Engineered Tissue Inhibitor of Metalloproteinases-3 Variants Resistant to Endocytosis Have Prolonged Chondroprotective Activity

Tissue inhibitor of metalloproteinase-3 (TIMP3) promotes endothelial apoptosis via a caspase-independent mechanism

(2015) Jian Hua Qi et al.   APOPTOSIS

Factor VIII Interacts with the Endocytic Receptor Low-density Lipoprotein Receptor-related Protein 1 via an Extended Surface Comprising “Hot-Spot” Lysine Residues

(2015) Maartje van den Biggelaar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interleukin-1 Acts via the JNK-2 Signaling Pathway to Induce Aggrecan Degradation by Human Chondrocytes

(2015) Heba M. Ismail et al.   Arthritis & Rheumatology

Sulfated Glycosaminoglycans Control the Extracellular Trafficking and the Activity of the Metalloprotease Inhibitor TIMP-3

(2014) Linda Troeberg et al.   CHEMISTRY & BIOLOGY

The heparin-binding growth factor midkine: the biological activities and candidate receptors

(2013) K. Kadomatsu et al.   JOURNAL OF BIOCHEMISTRY

Quantitative Dissection of the Binding Contributions of Ligand Lysines of the Receptor-associated Protein (RAP) to the Low Density Lipoprotein Receptor-related Protein (LRP1)

(2013) Klavs Dolmer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pentosan polysulfate increases affinity between ADAMTS-5 and TIMP-3 through formation of an electrostatically driven trimolecular complex

(2012) Linda Troeberg et al.   BIOCHEMICAL JOURNAL

LRP-1-mediated endocytosis regulates extracellular activity of ADAMTS-5 in articular cartilage

(2012) Kazuhiro Yamamoto et al.   FASEB JOURNAL

Differential Regulation of Extracellular Tissue Inhibitor of Metalloproteinases-3 Levels by Cell Membrane-bound and Shed Low Density Lipoprotein Receptor-related Protein 1

(2012) Simone D. Scilabra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

C1 domain residues Lys 2092 and Phe 2093 are of major importance for the endocytic uptake of coagulation factor VIII

(2011) Henriët Meems et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Glycosaminoglycans from aged human hippocampus have altered capacities to regulate trophic factors activities but not Aβ42 peptide toxicity

(2011) Minh Bao Huynh et al.   NEUROBIOLOGY OF AGING

Reactive-site mutants of N-TIMP-3 that selectively inhibit ADAMTS-4 and ADAMTS-5: biological and structural implications

(2010) Ngee H. Lim et al.   BIOCHEMICAL JOURNAL

Characterization of TIMP-3 in human articular talar cartilage

(2010) Kirsten J. Morris et al.   CONNECTIVE TISSUE RESEARCH

A single lysine of the two-lysine recognition motif of the D3 domain of receptor-associated protein is sufficient to mediate endocytosis by low-density lipoprotein receptor-related protein

(2010) Maartje van den Biggelaar et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Specificity of Binding of the Low Density Lipoprotein Receptor-related Protein to Different Conformational States of the Clade E Serpins Plasminogen Activator Inhibitor-1 and Proteinase Nexin-1

(2009) Jan K. Jensen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The C-terminal domains of ADAMTS-4 and ADAMTS-5 promote association with N-TIMP-3

(2009) Linda Troeberg et al.   MATRIX BIOLOGY

Trichloroacetic acid-induced protein precipitation involves the reversible association of a stable partially structured intermediate

(2009) Dakshinamurthy Rajalingam et al.   PROTEIN SCIENCE

Glycanogenomics: A qPCR-approach to investigate biological glycan function

(2008) Evelyn C. Krenn et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Calcium pentosan polysulfate is a multifaceted exosite inhibitor of aggrecanases

(2008) Linda Troeberg et al.   FASEB JOURNAL

Structural Determinants of the ADAM Inhibition by TIMP-3: Crystal Structure of the TACE-N-TIMP-3 Complex

(2008) Magdalena Wisniewska et al.   JOURNAL OF MOLECULAR BIOLOGY