomains

(2008) Bernd Fakler et al.   NEURON

TRPC3 Channels Are Required for Synaptic Transmission and Motor Coordination

(2008) Jana Hartmann et al.   NEURON

Distinct TRP channels are required for warm and cool avoidance in Drosophila melanogaster

(2008) M. Rosenzweig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA