Extracellular Matrix Component Remodeling in Respiratory Diseases: What Has Been Found in Clinical and Experimental Studies?

Th17/Treg imbalance in COPD progression: A temporal analysis using a CS-induced model

(2019) Juliana Tiyaki Ito et al.   PLoS One

Altered serum levels of type I collagen turnover indicators accompanied by IL-6 and IL-8 release in stable COPD

(2019) Ying-Ying Zeng et al.   International Journal of Chronic Obstructive Pulmonary Disease

A Guinea Pig Model of Airway Smooth Muscle Hyperreactivity Induced by Chronic Allergic Lung Inflammation: Contribution of Epithelium and Oxidative Stress

(2019) Luiz Henrique César Vasconcelos et al.   Frontiers in Pharmacology

Chest CT scan and alveolar procollagen III to predict lung fibroproliferation in acute respiratory distress syndrome

(2019) Annabelle Hamon et al.   Annals of Intensive Care

Protective effect of amygdalin on epithelial-mesenchymal transformation in experimental chronic obstructive pulmonary disease mice

(2019) Ziyan Wang et al.   PHYTOTHERAPY RESEARCH

Regulatory cytokine function in the respiratory tract

(2019) William J. Branchett et al.   Mucosal Immunology

Serum levels of hyaluronic acid are associated with COPD severity and predict survival

(2019) Eleni Papakonstantinou et al.   EUROPEAN RESPIRATORY JOURNAL

A theoretical model of inflammation- and mechanotransduction-driven asthmatic airway remodelling

(2018) Michael R. Hill et al.   Biomechanics and Modeling in Mechanobiology

Inflammation-dependent and independent airway remodelling in asthma

(2018) John G. Elliot et al.   RESPIROLOGY

Effects of Anti-IL-17 on Inflammation, Remodeling, and Oxidative Stress in an Experimental Model of Asthma Exacerbated by LPS

(2018) Leandro do Nascimento Camargo et al.   Frontiers in Immunology

Extracellular matrix promotes proliferation, migration and adhesion of airway smooth muscle cells in a rat model of chronic obstructive pulmonary disease via upregulation of the PI3K/AKT signaling pathway

(2018) Zhengyan Wang et al.   Molecular Medicine Reports

Effect of Anti-IL17 Antibody Treatment Alone and in Combination With Rho-Kinase Inhibitor in a Murine Model of Asthma

(2018) Tabata M. dos Santos et al.   Frontiers in Physiology

Escherichia coli lipopolysaccharide induces alveolar epithelial cell stiffening

(2018) Vinícius Rosa Oliveira et al.   JOURNAL OF BIOMECHANICS

Transforming Growth Factor-β1 in predicting early lung fibroproliferation in patients with acute respiratory distress syndrome

(2018) Jean-Marie Forel et al.   PLoS One

The Plant Proteinase Inhibitor CrataBL Plays a Role in Controlling Asthma Response in Mice

(2018) Anelize Sartori Santos Bortolozzo et al.   Biomed Research International

The instructive extracellular matrix of the lung: basic composition and alterations in chronic lung disease

(2017) Gerald Burgstaller et al.   EUROPEAN RESPIRATORY JOURNAL

Acute lung injury is reduced by the α7nAChR agonist PNU-282987 through changes in the macrophage profile

(2017) Nathalia M. Pinheiro et al.   FASEB JOURNAL

A Plant Proteinase Inhibitor from Enterolobium contortisiliquum Attenuates Pulmonary Mechanics, Inflammation and Remodeling Induced by Elastase in Mice

(2017) Osmar Theodoro-Júnior et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A murine model of elastase- and cigarette smoke-induced emphysema

(2017) Rubia Rodrigues et al.   Jornal Brasileiro de Pneumologia

ResolvinD1 stimulates epithelial wound repair and inhibits TGF-β-induced EMT whilst reducing fibroproliferation and collagen production

(2017) Shengxing Zheng et al.   LABORATORY INVESTIGATION

Early and late pulmonary effects of nebulized LPS in mice: An acute lung injury model

(2017) Natália de Souza Xavier Costa et al.   PLoS One

Plant Proteinase Inhibitor BbCI Modulates Lung Inflammatory Responses and Mechanic and Remodeling Alterations Induced by Elastase in Mice

(2017) Rafael Almeida-Reis et al.   Biomed Research International

Airway Mucus and Asthma: The Role of MUC5AC and MUC5B

(2017) Luke Bonser et al.   Journal of Clinical Medicine

Epidemiology of asthma

(2016) Patricia A. Loftus et al.   Current Opinion in Otolaryngology & Head and Neck Surgery

Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries

(2016) Giacomo Bellani et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The extracellular matrix - the under-recognized element in lung disease?

(2016) Janette K Burgess et al.   JOURNAL OF PATHOLOGY

Transforming growth factor (TGF) β1 and Smad signalling pathways: A likely key to EMT-associated COPD pathogenesis

(2016) Malik Q. Mahmood et al.   RESPIROLOGY

The tri-peptide GHK-Cu complex ameliorates lipopolysaccharide-induced acute lung injury in mice

(2016) Jeong-Ran Park et al.   Oncotarget

Association of symptom control with changes in lung function, bronchial hyperresponsiveness, and exhaled nitric oxide after inhaled corticosteroid treatment in children with asthma

(2016) Geun-Mi Park et al.   ALLERGOLOGY INTERNATIONAL

Airway Remodeling in Preschool Children with Severe Recurrent Wheeze

(2015) Guillaume Lezmi et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Studying human respiratory disease in animals - role of induced and naturally occurring models

(2015) Kurt Williams et al.   JOURNAL OF PATHOLOGY

Driving Pressure and Survival in the Acute Respiratory Distress Syndrome

(2015) Marcelo B.P. Amato et al.   NEW ENGLAND JOURNAL OF MEDICINE

Y-27632 is associated with corticosteroid-potentiated control of pulmonary remodeling and inflammation in guinea pigs with chronic allergic inflammation

(2015) Patricia Angeli Pigati et al.   BMC Pulmonary Medicine

Airway and Extracellular Matrix Mechanics in COPD

(2015) Cécile M. Bidan et al.   Frontiers in Physiology

Collagenase mRNA Overexpression and Decreased Extracellular Matrix Components Are Early Events in the Pathogenesis of Emphysema

(2015) Fabíola S. Z. Robertoni et al.   PLoS One

Reduction of Airway Smooth Muscle Mass by Bronchial Thermoplasty in Patients with Severe Asthma

(2014) Marina Pretolani et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Asthma Therapy and Its Effect on Airway Remodelling

(2014) Rachid Berair et al.   DRUGS

Effects of cigarette smoke extract on human airway smooth muscle cells in COPD

(2014) L. Chen et al.   EUROPEAN RESPIRATORY JOURNAL

Animal models of chronic obstructive pulmonary disease

(2014) Michael Fricker et al.   Expert Opinion on Drug Discovery

Biology of the Extracellular Matrix

(2014) Beatrice Yue   JOURNAL OF GLAUCOMA

LL-37 secreted by epithelium promotes fibroblast collagen production: a potential mechanism of small airway remodeling in chronic obstructive pulmonary disease

(2014) Congcong Sun et al.   LABORATORY INVESTIGATION

A Treatment with a Protease Inhibitor Recombinant from the Cattle Tick (Rhipicephalus Boophilus microplus) Ameliorates Emphysema in Mice

(2014) Juliana D. Lourenço et al.   PLoS One

Effects of Rho-kinase inhibition in lung tissue with chronic inflammation

(2014) Renato Fraga Righetti et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Role of Tyk-2 in Th9 and Th17 cells in allergic asthma

(2014) Caroline Übel et al.   Scientific Reports

Effects of bone marrow mononuclear cells from healthy or ovalbumin-induced lung inflammation donors on recipient allergic asthma mice

(2014) Soraia C Abreu et al.   Stem Cell Research & Therapy

Monocyte interaction accelerates HCl-induced lung epithelial remodeling

(2014) Qiuhua Chen et al.   BMC Pulmonary Medicine

Similar matrix alterations in alveolar and small airway walls of COPD patients

(2014) Irene MJ Eurlings et al.   BMC Pulmonary Medicine

Differential effects of fluticasone on extracellular matrix production by airway and parenchymal fibroblasts in severe COPD

(2013) Corry-Anke Brandsma et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Animal models of asthma: Reprise or reboot?

(2013) Kevin Mullane et al.   BIOCHEMICAL PHARMACOLOGY

The fibroproliferative response in acute respiratory distress syndrome: mechanisms and clinical significance

(2013) E. L. Burnham et al.   EUROPEAN RESPIRATORY JOURNAL

A new short-term mouse model of chronic obstructive pulmonary disease identifies a role for mast cell tryptase in pathogenesis

(2013) Emma L. Beckett et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Molecular Imaging of Heparan Sulfate Expression with Radiolabeled Recombinant Eosinophil Cationic Protein Predicts Allergic Lung Inflammation in a Mouse Model for Asthma

(2013) H.-C. Chen et al.   JOURNAL OF NUCLEAR MEDICINE

Effects of decorin proteoglycan on fibrillogenesis, ultrastructure, and mechanics of type I collagen gels

(2013) Shawn P. Reese et al.   MATRIX BIOLOGY

Epithelial to mesenchymal transition is increased in patients with COPD and induced by cigarette smoke

(2013) Javier Milara et al.   THORAX

Chronology of histological lesions in acute respiratory distress syndrome with diffuse alveolar damage: a prospective cohort study of clinical autopsies

(2013) Arnaud W Thille et al.   Lancet Respiratory Medicine

Extracellular matrix in airway smooth muscle is associated with dynamics of airway function in asthma

(2012) C. Y. Yick et al.   ALLERGY

Rho-kinase inhibition attenuates airway responsiveness, inflammation, matrix remodeling, and oxidative stress activation induced by chronic inflammation

(2012) Samantha Souza Possa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Ciliated Cells of Pseudostratified Airway Epithelium Do Not Become Mucous Cells after Ovalbumin Challenge

(2012) Ana Pardo-Saganta et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Extracellular matrix composition in COPD

(2012) Raquel Annoni et al.   EUROPEAN RESPIRATORY JOURNAL

Neutrophils in acute lung injury

(2012) Xiao et al.   Frontiers in Bioscience-Landmark

Inducible Nitric Oxide Synthase Inhibition Attenuates Physical Stress-Induced Lung Hyper-Responsiveness and Oxidative Stress in Animals with Lung Inflammation

(2012) Ricardo Henrique Marques et al.   NEUROIMMUNOMODULATION

Aerobic exercise attenuates pulmonary injury induced by exposure to cigarette smoke

(2011) A. C. Toledo et al.   EUROPEAN RESPIRATORY JOURNAL

Matrix metalloproteinases in COPD

(2011) A. Churg et al.   EUROPEAN RESPIRATORY JOURNAL

Remodeling in asthma

(2011) Saleh Al-Muhsen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Angiotensin receptor blockade attenuates cigarette smoke–induced lung injury and rescues lung architecture in mice

(2011) Megan Podowski et al.   JOURNAL OF CLINICAL INVESTIGATION

New insights into the immunology of chronic obstructive pulmonary disease

(2011) Guy G Brusselle et al.   LANCET

Fibrotic Response of Tissue Remodeling in COPD

(2011) Lina María Salazar et al.   LUNG

Effect of Bronchoconstriction on Airway Remodeling in Asthma

(2011) Christopher L. Grainge et al.   NEW ENGLAND JOURNAL OF MEDICINE

Functional Disability 5 Years after Acute Respiratory Distress Syndrome

(2011) Margaret S. Herridge et al.   NEW ENGLAND JOURNAL OF MEDICINE

Heparan Sulfate Proteoglycans

(2011) S. Sarrazin et al.   Cold Spring Harbor Perspectives in Biology

Tissue inhibitors of metalloproteinases

(2011) Gillian Murphy   GENOME BIOLOGY

Influence of airway wall stiffness and parenchymal tethering on the dynamics of bronchoconstriction

(2010) Mohammad Afzal Khan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

An update on the role of leukotrienes in asthma

(2010) Teal S Hallstrand et al.   Current Opinion in Allergy and Clinical Immunology

The Chitinase-like Protein YKL-40 Is Secreted by Airway Epithelial Cells at Base Line and in Response to Compressive Mechanical Stress

(2010) Jin-Ah Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extracellular matrix remodeling of lung alveolar walls in three dimensional space identified using second harmonic generation and multiphoton excitation fluorescence

(2010) Thomas Abraham et al.   JOURNAL OF STRUCTURAL BIOLOGY

The role of small leucine-rich proteoglycans in collagen fibrillogenesis

(2010) Sebastian Kalamajski et al.   MATRIX BIOLOGY

Repeated stress reduces mucociliary clearance in animals with chronic allergic airway inflammation

(2010) Rafael Almeida-Reis et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Can Animal Models of Disease Reliably Inform Human Studies?

(2010) H. Bart van der Worp et al.   PLOS MEDICINE

Chronic Intermittent Mechanical Stress Increases MUC5AC Protein Expression

(2009) Jin-Ah Park et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Airway remodeling in subjects with severe asthma with or without chronic persistent airflow obstruction

(2009) Marta Kaminska et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Compressive Force Induces VEGF Production in Periodontal Tissues

(2009) A. Miyagawa et al.   JOURNAL OF DENTAL RESEARCH

Fibrillin-1 staining anomalies are associated with increased staining for TGF-β and elastic fibre degradation; new clues to the pathogenesis of emphysema

(2009) Mieke MJF Koenders et al.   JOURNAL OF PATHOLOGY

Understanding Asthma Using Animal Models

(2009) Yoo Seob Shin et al.   Allergy Asthma & Immunology Research

Animal models of chronic obstructive pulmonary disease

(2008) Joanne L. Wright et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Mechanisms of cigarette smoke-induced COPD: insights from animal models

(2008) Andrew Churg et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Induction of Angiogenesis by Airway Smooth Muscle From Patients with Asthma

(2008) David E. Simcock et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Pathology of Chronic Obstructive Pulmonary Disease

(2008) James C. Hogg et al.   Annual Review of Pathology-Mechanisms of Disease

Sequential and Quantitative Analysis of a Murine Model of Elastase-Induced Emphysema

(2008) Masaki Kawakami et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Extracellular matrix components and regulators in the airway smooth muscle in asthma

(2008) B. B. Araujo et al.   EUROPEAN RESPIRATORY JOURNAL

Changes in elastic fibres in the small airways and alveoli in COPD

(2008) P. N. Black et al.   EUROPEAN RESPIRATORY JOURNAL

Expression of smooth muscle and extracellular matrix proteins in relation to airway function in asthma

(2008) Annelies M. Slats et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Airway mucus: The good, the bad, the sticky

(2008) Christopher M. Evans et al.   PHARMACOLOGY & THERAPEUTICS

Animal models of COPD: Barriers, successes, and challenges

(2008) Joanne L. Wright et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Extracellular matrix mechanics in lung parenchymal diseases

(2008) Béla Suki et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY