Slit-Robo signaling

Suppression of Slit2/Robo1 mediated HUVEC migration by Robo4

(2016) Satoshi Enomoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Calsyntenin 1-mediated trafficking of axon guidance receptors regulates the switch in axonal responsiveness at a choice point

(2016) Tobias A. Alther et al.   DEVELOPMENT

Recombinant Slit2 attenuates neuroinflammation after surgical brain injury by inhibiting peripheral immune cell infiltration via Robo1-srGAP1 pathway in a rat model

(2016) Prativa Sherchan et al.   NEUROBIOLOGY OF DISEASE

The differential roles of Slit2-exon 15 splicing variants in angiogenesis and HUVEC permeability

(2015) Yun-Chiu Yang et al.   ANGIOGENESIS

Disrupted Slit-Robo signalling results in membranous ventricular septum defects and bicuspid aortic valves

(2015) Mathilda T.M. Mommersteeg et al.   CARDIOVASCULAR RESEARCH

Slit and Receptor Tyrosine Phosphatase 69D Confer Spatial Specificity to Axon Branching via Dscam1

(2015) Dan Dascenco et al.   CELL

Targeting NCK-Mediated Endothelial Cell Front-Rear Polarity Inhibits NeovascularizationCLINICAL PERSPECTIVE

(2015) Alexandre Dubrac et al.   CIRCULATION

Slit cleavage is essential for producing an active, stable, non-diffusible short-range signal that guides muscle migration

(2015) E. Ordan et al.   DEVELOPMENT

A non-signaling role of Robo2 in tendons is essential for Slit processing and muscle patterning

(2015) Elly Ordan et al.   DEVELOPMENT

ROBO2 restricts the nephrogenic field and regulates Wolffian duct–nephrogenic cord separation

(2015) Elanor N. Wainwright et al.   DEVELOPMENTAL BIOLOGY

SrGAP2-Dependent Integration of Membrane Geometry and Slit-Robo-Repulsive Cues Regulates Fibroblast Contact Inhibition of Locomotion

(2015) Rafael Dominik Fritz et al.   DEVELOPMENTAL CELL

Mutations of the SLIT2–ROBO2 pathway genes SLIT2 and SRGAP1 confer risk for congenital anomalies of the kidney and urinary tract

(2015) Daw-Yang Hwang et al.   HUMAN GENETICS

Myo9b is a key player in SLIT/ROBO-mediated lung tumor suppression

(2015) Ruirui Kong et al.   JOURNAL OF CLINICAL INVESTIGATION

Slit2 signaling through Robo1 and Robo2 is required for retinal neovascularization

(2015) Nicolas Rama et al.   NATURE MEDICINE

Operational redundancy in axon guidance through the multifunctional receptor Robo3 and its ligand NELL2

(2015) A. Jaworski et al.   SCIENCE

Robo1/2 regulate follicle atresia through manipulating granulosa cell apoptosis in mice

(2015) Jiangchao Li et al.   Scientific Reports

Mammary Stem Cell Self-Renewal Is Regulated by Slit2/Robo1 Signaling through SNAI1 and mINSC

(2015) Mimmi S. Ballard et al.   Cell Reports

Slit-Dependent Endocytic Trafficking of the Robo Receptor Is Required for Son of Sevenless Recruitment and Midline Axon Repulsion

(2015) Rebecca K. Chance et al.   PLoS Genetics

Robo2 acts in trans to inhibit Slit-Robo1 repulsion in pre-crossing commissural axons

(2015) Timothy A Evans et al.   eLife

Slit2N and Robo4 regulate lymphangiogenesis through the VEGF-C/VEGFR-3 pathway

(2014) Jinlong Yu et al.   Cell Communication and Signaling

Convergent differential regulation of SLIT-ROBO axon guidance genes in the brains of vocal learners

(2014) Rui Wang et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Crystal structure of the extracellular juxtamembrane region of Robo1

(2014) Reut Barak et al.   JOURNAL OF STRUCTURAL BIOLOGY

PlexinA1 is a new Slit receptor and mediates axon guidance function of Slit C-terminal fragments

(2014) Céline Delloye-Bourgeois et al.   NATURE NEUROSCIENCE

Signaling Switch of the Axon Guidance Receptor Robo3 during Vertebrate Evolution

(2014) Pavol Zelina et al.   NEURON

Slit/Robo Signaling Regulates Cell Fate Decisions in the Intestinal Stem Cell Lineage of Drosophila

(2014) Benoît Biteau et al.   Cell Reports

Coordinate Regulation of Stem Cell Competition by Slit-Robo and JAK-STAT Signaling in the Drosophila Testis

(2014) Rachel R. Stine et al.   PLoS Genetics

SLIT/ROBO2 Signaling Promotes Mammary Stem Cell Senescence by Inhibiting Wnt Signaling

(2014) Gwyndolen Harburg et al.   Stem Cell Reports

Characterization of the interaction between Robo1 and heparin and other glycosaminoglycans

(2013) Fuming Zhang et al.   BIOCHIMIE

Regulation of Axon Guidance by Compartmentalized Nonsense-Mediated mRNA Decay

(2013) Dilek Colak et al.   CELL

Distinct functional domains of the Abelson tyrosine kinase control axon guidance responses to Netrin and Slit to regulate the assembly of neural circuits

(2013) Michael P. O’Donnell et al.   DEVELOPMENT

Roundabout Receptors Are Critical for Foregut Separation from the Body Wall

(2013) Eric Thomas Domyan et al.   DEVELOPMENTAL CELL

Requirement for commissureless2 function during dipteran insect nerve cord development

(2013) Joseph Sarro et al.   DEVELOPMENTAL DYNAMICS

Collaborative and Specialized Functions of Robo1 and Robo2 in Spinal Commissural Axon Guidance

(2013) A. Jaworski et al.   JOURNAL OF NEUROSCIENCE

The Expression Pattern of EVA1C, a Novel Slit Receptor, Is Consistent with an Axon Guidance Role in the Mouse Nervous System

(2013) Gregory James et al.   PLoS One

Slit–Roundabout Signaling Regulates the Development of the Cardiac Systemic Venous Return and Pericardium

(2012) Mathilda T.M. Mommersteeg et al.   CIRCULATION RESEARCH

Slit/Robo-mediated axon guidance in Tribolium and Drosophila: Divergent genetic programs build insect nervous systems

(2012) Timothy A. Evans et al.   DEVELOPMENTAL BIOLOGY

Autocrine/juxtaparacrine regulation of axon fasciculation by Slit-Robo signaling

(2012) Alexander Jaworski et al.   NATURE NEUROSCIENCE

RabGDI controls axonal midline crossing by regulating Robo1 surface expression

(2012) Melanie Philipp et al.   Neural Development

Dystroglycan Organizes Axon Guidance Cue Localization and Axonal Pathfinding

(2012) Kevin M. Wright et al.   NEURON

Slit/Robo Signaling Modulates the Proliferation of Central Nervous System Progenitors

(2012) Víctor Borrell et al.   NEURON

Inhibitory Effects of Robo2 on Nephrin: A Crosstalk between Positive and Negative Signals Regulating Podocyte Structure

(2012) Xueping Fan et al.   Cell Reports

Assembly of Lamina-Specific Neuronal Connections by Slit Bound to Type IV Collagen

(2011) Tong Xiao et al.   CELL

Presenilin-Dependent Receptor Processing Is Required for Axon Guidance

(2011) Ge Bai et al.   CELL

Erratum: Slit-Robo signaling induces malignant transformation through Hakai-mediated E-cadherin degradation during colorectal epithelial cell carcinogenesis

(2011) Wei-Jie Zhou et al.   CELL RESEARCH

Robo4 Cooperates with Cxcr4 to Specify Hematopoietic Stem Cell Localization to Bone Marrow Niches

(2011) Stephanie Smith-Berdan et al.   Cell Stem Cell

SLIT/ROBO1 Signaling Suppresses Mammary Branching Morphogenesis by Limiting Basal Cell Number

(2011) Hector Macias et al.   DEVELOPMENTAL CELL

Robo4 Maintains Vessel Integrity and Inhibits Angiogenesis by Interacting with UNC5B

(2011) Alexander W. Koch et al.   DEVELOPMENTAL CELL

The adaptor protein Nck2 mediates Slit1-induced changes in cortical neuron morphology

(2011) Jennifer E. Round et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

SLIT2 Attenuation during Lung Cancer Progression Deregulates  -Catenin and E-Cadherin and Associates with Poor Prognosis

(2010) R.-C. Tseng et al.   CANCER RESEARCH

Distinct Protein Domains and Expression Patterns Confer Divergent Axon Guidance Functions for Drosophila Robo Receptors

(2010) Bettina Spitzweck et al.   CELL

The Adam family metalloprotease Kuzbanian regulates the cleavage of the roundabout receptor to control axon repulsion at the midline

(2010) H. A. Coleman et al.   DEVELOPMENT

Human ROBO1 is cleaved by metalloproteinases and γ-secretase and migrates to the nucleus in cancer cells

(2010) Motoaki Seki et al.   FEBS LETTERS

Structure and functional relevance of the Slit2 homodimerization domain

(2009) Elena Seiradake et al.   EMBO REPORTS

Unidirectional startle responses and disrupted left-right co-ordination of motor behaviors inrobo3mutant zebrafish

(2009) H. A. Burgess et al.   GENES BRAIN AND BEHAVIOR

Slit2–Robo4 signalling promotes vascular stability by blocking Arf6 activity

(2009) Christopher A. Jones et al.   NATURE CELL BIOLOGY

Midline crossing and Slit responsiveness of commissural axons require USP33

(2009) Junichi Yuasa-Kawada et al.   NATURE NEUROSCIENCE

Structural insight into Slit–Robo signalling

(2008) Erhard Hohenester   BIOCHEMICAL SOCIETY TRANSACTIONS

SLITs Suppress Tumor Growth In vivo by Silencing Sdf1/Cxcr4 within Breast Epithelium

(2008) R. Marlow et al.   CANCER RESEARCH

Active involvement of Robo1 and Robo4 in filopodia formation and endothelial cell motility mediated via WASP and other actin nucleation-promoting factors

(2008) Helen Sheldon et al.   FASEB JOURNAL

Slit-2 Induces a Tumor-suppressive Effect by Regulating β-Catenin in Breast Cancer Cells

(2008) Anil Prasad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alternative Splicing of the Robo3 Axon Guidance Receptor Governs the Midline Switch from Attraction to Repulsion

(2008) Zhe Chen et al.   NEURON

Functional MRI, DTI and neurophysiology in horizontal gaze palsy with progressive scoliosis

(2008) Sven Haller et al.   NEURORADIOLOGY

Improvement of molecular phylogenetic inference and the phylogeny of Bilateria

(2008) N. Lartillot et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Redundant Mechanisms for Regulation of Midline Crossing in Drosophila

(2008) Giorgio F. Gilestro   PLoS One