Using mass spectrometry‐based methods to understand amyloid formation and inhibition of alpha‐synuclein and amyloid beta

The amyloid hypothesis in Alzheimer disease: new insights from new therapeutics

(2022) Eric Karran et al.   NATURE REVIEWS DRUG DISCOVERY

Mass Spectrometry Methods for Measuring Protein Stability

(2022) Daniel D. Vallejo et al.   CHEMICAL REVIEWS

Advances in mass spectrometry‐based footprinting of membrane proteins

(2022) Jie Sun et al.   PROTEOMICS

Catalytic Cross Talk between Key Peptide Fragments That Couple Alzheimer’s Disease with Amyotrophic Lateral Sclerosis

(2021) Veronica Laos et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pulsed Hydrogen–Deuterium Exchange Reveals Altered Structures and Mechanisms in the Aggregation of Familial Alzheimer’s Disease Mutants

(2021) Eva Illes-Toth et al.   ACS Chemical Neuroscience

The differential solvent exposure of N-terminal residues provides ‘fingerprints’ of alpha-synuclein fibrillar polymorphs

(2021) Maud Landureau et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enhancing Top-Down Proteomics of Brain Tissue with FAIMS

(2021) James M. Fulcher et al.   JOURNAL OF PROTEOME RESEARCH

Conformational Dynamics of α-Synuclein during the Interaction with Phospholipid Nanodiscs by Millisecond Hydrogen–Deuterium Exchange Mass Spectrometry

(2021) Irina Oganesyan et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Protein–Small Molecule Interactions in Native Mass Spectrometry

(2021) Jack L. Bennett et al.   CHEMICAL REVIEWS

In-Cell Labeling and Mass Spectrometry for Systems-Level Structural Biology

(2021) Juan D. Chavez et al.   CHEMICAL REVIEWS

Advances in Hydrogen/Deuterium Exchange Mass Spectrometry and the Pursuit of Challenging Biological Systems

(2021) Ellie I. James et al.   CHEMICAL REVIEWS

Structural and mechanistic insights into amyloid‐β and α‐synuclein fibril formation and polyphenol inhibitor efficacy in phospholipid bilayers

(2021) Henry M. Sanders et al.   FEBS Journal

The role of amyloid oligomers in neurodegenerative pathologies

(2021) Cameron Wells et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Fenton-Chemistry-Based Oxidative Modification of Proteins Reflects Their Conformation

(2021) Thomas Nehls et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cross-Linking Mass Spectrometry for Investigating Protein Conformations and Protein–Protein Interactions─A Method for All Seasons

(2021) Lolita Piersimoni et al.   CHEMICAL REVIEWS

Hydroxyl Radical Protein Footprinting: A Mass Spectrometry-Based Structural Method for Studying the Higher Order Structure of Proteins

(2021) Alan McKenzie-Coe et al.   CHEMICAL REVIEWS

Protein Chemistry Combined with Mass Spectrometry for Protein Structure Determination

(2021) Evgeniy V. Petrotchenko et al.   CHEMICAL REVIEWS

Applications of Charge Detection Mass Spectrometry in Molecular Biology and Biotechnology

(2021) Martin F. Jarrold   CHEMICAL REVIEWS

Sclerotiorin Stabilizes the Assembly of Nonfibrillar Abeta42 Oligomers with Low Toxicity, Seeding Activity, and Beta-sheet Content

(2020) Thomas Wiglenda et al.   JOURNAL OF MOLECULAR BIOLOGY

Higher-Order Structure Influences the Kinetics of Diethylpyrocarbonate Covalent Labeling of Proteins

(2020) Xiao Pan et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

A Multifunctional Chemical Agent as an Attenuator of Amyloid Burden and Neuroinflammation in Alzheimer’s Disease

(2020) Hong-Jun Cho et al.   ACS Chemical Neuroscience

Rationally Designed Peptide-Based Inhibitor of Aβ42 Fibril Formation and Toxicity: A Potential Therapeutic Strategy for Alzheimer’s Disease

(2020) John Robert Horsley et al.   BIOCHEMICAL JOURNAL

Mass Spectrometry-Based Protein Footprinting for Higher-Order Structure Analysis: Fundamentals and Applications

(2020) Xiaoran Roger Liu et al.   CHEMICAL REVIEWS

Amyloid β-protein and beyond: the path forward in Alzheimer’s disease

(2020) Dominic M Walsh et al.   CURRENT OPINION IN NEUROBIOLOGY

Applications of Mass Spectrometry in the Onset of Amyloid Fibril Formation: Focus on the Analysis of Early-Stage Oligomers

(2020) Jiaojiao Hu et al.   Frontiers in Chemistry

Amide derivatives of Gallic acid: Design, synthesis and evaluation of inhibitory activities against in vitro α-synuclein aggregation

(2020) Li Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Effects of Detergent on α-Synuclein Structure. A Native MS-Ion Mobility Study

(2020) Rani Moons et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Crocus-derived compounds alter the aggregation pathway of Alzheimer’s Disease: associated beta amyloid protein

(2020) Nikolaos Stavros Koulakiotis et al.   Scientific Reports

Metal ions shape α-synuclein

(2020) Rani Moons et al.   Scientific Reports

Structural rearrangement of amyloid-β upon inhibitor binding suppresses formation of Alzheimer disease related oligomers

(2020) Tobias Lieblein et al.   eLife

Solution Condition-Dependent Formation of Gas-Phase Protomers of Alpha-Synuclein in Electrospray Ionization

(2020) Frederik Lermyte et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

C-Phycocyanin from Spirulina Inhibits α-Synuclein and Amyloid-β Fibril Formation but Not Amorphous Aggregation

(2019) Yanqin Liu et al.   JOURNAL OF NATURAL PRODUCTS

Methionine oxidation in α-synuclein inhibits its propensity for ordered secondary structure

(2019) Erika Ponzini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Native Ion Mobility-Mass Spectrometry reveals the formation of β-barrel shaped Amyloid-β hexamers in a membrane-mimicking environment

(2019) Nicklas Österlund et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Anti-oligomerization sheet molecules: Design, synthesis and evaluation of inhibitory activities against α-synuclein aggregation

(2019) Hao Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Fast photochemical oxidation of proteins(FPOP): A powerful mass spectrometry based structural proteomics tool

(2019) Danté T Johnson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metal Ion Binding to the Amyloid β Monomer Studied by Native Top-Down FTICR Mass Spectrometry

(2019) Frederik Lermyte et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Ion mobility spectrometry combined with multivariate statistical analysis: revealing the effects of a drug candidate for Alzheimer’s disease on Aβ1-40 peptide early assembly

(2019) Serena Lazzaro et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Advanced analytical methodologies in Alzheimer’s disease drug discovery

(2019) Angela De Simone et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Application of native mass spectrometry in studying intrinsically disordered proteins: A special focus on neurodegenerative diseases

(2019) Gopa Mitra   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Hydrogen-Deuterium Exchange and Hydroxyl Radical Footprinting for Mapping Hydrophobic Interactions of Human Bromodomain with a Small Molecule Inhibitor

(2019) Ke Sherry Li et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

SERF engages in a fuzzy complex that accelerates primary nucleation of amyloid proteins

(2019) Ben A. Meinen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How Western Diet And Lifestyle Drive The Pandemic Of Obesity And Civilization Diseases

(2019) Wolfgang Kopp   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Subresidue-Resolution Footprinting of Ligand–Protein Interactions by Carbene Chemistry and Ion Mobility–Mass Spectrometry

(2019) Gaoyuan Lu et al.   ANALYTICAL CHEMISTRY

Mass Spectrometry-Based Fast Photochemical Oxidation of Proteins (FPOP) for Higher Order Structure Characterization

(2018) Ke Sherry Li et al.   ACCOUNTS OF CHEMICAL RESEARCH

Pulsed Hydrogen–Deuterium Exchange Illuminates the Aggregation Kinetics of α-Synuclein, the Causative Agent for Parkinson’s Disease

(2018) Eva Illes-Toth et al.   ACS Chemical Neuroscience

Direct Evidence of the Presence of Cross-Linked Aβ Dimers in the Brains of Alzheimer’s Disease Patients

(2018) Aurelio Vázquez de la Torre et al.   ANALYTICAL CHEMISTRY

Different Structural Conformers of Monomeric α-Synuclein Identified after Lyophilizing and Freezing

(2018) Amberley D. Stephens et al.   ANALYTICAL CHEMISTRY

Cross-Linking/Mass Spectrometry for Studying Protein Structures and Protein-Protein Interactions: Where Are We Now and Where Should We Go from Here?

(2018) Andrea Sinz   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Isoindole Linkages Provide a Pathway for DOPAL-Mediated Cross-Linking of α-Synuclein

(2018) Jonathan W. Werner-Allen et al.   BIOCHEMISTRY

Structural characterisation of medically relevant protein assemblies by integrating mass spectrometry with computational modelling

(2018) Argyris Politis et al.   Journal of Proteomics

Inhibiting and Remodeling Toxic Amyloid-Beta Oligomer Formation Using a Computationally Designed Drug Molecule That Targets Alzheimer’s Disease

(2018) Matthew A. Downey et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Covalent labeling-mass spectrometry with non-specific reagents for studying protein structure and interactions

(2018) Patanachai Limpikirati et al.   METHODS

Distal amyloid β-protein fragments template amyloid assembly

(2018) Thanh D. Do et al.   PROTEIN SCIENCE

Mass and charge distributions of amyloid fibers involved in neurodegenerative diseases: mapping heterogeneity and polymorphism

(2018) Jonathan Pansieri et al.   Chemical Science

Molecular Role of Ca2+ and Hard Divalent Metal Cations on Accelerated Fibrillation and Interfibrillar Aggregation of α-Synuclein

(2018) Jong Yoon Han et al.   Scientific Reports

Exploring the Structural Diversity in Inhibitors of α-Synuclein Amyloidogenic Folding, Aggregation, and Neurotoxicity

(2018) Sukanya Das et al.   Frontiers in Chemistry

Discovery and Identification of an Endogenous Metabolite of Tramiprosate and Its Prodrug ALZ-801 that Inhibits Beta Amyloid Oligomer Formation in the Human Brain

(2018) John A. Hey et al.   CNS DRUGS

Rationally designed divalent caffeic amides inhibit amyloid-β fibrillization, induce fibril dissociation, and ameliorate cytotoxicity

(2018) Ling-Hsien Tu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Side-chain moieties from the N-terminal region of Aβ are Involved in an oligomer-stabilizing network of interactions

(2018) Kaja Przygońska et al.   PLoS One

Cryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel

(2018) Binsen Li et al.   Nature Communications

A Novel Crosslinking Protocol Stabilizes Amyloid β Oligomers Capable of Inducing Alzheimer's-Associated Pathologies

(2018) Erika N. Cline et al.   JOURNAL OF NEUROCHEMISTRY

Copper Induced Radical Dimerization of α-Synuclein Requires Histidine

(2018) Dinendra L. Abeyawardhane et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cross-linking mass spectrometry: methods and applications in structural, molecular and systems biology

(2018) Francis J. O’Reilly et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Chemical Generation of Hydroxyl Radical for Oxidative Footprinting

(2018) Michael Brenowitz et al.   PROTEIN AND PEPTIDE LETTERS

Chemical cross-linking with mass spectrometry: a tool for systems structural biology

(2018) Juan D Chavez et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

1,2,3,4,6-penta- O -galloyl-β- d -glucopyranose binds to the N-terminal metal binding region to inhibit amyloid β -protein oligomer and fibril formation

(2017) Natália E.C. de Almeida et al.   INTERNATIONAL JOURNAL OF MASS SPECTROMETRY

Modulation of the extent of structural heterogeneity in α-synuclein fibrils by the small molecule thioflavin T

(2017) Harish Kumar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Insights into Human Serum Albumin as a Receptor of Amyloid-β in the Extracellular Region

(2017) Tae Su Choi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fibril structure of amyloid-β(1–42) by cryo–electron microscopy

(2017) Lothar Gremer et al.   SCIENCE

Opposite Structural Effects of Epigallocatechin-3-gallate and Dopamine Binding to α-Synuclein

(2016) Albert Konijnenberg et al.   ANALYTICAL CHEMISTRY

Copper Binding and Subsequent Aggregation of α-Synuclein Are Modulated by N-Terminal Acetylation and Ablated by the H50Q Missense Mutation

(2016) Rebecca J. Mason et al.   BIOCHEMISTRY

Protein aggregation and neurodegenerative diseases: From theory to therapy

(2016) Vijay Kumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

C-Terminal Threonine Reduces Aβ 43 Amyloidogenicity Compared with Aβ 42

(2016) Saketh Chemuru et al.   JOURNAL OF MOLECULAR BIOLOGY

The novel isotopically coded short-range photo-reactive crosslinker 2,4,6-triazido-1,3,5-triazine (TATA) for studying protein structures

(2016) Nicholas I. Brodie et al.   Journal of Proteomics

Conformational-Sensitive Fast Photochemical Oxidation of Proteins and Mass Spectrometry Characterize Amyloid Beta 1–42 Aggregation

(2016) Ke Sherry Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Amyloid β-Protein C-Terminal Fragments: Formation of Cylindrins and β-Barrels

(2016) Thanh D. Do et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

ESI-IMS–MS: A method for rapid analysis of protein aggregation and its inhibition by small molecules

(2016) Lydia M. Young et al.   METHODS

Recent Advances and Applications in Synchrotron X-Ray Protein Footprinting for Protein Structure and Dynamics Elucidation

(2016) Sayan Gupta et al.   PROTEIN AND PEPTIDE LETTERS

Carbene footprinting accurately maps binding sites in protein–ligand and protein–protein interactions

(2016) Lucio Manzi et al.   Nature Communications

Structure-mechanism-based engineering of chemical regulators targeting distinct pathological factors in Alzheimer’s disease

(2016) Michael W. Beck et al.   Nature Communications

The involvement of dityrosine crosslinking in α-synuclein assembly and deposition in Lewy Bodies in Parkinson’s disease

(2016) Youssra K. Al-Hilaly et al.   Scientific Reports

The Impact of the ‘Austrian’ Mutation of the Amyloid Precursor Protein Transmembrane Helix is Communicated to the Hinge Region

(2016) Walter Stelzer et al.   ChemistrySelect

Role of Species-Specific Primary Structure Differences in Aβ42 Assembly and Neurotoxicity

(2015) Robin Roychaudhuri et al.   ACS Chemical Neuroscience

Opposing Effects of Cucurbit[7]uril and 1,2,3,4,6-Penta-O-galloyl-β-d-glucopyranose on Amyloid β25–35 Assembly

(2015) Natália E. C. de Almeida et al.   ACS Chemical Neuroscience

Amyloid β-Protein Assembly: Differential Effects of the Protective A2T Mutation and Recessive A2V Familial Alzheimer’s Disease Mutation

(2015) Xueyun Zheng et al.   ACS Chemical Neuroscience

Conformational dynamics of α-synuclein: insights from mass spectrometry

(2015) Ashley S. Phillips et al.   ANALYST

Review on Ion Mobility Spectrometry. Part 1: current instrumentation

(2015) R. Cumeras et al.   ANALYST

Distinct higher-order α-synuclein oligomers induce intracellular aggregation

(2015) Eva Illes-Toth et al.   BIOCHEMICAL JOURNAL

Oxidative footprinting in the study of structure and function of membrane proteins: current state and perspectives

(2015) V. N. Bavro et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Single-Particle Cryo-EM at Crystallographic Resolution

(2015) Yifan Cheng   CELL

Inhibition of protein aggregation and amyloid formation by small molecules

(2015) Andrew J Doig et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Ion Mobility—Mass Spectrometry-Based Screening for Inhibition of α-Synuclein Aggregation

(2015) Yanqin Liu et al.   EUROPEAN JOURNAL OF MASS SPECTROMETRY

Re-print of “Ion Mobility Spectrometry: A Personal View of its Development at UCSB”

(2015) Michael T. Bowers   INTERNATIONAL JOURNAL OF MASS SPECTROMETRY

Amyloid β-Protein Assembly: The Effect of Molecular Tweezers CLR01 and CLR03

(2015) Xueyun Zheng et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Mechanism of C-Terminal Fragments of Amyloid β-Protein as Aβ Inhibitors: Do C-Terminal Interactions Play a Key Role in Their Inhibitory Activity?

(2015) Xueyun Zheng et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Isotopically-coded short-range hetero-bifunctional photo-reactive crosslinkers for studying protein structure

(2015) Nicholas I. Brodie et al.   Journal of Proteomics

The Effect of Glycosaminoglycans (GAGs) on Amyloid Aggregation and Toxicity

(2015) Clara Iannuzzi et al.   MOLECULES

On the lag phase in amyloid fibril formation

(2015) Paolo Arosio et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Relating gas phase to solution conformations: Lessons from disordered proteins

(2015) Rebecca Beveridge et al.   PROTEOMICS

SDS-PAGE analysis of Aβ oligomers is disserving research into Alzheimer´s disease: appealing for ESI-IM-MS

(2015) Rosa Pujol-Pina et al.   Scientific Reports

Hydrogen/Deuterium Exchange-Protected Oligomers Populated during Aβ Fibril Formation Correlate with Neuronal Cell Death

(2014) Bernat Serra-Vidal et al.   ACS Chemical Biology

A Mass-Spectrometry-Based Framework To Define the Extent of Disorder in Proteins

(2014) Rebecca Beveridge et al.   ANALYTICAL CHEMISTRY

Probing Conformational Change of Intrinsically Disordered α-Synuclein to Helical Structures by Distinctive Regional Interactions with Lipid Membranes

(2014) Shin Jung C. Lee et al.   ANALYTICAL CHEMISTRY

Co-existence of Two Different α-Synuclein Oligomers with Different Core Structures Determined by Hydrogen/Deuterium Exchange Mass Spectrometry

(2014) Wojciech Paslawski et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Synchrotron-Based Hydroxyl Radical Footprinting Analysis of Amyloid Fibrils and Prefibrillar Intermediates with Residue-Specific Resolution

(2014) Alexandra L. Klinger et al.   BIOCHEMISTRY

Gallic acid interacts with α-synuclein to prevent the structural collapse necessary for its aggregation

(2014) Yanqin Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Differences between amyloid-β aggregation in solution and on the membrane: insights into elucidation of the mechanistic details of Alzheimer's disease

(2014) Samuel A. Kotler et al.   CHEMICAL SOCIETY REVIEWS

The triple power of D³: Protein intrinsic disorder in degenerative diseases

(2014) Vladimir Uversky   Frontiers in Bioscience-Landmark

Factors Influencing Compact–Extended Structure Equilibrium in Oligomers of Aβ1–40 Peptide—An Ion Mobility Mass Spectrometry Study

(2014) Ewa Sitkiewicz et al.   JOURNAL OF MOLECULAR BIOLOGY

Gly25-Ser26 Amyloid β-Protein Structural Isomorphs Produce Distinct Aβ42 Conformational Dynamics and Assembly Characteristics

(2014) Robin Roychaudhuri et al.   JOURNAL OF MOLECULAR BIOLOGY

Alzheimer's disease: The forgetting gene

(2014) Laura Spinney   NATURE

Chemistry: Chemical con artists foil drug discovery

(2014) Jonathan Baell et al.   NATURE

Screening and classifying small-molecule inhibitors of amyloid formation using ion mobility spectrometry–mass spectrometry

(2014) Lydia M. Young et al.   Nature Chemistry

Di-Tyrosine Cross-Link Decreases the Collisional Cross-Section of Aβ Peptide Dimers and Trimers in the Gas Phase: An Ion Mobility Study

(2014) Ewa Sitkiewicz et al.   PLoS One

Analysis of Disordered Proteins Using a Simple Apparatus for Millisecond Quench-Flow H/D Exchange

(2013) Theodore R. Keppel et al.   ANALYTICAL CHEMISTRY

Characterizing the Dynamics of α-Synuclein Oligomers Using Hydrogen/Deuterium Exchange Monitored by Mass Spectrometry

(2013) Simon Mysling et al.   BIOCHEMISTRY

Native mass spectrometry of photosynthetic pigment-protein complexes

(2013) Hao Zhang et al.   FEBS LETTERS

Molecular Mechanism of the Inhibition of EGCG on the Alzheimer Aβ1–42 Dimer

(2013) Tong Zhang et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Rational Design of a Structural Framework with Potential Use to Develop Chemical Reagents That Target and Modulate Multiple Facets of Alzheimer’s Disease

(2013) Sanghyun Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ion Mobility Spectrometry Reveals the Mechanism of Amyloid Formation of Aβ(25–35) and Its Modulation by Inhibitors at the Molecular Level: Epigallocatechin Gallate and Scyllo-inositol

(2013) Christian Bleiholder et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Binding of Dopamine to Alpha-Synuclein is Mediated by Specific Conformational States

(2013) Eva Illes-Toth et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Novel insights into protein misfolding diseases revealed by ion mobility-mass spectrometry

(2013) Danielle M. Williams et al.   MASS SPECTROMETRY REVIEWS

Insights into antiamyloidogenic properties of the green tea extract (-)-epigallocatechin-3-gallate toward metal-associated amyloid-  species

(2013) S.-J. Hyung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pulsed hydrogen–deuterium exchange mass spectrometry probes conformational changes in amyloid beta (Aβ) peptide aggregation

(2013) Ying Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Familial Alzheimer’s Disease Mutations Differentially Alter Amyloid β-Protein Oligomerization

(2012) Megan Murray Gessel et al.   ACS Chemical Neuroscience

Covalent Cross-Linking within Supramolecular Peptide Structures

(2012) George W. Preston et al.   ANALYTICAL CHEMISTRY

High-Resolution Mapping of Carbene-Based Protein Footprints

(2012) Chanelle C. Jumper et al.   ANALYTICAL CHEMISTRY

The N-Methylated Peptide SEN304 Powerfully Inhibits Aβ(1–42) Toxicity by Perturbing Oligomer Formation

(2012) Hozefa Amijee et al.   BIOCHEMISTRY

Structure and Dynamics of Small Soluble Aβ(1–40) Oligomers Studied by Top-Down Hydrogen Exchange Mass Spectrometry

(2012) Jingxi Pan et al.   BIOCHEMISTRY

Advances in ion mobility spectrometry–mass spectrometry reveal key insights into amyloid assembly

(2012) L.A. Woods et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

The Amyloid State of Proteins in Human Diseases

(2012) David Eisenberg et al.   CELL

The Amyloid Beta Peptide: A Chemist’s Perspective. Role in Alzheimer’s and Fibrillization

(2012) I. W. Hamley   CHEMICAL REVIEWS

Protein aggregation: Mechanisms and functional consequences

(2012) Gaetano Invernizzi et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Z-Phe-Ala-diazomethylketone (PADK) Disrupts and Remodels Early Oligomer States of the Alzheimer Disease Aβ42 Protein

(2012) Xueyun Zheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conformer-Specific Hydrogen Exchange Analysis of Aβ(1–42) Oligomers by Top-Down Electron Capture Dissociation Mass Spectrometry

(2011) Jingxi Pan et al.   ANALYTICAL CHEMISTRY

Structural Mass Spectrometry of Proteins Using Hydroxyl Radical Based Protein Footprinting

(2011) Liwen Wang et al.   ANALYTICAL CHEMISTRY

Mass Spectrometry of Laser-Initiated Carbene Reactions for Protein Topographic Analysis

(2011) Chanelle C. Jumper et al.   ANALYTICAL CHEMISTRY

Ion Mobility Mass Spectrometry Studies of the Inhibition of Alpha Synuclein Amyloid Fibril Formation by (–)-Epigallocatechin-3-Gallate

(2011) Yanqin Liu et al.   AUSTRALIAN JOURNAL OF CHEMISTRY

Aβ(39–42) Modulates Aβ Oligomerization but Not Fibril Formation

(2011) Megan Murray Gessel et al.   BIOCHEMISTRY

Structural Insights into the Pre-Amyloid Tetramer of β-2-Microglobulin from Covalent Labeling and Mass Spectrometry

(2011) Vanessa Leah Mendoza et al.   BIOCHEMISTRY

Protective effect of ε-viniferin on β-amyloid peptide aggregation investigated by electrospray ionization mass spectrometry

(2011) Tristan Richard et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Autoproteolytic Fragments Are Intermediates in the Oligomerization/Aggregation of the Parkinson's Disease Protein Alpha-Synuclein as Revealed by Ion Mobility Mass Spectrometry

(2011) Camelia Vlad et al.   CHEMBIOCHEM

Aliphatic Diazirines as Photoaffinity Probes for Proteins: Recent Developments

(2011) Joydip Das   CHEMICAL REVIEWS

New developments in protein structure-function analysis by MS and use of hydrogen-deuterium exchange microfluidics

(2011) Michael Landreh et al.   FEBS Journal

Tissue Transglutaminase-mediated Glutamine Deamidation of β-Amyloid Peptide Increases Peptide Solubility, Whereas Enzymatic Cross-linking and Peptide Fragmentation May Serve as Molecular Triggers for Rapid Peptide Aggregation

(2011) Adrien W. Schmid et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ion Mobility Separation Coupled with MS Detects Two Structural States of Alzheimer's Disease Aβ1–40 Peptide Oligomers

(2011) Marcin Kłoniecki et al.   JOURNAL OF MOLECULAR BIOLOGY

Aβ40 and Aβ42 Amyloid Fibrils Exhibit Distinct Molecular Recycling Properties

(2011) Laia Sánchez et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure and Intermolecular Dynamics of Aggregates Populated during Amyloid Fibril Formation Studied by Hydrogen/Deuterium Exchange

(2010) Natàlia Carulla et al.   ACCOUNTS OF CHEMICAL RESEARCH

Structure of the Preamyloid Dimer of β-2-Microglobulin from Covalent Labeling and Mass Spectrometry

(2010) Vanessa Leah Mendoza et al.   BIOCHEMISTRY

Characterization of the Interaction of β-Amyloid with Transthyretin Monomers and Tetramers

(2010) Jiali Du et al.   BIOCHEMISTRY

Aβ(1–40) Forms Five Distinct Amyloid Structures whose β-Sheet Contents and Fibril Stabilities Are Correlated

(2010) Ravindra Kodali et al.   JOURNAL OF MOLECULAR BIOLOGY

The use of mass spectrometry to study amyloid-β peptides

(2010) Giuseppe Grasso   MASS SPECTROMETRY REVIEWS

Quench-flow experiments combined with mass spectrometry show apomyoglobin folds through an obligatory intermediate

(2010) Vickie Tsui et al.   PROTEIN SCIENCE

Structural characterization of ß-amyloid oligomer-aggregates by ion mobility mass spectrometry and electron spin resonance spectroscopy

(2009) Marius Ionuţ Iuraşcu et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Biophysical Analyses of Synthetic Amyloid-β(1−42) Aggregates before and after Covalent Cross-Linking. Implications for Deducing the Structure of Endogenous Amyloid-β Oligomers

(2009) Brenda D. Moore et al.   BIOCHEMISTRY

Copper Binding to β-2-Microglobulin and Its Pre-Amyloid Oligomers

(2009) Rapole Srikanth et al.   BIOCHEMISTRY

Two Disaccharides and TrimethylamineN-Oxide Affect Aβ Aggregation Differently, but All Attenuate Oligomer-Induced Membrane Permeability

(2009) Wei Qi et al.   BIOCHEMISTRY

Membrane interactions of a self-assembling model peptide that mimics the self-association, structure and toxicity of Aβ(1–40)

(2009) Luiz C. Salay et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Structural Differences between Aβ(1-40) Intermediate Oligomers and Fibrils Elucidated by Proteolytic Fragmentation and Hydrogen/Deuterium Exchange

(2009) Aming Zhang et al.   BIOPHYSICAL JOURNAL

Dissecting the Mechanisms of Tissue Transglutaminase-induced Cross-linking of α-Synuclein

(2009) Adrien W. Schmid et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid β-Protein: Experiment and Theory on the 21−30 Fragment

(2009) Megan M. Murray et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Amyloid β Protein: Aβ40 Inhibits Aβ42 Oligomerization

(2009) Megan M. Murray et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease

(2009) Summer L. Bernstein et al.   Nature Chemistry

Characterization of intrinsically disordered proteins with electrospray ionization mass spectrometry: Conformational heterogeneity of α-synuclein

(2009) Agya K. Frimpong et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Identification of the Copper(II) Coordinating Residues in the Prion Protein by Metal-Catalyzed Oxidation Mass Spectrometry: Evidence for Multiple Isomers at Low Copper(II) Loadings†

(2008) Rapole Srikanth et al.   BIOCHEMISTRY

Simultaneous monitoring of peptide aggregate distributions, structure, and kinetics using amide hydrogen exchange: Application to Aβ(1-40) fibrillogenesis

(2008) Wei Qi et al.   BIOTECHNOLOGY AND BIOENGINEERING

Protein structure and dynamics studied by mass spectrometry: H/D exchange, hydroxyl radical labeling, and related approaches

(2008) Lars Konermann et al.   JOURNAL OF MASS SPECTROMETRY

Effects of Familial Alzheimer’s Disease Mutations on the Folding Nucleation of the Amyloid β-Protein

(2008) Mary Griffin Krone et al.   JOURNAL OF MOLECULAR BIOLOGY

Spermine Binding to Parkinson’s Protein α-Synuclein and Its Disease-Related A30P and A53T Mutants

(2008) Megan Grabenauer et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Probing protein structure by amino acid-specific covalent labeling and mass spectrometry

(2008) Vanessa Leah Mendoza et al.   MASS SPECTROMETRY REVIEWS

Footprinting protein–DNA complexes using the hydroxyl radical

(2008) Swapan S Jain et al.   Nature Protocols

EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers

(2008) Dagmar E Ehrnhoefer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY