A top-down approach to uncover the hidden ligandome of low-density lipoprotein receptor-related protein 1 in cartilage

Cell surface nucleolin is a novel ADAMTS5 receptor mediating endothelial cell apoptosis

(2022) Dogan Can Kirman et al.   Cell Death & Disease

The low-density lipoprotein receptor-related protein 1 (LRP1) interactome in the human cornea

(2022) Emilie Hage Mogensen et al.   EXPERIMENTAL EYE RESEARCH

Deletion of Hyaluronan-Binding Protein Involved in Hyaluronan Depolymerization (HYBID) Results in Attenuation of Osteoarthritis in Mice

(2021) Masahiro Momoeda et al.   AMERICAN JOURNAL OF PATHOLOGY

Post-translational regulation and proteolytic activity of the metalloproteinase ADAMTS8

(2021) Salvatore Santamaria et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Implication of cell migration inducing hyaluronidase 1 (CEMIP) in hyaluronan degradation by synovial fibroblasts in patients with knee osteoarthritis

(2020) Jun Shiozawa et al.   AMERICAN JOURNAL OF PATHOLOGY

Hyaluronan Degradation by Cemip Regulates Host Defense against Staphylococcus aureus Skin Infection

(2020) Tatsuya Dokoshi et al.   Cell Reports

Induction of CEMIP in Chondrocytes by Inflammatory Cytokines: Underlying Mechanisms and Potential Involvement in Osteoarthritis

(2020) Takashi Ohtsuki et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

CRELD2 is a novel LRP1 chaperone that regulates non‐canonical WNT signalling in skeletal development.

(2020) Ella P. Dennis et al.   JOURNAL OF BONE AND MINERAL RESEARCH

TIMP-3 facilitates binding of target metalloproteinases to the endocytic receptor LRP-1 and promotes scavenging of MMP-1

(2020) Anna P. Carreca et al.   Scientific Reports

PANTHER version 16: a revised family classification, tree-based classification tool, enhancer regions and extensive API

(2020) Huaiyu Mi et al.   NUCLEIC ACIDS RESEARCH

ADAMTS proteases in cardiovascular physiology and disease

(2020) Salvatore Santamaria et al.   Open Biology

CEMIP (KIAA1199) induces a fibrosis-like process in osteoarthritic chondrocytes

(2019) Céline Deroyer et al.   Cell Death & Disease

KIAA1199 is a secreted molecule that enhances osteoblastic stem cell migration and recruitment

(2019) Li Chen et al.   Cell Death & Disease

Exosites in Hypervariable Loops of ADAMTS Spacer Domains control Substrate Recognition and Proteolysis

(2019) Salvatore Santamaria et al.   Scientific Reports

Knockdown of KIAA1199 suppresses IL-1β-induced cartilage degradation and inflammatory responses in human chondrocytes through the Wnt/β-catenin signalling pathway

(2019) Qian-hai Ding et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Matrix-degrading protease ADAMTS-5 cleaves inter-α-inhibitor and releases active heavy chain 2 in synovial fluids from arthritic patients

(2019) Carsten Scavenius et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hyaluronan-Binding Protein Involved in Hyaluronan Depolymerization Is Up-Regulated and Involved in Hyaluronan Degradation in Human Osteoarthritic Cartilage

(2018) Hidenori Shimizu et al.   AMERICAN JOURNAL OF PATHOLOGY

Role of the LDL Receptor-Related Protein 1 in Regulating Protease Activity and Signaling Pathways in the Vasculature

(2018) Dianaly T. Au et al.   CURRENT DRUG TARGETS

TSG-6 – a double-edged sword for osteoarthritis (OA)

(2018) C.-H. Chou et al.   OSTEOARTHRITIS AND CARTILAGE

Increased TIMP-3 expression alters the cellular secretome through dual inhibition of the metalloprotease ADAM10 and ligand-binding of the LRP-1 receptor

(2018) Simone D. Scilabra et al.   Scientific Reports

p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop

(2018) Patrick L. Leslie et al.   Cell Reports

Macrophage LRP1 Promotes Diet-Induced Hepatic Inflammation and Metabolic Dysfunction by Modulating Wnt Signaling

(2018) Dianaly T. Au et al.   MEDIATORS OF INFLAMMATION

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

(2018) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Dissecting the interaction between tissue inhibitor of metalloproteinases-3 (TIMP-3) and low density lipoprotein receptor-related protein-1 (LRP-1): Development of a “TRAP” to increase levels of TIMP-3 in the tissue

(2017) Simone D. Scilabra et al.   MATRIX BIOLOGY

HMGB proteins and arthritis

(2017) Noboru Taniguchi et al.   Human Cell

The LDL Receptor-Related Protein 1: At the Crossroads of Lipoprotein Metabolism and Insulin Signaling

(2017) Dianaly T. Au et al.   Journal of Diabetes Research

Inhibition of Shedding of Low-Density Lipoprotein Receptor-Related Protein 1 Reverses Cartilage Matrix Degradation in Osteoarthritis

(2017) Kazuhiro Yamamoto et al.   Arthritis & Rheumatology

Slit-Robo signaling

(2016) Heike Blockus et al.   DEVELOPMENT

Low density lipoprotein receptor-related protein 1 mediated endocytosis of β1-integrin influences cell adhesion and cell migration

(2016) Verena K. Rabiej et al.   EXPERIMENTAL CELL RESEARCH

LRP1 Protein Deficiency Exacerbates Palmitate-induced Steatosis and Toxicity in Hepatocytes

(2016) Allyson N. Hamlin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Engineered Tissue Inhibitor of Metalloproteinases-3 Variants Resistant to Endocytosis Have Prolonged Chondroprotective Activity

(2016) Christine M. Doherty et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MMP-13 is constitutively produced in human chondrocytes and co-endocytosed with ADAMTS-5 and TIMP-3 by the endocytic receptor LRP1

(2016) Kazuhiro Yamamoto et al.   MATRIX BIOLOGY

The Perseus computational platform for comprehensive analysis of (prote)omics data

(2016) Stefka Tyanova et al.   NATURE METHODS

LDL receptor-related protein-1 regulates NFκB and microRNA-155 in macrophages to control the inflammatory response

(2016) Elisabetta Mantuano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prosaposin is a regulator of progranulin levels and oligomerization

(2016) Alexandra M. Nicholson et al.   Nature Communications

Low-Density Lipoprotein Receptor-Related Protein-1 Protects Against Hepatic Insulin Resistance and Hepatic Steatosis

(2016) Yinyuan Ding et al.   EBioMedicine

LRP1 Regulates Retinal Angiogenesis by Inhibiting PARP-1 Activity and Endothelial Cell ProliferationSignificance

(2015) Hua Mao et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Antibody-based exosite inhibitors of ADAMTS-5 (aggrecanase-2)

(2015) S. Santamaria et al.   BIOCHEMICAL JOURNAL

Emerging targets in osteoarthritis therapy

(2015) Mary B Goldring et al.   CURRENT OPINION IN PHARMACOLOGY

Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin

(2015) Xiaolai Zhou et al.   JOURNAL OF CELL BIOLOGY

Extracellular regulation of metalloproteinases

(2015) Kazuhiro Yamamoto et al.   MATRIX BIOLOGY

Insights into osteoarthritis progression revealed by analyses of both knee tibiofemoral compartments

(2015) C.-H. Chou et al.   OSTEOARTHRITIS AND CARTILAGE

Hyaluronan molecular weight distribution is associated with the risk of knee osteoarthritis progression

(2015) P.A. Band et al.   OSTEOARTHRITIS AND CARTILAGE

Lentivirus-induced knockdown of LRP1 induces osteoarthritic-like effects and increases susceptibility to apoptosis in chondrocytes via the nuclear factor-κB pathway

(2015) ERPING YANG et al.   Experimental and Therapeutic Medicine

The Matricellular Receptor LRP1 Forms an Interface for Signaling and Endocytosis in Modulation of the Extracellular Tumor Environment

(2015) Bart Van Gool et al.   Frontiers in Pharmacology

Slit2 Inhibits Growth and Metastasis of Fibrosarcoma and Squamous Cell Carcinoma

(2015) Hee Kyung Kim et al.   NEOPLASIA

Sulfated Glycosaminoglycans Control the Extracellular Trafficking and the Activity of the Metalloprotease Inhibitor TIMP-3

(2014) Linda Troeberg et al.   CHEMISTRY & BIOLOGY

The lipoprotein receptor LRP1 modulates sphingosine-1-phosphate signaling and is essential for vascular development

(2014) C. Nakajima et al.   DEVELOPMENT

Low Density Lipoprotein Receptor-related Protein 1 (LRP1)-mediated Endocytic Clearance of a Disintegrin and Metalloproteinase with Thrombospondin Motifs-4 (ADAMTS-4)

(2014) Kazuhiro Yamamoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LRP1 Protects the Vasculature by Regulating Levels of Connective Tissue Growth Factor and HtrA1

(2013) Selen C. Muratoglu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Immobilized Heavy Chain-Hyaluronic Acid Polarizes Lipopolysaccharide-activated Macrophages toward M2 Phenotype

(2013) Hua He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

KIAA1199, a deafness gene of unknown function, is a new hyaluronan binding protein involved in hyaluronan depolymerization

(2013) H. Yoshida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct Proteomic Quantification of the Secretome of Activated Immune Cells

(2013) F. Meissner et al.   SCIENCE

Murine homologue of the human KIAA1199 is implicated in hyaluronan binding and depolymerization

(2013) Hiroyuki Yoshida et al.   FEBS Open Bio

LRP-1-mediated endocytosis regulates extracellular activity of ADAMTS-5 in articular cartilage

(2012) Kazuhiro Yamamoto et al.   FASEB JOURNAL

Identification of the Low Density Lipoprotein (LDL) Receptor-related Protein-1 Interactome in Central Nervous System Myelin Suggests a Role in the Clearance of Necrotic Cell Debris

(2012) Anthony Fernandez-Castaneda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Regulation of Extracellular Tissue Inhibitor of Metalloproteinases-3 Levels by Cell Membrane-bound and Shed Low Density Lipoprotein Receptor-related Protein 1

(2012) Simone D. Scilabra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteases involved in cartilage matrix degradation in osteoarthritis

(2011) Linda Troeberg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

IGFBP7 reduces breast tumor growth by induction of senescence and apoptosis pathways

(2011) Tania Benatar et al.   BREAST CANCER RESEARCH AND TREATMENT

Cell cholesterol modulates metalloproteinase-dependent shedding of low-density lipoprotein receptor-related protein-1 (LRP-1) and clearance function

(2011) Charlotte Selvais et al.   FASEB JOURNAL

Proteolytic Cleavage of Versican During Limb Joint Development

(2010) Anthony A. Capehart   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Hepatocyte growth factor activator (HGFA): pathophysiological functions in vivo

(2010) Hiroaki Kataoka et al.   FEBS Journal

Hepatocyte growth factor activator (HGFA): a serine protease that links tissue injury to activation of hepatocyte growth factor

(2010) Keiji Miyazawa   FEBS Journal

Pro-cathepsin D interacts with the extracellular domain of the   chain of LRP1 and promotes LRP1-dependent fibroblast outgrowth

(2010) M. Beaujouin et al.   JOURNAL OF CELL SCIENCE

Inflammatory mediators promote production of shed LRP1/CD91, which regulates cell signaling and cytokine expression by macrophages

(2010) Matvey Gorovoy et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Insulin-Like Growth Factor-Binding Protein 7 Regulates Keratinocyte Proliferation, Differentiation and Apoptosis

(2009) Janna Nousbeck et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Aging-related loss of the chromatin protein HMGB2 in articular cartilage is linked to reduced cellularity and osteoarthritis

(2009) N. Taniguchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chromatin protein HMGB2 regulates articular cartilage surface maintenance via  -catenin pathway

(2009) N. Taniguchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calcium pentosan polysulfate is a multifaceted exosite inhibitor of aggrecanases

(2008) Linda Troeberg et al.   FASEB JOURNAL

LRP1 Controls Intracellular Cholesterol Storage and Fatty Acid Synthesis through Modulation of Wnt Signaling

(2008) Jérome Terrand et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LRP-1 Silencing Prevents Malignant Cell Invasion despite Increased Pericellular Proteolytic Activities

(2008) S. Dedieu et al.   MOLECULAR AND CELLULAR BIOLOGY