Mechanism for phosphoinositide selectivity and activation of TRPV1 ion channels

Regulation of TRPV1 Ion Channel by Phosphoinositide (4,5)-Bisphosphate

(2014) Eric N. Senning et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Short-Chain Phosphoinositide Partitioning into Plasma Membrane Models

(2013) Marcus D. Collins et al.   BIOPHYSICAL JOURNAL

Promiscuous Activation of Transient Receptor Potential Vanilloid 1 (TRPV1) Channels by Negatively Charged Intracellular Lipids

(2013) Viktor Lukacs et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Permeation and block of TRPV1 channels by the cationic lidocaine derivative QX-314

(2013) Michelino Puopolo et al.   JOURNAL OF NEUROPHYSIOLOGY

Phenotyping the Function of TRPV1-Expressing Sensory Neurons by Targeted Axonal Silencing

(2013) C. Brenneis et al.   JOURNAL OF NEUROSCIENCE

Distinctive Changes in Plasma Membrane Phosphoinositides Underlie Differential Regulation of TRPV1 in Nociceptive Neurons

(2013) V. Lukacs et al.   JOURNAL OF NEUROSCIENCE

TRPV1 structures in distinct conformations reveal activation mechanisms

(2013) Erhu Cao et al.   NATURE

Structure of the TRPV1 ion channel determined by electron cryo-microscopy

(2013) Maofu Liao et al.   NATURE

Activity-dependent silencing reveals functionally distinct itch-generating sensory neurons

(2013) David P Roberson et al.   NATURE NEUROSCIENCE

TRPV1 Channels Are Intrinsically Heat Sensitive and Negatively Regulated by Phosphoinositide Lipids

(2013) Erhu Cao et al.   NEURON

PI4P and PI(4,5)P2 Are Essential But Independent Lipid Determinants of Membrane Identity

(2012) G. R. V. Hammond et al.   SCIENCE

The GRP1 PH Domain, Like the AKT1 PH Domain, Possesses a Sentry Glutamate Residue Essential for Specific Targeting to Plasma Membrane PI(3,4,5)P3

(2011) Carissa Pilling et al.   BIOCHEMISTRY

Crystal Structure of the Mammalian GIRK2 K+ Channel and Gating Regulation by G Proteins, PIP2, and Sodium

(2011) Matthew R. Whorton et al.   CELL

Localization of the PIP2 Sensor of TRPV1 Ion Channels

(2011) Carmen A. Ufret-Vincenty et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis for the cAMP-dependent Gating in the Human HCN4 Channel

(2010) Xinping Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ca2+-Dependent Desensitization of TRPV2 Channels Is Mediated by Hydrolysis of Phosphatidylinositol 4,5-Bisphosphate

(2010) J. Mercado et al.   JOURNAL OF NEUROSCIENCE

SYMPOSIUM REVIEW: Phosphoinositides: lipid regulators of membrane proteins

(2010) Björn H. Falkenburger et al.   JOURNAL OF PHYSIOLOGY-LONDON

Selectively targeting pain in the trigeminal system

(2010) Hyun Yeong Kim et al.   PAIN

Excitation and sensitization of nociceptors by bradykinin: what do we know?

(2009) Kazue Mizumura et al.   EXPERIMENTAL BRAIN RESEARCH

PIP2 Is a Necessary Cofactor for Ion Channel Function: How and Why?

(2008) Byung-Chang Suh et al.   Annual Review of Biophysics

Pirt, a Phosphoinositide-Binding Protein, Functions as a Regulatory Subunit of TRPV1

(2008) Andrew Y. Kim et al.   CELL

Determinants of Molecular Specificity in Phosphoinositide Regulation

(2008) Rebecca M. Klein et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ci-VSP Is a Depolarization-activated Phosphatidylinositol-4,5-bisphosphate and Phosphatidylinositol-3,4,5-trisphosphate 5′-Phosphatase

(2008) Christian R. Halaszovich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane recognition by phospholipid-binding domains

(2008) Mark A. Lemmon   NATURE REVIEWS MOLECULAR CELL BIOLOGY