Structures of the TRPM5 channel elucidate mechanisms of activation and inhibition

Extracellular cap domain is an essential component of the TRPV1 gating mechanism

(2021) Kirill D. Nadezhdin et al.   Nature Communications

Global alignment and assessment of TRP channel transmembrane domain structures to explore functional mechanisms

(2020) Katherine E Huffer et al.   eLife

A Non-covalent Ligand Reveals Biased Agonism of the TRPA1 Ion Channel

(2020) Chang Liu et al.   NEURON

Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel

(2019) Ying Yin et al.   SCIENCE

TRPM4 and TRPM5 Channels Share Crucial Amino Acid Residues for Ca2+ Sensitivity but Not Significance of PI(4,5)P2

(2019) Soichiro Yamaguchi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Structural insights into TRPM8 inhibition and desensitization

(2019) Melinda M. Diver et al.   SCIENCE

Ligand recognition and gating mechanism through three ligand-binding sites of human TRPM2 channel

(2019) Yihe Huang et al.   eLife

Positive-unlabeled convolutional neural networks for particle picking in cryo-electron micrographs

(2019) Tristan Bepler et al.   NATURE METHODS

Structural basis of TRPV5 channel inhibition by econazole revealed by cryo-EM

(2018) Taylor E. T. Hughes et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of full-length human TRPM4

(2018) Jingjing Duan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis of TRPV5 channel inhibition by econazole revealed by cryo-EM

(2018) Taylor E. T. Hughes et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of a TRPM2 channel in complex with Ca2+ explains unique gating regulation

(2018) Zhe Zhang et al.   eLife

Architecture of the TRPM2 channel and its activation mechanism by ADP-ribose and calcium

(2018) Yihe Huang et al.   NATURE

New tools for the analysis and validation of cryo-EM maps and atomic models

(2018) Pavel V. Afonine et al.   Acta Crystallographica Section D-Structural Biology

Structures and gating mechanism of human TRPM2

(2018) Longfei Wang et al.   SCIENCE

A Bayesian approach to beam-induced motion correction in cryo-EM single-particle analysis

(2018) Jasenko Zivanov et al.   IUCrJ

Structures of the calcium-activated, non-selective cation channel TRPM4

(2017) Jiangtao Guo et al.   NATURE

Electron cryo-microscopy structure of a human TRPM4 channel

(2017) Paige A. Winkler et al.   NATURE

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

(2017) Ali Punjani et al.   NATURE METHODS

UCSF ChimeraX: Meeting modern challenges in visualization and analysis

(2017) Thomas D. Goddard et al.   PROTEIN SCIENCE

Structure of the human TRPM4 ion channel in a lipid nanodisc

(2017) Henriette E. Autzen et al.   SCIENCE

Steviol glycosides enhance pancreatic beta-cell function and taste sensation by potentiation of TRPM5 channel activity

(2017) Koenraad Philippaert et al.   Nature Communications

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action

(2016) Yuan Gao et al.   NATURE

Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut

(2016) M. R. Howitt et al.   SCIENCE

GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation

(2015) Makoto Shigeto et al.   JOURNAL OF CLINICAL INVESTIGATION

CTFFIND4: Fast and accurate defocus estimation from electron micrographs

(2015) Alexis Rohou et al.   JOURNAL OF STRUCTURAL BIOLOGY

L596–W733 bond between the start of the S4–S5 linker and the TRP box stabilizes the closed state of TRPV4 channel

(2015) Jinfeng Teng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sampling the conformational space of the catalytic subunit of human γ-secretase

(2015) Xiao-chen Bai et al.   eLife

Mutation of I696 and W697 in the TRP box of vanilloid receptor subtype I modulates allosteric channel activation

(2014) Lucia Gregorio-Teruel et al.   JOURNAL OF GENERAL PHYSIOLOGY

Screening and large-scale expression of membrane proteins in mammalian cells for structural studies

(2014) April Goehring et al.   Nature Protocols

CALHM1 ion channel mediates purinergic neurotransmission of sweet, bitter and umami tastes

(2013) Akiyuki Taruno et al.   NATURE

Structural basis for Ca2+ selectivity of a voltage-gated calcium channel

(2013) Lin Tang et al.   NATURE

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

(2012) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

A Study of the Hydration of the Alkali Metal Ions in Aqueous Solution

(2011) Johan Mähler et al.   INORGANIC CHEMISTRY

The transient receptor potential family of ion channels

(2011) Bernd Nilius et al.   GENOME BIOLOGY

TRPM5 regulates glucose-stimulated insulin secretion

(2010) Lili R. Brixel et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Loss of high-frequency glucose-induced Ca2+ oscillations in pancreatic islets correlates with impaired glucose tolerance in Trpm5-/- mice

(2010) B. Colsoul et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of molecular determinants of channel gating in the transient receptor potential box of vanilloid receptor I

(2008) Pierluigi Valente et al.   FASEB JOURNAL