CNNM proteins selectively bind to the TRPM7 channel to stimulate divalent cation entry into cells

Structural basis for the Mg2+ recognition and regulation of the CorC Mg2+ transporter

(2021) Yichen Huang et al.   Science Advances

TRPM7 kinase-mediated immunomodulation in macrophage plays a central role in magnesium ion-induced bone regeneration

(2021) Wei Qiao et al.   Nature Communications

Cyclin M2 (CNNM2) knockout mice show mild hypomagnesaemia and developmental defects

(2021) Gijs A. C. Franken et al.   Scientific Reports

Crystal structure of an archaeal CorB magnesium transporter

(2021) Yu Seby Chen et al.   Nature Communications

The molecular appearance of native TRPM7 channel complexes identified by high-resolution proteomics

(2021) Astrid Kollewe et al.   eLife

TRPM7 is the central gatekeeper of intestinal mineral absorption essential for postnatal survival

(2019) Lorenz Mittermeier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Magnesium-sensitive upstream ORF controls PRL phosphatase expression to mediate energy metabolism

(2019) Serge Hardy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CNNM2 homozygous mutations cause severe refractory hypomagnesemia, epileptic encephalopathy and brain malformations

(2018) Andrea Accogli et al.   European Journal of Medical Genetics

CrossTalk proposal: CNNM proteins are Na+ /Mg2+ exchangers playing a central role in transepithelial Mg2+ (re)absorption

(2018) Yosuke Funato et al.   JOURNAL OF PHYSIOLOGY-LONDON

CrossTalk opposing view: CNNM proteins are not Na+ /Mg2+ exchangers but Mg2+ transport regulators playing a central role in transepithelial Mg2+ (re)absorption

(2018) Francisco J. Arjona et al.   JOURNAL OF PHYSIOLOGY-LONDON

Suppression of cortical TRPM7 protein attenuates oxidative damage after traumatic brain injury via Akt/endothelial nitric oxide synthase pathway

(2018) Hong-Liang Xu et al.   NEUROCHEMISTRY INTERNATIONAL

Molecular Expression of Mg2+ regulator TRPM7 and CNNM4 in rat odontoblasts

(2018) Jonghwa Won et al.   ARCHIVES OF ORAL BIOLOGY

Efficient proximity labeling in living cells and organisms with TurboID

(2018) Tess C Branon et al.   NATURE BIOTECHNOLOGY

The cyclic nucleotide–binding homology domain of the integral membrane protein CNNM mediates dimerization and is required for Mg2+ efflux activity

(2018) Yu Seby Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SLC41A1 is essential for magnesium homeostasis in vivo

(2018) Francisco J. Arjona et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

TRPM7 senses oxidative stress to release Zn2+from unique intracellular vesicles

(2017) Sunday A. Abiria et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PRL3 phosphatase active site is required for binding the putative magnesium transporter CNNM3

(2017) Huizhi Zhang et al.   Scientific Reports

Mass Spectrometric Analysis of TRPM6 and TRPM7 Phosphorylation Reveals Regulatory Mechanisms of the Channel-Kinases

(2017) Na Cai et al.   Scientific Reports

Complementary role of CNNM2 in sperm motility and Ca 2+ influx during capacitation

(2016) Daisuke Yamazaki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibition of PRL-2·CNNM3 Protein Complex Formation Decreases Breast Cancer Proliferation and Tumor Growth

(2016) Elie Kostantin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human CNNM2 is not a Mg2+ transporter per se

(2016) Gerhard Sponder et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Meet the neighbors: Mapping local protein interactomes by proximity-dependent labeling with BioID

(2016) Renata Varnaitė et al.   PROTEOMICS

Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival

(2016) Vladimir Chubanov et al.   eLife

Influences of schizophrenia risk variant rs7914558 at CNNM2 on brain structure

(2015) Kazutaka Ohi   BRITISH JOURNAL OF PSYCHIATRY

Magnesium in Man: Implications for Health and Disease

(2015) Jeroen H. F. de Baaij et al.   PHYSIOLOGICAL REVIEWS

Basolateral sorting of the Mg2+ transporter CNNM4 requires interaction with AP-1A and AP-1B

(2014) Yusuke Hirata et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Nucleotide binding triggers a conformational change of the CBS module of the magnesium transporter CNNM2 from a twisted towards a flat structure

(2014) María Ángeles Corral-Rodríguez et al.   BIOCHEMICAL JOURNAL

Mg2+-dependent Interactions of ATP with the Cystathionine-β-Synthase (CBS) Domains of a Magnesium Transporter

(2014) Yusuke Hirata et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane protein CNNM4–dependent Mg2+ efflux suppresses tumor progression

(2014) Yosuke Funato et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of a Mg2+-sensitive ORF in the 5′-leader of TRPM7 magnesium channel mRNA

(2014) Inna A. Nikonorova et al.   NUCLEIC ACIDS RESEARCH

The protein tyrosine phosphatase PRL-2 interacts with the magnesium transporter CNNM3 to promote oncogenesis

(2014) S Hardy et al.   ONCOGENE

CNNM2 Mutations Cause Impaired Brain Development and Seizures in Patients with Hypomagnesemia

(2014) Francisco J. Arjona et al.   PLoS Genetics

Effects of a novel schizophrenia risk variant rs7914558 at CNNM2 on brain structure and attributional style

(2013) Emma Jane Rose et al.   BRITISH JOURNAL OF PSYCHIATRY

TRPM7 triggers Ca2+ sparks and invadosome formation in neuroblastoma cells

(2013) Daan Visser et al.   CELL CALCIUM

Timing of Myocardial Trpm7 Deletion During Cardiogenesis Variably Disrupts Adult Ventricular Function, Conduction, and Repolarization

(2013) Rajan Sah et al.   CIRCULATION

Ion channel-kinase TRPM7 is required for maintaining cardiac automaticity

(2013) R. Sah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Basolateral Mg2+ Extrusion via CNNM4 Mediates Transcellular Mg2+ Transport across Epithelia: A Mouse Model

(2013) Daisuke Yamazaki et al.   PLoS Genetics

Natural and synthetic modulators of SK (Kca2) potassium channels inhibit magnesium-dependent activity of the kinase-coupled cation channel TRPM7

(2012) V Chubanov et al.   BRITISH JOURNAL OF PHARMACOLOGY

Membrane Topology and Intracellular Processing of Cyclin M2 (CNNM2)

(2012) Jeroen H. F. de Baaij et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

CNNM2, Encoding a Basolateral Protein Required for Renal Mg2+ Handling, Is Mutated in Dominant Hypomagnesemia

(2011) Marchel Stuiver et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Silencing TRPM7 mimics the effects of magnesium deficiency in human microvascular endothelial cells

(2011) Erika Baldoli et al.   ANGIOGENESIS

Cellular magnesium homeostasis

(2011) Andrea M.P. Romani   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

TRPM7 regulates polarized cell movements

(2011) Li-Ting Su et al.   BIOCHEMICAL JOURNAL

Waixenicin A Inhibits Cell Proliferation through Magnesium-dependent Block of Transient Receptor Potential Melastatin 7 (TRPM7) Channels

(2011) Susanna Zierler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The channel kinase, TRPM7, is required for early embryonic development

(2011) J. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRPM7 regulates gastrulation during vertebrate embryogenesis

(2010) Wei Liu et al.   DEVELOPMENTAL BIOLOGY

TRPM7 is essential for Mg2+ homeostasis in mammals

(2010) Lillia V. Ryazanova et al.   Nature Communications

Mutations in CNNM4 Cause Jalili Syndrome, Consisting of Autosomal-Recessive Cone-Rod Dystrophy and Amelogenesis Imperfecta

(2009) David A. Parry et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Calcium flickers steer cell migration

(2009) Chaoliang Wei et al.   NATURE

Suppression of hippocampal TRPM7 protein prevents delayed neuronal death in brain ischemia

(2009) Hong-Shuo Sun et al.   NATURE NEUROSCIENCE

Deletion of Trpm7 Disrupts Embryonic Development and Thymopoiesis Without Altering Mg2+ Homeostasis

(2008) J. Jin et al.   SCIENCE