Article
Pharmacology & Pharmacy
Xiao-Yu Cheng, Shu-Fang Li, Yong Chen, Ying-Jie Zhao, Wei Hu, Chao Lu, Ren-Peng Zhou
Summary: TRPM7 is a channel protein located on the cell membrane that regulates the balance of intracellular Mg2+. It plays an important role in cell proliferation, adhesion, migration, and is directly related to disease occurrence and development.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Ruixue Shi, Yu Fu, Dongyi Zhao, Tomasz Boczek, Wuyang Wang, Feng Guo
Summary: TRPM channels, important members of the TRP family, play crucial roles in cell physiology and cell death. Studies have shown their involvement in various cell death modalities, suggesting their potential as therapeutic targets in cell death-related diseases.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Md Zubayer Hossain Saad, Liuruimin Xiang, Yan-Shin Liao, Leah R. Reznikov, Jianyang Du
Summary: The study identified molecular determinants responsible for the pH regulation of TRPM3, showing that both intracellular and extracellular protons block TRPM3 through binding sites in the pore region. Specific residue D1073 was found to be essential for pH sensitivity in TRPM3 channel.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Neurosciences
Makiko Kashio, Satoru Masubuchi, Makoto Tominaga
Summary: The temperature thresholds of TRPM2 channels can be regulated by cytosolic Ca2+ and TRPM2 phosphorylation, providing structural evidence for the determination and regulation of temperature thresholds in thermo-TRP channels.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Neurosciences
Marc Behrendt, Hans Juergen Solinski, Martin Schmelz, Richard Carr
Summary: This study found that the inflammatory mediators prostaglandins and bradykinin inhibit TRPM3, while preceding activation of cultured mouse DRG neurons by bradykinin enhances TRPM3-mediated calcium responses. These findings suggest that BK-mediated activation of intracellular signaling pathways may contribute to TRPM3 sensitization during inflammation.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Cell Biology
Bethan A. Cole, Esther B. E. Becker
Summary: The TRPC3 channel is a crucial player in calcium signaling and is regulated by various endogenous and exogenous factors. Recent studies have advanced our understanding of the regulatory mechanisms of TRPC3, which has implications for the development of therapeutic interventions for diseases associated with this channel.
Article
Immunology
Omar Rafael Aleman, Nancy Mora, Carlos Rosales
Summary: Human neutrophils express two unique antibody receptors for IgG, Fc gamma RIIa and Fc gamma RIIIb, which are capable of initiating distinct cellular functions. Fc gamma RIIa induces an increase in L-selectin expression and phagocytosis, while Fc gamma RIIIb promotes actin polymerization, activation of beta 1 integrins, and formation of neutrophils extracellular traps (NET) more efficiently.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Lejla Zubcevic
Summary: Temperature-sensitive transient receptor potential vanilloid ion channel subtypes 1-4 (thermoTRPV1-thermoTRPV4) play important roles in various physiological processes and can be modulated by natural product compounds. Understanding their activation mechanisms and mapping the binding sites for modulatory compounds is crucial for drug development.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Review
Environmental Sciences
Stanley Du Preez, Helene Cabanas, Donald Staines, Sonya Marshall-Gradisnik
Summary: The TRP superfamily of ion channels plays a crucial role in neuroimmune interactions and is implicated in various neuroimmune disorders. TRPM7 is identified as a potential candidate in the pathomechanism of ME/CFS due to its key roles in multiple organ systems and limited literature on its role in the disorder. This review discusses TRPM7's biochemistry, its role in neurological and immunological systems, and its potential involvement in the pathophysiology of ME/CFS.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Pharmacology & Pharmacy
Jian Huang, Ruilin Zhang, Shangwen Wang, Dongxian Zhang, Chi-Kwan Leung, Genmeng Yang, Yuanyuan Li, Liu Liu, Yue Xu, Shucheng Lin, Chan Wang, Xiaofeng Zeng, Juan Li
Summary: The cooperation between METH and HIV-Tat exacerbates BBB impairment, involving oxidative stress and TRPM2 channel activation. Inhibiting oxidative stress or TRPM2 channel activity may provide therapeutic targets for attenuating BBB injury in HIV-positive METH abusers.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Etianne Martini Sasso, Katsuhiko Muraki, Natalie Eaton-Fitch, Peter Smith, Olivia Ly Lesslar, Gary Deed, Sonya Marshall-Gradisnik
Summary: This study found that patients with post COVID-19 condition may have impaired TRPM3 ion channel function and similarities with ME/CFS.
MOLECULAR MEDICINE
(2022)
Article
Immunology
Helene Cabanas, Katsuhiko Muraki, Natalie Eaton-Fitch, Donald Ross Staines, Sonya Marshall-Gradisnik
Summary: The study found that ME/CFS patients taking LDN had restored TRPM3-like ionic currents in NK cells, suggesting LDN may be a potential treatment for ME/CFS. The therapeutic effect of LDN in regulating the underlying mechanisms involving TRPM3 and opioid receptors in NK cells was highlighted. This study may lead to the repurpose of marketed drugs and support prospective randomized clinical studies on the role and dose of NTX in treating ME/CFS patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Clinical Neurology
Zehua Zhang, Le Kang, Xiaohan Yan, Zhuyun Leng, Kang Fang, Tao Chen, Meidong Xu
Summary: Transient receptor potential melastatin 8 (TRPM8) is a major temperature and nociceptive receptor in the human body. The number of TRPM8 studies has significantly increased over the past two decades, with a focus on neurological journals. Research hotspots in TRPM8 include TRP channels, calcium, prostate cancer, proliferation, pain, and inflammation.
JOURNAL OF PAIN RESEARCH
(2022)
Review
Physiology
Asfree Gwanyanya, Kanigula Mubagwa
Summary: Cardiac fibroblasts play an important role in the heart and can differentiate into myofibroblasts for tissue repair. Transient receptor potential (TRP) channels in cardiac fibroblasts have been found to be involved in various cellular processes and could be potential drug targets for cardiac diseases.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Gang-Fan Zong, Rui Deng, Su-Yun Yu, Ai-Yun Wang, Zhong-Hong Wei, Yang Zhao, Yin Lu
Summary: This paper summarizes the existing literature on the changes in thermo-TRP protein expression that are associated with the incidence and progression of gastric cancer (GC). The elucidation of the mechanisms underlying the response of thermo-TRPs to physiological stimuli or drugs is crucial for advancements in GC treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)