The extracellular matrix proteoglycan lumican improves survival and counteracts cardiac dilatation and failure in mice subjected to pressure overload

The extracellular matrix as a multitasking player in disease

(2019) Achilleas D. Theocharis et al.   FEBS Journal

Sweet, yet underappreciated: Proteoglycans and extracellular matrix remodeling in heart disease

(2018) Geir Christensen et al.   MATRIX BIOLOGY

A role for proteoglycans in vascular disease

(2018) Thomas N. Wight   MATRIX BIOLOGY

Emerging roles of proteoglycans in cardiac remodeling

(2018) Xiaoya Wang et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

miR-21 promotes fibrosis in an acute cardiac allograft transplantation model

(2016) Shashi Kumar Gupta et al.   CARDIOVASCULAR RESEARCH

Syndecans in heart fibrosis

(2016) Ida G. Lunde et al.   CELL AND TISSUE RESEARCH

Growth Differentiation Factor 15 as a Biomarker in Cardiovascular Disease

(2016) Kai C. Wollert et al.   CLINICAL CHEMISTRY

Development of myotendinous-like junctions that anchor cardiac valves requires fibromodulin and lumican

(2016) Loren E. Dupuis et al.   DEVELOPMENTAL DYNAMICS

The Heparan Sulfate Proteoglycan Glypican-6 Is Upregulated in the Failing Heart, and Regulates Cardiomyocyte Growth through ERK1/2 Signaling

(2016) Arne O. Melleby et al.   PLoS One

Syndecan-4 is a key determinant of collagen cross-linking and passive myocardial stiffness in the pressure-overloaded heart

(2015) Kate M. Herum et al.   CARDIOVASCULAR RESEARCH

The small leucine-rich repeat proteoglycans in tissue repair and atherosclerosis

(2015) A. Hultgårdh-Nilsson et al.   JOURNAL OF INTERNAL MEDICINE

Shedding of syndecan-4 promotes immune cell recruitment and mitigates cardiac dysfunction after lipopolysaccharide challenge in mice

(2015) Mari E. Strand et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Lumican deficiency results in cardiomyocyte hypertrophy with altered collagen assembly

(2015) Loren E. Dupuis et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Proteoglycan form and function: A comprehensive nomenclature of proteoglycans

(2015) Renato V. Iozzo et al.   MATRIX BIOLOGY

TNF-α–stimulated fibroblasts secrete lumican to promote fibrocyte differentiation

(2015) Darrell Pilling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

5′RNA-Seq identifies Fhl1 as a genetic modifier in cardiomyopathy

(2014) Danos C. Christodoulou et al.   JOURNAL OF CLINICAL INVESTIGATION

Interclass small leucine-rich repeat proteoglycan interactions regulate collagen fibrillogenesis and corneal stromal assembly

(2014) Shoujun Chen et al.   MATRIX BIOLOGY

Innate immune signaling induces expression and shedding of the heparan sulfate proteoglycan syndecan-4 in cardiac fibroblasts and myocytes, affecting inflammation in the pressure-overloaded heart

(2013) Mari E. Strand et al.   FEBS Journal

Lumican is increased in experimental and clinical heart failure, and its production by cardiac fibroblasts is induced by mechanical and proinflammatory stimuli

(2013) Kristin V. T. Engebretsen et al.   FEBS Journal

Myocardial stress and hypertrophy: a complex interface between biophysics and cardiac remodeling

(2013) William Grossman et al.   JOURNAL OF CLINICAL INVESTIGATION

Lumican affects tumor cell functions, tumor–ECM interactions, angiogenesis and inflammatory response

(2013) Dragana Nikitovic et al.   MATRIX BIOLOGY

Lumican Binds ALK5 to Promote Epithelium Wound Healing

(2013) Osamu Yamanaka et al.   PLoS One

Time course of right ventricular pressure-overload induced myocardial fibrosis: relationship to changes in fibroblast postsynthetic procollagen processing

(2012) Catalin F. Baicu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Disruption of mindin exacerbates cardiac hypertrophy and fibrosis

(2012) Zhou-Yan Bian et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Lumican, an extracellular matrix proteoglycan, is a novel requisite for hepatic fibrosis

(2012) Anuradha Krishnan et al.   LABORATORY INVESTIGATION

A mouse model of reverse cardiac remodelling following banding-debanding of the ascending aorta

(2011) J. L. Bjørnstad et al.   Acta Physiologica

Cardiac-specific mindin overexpression attenuates cardiac hypertrophy via blocking AKT/GSK3β and TGF-β1–Smad signalling

(2011) Ling Yan et al.   CARDIOVASCULAR RESEARCH

Lumican regulates osteosarcoma cell adhesion by modulating TGFβ2 activity

(2011) Dragana Nikitovic et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Syndecan-4 Is Essential for Development of Concentric Myocardial Hypertrophy via Stretch-Induced Activation of the Calcineurin-NFAT Pathway

(2011) Alexandra V. Finsen et al.   PLoS One

Impaired skin wound healing in lumican-null mice

(2010) J-T. Yeh et al.   BRITISH JOURNAL OF DERMATOLOGY

Molecular Pathways Underlying Cardiac Remodeling During Pathophysiological Stimulation

(2010) Izhak Kehat et al.   CIRCULATION

Collagen isoform shift during the early phase of reverse left ventricular remodelling after relief of pressure overload

(2010) J. L. Bjornstad et al.   EUROPEAN HEART JOURNAL

Lumican is required for neutrophil extravasation following corneal injury and wound healing

(2010) Y. Hayashi et al.   JOURNAL OF CELL SCIENCE

The role of small leucine-rich proteoglycans in collagen fibrillogenesis

(2010) Sebastian Kalamajski et al.   MATRIX BIOLOGY

Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver

(2010) C. H. Osterreicher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular Matrix Lumican Deposited on the Surface of Neutrophils Promotes Migration by Binding to β2Integrin

(2009) Seakwoo Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Accelerated arterial stiffening and gene expression profile of the aorta in patients with coronary artery disease

(2009) Céline Fassot et al.   JOURNAL OF HYPERTENSION

Impact of Treatment on Myocardial Lysyl Oxidase Expression and Collagen Cross-Linking in Patients With Heart Failure

(2008) Begoña López et al.   HYPERTENSION

MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts

(2008) Thomas Thum et al.   NATURE