Condensed-phase signaling can expand kinase specificity and respond to macromolecular crowding

Conformational Dynamics of Intrinsically Disordered Proteins Regulate Biomolecular Condensate Chemistry

(2022) Anton Abyzov et al.   CHEMICAL REVIEWS

Macromolecular crowding limits growth under pressure

(2022) Baptiste Alric et al.   Nature Physics

Chromatin mechanics dictates subdiffusion and coarsening dynamics of embedded condensates

(2021) Daniel S. W. Lee et al.   Nature Physics

Designer Condensates: A Toolkit for the Biomolecular Architect

(2021) Renee L. Hastings et al.   JOURNAL OF MOLECULAR BIOLOGY

Stress-induced nuclear condensation of NELF drives transcriptional downregulation

(2021) Prashant Rawat et al.   MOLECULAR CELL

Biomolecular condensates at the nexus of cellular stress, protein aggregation disease and ageing

(2021) Simon Alberti et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A subcellular map of the human kinome

(2021) Haitao Zhang et al.   eLife

Mechanistic dissection of increased enzymatic rate in a phase-separated compartment

(2021) William Peeples et al.   Nature Chemical Biology

Mechanical Frustration of Phase Separation in the Cell Nucleus by Chromatin

(2021) Yaojun Zhang et al.   PHYSICAL REVIEW LETTERS

Designer protein assemblies with tunable phase diagrams in living cells

(2020) Meta Heidenreich et al.   Nature Chemical Biology

Disease‐associated tau phosphorylation hinders tubulin assembly within tau condensates

(2020) Adriana Savastano et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer’s Disease

(2020) Hendrik Wesseling et al.   CELL

A new linear cyclin docking motif that mediates exclusively S‐phase CDK‐specific signaling

(2020) Ilona Faustova et al.   EMBO JOURNAL

Mapping Local and Global Liquid Phase Behavior in Living Cells Using Photo-Oligomerizable Seeds

(2019) Dan Bracha et al.   CELL

How the cell cycle clock ticks

(2019) Mihkel Örd et al.   MOLECULAR BIOLOGY OF THE CELL

Template-directed RNA polymerization and enhanced ribozyme catalysis inside membraneless compartments formed by coacervates

(2019) Raghav R. Poudyal et al.   Nature Communications

A molecular assembly phase transition and kinetic proofreading modulate Ras activation by SOS

(2019) William Y. C. Huang et al.   SCIENCE

Multisite phosphorylation code of CDK

(2019) Mihkel Örd et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Lysine/RNA-interactions drive and regulate biomolecular condensation

(2019) Tina Ukmar-Godec et al.   Nature Communications

Phase separation of YAP reorganizes genome topology for long-term YAP target gene expression

(2019) Danfeng Cai et al.   NATURE CELL BIOLOGY

mTORC1 Controls Phase Separation and the Biophysical Properties of the Cytoplasm by Tuning Crowding

(2018) M. Delarue et al.   CELL

Tau protein liquid–liquid phase separation can initiate tau aggregation

(2018) Susanne Wegmann et al.   EMBO JOURNAL

Homing in: Mechanisms of Substrate Targeting by Protein Kinases

(2018) Chad J. Miller et al.   TRENDS IN BIOCHEMICAL SCIENCES

Kinases and Cancer

(2018) Jonas Cicenas et al.   Cancers

TrackMate: An open and extensible platform for single-particle tracking

(2017) Jean-Yves Tinevez et al.   METHODS

Biomolecular condensates: organizers of cellular biochemistry

(2017) Salman F. Banani et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Liquid phase condensation in cell physiology and disease

(2017) Yongdae Shin et al.   SCIENCE

Liquid–liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau

(2017) Susmitha Ambadipudi et al.   Nature Communications

RNA stores tau reversibly in complex coacervates

(2017) Xuemei Zhang et al.   PLOS BIOLOGY

Amyloid β1-42 (Aβ1-42) Induces the CDK2-Mediated Phosphorylation of Tau through the Activation of the mTORC1 Signaling Pathway While Promoting Neuronal Cell Death

(2017) Ki Hoon Lee et al.   Frontiers in Molecular Neuroscience

Compositional Control of Phase-Separated Cellular Bodies

(2016) Salman F. Banani et al.   CELL

Opposing effects of Elk-1 multisite phosphorylation shape its response to ERK activation

(2016) A. Mylona et al.   SCIENCE

JASSA: a comprehensive tool for prediction of SUMOylation sites and SIMs

(2015) Guillaume Beauclair et al.   BIOINFORMATICS

Residue-by-Residue View of In Vitro FUS Granules that Bind the C-Terminal Domain of RNA Polymerase II

(2015) Kathleen A. Burke et al.   MOLECULAR CELL

Tau missorting and spastin-induced microtubule disruption in neurodegeneration: Alzheimer Disease and Hereditary Spastic Paraplegia

(2015) Hans Zempel et al.   Molecular Neurodegeneration

The ImageJ ecosystem: An open platform for biomedical image analysis

(2015) Johannes Schindelin et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Yeast Golden Gate (yGG) for the Efficient Assembly of S. cerevisiae Transcription Units

(2015) Neta Agmon et al.   ACS Synthetic Biology

NMRFAM-SPARKY: enhanced software for biomolecular NMR spectroscopy

(2014) Woonghee Lee et al.   BIOINFORMATICS

Ancestral resurrection reveals evolutionary mechanisms of kinase plasticity

(2014) Conor J Howard et al.   eLife

Cyclin-dependent kinases

(2014) Marcos Malumbres   GENOME BIOLOGY

MosaicIA: an ImageJ/Fiji plugin for spatial pattern and interaction analysis

(2013) Arun Shivanandan et al.   BMC BIOINFORMATICS

Dual Specificity Kinase DYRK3 Couples Stress Granule Condensation/Dissolution to mTORC1 Signaling

(2013) Frank Wippich et al.   CELL

Phase transitions in the assembly of multivalent signalling proteins

(2012) Pilong Li et al.   NATURE

Rapid and orthogonal logic gating with a gibberellin-induced dimerization system

(2012) Takafumi Miyamoto et al.   Nature Chemical Biology

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Composite low affinity interactions dictate recognition of the cyclin-dependent kinase inhibitor Sic1 by the SCFCdc4 ubiquitin ligase

(2012) X. Tang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insights into High Affinity Small Ubiquitin-like Modifier (SUMO) Recognition by SUMO-interacting Motifs (SIMs) Revealed by a Combination of NMR and Peptide Array Analysis

(2011) Andrew T. Namanja et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cascades of multisite phosphorylation control Sic1 destruction at the onset of S phase

(2011) Mardo Kõivomägi et al.   NATURE

Dimer formation and conformational flexibility ensure cytoplasmic stability and nuclear accumulation of Elk-1

(2011) Emma L. Evans et al.   NUCLEIC ACIDS RESEARCH

Spatial Exclusivity Combined with Positive and Negative Selection of Phosphorylation Motifs Is the Basis for Context-Dependent Mitotic Signaling

(2011) J. Alexander et al.   Science Signaling

Deciphering Protein Kinase Specificity Through Large-Scale Analysis of Yeast Phosphorylation Site Motifs

(2010) J. Mok et al.   Science Signaling

An overview of Cdk1-controlled targets and processes

(2010) Jorrit M Enserink et al.   Cell Division

Enzymatic assembly of DNA molecules up to several hundred kilobases

(2009) Daniel G Gibson et al.   NATURE METHODS

Structural Polymorphism of 441-Residue Tau at Single Residue Resolution

(2009) Marco D Mukrasch et al.   PLOS BIOLOGY

Isolation of Intrinsically Active (MEK-independent) Variants of the ERK Family of Mitogen-activated Protein (MAP) Kinases

(2008) Vered Levin-Salomon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY