Computational and functional studies of the PI(4,5)P2 binding site of the TRPM3 ion channel reveal interactions with other regulators

Search and sequence analysis tools services from EMBL-EBI in 2022

(2022) Fábio Madeira et al.   NUCLEIC ACIDS RESEARCH

Structural basis of TRPV5 regulation by physiological and pathophysiological modulators

(2022) Edwin C. Fluck et al.   Cell Reports

TRPM3 channels play roles in heat hypersensitivity and spontaneous pain after nerve injury

(2021) Songxue Su et al.   JOURNAL OF NEUROSCIENCE

TRPM3 in Brain (Patho)Physiology

(2021) Katharina Held et al.   Frontiers in Cell and Developmental Biology

PIP2 regulation of TRPC5 channel activation and desensitization

(2021) Mehek Ningoo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dual regulation of TRPV1 channels by phosphatidylinositol via functionally distinct binding sites

(2021) Aysenur Torun Yazici et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impact of the Protonation State of Phosphatidylinositol 4,5-Bisphosphate (PIP2) on the Binding Kinetics and Thermodynamics to Transient Receptor Potential Vanilloid (TRPV5): A Milestoning Study

(2021) Arman Fathizadeh et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

Structures of the TRPM5 channel elucidate mechanisms of activation and inhibition

(2021) Zheng Ruan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models

(2021) Mihaly Varadi et al.   NUCLEIC ACIDS RESEARCH

Disease-associated mutations in the human TRPM3 render the channel overactive via two distinct mechanisms

(2020) Siyuan Zhao et al.   eLife

Gain of channel function and modified gating properties in TRPM3 mutants causing intellectual disability and epilepsy

(2020) Evelien Van Hoeymissen et al.   eLife

Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel

(2019) Ying Yin et al.   SCIENCE

De novo substitutions of TRPM3 cause intellectual disability and epilepsy

(2019) David A. Dyment et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Promiscuous G-Protein-Coupled Receptor Inhibition of Transient Receptor Potential Melastatin 3 Ion Channels by Gβγ Subunits

(2019) Omar Alkhatib et al.   JOURNAL OF NEUROSCIENCE

A structural overview of the ion channels of the TRPM family

(2019) Yihe Huang et al.   CELL CALCIUM

TRPA1 modulation by piperidine carboxamides suggests an evolutionarily conserved binding site and gating mechanism

(2019) Tania Chernov-Rogan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SWISS-MODEL: homology modelling of protein structures and complexes

(2018) Andrew Waterhouse et al.   NUCLEIC ACIDS RESEARCH

A TRP channel trio mediates acute noxious heat sensing

(2018) Ine Vandewauw et al.   NATURE

Architecture of the TRPM2 channel and its activation mechanism by ADP-ribose and calcium

(2018) Yihe Huang et al.   NATURE

Structure of the mammalian TRPM7, a magnesium channel required during embryonic development

(2018) Jingjing Duan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural insights on TRPV5 gating by endogenous modulators

(2018) Taylor E. T. Hughes et al.   Nature Communications

Structures of the calcium-activated, non-selective cation channel TRPM4

(2017) Jiangtao Guo et al.   NATURE

Electron cryo-microscopy structure of a human TRPM4 channel

(2017) Paige A. Winkler et al.   NATURE

Primidone inhibits TRPM3 and attenuates thermal nociception in vivo

(2017) Ute Krügel et al.   PAIN

Structure of the cold- and menthol-sensing ion channel TRPM8

(2017) Ying Yin et al.   SCIENCE

G protein βγ subunits inhibit TRPM3 ion channels in sensory neurons

(2017) Talisia Quallo et al.   eLife

Inhibition of Transient Receptor Potential Melastatin 3 ion channels by G-protein βγ subunits

(2017) Doreen Badheka et al.   eLife

Anti-nociceptive action of peripheral mu-opioid receptors by G-beta-gamma protein-mediated inhibition of TRPM3 channels

(2017) Sandeep Dembla et al.   eLife

Phosphoinositide Control of Membrane Protein Function: A Frontier Led by Studies on Ion Channels

(2015) Diomedes E. Logothetis et al.   Annual Review of Physiology

Mechanism for phosphoinositide selectivity and activation of TRPV1 ion channels

(2015) Carmen A. Ufret-Vincenty et al.   JOURNAL OF GENERAL PHYSIOLOGY

Transient receptor potential melastatin 3 is a phosphoinositide-dependent ion channel

(2015) Doreen Badheka et al.   JOURNAL OF GENERAL PHYSIOLOGY

Regulation of the transient receptor potential channel TRPM3 by phosphoinositides

(2015) Balázs I. Tóth et al.   JOURNAL OF GENERAL PHYSIOLOGY

Phosphoinositide regulation of TRPV1 revisited

(2015) Tibor Rohacs   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Activation of TRPM3 by a potent synthetic ligand reveals a role in peptide release

(2015) Katharina Held et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Opening of an alternative ion permeation pathway in a nociceptor TRP channel

(2014) Joris Vriens et al.   Nature Chemical Biology

Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments

(2013) G. Madhavi Sastry et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Applying Physics-Based Scoring to Calculate Free Energies of Binding for Single Amino Acid Mutations in Protein-Protein Complexes

(2013) Hege Beard et al.   PLoS One

G-protein-mediated inhibition of the Trp channel TRPM1 requires the G   dimer

(2012) Y. Shen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRPM3 Is a Nociceptor Channel Involved in the Detection of Noxious Heat

(2011) Joris Vriens et al.   NEURON

The VSGB 2.0 model: A next generation energy model for high resolution protein structure modeling

(2011) Jianing Li et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Identifying and Characterizing Binding Sites and Assessing Druggability

(2009) Thomas A. Halgren   Journal of Chemical Information and Modeling

PIP2 Is a Necessary Cofactor for Ion Channel Function: How and Why?

(2008) Byung-Chang Suh et al.   Annual Review of Biophysics

Transient receptor potential channels meet phosphoinositides

(2008) Bernd Nilius et al.   EMBO JOURNAL

Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic β cells

(2008) Thomas F.J. Wagner et al.   NATURE CELL BIOLOGY

Complex functions of phosphatidylinositol 4,5-bisphosphate in regulation of TRPC5 cation channels

(2008) Mohamed Trebak et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY