Large-scale sequencing identifies multiple genes and rare variants associated with Crohn’s disease susceptibility

QRICH1 dictates the outcome of ER stress through transcriptional control of proteostasis

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EPB41L5 controls podocyte extracellular matrix assembly by adhesome-dependent force transmission

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Prolonged Exposure to Platelet Activating Factor Transforms Breast Epithelial Cells

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Serum Analyte Profiles Associated With Crohn’s Disease and Disease Location

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The fate of myofibroblasts during the development of fibrosis in Crohn's Disease

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TAGAP instructs Th17 differentiation by bridging Dectin activation to EPHB2 signaling in innate antifungal response

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PDLIM5 inhibits STUB1-mediated degradation of SMAD3 and promotes the migration and invasion of lung cancer cells

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Neutrophilic HGF-MET Signalling Exacerbates Intestinal Inflammation

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Pleiotropic ZIP8 A391T implicates abnormal manganese homeostasis in complex human disease

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Hepatic Sdf2l1 controls feeding-induced ER stress and regulates metabolism

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Platelet activating factor receptor regulates colitis-induced pulmonary inflammation through the NLRP3 inflammasome

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Single-Cell Analysis of Crohn’s Disease Lesions Identifies a Pathogenic Cellular Module Associated with Resistance to Anti-TNF Therapy

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Protein-coding variants contribute to the risk of atopic dermatitis and skin-specific gene expression

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SDF2-like protein 1 (SDF2L1) regulates the endoplasmic reticulum localization and chaperone activity of ERdj3 protein

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TLR4-RelA-miR-30a signal pathway regulates Th17 differentiation during experimental autoimmune encephalomyelitis development

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C1orf106is a colitis risk gene that regulates stability of epithelial adherens junctions

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Regulation of thymocyte trafficking by Tagap, a GAP domain protein linked to human autoimmunity

(2018) Jonathan S. Duke-Cohan et al.   Science Signaling

Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population

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Regulation of thymocyte trafficking by Tagap, a GAP domain protein linked to human autoimmunity

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Structural Remodeling of the Human Colonic Mesenchyme in Inflammatory Bowel Disease

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Treatments for Crohn’s Disease–Associated Bowel Damage: A Systematic Review

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The NFkB subunit RELA is a master transcriptional regulator of the committed epithelial-mesenchymal transition in airway epithelial cells

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Hepatocyte Growth Factor Activator: A Proteinase Linking Tissue Injury with Repair

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Mesenchymal Cells in Colon Cancer

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Endoplasmic reticulum proteins SDF2 and SDF2L1 act as components of the BiP chaperone cycle to prevent protein aggregation

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T-cell activation RhoGTPase-activating protein plays an important role in TH 17-cell differentiation

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HumanRELAhaploinsufficiency results in autosomal-dominant chronic mucocutaneous ulceration

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Fine-mapping inflammatory bowel disease loci to single-variant resolution

(2017) Hailiang Huang et al.   NATURE

Exploring the genetic architecture of inflammatory bowel disease by whole-genome sequencing identifies association at ADCY7

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Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease

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Small-molecule inhibitors directly target CARD9 and mimic its protective variant in inflammatory bowel disease

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Cigarette smoke promotes COPD by activating platelet-activating factor receptor and inducing neutrophil autophagic death in mice

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Intestinal Stem Cell Niche: The Extracellular Matrix and Cellular Components

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Mucosal Mesenchymal Cells: Secondary Barrier and Peripheral Educator for the Gut Immune System

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Loss of Dok-1 and Dok-2 in mice causes severe experimental colitis accompanied by reduced expression of IL-17A and IL-22

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Epithelial-mesenchymal transition in tissue repair and fibrosis

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A Pleiotropic Missense Variant in SLC39A8 Is Associated With Crohn’s Disease and Human Gut Microbiome Composition

(2016) Dalin Li et al.   GASTROENTEROLOGY

IL23R (Interleukin 23 Receptor) Variants Protective against Inflammatory Bowel Diseases (IBD) Display Loss of Function due to Impaired Protein Stability and Intracellular Trafficking

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Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci

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A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis

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Ubiquitin Ligase TRIM62 Regulates CARD9-Mediated Anti-fungal Immunity and Intestinal Inflammation

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FOXO3–NF-κB RelA Protein Complexes Reduce Proinflammatory Cell Signaling and Function

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Chemokine receptor CCR7 regulates the intestinal TH 1/TH 17/Treg balance during Crohnˈs-like murine ileitis

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MET is required for the recruitment of anti-tumoural neutrophils

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Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations

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TYK2 Protein-Coding Variants Protect against Rheumatoid Arthritis and Autoimmunity, with No Evidence of Major Pleiotropic Effects on Non-Autoimmune Complex Traits

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Dok1 and Dok2 proteins regulate natural killer cell development and function

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Very Early Onset Inflammatory Bowel Disease Associated with Aberrant Trafficking of IL-10R1 and Cure by T Cell Replete Haploidentical Bone Marrow Transplantation

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Analysis of the STAT3 interactome using in-situ biotinylation and SILAC

(2013) Conny Blumert et al.   Journal of Proteomics

Deep Resequencing of GWAS Loci Identifies Rare Variants in CARD9, IL23R and RNF186 That Are Associated with Ulcerative Colitis

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Microbial Modulation of Host Immunity with the Small Molecule Phosphorylcholine

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Mucosal genome-wide methylation changes in inflammatory bowel disease

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Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease

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Role of the endothelium in inflammatory bowel diseases

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A Meta-Analysis of Genome-Wide Association Scans Identifies IL18RAP, PTPN2, TAGAP, and PUS10 As Shared Risk Loci for Crohn's Disease and Celiac Disease

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METAL: fast and efficient meta-analysis of genomewide association scans

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Monocytes/macrophages and/or neutrophils are the target of IL-10 in the LPS endotoxemia model

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Inflammatory Bowel Disease and Mutations Affecting the Interleukin-10 Receptor

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Endoplasmic reticulum stress in the intestinal epithelium and inflammatory bowel disease

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Tiam1 and Rac1 Are Required for Platelet-activating Factor-induced Endothelial Junctional Disassembly and Increase in Vascular Permeability

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Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease

(2008) Steven A McCarroll et al.   NATURE GENETICS

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

(2008) Jeffrey C Barrett et al.   NATURE GENETICS