Modulation of the extent of structural heterogeneity in α-synuclein fibrils by the small molecule thioflavin T
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Title
Modulation of the extent of structural heterogeneity in α-synuclein fibrils by the small molecule thioflavin T
Authors
Keywords
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Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 292, Issue 41, Pages 16891-16903
Publisher
American Society for Biochemistry & Molecular Biology (ASBMB)
Online
2017-08-01
DOI
10.1074/jbc.m117.795617
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Note: Only part of the references are listed.- Structural variation in amyloid-β fibrils from Alzheimer's disease clinical subtypes
- (2017) Wei Qiang et al. NATURE
- Stabilization of α-Synuclein Fibril Clusters Prevents Fragmentation and Reduces Seeding Activity and Toxicity
- (2016) Huy T. Lam et al. BIOCHEMISTRY
- Binding Modes of Thioflavin T on the Surface of Amyloid Fibrils Studied by NMR
- (2016) Valerie A. Ivancic et al. CHEMPHYSCHEM
- Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein
- (2016) Marcus D Tuttle et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein
- (2016) Marcus D Tuttle et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Molecular Mechanism of the Misfolding and Oligomerization of the Prion Protein: Current Understanding and Its Implications
- (2015) Jogender Singh et al. BIOCHEMISTRY
- α-Synuclein Amyloid Fibrils with Two Entwined, Asymmetrically Associated Protofibrils
- (2015) Altaira D. Dearborn et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- α-Synuclein strains cause distinct synucleinopathies after local and systemic administration
- (2015) W. Peelaerts et al. NATURE
- Structure of the toxic core of α-synuclein from invisible crystals
- (2015) Jose A. Rodriguez et al. NATURE
- Layers of structure and function in protein aggregation
- (2015) Motomasa Tanaka et al. Nature Chemical Biology
- A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers
- (2015) Samuel I A Cohen et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers
- (2015) Samuel I A Cohen et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Co-existence of Two Different α-Synuclein Oligomers with Different Core Structures Determined by Hydrogen/Deuterium Exchange Mass Spectrometry
- (2014) Wojciech Paslawski et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Sequestration of a β-Hairpin for Control of α-Synuclein Aggregation
- (2014) Ewa A. Mirecka et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Pitfalls associated with the use of Thioflavin-T to monitor anti-fibrillogenic activity
- (2014) Eduardo Coelho-Cerqueira et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- The Role of Stable α-Synuclein Oligomers in the Molecular Events Underlying Amyloid Formation
- (2014) Nikolai Lorenzen et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- The relationship between amyloid structure and cytotoxicity
- (2014) Karen E Marshall et al. Prion
- Physical and structural basis for polymorphism in amyloid fibrils
- (2014) Robert Tycko PROTEIN SCIENCE
- Characterizing the Dynamics of α-Synuclein Oligomers Using Hydrogen/Deuterium Exchange Monitored by Mass Spectrometry
- (2013) Simon Mysling et al. BIOCHEMISTRY
- Molecular Structure of β-Amyloid Fibrils in Alzheimer’s Disease Brain Tissue
- (2013) Jun-Xia Lu et al. CELL
- Remaining structures at the N- and C-terminal regions of alpha-synuclein accurately elucidated by amide-proton exchange NMR with fitting
- (2013) Honoka Okazaki et al. FEBS LETTERS
- Dissection of Conformational Conversion Events during Prion Amyloid Fibril Formation Using Hydrogen Exchange and Mass Spectrometry
- (2013) Jogender Singh et al. JOURNAL OF MOLECULAR BIOLOGY
- The Dynamic Structure of α-Synuclein Multimers
- (2013) Thomas Gurry et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Polymorph-Specific Kinetics and Thermodynamics of β-Amyloid Fibril Growth
- (2013) Wei Qiang et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Atomic structure and hierarchical assembly of a cross- amyloid fibril
- (2013) A. W. P. Fitzpatrick et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural and functional characterization of two alpha-synuclein strains
- (2013) Luc Bousset et al. Nature Communications
- Structure-based discovery of fiber-binding compounds that reduce the cytotoxicity of amyloid beta
- (2013) Lin Jiang et al. eLife
- Dye-Binding Assays for Evaluation of the Effects of Small Molecule Inhibitors on Amyloid (Aβ) Self-Assembly
- (2012) Laramie P. Jameson et al. ACS Chemical Neuroscience
- Fibrillar α-Synuclein and Huntingtin Exon 1 Assemblies Are Toxic to the Cells
- (2012) Laura Pieri et al. BIOPHYSICAL JOURNAL
- Direct Observation of the Interconversion of Normal and Toxic Forms of α-Synuclein
- (2012) Nunilo Cremades et al. CELL
- α-Synuclein in Central Nervous System and from Erythrocytes, Mammalian Cells, andEscherichia coliExists Predominantly as Disordered Monomer
- (2012) Bruno Fauvet et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Development of the Structural Core and of Conformational Heterogeneity during the Conversion of Oligomers of the Mouse Prion Protein to Worm-like Amyloid Fibrils
- (2012) Jogender Singh et al. JOURNAL OF MOLECULAR BIOLOGY
- Systematic Mutagenesis of -Synuclein Reveals Distinct Sequence Requirements for Physiological and Pathological Activities
- (2012) J. Burre et al. JOURNAL OF NEUROSCIENCE
- Thioflavin T Promotes Aβ(1–40) Amyloid Fibrils Formation
- (2012) Michele D’Amico et al. Journal of Physical Chemistry Letters
- The many faces of α-synuclein: from structure and toxicity to therapeutic target
- (2012) Hilal A. Lashuel et al. NATURE REVIEWS NEUROSCIENCE
- Purified and synthetic Alzheimer's amyloid beta (A ) prions
- (2012) J. Stohr et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Binding Modes of Thioflavin T Molecules to Prion Peptide Assemblies Identified by Using Scanning Tunneling Microscopy
- (2011) Xiaobo Mao et al. ACS Chemical Neuroscience
- Structural Role of Compensatory Amino Acid Replacements in the α-Synuclein Protein
- (2011) Valeria Losasso et al. BIOCHEMISTRY
- Small-molecule conversion of toxic oligomers to nontoxic β-sheet–rich amyloid fibrils
- (2011) Jan Bieschke et al. Nature Chemical Biology
- In vivo demonstration that -synuclein oligomers are toxic
- (2011) B. Winner et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Amyloidogenic Protein-Membrane Interactions: Mechanistic Insight from Model Systems
- (2010) Sara M. Butterfield et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Salt-Induced Modulation of the Pathway of Amyloid Fibril Formation by the Mouse Prion Protein
- (2010) Shweta Jain et al. BIOCHEMISTRY
- The Conformation and the Aggregation Kinetics of α-Synuclein Depend on the Proline Residues in Its C-Terminal Region
- (2010) Jessika Meuvis et al. BIOCHEMISTRY
- Fluoroalcohol-Induced Modulation of the Pathway of Amyloid Protofibril Formation by Barstar
- (2010) Amrita Sekhar et al. BIOCHEMISTRY
- Crystal structure of thioflavin-T and its binding to amyloid fibrils: insights at the molecular level
- (2010) Cristina Rodríguez-Rodríguez et al. CHEMICAL COMMUNICATIONS
- Detection of Transient Interchain Interactions in the Intrinsically Disordered Protein α-Synuclein by NMR Paramagnetic Relaxation Enhancement
- (2010) Kuen-Phon Wu et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Fibril fragmentation in amyloid assembly and cytotoxicity
- (2010) Wei-Feng Xue et al. Prion
- EGCG remodels mature α-synuclein and amyloid-β fibrils and reduces cellular toxicity
- (2010) Jan Bieschke et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Determination of amide hydrogen exchange by mass spectrometry: A new tool for protein structure elucidation
- (2010) Zhongqi Zhang et al. PROTEIN SCIENCE
- Thioflavine T interaction with synthetic Alzheimer's disease β-amyloid peptides: Detection of amyloid aggregation in solution
- (2010) Harry Levine PROTEIN SCIENCE
- Conserved core of amyloid fibrils of wild type and A30P mutant α-synuclein
- (2010) Min-Kyu Cho et al. PROTEIN SCIENCE
- Structurally Distinct Amyloid Protofibrils Form on Separate Pathways of Aggregation of a Small Protein
- (2009) Santosh Kumar et al. BIOCHEMISTRY
- Binding Modes of Thioflavin-T to the Single-Layer β-Sheet of the Peptide Self-Assembly Mimics
- (2009) Chun Wu et al. JOURNAL OF MOLECULAR BIOLOGY
- Tryptophan Fluorescence Reveals Structural Features of α-Synuclein Oligomers
- (2009) B.D. van Rooijen et al. JOURNAL OF MOLECULAR BIOLOGY
- Solid-State NMR Reveals Structural Differences between Fibrils of Wild-Type and Disease-Related A53T Mutant α-Synuclein
- (2008) Henrike Heise et al. JOURNAL OF MOLECULAR BIOLOGY
- Molecular Mechanism of Thioflavin-T Binding to the Surface of β-Rich Peptide Self-Assemblies
- (2008) Matthew Biancalana et al. JOURNAL OF MOLECULAR BIOLOGY
- On the binding of Thioflavin-T to HET-s amyloid fibrils assembled at pH 2
- (2008) Raimon Sabaté et al. JOURNAL OF STRUCTURAL BIOLOGY
- EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers
- (2008) Dagmar E Ehrnhoefer et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Molecular structural basis for polymorphism in Alzheimer's -amyloid fibrils
- (2008) A. K. Paravastu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structure of membrane-bound -synuclein from site-directed spin labeling and computational refinement
- (2008) C. C. Jao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The fold of -synuclein fibrils
- (2008) M. Vilar et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Conformational Equilibria in Monomeric α-Synuclein at the Single-Molecule Level
- (2008) Massimo Sandal et al. PLOS BIOLOGY
- FTIR reveals structural differences between native β-sheet proteins and amyloid fibrils
- (2004) Giorgia Zandomeneghi et al. PROTEIN SCIENCE
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