Analysis of Gene Expression in 3D Spheroids Highlights a Survival Role for ASS1 in Mesothelioma

Expression status of candidate genes in mesothelioma tissues and cell lines

(2015) Ombretta Melaiu et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis

(2015) Shiran Rabinovich et al.   NATURE

Argininosuccinate synthetase 1 suppression and arginine restriction inhibit cell migration in gastric cancer cell lines

(2015) Yan-Shen Shan et al.   Scientific Reports

Whole-Exome Sequencing Reveals Frequent Genetic Alterations in BAP1, NF2, CDKN2A, and CUL1 in Malignant Pleural Mesothelioma

(2014) G. Guo et al.   CANCER RESEARCH

ASS1 as a Novel Tumor Suppressor Gene in Myxofibrosarcomas: Aberrant Loss via Epigenetic DNA Methylation Confers Aggressive Phenotypes, Negative Prognostic Impact, and Therapeutic Relevance

(2013) H.-Y. Huang et al.   CLINICAL CANCER RESEARCH

Metabolic Response to Pegylated Arginine Deiminase in Mesothelioma With Promoter Methylation of Argininosuccinate Synthetase

(2013) Peter W. Szlosarek et al.   JOURNAL OF CLINICAL ONCOLOGY

Epigenetic status of argininosuccinate synthetase and argininosuccinate lyase modulates autophagy and cell death in glioblastoma

(2013) N Syed et al.   Cell Death & Disease

Perifosine as a Potential Novel Anti-Cancer Agent Inhibits EGFR/MET-AKT Axis in Malignant Pleural Mesothelioma

(2012) Giulia Pinton et al.   PLoS One

Changes in Global Gene Expression Associated with 3D Structure of Tumors: An Ex Vivo Matrix-Free Mesothelioma Spheroid Model

(2012) Heungnam Kim et al.   PLoS One

Vorinostat Eliminates Multicellular Resistance of Mesothelioma 3D Spheroids via Restoration of Noxa Expression

(2012) Dario Barbone et al.   PLoS One

Promoter methylation of argininosuccinate synthetase-1 sensitises lymphomas to arginine deiminase treatment, autophagy and caspase-dependent apoptosis

(2012) B Delage et al.   Cell Death & Disease

Nutritional Stress and Arginine Auxotrophy Confer High Sensitivity to Chloroquine Toxicity in Mesothelioma Cells

(2011) Sonia Battisti et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

A review of transcriptome studies combined with data mining reveals novel potential markers of malignant pleural mesothelioma

(2011) Ombretta Melaiu et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

The Bcl-2 repertoire of mesothelioma spheroids underlies acquired apoptotic multicellular resistance

(2011) D Barbone et al.   Cell Death & Disease

Fine-Needle Aspiration Biopsies for Gene Expression Ratio-Based Diagnostic and Prognostic Tests in Malignant Pleural Mesothelioma

(2010) A. De Rienzo et al.   CLINICAL CANCER RESEARCH

Malignant pleural mesothelioma cells resist anoikis as quiescent pluricellular aggregates

(2009) J Daubriac et al.   CELL DEATH AND DIFFERENTIATION

Comparative Analysis of Gene Expression in Rat Liver Tissue and Monolayer- and Spheroid-Cultured Hepatocytes

(2009) Yusuke Sakai et al.   CELLS TISSUES ORGANS

Genomic and Expression Profiling of Glioblastoma Stem Cell-Like Spheroid Cultures Identifies Novel Tumor-Relevant Genes Associated with Survival

(2009) A. Ernst et al.   CLINICAL CANCER RESEARCH

Epigenetic silencing of argininosuccinate synthetase confers resistance to platinum-induced cell death but collateral sensitivity to arginine auxotrophy in ovarian cancer

(2009) Linda J. Nicholson et al.   INTERNATIONAL JOURNAL OF CANCER

Four-Gene Expression Ratio Test for Survival in Patients Undergoing Surgery for Mesothelioma

(2009) G. J. Gordon et al.   JNCI-Journal of the National Cancer Institute

Spheroid-based drug screen: considerations and practical approach

(2009) Juergen Friedrich et al.   Nature Protocols

Global Gene Expression Profiling Of Human Pleural Mesotheliomas: Identification of Matrix Metalloproteinase 14 (MMP-14) as Potential Tumour Target

(2009) Stefania Crispi et al.   PLoS One

CaSm (LSm-1) Overexpression in Lung Cancer and Mesothelioma Is Required for Transformed Phenotypes

(2008) Patricia M. Watson et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Mammalian Target of Rapamycin Contributes to the Acquired Apoptotic Resistance of Human Mesothelioma Multicellular Spheroids

(2008) Dario Barbone et al.   JOURNAL OF BIOLOGICAL CHEMISTRY