Article
Chemistry, Applied
Chun-Hsiang Chan, Ri-Gui Wu, Yi-Yuan Shao
Summary: High- and low-temperature ultrasonication enhanced the short-range ordered molecular structure and apparent amylose content of semigelatinized high amylose maize starch. High-temperature ultrasonication increased slowly digestible starch and resistant starch, while low-temperature ultrasonication only decreased resistant starch.
FOOD HYDROCOLLOIDS
(2021)
Article
Chemistry, Applied
Jiayi Li, Xinjing Kong, Yongfeng Ai
Summary: Maltogenic alpha-amylase (MGA) was used to modify starches for improved functionality. MGA treatment reduced retrogradation and viscosity of the starches, increased resistant starch content in NMS, and had limited influence on HAMS functionality. These findings are important for developing starch ingredients with enhanced functionality.
CARBOHYDRATE POLYMERS
(2022)
Article
Food Science & Technology
Tomoko Sasaki, Yasuhiro Suzuki
Summary: This study explores the impacts of apparent amylose content and amylopectin structure on the physical and nutritional properties of rice starch by comparing novel mutants with conventional rice varieties. The rice mutants demonstrated a specific amylopectin characteristic, indicating higher resistance to digestion due to its amylopectin structure and formation of harder gel.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Applied
Caili Li, Sushil Dhital, Michael J. Gidley
Summary: Research has found that the incorporation of high amylose wheat flour (HAWF) can increase the nutritional functionality of bread and noodles. This study explores the application of HAWF in tortillas and reveals that tortillas made with HAWF have lower breaking force and extensibility, but higher resistant starch content. Compared to loaf bread or noodles, tortillas exhibit lower starch digestion and higher resistant starch content.
FOOD HYDROCOLLOIDS
(2023)
Article
Chemistry, Applied
Caili Li, Sushil Dhital, Michael J. Gidley
Summary: High amylose wheat flour (HAWF) has potential for enhancing nutritional functionality due to its slower digestion and greater resistant starch levels. Research showed that bread made with HAWF had more retained crystalline structure, lower loaf volume, denser crumb structure, and higher hardness compared to wild-type wheat bread (WTWB). This study highlighted the importance of starch amylose content in the baking process and nutritional functionality, and its correlation with crumb hardness and starch thermal properties.
FOOD HYDROCOLLOIDS
(2022)
Article
Food Science & Technology
Noraidah Haini, Lee Jau-Shya, Ramlah George Mohd Rosli, Hasmadi Mamat
Summary: The study demonstrated the impact of high-amylose maize starch on the rheological and physicochemical properties, as well as the nutritional values of Chinese steamed buns. High HM incorporation increased RS and dietary fibre contents, reduced calorific values and pasting viscosities, while decreasing starch susceptibility to digestive enzymes in vitro.
JOURNAL OF CEREAL SCIENCE
(2021)
Article
Chemistry, Applied
Yu Tian, Ying Wang, Klaus Herbuger, Bent L. Petersen, Ying Cui, Andreas Blennow, Xingxun Liu, Yuyue Zhong
Summary: Microwave treatment affects the structure and pasting properties of high-amylose maize starches differently depending on their amylose content. Starches with lower amylose content show similar changes to those with no amylose and 25% amylose after microwave treatment, while starches with higher amylose content are almost unaffected.
CARBOHYDRATE POLYMERS
(2023)
Article
Chemistry, Applied
Hai-Teng Li, Wenyu Zhang, Yangyang Chen, Wenwen Pan, Yulong Bao
Summary: This study investigates a new approach to manipulate the digestibility of high-amylose maize starch (HAMS) through combinative modifications - depolymerization via electron beam irradiation (EBI) and reorganizing glucan chains via heat moisture treatment (HMT). The results show that EBI increases the branching degree of the starch, while HMT increases the relative crystallinity and V-type fraction. However, the combination of EBI and HMT may have a negative effect on starch enzymatic resistance under simulated gastrointestinal conditions.
Article
Chemistry, Applied
Ruifen Li, Li Ding, Ke Guo, Jianzhou Qu, Klaus Herburger, Staffan Persson, Andreas Blennow, Yuyue Zhong
Summary: This study investigated the effects of high-amylose maize starch (HAMS) on the functionality of casein and/or whey protein networks in acidified milk gels. The results showed that HAMS performed better than normal maize starch (NMS) in increasing the resistant starch content, storage modulus, loss modulus, and complex viscosity of the milk gels. Microscopy observations revealed that HAMS retained the starch granular integrity during the preparation of the milk gels. Among the HAMSs tested, HylonVII exhibited the highest resistant starch content and viscosity in all milk gel systems.
Article
Chemistry, Applied
Mingjing Zheng, Aiqian Ye, Harjinder Singh, Yi Zhang
Summary: This study investigated the in-vitro digestibility of differently structured starch gels formed by corn starches with different amylose contents. The findings suggest that the hardness, fragmentation, and particle size of the gels affect starch hydrolysis in the oral-gastric step, while the release of starch in the intestinal step is influenced by the starch content and granular structure of the gastric digesta.
FOOD HYDROCOLLOIDS
(2021)
Review
Food Science & Technology
Hai-Teng Li, Wenyu Zhang, Yulong Bao, Sushil Dhital
Summary: The demand for cleaner-label starch has driven the advancement of food physical processing technologies aimed at modifying starch to reduce glycaemic potency and increase resistant starch content. This review provides an overview of recent updates in physical processing techniques and discusses potential structures that enhance enzyme-digestion resistance in starch. The effectiveness of current physical modifications in improving starch enzymatic resistance has not been consistent, suggesting the need for exploring novel strategies and identifying modification conditions that maintain starch structure.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Xiaosong Zhai, Shan Gao, Yamei Xiang, Aiyue Wang, Zisong Li, Bo Cui, Wentao Wang
Summary: A novel strategy for modifying nanocellulose by borax cross-linking was developed in this study, which successfully improved the tensile strength and water resistance of starch films. The borax modified nanocellulose showed increased crystallinity and enhanced thermal stability, while effectively improving the dispersion of nanocellulose in the films. The composite films exhibited higher mechanical properties and water resistance compared to pure starch films.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Food Science & Technology
Zhuqing Xie, Minghua Yao, Josue L. Castro-Mejia, Ming Ma, Yuyan Zhu, Xiong Fu, Qiang Huang, Bin Zhang
Summary: The study investigated the anti-obesity effects and gut microbiota changes of propionylated high-amylose maize starch (PS) in mice fed with a high-fat diet (HFD). PS reduced body weight, improved glucose stability and insulin resistance in HFD-fed mice. PS also regulated serum lipid levels and inflammatory response. Furthermore, PS altered gut microbiota, increasing beneficial bacteria (S24-7 and Ruminococcus) and decreasing harmful genera, suggesting its potential anti-obesity effect.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Biochemistry & Molecular Biology
Hai-Teng Li, Wenyu Zhang, Wenwen Pan, Yangyang Chen, Yulong Bao, Alexander T. Bui
Summary: Limited knowledge exists on the regulation of molecular composition of starch leachates through irradiative depolymerization. This study investigated the leaching behavior of electron beam depolymerized maize starch and its relationship with modified starch granule structures. The findings showed a decrease in branching degree and the presence of a smaller amylopectin fraction in the leached starch, as well as changes in the granule properties. Principal component and Pearson correlation analysis revealed that the degree of branching and the newly-derived amylopectin fraction significantly correlated with the molecular size of leached starch molecules. The study suggests that cleavage of alpha-1,6 linkage plays a critical role in controlling the leaching process of irradiated starch granules, offering potential for optimizing starch-based food properties.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Applied
Lingshang Lin, Shengnan Zhao, Enpeng Li, Dongwei Guo, Cunxu Wei
Summary: The study found that starches from kernels with different weights have varying amylose contents, amylopectin structures, and thermal properties, showing distinct relationships with each other.
FOOD HYDROCOLLOIDS
(2022)
Review
Food Science & Technology
William Leonard, Pangzhen Zhang, Danyang Ying, Zhongxiang Fang
Summary: Lignanamides are natural plant secondary metabolites with powerful anti-inflammatory, antioxidant, anti-cancer, and anti-hyperlipidemic capacities, attracting researchers' interest for their potential in protecting against human chronic diseases. Although details in molecular regulation of the coupling process remain unclear, the general biosynthesis pathway for lignanamides is comprehensively summarized, calling for additional clinical studies to prove their health benefits.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Article
Agricultural Engineering
Wu Li, Ruili Yang, Danyang Ying, Jiawen Yu, Luz Sanguansri, Mary Ann Augustin
INDUSTRIAL CROPS AND PRODUCTS
(2020)
Article
Biochemistry & Molecular Biology
Riley D. Metcalfe, Kaheina Aizel, Courtney O. Zlatic, Paul M. Nguyen, Craig J. Morton, Daisy Sio-Seng Lio, Heung-Chin Cheng, Renwick C. J. Dobson, Michael W. Parker, Paul R. Gooley, Tracy L. Putoczki, Michael D. W. Griffin
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Article
Food Science & Technology
Meng Shi, DanYang Ying, Mya Myintzu Hlaing, JianHui Ye, Luz Sanguansri, Mary Ann Augustin
FOOD RESEARCH INTERNATIONAL
(2020)
Article
Food Science & Technology
S. Zhang, D. Y. Ying, L. J. Cheng, M. Bayrak, H. Jegasothy, L. Sanguansri, M. A. Augustin
LWT-FOOD SCIENCE AND TECHNOLOGY
(2020)
Article
Chemistry, Applied
Meng Shi, Dan-Yang Ying, Jian-Hui Ye, Luz Sanguansri, Mary Ann Augustin
Review
Food Science & Technology
William Leonard, Pangzhen Zhang, Danyang Ying, Zhongxiang Fang
Summary: This review provides an overview of tyramine-derived hydroxycinnamic acid amines (HCAAT), including their sources, roles in plants, biosynthetic pathways, metabolic engineering, and chemical synthesis. The focus of this paper is on the biological properties of HCAAT, such as antioxidant, anti-inflammatory, anti-cancer, anti-diabetic, anti-melanogenesis, and neuroprotective activities. The effects of food processing and technology on HCAAT are also discussed. Future directions for the study of HCAAT and its potential applications in the food and pharmaceutical industry are proposed.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Chemistry, Applied
William Leonard, Pangzhen Zhang, Danyang Ying, Yun Xiong, Zhongxiang Fang
Summary: Extrusion of hempseed hull at different barrel temperature and screw speed led to increased total phenolic content, antioxidant activities, and inhibition of α-glucosidase and acetylcholinesterase. Interaction between extrusion parameters influenced the phenolic/flavonoid content, antioxidant activities, and enzyme inhibition. Various phenylpropionamides were identified, with N-trans-caffeoyltyramine showing significant positive correlation with biological activities.
Article
Food Science & Technology
Yanfei Gong, Ang Meng, Yingquan Zhang, Bo Zhang, Danyang Ying, Boli Guo, Yimin Wei
Summary: This study investigates the effects of the difference between water activity of noodles and the relative humidity of the environment on the water loss rate and deformation degree of wheat starch/gluten extruded noodles.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Applied
William Leonard, Pangzhen Zhang, Danyang Ying, Shuai Nie, Siyao Liu, Zhongxiang Fang
Summary: This study provides a comprehensive investigation of fiber-rich hempseed hull, covering monosaccharide-linkage composition, physical properties, functional characteristics, and its impact on microbiota. The findings offer valuable insights for the processing and utilization of hempseed fiber.
FOOD HYDROCOLLOIDS
(2022)
Review
Biochemistry & Molecular Biology
Katherine Huang, Natalie Thomas, Paul R. Gooley, Christopher W. Armstrong
Summary: Nuclear magnetic resonance (NMR) spectroscopy is a widely used analytical technique in metabolomics, providing minimal sample preparation and high reproducibility. This systematic review summarizes the most commonly employed NMR metabolomics methods for serum, plasma, and urine studies from 2019 to 2020 and discusses their impact on data and result interpretation, as well as the importance of reporting.
Article
Pharmacology & Pharmacy
Kazem Asadollahi, Daniel J. Scott, Paul R. Gooley
Summary: This review discusses the modulation of activity of over 120 different GPCRs by peptides, which form the largest group of ligands. Linear disordered peptide ligands usually undergo significant conformational changes upon binding, which are crucial for receptor recognition and activation. Conformational selection and induced fit, two mechanisms of coupled folding and binding, can be differentiated by NMR analysis, but the large size of GPCRs in membrane-mimetic environments limits the application of NMR. This review highlights advancements in the field for addressing the coupled folding and binding of peptide ligands to their cognate receptors.
CURRENT OPINION IN PHARMACOLOGY
(2023)
Article
Biochemical Research Methods
Kazem Asadollahi, Katherine Huang, Fei Yan, Lazarus A. de Zhang, Daniel J. Scott, Paul R. Gooley
Summary: Neurotensin (NT) is an endogenous peptide in mammals with neurotransmission and hormonal roles. The expression and purification of NT with native modification is challenging due to the presence of pyro-glutamate (pGlu) at the first residue. In this study, a simple and efficient method using the small ubiquitin-like modifier (SUMO) as a fusion partner and enzymatic conversion of glutamine to pGlu was described for expression and purification of large amounts of NT. The method yielded 13 mg/L and 8 mg/L of pure peptide in rich and minimal media, respectively, and can be adapted for modification of other proteins and peptides in various expression hosts.
PROTEIN EXPRESSION AND PURIFICATION
(2023)
Article
Biochemistry & Molecular Biology
Kazem Asadollahi, Sunnia Rajput, Guy N. L. Jameson, Daniel J. Scott, Paul R. Gooley
Summary: This study investigated the binding mechanisms between neurotensin (NT) and neurotensin receptor 1 (NTS1) using NMR experiments and kinetic analysis. The results revealed the presence of transient structures in NT that regulate its binding to NTS1 through electrostatic interactions between the N-terminal region of NT and the extracellular loop 2 of NTS1.
JOURNAL OF MOLECULAR BIOLOGY
(2023)
Review
Food Science & Technology
William Leonard, Pangzhen Zhang, Danyang Ying, Zhongxiang Fang
Summary: Hydroxycinnamic acids (HCAs) are a major class of phenolic acids with a characteristic phenylpropanoid C-6-C-3 backbone. Despite being typically conjugated with plant cell wall components and liberated by limited enzymes, HCAs have been neglected by researchers compared to flavonoid-type polyphenols. Recently, there has been a growing interest in the interactions between polyphenols and gut microbiota, with significant progress in understanding the gut microbiota-modulating effect of HCA using animal model studies.
COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY
(2021)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
