Amyloid Peptide β1-42 Induces Integrin αIIbβ3 Activation, Platelet Adhesion, and Thrombus Formation in a NADPH Oxidase-Dependent Manner

Relevance of N-terminal residues for amyloid-β binding to platelet integrin α IIb β 3 , integrin outside-in signaling and amyloid-β fibril formation

(2018) Lili Donner et al.   CELLULAR SIGNALLING

Not Oligomers but Amyloids are Cytotoxic in the Membrane-Mediated Amyloidogenesis of Amyloid-β Peptides

(2018) Naoya Itoh et al.   CHEMBIOCHEM

Amyloid precursor protein is required for in vitro platelet adhesion to amyloid peptides and potentiation of thrombus formation

(2018) Caterina Visconte et al.   CELLULAR SIGNALLING

Fibrinogen and Altered Hemostasis in Alzheimer's Disease

(2018) Marta Cortes-Canteli et al.   JOURNAL OF ALZHEIMERS DISEASE

Oligomeric and fibrillar amyloid beta 42 induce platelet aggregation partially through GPVI

(2017) O. Elaskalani et al.   PLATELETS

A novel flow cytometry assay using dihydroethidium as redox-sensitive probe reveals NADPH oxidase-dependent generation of superoxide anion in human platelets exposed to amyloid peptide β

(2017) Aisha Alsheikh Abubaker et al.   PLATELETS

Amyloid β-peptides 1–40 and 1–42 form oligomers with mixed β-sheets

(2017) Maurizio Baldassarre et al.   Chemical Science

Monomeric Aβ1–40 and Aβ1–42 Peptides in Solution Adopt Very Similar Ramachandran Map Distributions That Closely Resemble Random Coil

(2016) Julien Roche et al.   BIOCHEMISTRY

Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer's disease

(2016) Amy R. Nelson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Increased platelet adhesion and thrombus formation in a mouse model of Alzheimer's disease

(2016) Ilaria Canobbio et al.   CELLULAR SIGNALLING

The Alzheimer's disease peptide β-amyloid promotes thrombin generation through activation of coagulation factor XII

(2016) D. Zamolodchikov et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Plasma Fibrinogen Is a Natural Deterrent to Amyloid β-Induced Platelet Activation and Neuronal Toxicity

(2016) Vijay K Sonkar et al.   MOLECULAR MEDICINE

1,25-Dihydroxyvitamin D3 regulates expression of LRP1 and RAGE in vitro and in vivo, enhancing Aβ1–40 brain-to-blood efflux and peripheral uptake transport

(2016) Y.-X. Guo et al.   NEUROSCIENCE

Platelets contribute to amyloid-β aggregation in cerebral vessels through integrin αIIbβ3–induced outside-in signaling and clusterin release

(2016) Lili Donner et al.   Science Signaling

Platelets contribute to amyloid-β aggregation in cerebral vessels through integrin αIIbβ3–induced outside-in signaling and clusterin release

(2016) Lili Donner et al.   Science Signaling

Impact of the PI3-kinase/Akt pathway on ITAM and hemITAM receptors: Haemostasis, platelet activation and antithrombotic therapy

(2015) Alyssa J. Moroi et al.   BIOCHEMICAL PHARMACOLOGY

Oxidized LDL activates blood platelets through CD36/NOX2-mediated inhibition of the cGMP/protein kinase G signaling cascade

(2015) S. Magwenzi et al.   BLOOD

Overestimating the Effects of Healthy Aging

(2015) Vanja Kljajevic   Frontiers in Aging Neuroscience

Amyloid β-peptide-dependent activation of human platelets: essential role for Ca2+and ADP in aggregation and thrombus formation

(2014) Ilaria Canobbio et al.   BIOCHEMICAL JOURNAL

Vascular risk factors and Alzheimer’s disease

(2014) John T O’Brien et al.   BMC Medicine

Pre-activated blood platelets and a pro-thrombotic phenotype in APP23 mice modeling Alzheimer's disease

(2014) Andrea Jarre et al.   CELLULAR SIGNALLING

Amyloid β peptide stimulates platelet activation through RhoA-dependent modulation of actomyosin organization

(2014) Vijay K. Sonkar et al.   FASEB JOURNAL

Blood Platelets in the Progression of Alzheimer’s Disease

(2014) Nina S. Gowert et al.   PLoS One

The role of Nox1 and Nox2 in GPVI-dependent platelet activation and thrombus formation

(2014) T.G. Walsh et al.   Redox Biology

Immobilized amyloid Aβ peptides support platelet adhesion and activation

(2013) Ilaria Canobbio et al.   FEBS LETTERS

Alzheimer disease and risk of stroke: A population-based cohort study

(2013) N.-F. Chi et al.   NEUROLOGY

Increased Number of Microinfarcts in Alzheimer Disease at 7-T MR Imaging

(2013) Sanneke van Rooden et al.   RADIOLOGY

The novel NOX inhibitor 2-acetylphenothiazine impairs collagen-dependent thrombus formation in a GPVI-dependent manner

(2012) D Vara et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cell Signaling through Protein Kinase C Oxidation and Activation

(2012) Daniela Cosentino-Gomes et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Visualization of co-localization in Aβ42-administered neuroblastoma cells reveals lysosome damage and autophagosome accumulation related to cell death

(2011) Violetta Soura et al.   BIOCHEMICAL JOURNAL

Coated-platelet levels and progression from mild cognitive impairment to Alzheimer disease

(2011) C. I. Prodan et al.   NEUROLOGY

Chronic mild cerebrovascular dysfunction as a cause for Alzheimer's disease?

(2010) Christian Humpel   EXPERIMENTAL GERONTOLOGY

Cerebral microbleeds and vascular cognitive impairment

(2010) David J. Werring et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Diverse functions of protein kinase C isoforms in platelet activation and thrombus formation

(2009) M. T. HARPER et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

β-Amyloid, Blood Vessels, and Brain Function

(2009) Eric E. Smith et al.   STROKE

Amyloid beta peptide-activated signal pathways in human platelets

(2008) Ming Y. Shen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Platelet β-secretase activity is increased in Alzheimer's disease

(2006) J.A. Johnston et al.   NEUROBIOLOGY OF AGING