Pharmacological inhibition of O-GlcNAcase (OGA) prevents cognitive decline and amyloid plaque formation in bigenic tau/APP mutant mice

Increasing Brain Protein O-GlcNAc-ylation Mitigates Breathing Defects and Mortality of Tau.P301L Mice

(2013) Peter Borghgraef et al.   PLoS One

Aging brain microenvironment decreases hippocampal neurogenesis through Wnt-mediated survivin signaling

(2012) Carlos J. Miranda et al.   AGING CELL

PUGNAc treatment leads to an unusual accumulation of free oligosaccharides in CHO cells

(2012) A. Mehdy et al.   JOURNAL OF BIOCHEMISTRY

Inhibition of GSK3β-mediated BACE1 expression reduces Alzheimer-associated phenotypes

(2012) Philip T.T. Ly et al.   JOURNAL OF CLINICAL INVESTIGATION

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

(2012) Thorlakur Jonsson et al.   NATURE

Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation

(2012) Scott A Yuzwa et al.   Nature Chemical Biology

O-linked β-N-acetylglucosaminidase inhibitor attenuates β-amyloid plaque and rescues memory impairment

(2012) Chaeyoung Kim et al.   NEUROBIOLOGY OF AGING

Functional Screening of Alzheimer Pathology Genome-wide Association Signals in Drosophila

(2011) Joshua M. Shulman et al.   AMERICAN JOURNAL OF HUMAN GENETICS

O-GlcNAcylation increases non-amyloidogenic processing of the amyloid-β precursor protein (APP)

(2010) Kristin T. Jacobsen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A Selective Inhibitor Gal-PUGNAc of Human Lysosomal β-Hexosaminidases Modulates Levels of the Ganglioside GM2 in Neuroblastoma Cells

(2009) Keith A. Stubbs et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease

(2009) F. Liu et al.   BRAIN

Brain glucose transporters,O-GlcNAcylation and phosphorylation of tau in diabetes and Alzheimer’s disease

(2009) Ying Liu et al.   JOURNAL OF NEUROCHEMISTRY

Decreased glucose transporters correlate to abnormal hyperphosphorylation of tau in Alzheimer disease

(2008) Ying Liu et al.   FEBS LETTERS

Valproic acid inhibits Aβ production, neuritic plaque formation, and behavioral deficits in Alzheimer's disease mouse models

(2008) Hong Qing et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo

(2008) Scott A Yuzwa et al.   Nature Chemical Biology