Research progress on antidiabetic activity of apigenin derivatives

Phenolic Bioactives From Plant-Based Foods for Glycemic Control

(2022) Dipayan Sarkar et al.   Frontiers in Endocrinology

Bioactive Apigenin loaded oral nano bilosomes: Formulation optimization to preclinical assessment

(2021) Ameeduzzafar Zafar et al.   SAUDI PHARMACEUTICAL JOURNAL

Does Oral Apigenin Have Real Potential for a Therapeutic Effect in the Context of Human Gastrointestinal and Other Cancers?

(2021) Eva F. DeRango-Adem et al.   Frontiers in Pharmacology

Chemoprotective and chemosensitizing effects of apigenin on cancer therapy

(2021) Zahra Nozhat et al.   Cancer Cell International

Apigenin alleviates renal fibroblast activation through AMPK and ERK signaling pathways in vitro

(2020) Ningning Li et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

The Therapeutic Potential of Apigenin

(2019) Bahare Salehi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Natural Products: Potential Source of DPP-IV Inhibitors

(2019) Rajeev K Singla et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Antidiabetic Potential of Flavonoids from Traditional Chinese Medicine: A Review

(2019) Lan Bai et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Antibacterial and Potential Antidiabetic Activities of Flavone C-glycosides Isolated from Beta vulgaris Subspecies cicla L. var. Flavescens (Amaranthaceae) Cultivated in Egypt

(2019) Hala Sh. Mohammed et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

WITHDRAWN: Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the International Diabetes Federation Diabetes Atlas, 9th edition

(2019) Pouya Saeedi et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Comparative Study of Dietary Flavonoids with Different Structures as α-Glucosidase Inhibitors and Insulin Sensitizers

(2019) Yijia Jia et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Discovery of Novel DPP-IV Inhibitors as Potential Candidates for the Treatment of Type 2 Diabetes mellitus Predicted by 3D QSAR Pharmacophore Models, Molecular Docking and de novo Evolution

(2019) Musoev et al.   MOLECULES

Apigenin reduces the excessive accumulation of lipids induced by palmitic acid via the AMPK signaling pathway in HepG2 cells

(2019) Jing Lu et al.   Experimental and Therapeutic Medicine

Flavonoids and Their Anti-Diabetic Effects: Cellular Mechanisms and Effects to Improve Blood Sugar Levels

(2019) AL-Ishaq et al.   Biomolecules

A Review on Flavonoid Apigenin: Dietary Intake, ADME, Antimicrobial Effects, and Interactions with Human Gut Microbiota

(2019) Minqian Wang et al.   Biomed Research International

Synthesis & α-glucosidase inhibitory & glucose consumption-promoting activities of flavonoid–coumarin hybrids

(2018) Hua Sun et al.   Future Medicinal Chemistry

Traversal of the Blood–Brain Barrier by Cleavable l-Lysine Conjugates of Apigenin

(2018) Tsung-Yun Wong et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

In vitro and in silico analyses of Vicia faba L. on Peroxisome proliferator-activated receptor gamma

(2018) D. Sathya Prabhu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Apigenin suppresses the apoptosis of H9C2 rat cardiomyocytes subjected to myocardial ischemia‑reperfusion injury via upregulation of the PI3K/Akt pathway

(2018) Zhengwen Zhou et al.   Molecular Medicine Reports

Chemical and Biological insights of Ouratea hexasperma (A. St.-Hil.) Baill.: a source of bioactive compounds with multifunctional properties

(2018) Queli Cristina Fidelis et al.   NATURAL PRODUCT RESEARCH

Comparative bio-accessibility, bioavailability and bioequivalence of quercetin, apigenin, glucoraphanin and carotenoids from freeze-dried vegetables incorporated into a baked snack versus minimally processed vegetables: Evidence from in vitro models and a human bioavailability study

(2018) Natalia Perez-Moral et al.   Journal of Functional Foods

Acute metabolic actions of the major polyphenols in chamomile: an in vitro mechanistic study on their potential to attenuate postprandial hyperglycaemia

(2018) Jose A. Villa-Rodriguez et al.   Scientific Reports

Antidiabetic Activity of a Flavonoid-Rich Extract From Sophora davidii (Franch.) Skeels in KK-Ay Mice via Activation of AMP-Activated Protein Kinase

(2018) Yun Huang et al.   Frontiers in Pharmacology

Correction to: Indirect and direct routes to C-glycosylated flavones in Saccharomyces cerevisiae

(2018) Katherina Garcia Vanegas et al.   Microbial Cell Factories

The Protective Effect of Apigenin on Myocardial Injury in Diabetic Rats mediating Activation of the PPAR-γ Pathway

(2017) Umesh Mahajan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Apigenin alleviates STZ-induced diabetic cardiomyopathy

(2017) Huang-Jun Liu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Effects of Silymarin on Diabetes Mellitus Complications: A Review

(2017) Aline Maria Stolf et al.   PHYTOTHERAPY RESEARCH

Total synthesis of 8-(6″-umbelliferyl)-apigenin and its analogs as anti-diabetic reagents

(2016) Guojun Pan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Apigenin and naringenin regulate glucose and lipid metabolism, and ameliorate vascular dysfunction in type 2 diabetic rats

(2016) Bei Ren et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Pharmacokinetic properties and drug interactions of apigenin, a natural flavone

(2016) Ding Tang et al.   Expert Opinion on Drug Metabolism & Toxicology

Apigenin Ameliorates Dyslipidemia, Hepatic Steatosis and Insulin Resistance by Modulating Metabolic and Transcriptional Profiles in the Liver of High-Fat Diet-Induced Obese Mice

(2016) Un Jung et al.   Nutrients

Discovery of xanthine oxidase inhibitors and/or α-glucosidase inhibitors by carboxyalkyl derivatization based on the flavonoid of apigenin

(2015) Zhuo-Ran Su et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Flavones inhibit breast cancer proliferation through the Akt/FOXO3a signaling pathway

(2015) Chia-Hung Lin et al.   BMC CANCER

Chalcones and their therapeutic targets for the management of diabetes: Structural and pharmacological perspectives

(2015) Debarshi Kar Mahapatra et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Recent progress in natural products as DPP-4 inhibitors

(2015) Yuanyuan Gao et al.   Future Medicinal Chemistry

Growth inhibition of human liver carcinoma HepG2 cells and α-glucosidase inhibitory activity of Murdannia bracteata (C.B. Clarke) Kuntze ex J.K. Morton extracts

(2015) Kheng Leong Ooi et al.   JOURNAL OF ETHNOPHARMACOLOGY

Antidiabetic properties of dietary flavonoids: a cellular mechanism review

(2015) Ramachandran Vinayagam et al.   Nutrition & Metabolism

Synthesis, nitric oxide release, and α-glucosidase inhibition of nitric oxide donating apigenin and chrysin derivatives

(2014) Qi-Qin Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and α-glucosidase inhibitory activity of chrysin, diosmetin, apigenin, and luteolin derivatives

(2014) Ning Cheng et al.   CHINESE CHEMICAL LETTERS

AMPK activation: a therapeutic target for type 2 diabetes?

(2014) Asish Saha et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Opposite effects of genistein on the regulation of insulin-mediated glucose homeostasis in adipose tissue

(2013) M Wang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Vascular Complications of Diabetes: Mechanisms of Injury and Protective Factors

(2013) Christian Rask-Madsen et al.   Cell Metabolism

Berry and Citrus Phenolic Compounds Inhibit Dipeptidyl Peptidase IV: Implications in Diabetes Management

(2013) Junfeng Fan et al.   Evidence-based Complementary and Alternative Medicine

Effects of C-glycosylation on anti-diabetic, anti-Alzheimer’s disease and anti-inflammatory potential of apigenin

(2013) Jae Sue Choi et al.   FOOD AND CHEMICAL TOXICOLOGY

AMPK, insulin resistance, and the metabolic syndrome

(2013) Neil B. Ruderman et al.   JOURNAL OF CLINICAL INVESTIGATION

Recent advances in understanding the anti-diabetic actions of dietary flavonoids

(2013) Pon Velayutham Anandh Babu et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium

(2013) Ratana Lim et al.   MOLECULAR HUMAN REPRODUCTION

Enzymatic synthesis of apigenin glucosides by glucosyltransferase (YjiC) from Bacillus licheniformis DSM 13

(2013) Rit Bahadur Gurung et al.   MOLECULES AND CELLS

Apigenin Attenuates 2-Deoxy-D-ribose-Induced Oxidative Cell Damage in HIT-T15 Pancreatic β-Cells

(2012) Kwang Sik Suh et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Anti-hyperglycemic action of apigenin-6-C-β-fucopyranoside from Averrhoa carambola

(2012) Luisa Helena Cazarolli et al.   FITOTERAPIA

Biopharmaceutics classification and intestinal absorption study of apigenin

(2012) Jianjun Zhang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Structure-activity relationships of bergenin derivatives effect on α-glucosidase inhibition

(2012) Yusei Kashima et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Apigenin: A Promising Molecule for Cancer Prevention

(2010) Sanjeev Shukla et al.   PHARMACEUTICAL RESEARCH

Antihyperglycaemic and protective effects of flavonoids on streptozotocin-induced diabetic rats

(2010) Amélia P. Rauter et al.   PHYTOTHERAPY RESEARCH

Comparative Evaluation of Quercetin, Isoquercetin and Rutin as Inhibitors of α-Glucosidase

(2009) Yan Qin Li et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

α-Glucosidase inhibitory activity of cyanidin-3-galactoside and synergistic effect with acarbose

(2008) Sirichai Adisakwattana et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY