Lumican is elevated in the lung in human and experimental acute respiratory distress syndrome and promotes early fibrotic responses to lung injury

The Role of Cytokines including Interleukin-6 in COVID-19 induced Pneumonia and Macrophage Activation Syndrome-Like Disease

(2020) Dennis McGonagle et al.   AUTOIMMUNITY REVIEWS

Extracellular Matrix Component Remodeling in Respiratory Diseases: What Has Been Found in Clinical and Experimental Studies?

(2019) Juliana T. Ito et al.   Cells

Type III collagen (COL3A1): Gene and protein structure, tissue distribution, and associated diseases

(2019) Helena Kuivaniemi et al.   GENE

Extracellular-Signal Regulated Kinase: A Central Molecule Driving Epithelial–Mesenchymal Transition in Cancer

(2019) Monserrat Olea-Flores et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The extracellular matrix proteoglycan lumican improves survival and counteracts cardiac dilatation and failure in mice subjected to pressure overload

(2019) Naiyereh Mohammadzadeh et al.   Scientific Reports

Epithelial-to-mesenchymal transition and invadopodia markers in breast cancer: Lumican a key regulator

(2019) Konstantina Karamanou et al.   SEMINARS IN CANCER BIOLOGY

Lumican as a multivalent effector in wound healing

(2018) Konstantina Karamanou et al.   ADVANCED DRUG DELIVERY REVIEWS

Salvage therapies for refractory hypoxemia in ARDS

(2018) Sujith V. Cherian et al.   RESPIRATORY MEDICINE

Mitochondrial peptides cause proinflammatory responses in the alveolar epithelium via FPR-1, MAPKs, and AKT: a potential mechanism involved in acute lung injury

(2018) Xue Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Inflammatory and Fibrinolytic System in Acute Respiratory Distress Syndrome

(2018) Mahesh Manjunath Gouda et al.   LUNG

Hypoxia-induced autophagy of stellate cells inhibits expression and secretion of lumican into microenvironment of pancreatic ductal adenocarcinoma

(2018) Xinqun Li et al.   CELL DEATH AND DIFFERENTIATION

Cancer-associated fibroblast-derived Lumican promotes gastric cancer progression via the integrin β1-FAK signaling pathway

(2017) Xiaofeng Wang et al.   INTERNATIONAL JOURNAL OF CANCER

Anti-TNFα therapy in inflammatory lung diseases

(2017) Rama Malaviya et al.   PHARMACOLOGY & THERAPEUTICS

Acute Lung Injury: A Clinical and Molecular Review

(2016) Yasmeen Butt et al.   ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries

(2016) Giacomo Bellani et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Understanding ARDS-associated fibroproliferation

(2015) Gianfranco Umberto Meduri et al.   INTENSIVE CARE MEDICINE

Self-Assembly and Collagen-Stimulating Activity of a Peptide Amphiphile Incorporating a Peptide Sequence from Lumican

(2015) Ian W. Hamley et al.   LANGMUIR

TNF-α–stimulated fibroblasts secrete lumican to promote fibrocyte differentiation

(2015) Darrell Pilling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Type III procollagen is a reliable marker of ARDS-associated lung fibroproliferation

(2014) Jean-Marie Forel et al.   INTENSIVE CARE MEDICINE

Lumican Regulates Ventilation-Induced Epithelial-Mesenchymal Transition Through Extracelluar Signal-Regulated Kinase Pathway

(2013) Li-Fu Li et al.   CHEST

The fibroproliferative response in acute respiratory distress syndrome: mechanisms and clinical significance

(2013) E. L. Burnham et al.   EUROPEAN RESPIRATORY JOURNAL

Lumican is increased in experimental and clinical heart failure, and its production by cardiac fibroblasts is induced by mechanical and proinflammatory stimuli

(2013) Kristin V. T. Engebretsen et al.   FEBS Journal

A universal definition of ARDS: the PaO2/FiO2 ratio under a standard ventilatory setting—a prospective, multicenter validation study

(2013) Jesús Villar et al.   INTENSIVE CARE MEDICINE

Chronology of histological lesions in acute respiratory distress syndrome with diffuse alveolar damage: a prospective cohort study of clinical autopsies

(2013) Arnaud W Thille et al.   Lancet Respiratory Medicine

An Official American Thoracic Society Clinical Practice Guideline: The Clinical Utility of Bronchoalveolar Lavage Cellular Analysis in Interstitial Lung Disease

(2012) Keith C. Meyer et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The acute respiratory distress syndrome

(2012) Michael A. Matthay et al.   JOURNAL OF CLINICAL INVESTIGATION

Lumican, an extracellular matrix proteoglycan, is a novel requisite for hepatic fibrosis

(2012) Anuradha Krishnan et al.   LABORATORY INVESTIGATION

Fibroproliferative changes on high-resolution CT in the acute respiratory distress syndrome predict mortality and ventilator dependency: a prospective observational cohort study

(2012) Kazuya Ichikado et al.   BMJ Open

Epithelial-Mesenchymal Interactions in Pulmonary Fibrosis

(2011) Harold A. Chapman   Annual Review of Physiology

The EMT regulator slug and lung carcinogenesis

(2011) J.-Y. Shih et al.   CARCINOGENESIS

Lumican inhibits angiogenesis by interfering with α2β1 receptor activity and downregulating MMP-14 expression

(2011) Jolanta Niewiarowska et al.   THROMBOSIS RESEARCH

Proteoglycans in health and disease: novel regulatory signaling mechanisms evoked by the small leucine-rich proteoglycans

(2010) Renato V. Iozzo et al.   FEBS Journal

Therapies for Refractory Hypoxemia in Acute Respiratory Distress Syndrome

(2010) Matthew R. Pipeling et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Lumican, a small leucine-rich proteoglycan

(2008) Dragana Nikitovic et al.   IUBMB LIFE

Biological Functions of the Small Leucine-rich Proteoglycans: From Genetics to Signal Transduction

(2008) Liliana Schaefer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Essential Role for Fibronectin Extra Type III Domain A in Pulmonary Fibrosis

(2007) Andrés F. Muro et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE