Perspectives for the Use of Fucoidans in Clinical Oncology

Fucoidan ameliorates glucose metabolism by the improvement of intestinal barrier and inflammatory damage in type 2 diabetic rats

(2022) Yaping Liu et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Development of self-assembled zein-fucoidan complex nanoparticles as a delivery system for resveratrol

(2022) Qianyuan Liu et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Recent Discoveries on Marine Organism Immunomodulatory Activities

(2022) Eleonora Montuori et al.   Marine Drugs

Linking gastrointestinal microbiota and metabolome dynamics to clinical outcomes in paediatric haematopoietic stem cell transplantation

(2022) Gintare Vaitkute et al.   Microbiome

Enhancing adoptive T‐cell therapy with fucoidan‐based IL ‐2 delivery microcapsules

(2022) Eun Young Jeon et al.   Bioengineering & Translational Medicine

Fucoidan-active α-L-fucosidases of the GH29 and GH95 families from a fucoidan degrading cluster of the marine bacterium Wenyingzhuangia fucanilytica

(2022) Artem S. Silchenko et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Antitumor immunity and therapeutic properties of marine seaweeds-derived extracts in the treatment of cancer

(2022) Mostafa M. El-Sheekh et al.   Cancer Cell International

Active Targeting of P-Selectin by Fucoidan Modulates the Molecular Profiling of Metastasis in Docetaxel-Resistant Prostate Cancer

(2022) Chang-Hsun Ho et al.   Marine Drugs

Comparison of human peripheral blood dendritic cell activation by four fucoidans

(2021) Wei Zhang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Supramolecular metal-based nanoparticles for drug delivery and cancer therapy

(2021) Xiaomin Jiang et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

The Therapeutic Potential of the Anticancer Activity of Fucoidan: Current Advances and Hurdles

(2021) Jun-O. Jin et al.   Marine Drugs

G-CSF in tumors: Aggressiveness, tumor microenvironment and immune cell regulation

(2021) Ioannis Karagiannidis et al.   CYTOKINE

Enhancement of Immune Checkpoint Inhibitor-Mediated Anti-Cancer Immunity by Intranasal Treatment of Ecklonia cava Fucoidan against Metastatic Lung Cancer

(2021) Wei Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effects of Ingesting Fucoidan Derived from Cladosiphon okamuranus Tokida on Human NK Cells: A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Pilot Study

(2021) Makoto Tomori et al.   Marine Drugs

In Vitro Strategies to Vascularize 3D Physiologically Relevant Models

(2021) Alessandra Dellaquila et al.   Advanced Science

The Use of Oligo Fucoidan in Cancer Bearing Dogs Undergoing Chemotherapy: A Double-Blinded Study

(2021) Gerald S. Post et al.   Topics in Companion Animal Medicine

Antitumor activity of fucoidan: a systematic review and meta-analysis

(2021) Ling-Min Cao et al.   Translational Cancer Research

Fucoidan-Based Nanoparticles with Inherently Therapeutic Efficacy for Cancer Treatment

(2021) Chih-Sheng Chiang et al.   Pharmaceutics

Chondroitin Sulfate and Fucosylated Chondroitin Sulfate as Stimulators of Hematopoiesis in Cyclophosphamide-Induced Mice

(2021) Nadezhda E. Ustyuzhanina et al.   Pharmaceuticals

Prevention and treatment of thrombosis in cancer and oncohematological patients

(2021) O. V. Somonova et al.   Oncogematologiya

Fucoidan-Based Theranostic Nanogel for Enhancing Imaging and Photodynamic Therapy of Cancer

(2020) Mi Hyeon Cho et al.   Nano-Micro Letters

α3β1 Integrin-Targeting Polymersomal Docetaxel as an Advanced Nanotherapeutic for Nonsmall Cell Lung Cancer Treatment

(2020) Yan Zou et al.   ACS Applied Materials & Interfaces

The anti-cancer effects of fucoidan: a review of both in vivo and in vitro investigations

(2020) Yuan Lin et al.   Cancer Cell International

Gd(DOTA)-grafted submicronic polysaccharide-based particles functionalized with fucoidan as potential MR contrast agent able to target human activated platelets

(2020) Laura Marcela Forero Ramirez et al.   CARBOHYDRATE POLYMERS

Dendritic cell-mediated cancer immunotherapy with Ecklonia cava fucoidan

(2020) Hae-Bin Park et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

The Natural Product Fucoidan Inhibits Proliferation and Induces Apoptosis of Human Ovarian Cancer Cells: Focus on the PI3K/Akt Signaling Pathway

(2020) Shuhan Liu et al.   Cancer Management and Research

Functional and phylogenetic alterations in gut microbiome are linked to graft-versus-host disease severity

(2020) Mathilde Payen et al.   Blood Advances

Immunomodulatory and Anti-Inflammatory Effects of Fucoidan: A Review

(2020) Elisaveta Apostolova et al.   Polymers

Biological Activities of Fucoidan and the Factors Mediating Its Therapeutic Effects: A Review of Recent Studies

(2019) Yu Wang et al.   Marine Drugs

Piperlongumine increases sensitivity of colorectal cancer cells to radiation: Involvement of ROS production via dual inhibition of glutathione and thioredoxin systems

(2019) Hui Wang et al.   CANCER LETTERS

Intestinal Microbiota Can Predict Acute Graft-versus-Host Disease Following Allogeneic Hematopoietic Stem Cell Transplantation

(2019) Lijie Han et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

The combination of wheat peptides and fucoidan protects against chronic superficial gastritis and alters gut microbiota: a double-blinded, placebo-controlled study

(2019) Juntao Kan et al.   EUROPEAN JOURNAL OF NUTRITION

Selective Anticancer Therapy Using Pro-Oxidant Drug-Loaded Chitosan–Fucoidan Nanoparticles

(2019) Dae Gun Choi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Evaluation of the Immunomodulatory Effects of Fucoidan Derived from Cladosiphon Okamuranus Tokida in Mice

(2019) Makoto Tomori et al.   Marine Drugs

Therapies from Fucoidan: New Developments

(2019) Fitton et al.   Marine Drugs

Marine Polysaccharides in Pharmaceutical Applications: Fucoidan and Chitosan as Key Players in the Drug Delivery Match Field

(2019) Ana Isabel Barbosa et al.   Marine Drugs

ID1 Mediates Escape from TGFβ Tumor Suppression in Pancreatic Cancer

(2019) Yun-Han Huang et al.   Cancer Discovery

Engineered T Cell Therapy for Cancer in the Clinic

(2019) Lijun Zhao et al.   Frontiers in Immunology

Pharmaceutical Development and Safety Evaluation of a GMP-Grade Fucoidan for Molecular Diagnosis of Cardiovascular Diseases

(2019) Cédric Chauvierre et al.   Marine Drugs

Tumor Angiogenesis and Anti-Angiogenic Strategies for Cancer Treatment

(2019) Raluca Ioana Teleanu et al.   Journal of Clinical Medicine

Fucoidan Prolongs the Circulation Time of Dextran-Coated Iron Oxide Nanoparticles

(2018) Maha R. A. Abdollah et al.   ACS Nano

Fucoidan upregulates TLR4/CHOP-mediated caspase-3 and PARP activation to enhance cisplatin-induced cytotoxicity in human lung cancer cells

(2018) Hsien-Yeh Hsu et al.   CANCER LETTERS

Pharmacokinetic and Tissue Distribution of Fucoidan from Fucus vesiculosus after Oral Administration to Rats

(2018) Olga Pozharitskaya et al.   Marine Drugs

Preparation, Characterization and Biological Applications of Biosynthesized Silver Nanoparticles with Chitosan-Fucoidan Coating

(2018) Jayachandran Venkatesan et al.   MOLECULES

Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia

(2018) Shannon L. Maude et al.   NEW ENGLAND JOURNAL OF MEDICINE

A sulfated galactofucan from the brown alga Hormophysa cuneiformis (Fucales, Sargassaceae)

(2018) Maria I. Bilan et al.   CARBOHYDRATE RESEARCH

Influence of Modified Fucoidan and Related Sulfated Oligosaccharides on Hematopoiesis in Cyclophosphamide-Induced Mice

(2018) Natalia Anisimova et al.   Marine Drugs

Gemcitabine delivered by fucoidan/chitosan nanoparticles presents increased toxicity over human breast cancer cells

(2018) Catarina Oliveira et al.   Nanomedicine

Fucoidan Inhibits Radiation-Induced Pneumonitis and Lung Fibrosis by Reducing Inflammatory Cytokine Expression in Lung Tissues

(2018) Hsin-Hsien Yu et al.   Marine Drugs

In vitro and in vivo immunomodulatory effects of fucoidan compound agents

(2018) Yongbo Peng et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Laminaria Japonica Polysaccharides effectively inhibited the growth of nasopharyngeal carcinoma cells in vivo and in vitro study

(2017) Manli Zeng et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

An Exploratory Study on the Anti-inflammatory Effects of Fucoidan in Relation to Quality of Life in Advanced Cancer Patients

(2017) Hidenori Takahashi et al.   INTEGRATIVE CANCER THERAPIES

Efficacy of Low-Molecular-Weight Fucoidan as a Supplemental Therapy in Metastatic Colorectal Cancer Patients: A Double-Blind Randomized Controlled Trial

(2017) Hsiang-Lin Tsai et al.   Marine Drugs

Promoting Wound Healing Using Low Molecular Weight Fucoidan in a Full-Thickness Dermal Excision Rat Model

(2017) Jun-Hyeong Park et al.   Marine Drugs

Induction of p53-Independent Apoptosis and G1 Cell Cycle Arrest by Fucoidan in HCT116 Human Colorectal Carcinoma Cells

(2017) Hye Park et al.   Marine Drugs

Anti-Coagulant and Anti-Thrombotic Properties of Blacklip Abalone (Haliotis rubra): In Vitro and Animal Studies

(2017) Hafiz Suleria et al.   Marine Drugs

Tumour-specific PI3K inhibition via nanoparticle-targeted delivery in head and neck squamous cell carcinoma

(2017) Aviram Mizrachi et al.   Nature Communications

Fucoidan-induced ID-1 suppression inhibits the in vitro and in vivo invasion of hepatocellular carcinoma cells

(2016) Yuri Cho et al.   BIOMEDICINE & PHARMACOTHERAPY

Dual and antagonic therapeutic effects of sulfated glycans

(2016) Vitor H. Pomin   BIOORGANIC & MEDICINAL CHEMISTRY

Effect of fucoidan from Turbinaria conoides on human lung adenocarcinoma epithelial (A549) cells

(2016) Madhavarani Alwarsamy et al.   CARBOHYDRATE POLYMERS

Anticoagulant and antithrombotic activities of modified xylofucan sulfate from the brown alga Punctaria plantaginea

(2016) Nadezhda E. Ustyuzhanina et al.   CARBOHYDRATE POLYMERS

Structural characterization and effect on anti-angiogenic activity of a fucoidan from Sargassum fusiforme

(2016) Qifei Cong et al.   CARBOHYDRATE POLYMERS

Doxorubicin-loaded fucoidan capped gold nanoparticles for drug delivery and photoacoustic imaging

(2016) Panchanathan Manivasagan et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Fucoidans in Nanomedicine

(2016) Lucas Chollet et al.   Marine Drugs

The synthesis of heterosaccharides related to the fucoidan from Chordaria flagelliformis bearing an α-l-fucofuranosyl unit

(2016) Dmitry Z. Vinnitskiy et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

P-selectin is a nanotherapeutic delivery target in the tumor microenvironment

(2016) Y. Shamay et al.   Science Translational Medicine

Antitumor activity of fucoidan against diffuse large B cell lymphomain vitroandin vivo

(2015) Guang Yang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Fucoidan from Turbinaria conoides: A multifaceted ‘deliverable’ to combat pancreatic cancer progression

(2015) Caroline R. Delma et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Fucoidan from Macrocystis pyrifera Has Powerful Immune-Modulatory Effects Compared to Three Other Fucoidans

(2015) Wei Zhang et al.   Marine Drugs

Fucoidan and Cancer: A Multifunctional Molecule with Anti-Tumor Potential

(2015) Farzaneh Atashrazm et al.   Marine Drugs

Low Molecular Weight Fucoidan Inhibits Tumor Angiogenesis through Downregulation of HIF-1/VEGF Signaling under Hypoxia

(2015) Meng-Chuan Chen et al.   Marine Drugs

Adoptive cell transfer as personalized immunotherapy for human cancer

(2015) S. A. Rosenberg et al.   SCIENCE

The Treg/Th17 Axis: A Dynamic Balance Regulated by the Gut Microbiome

(2015) Sara Omenetti et al.   Frontiers in Immunology

Fucoidan Extracts Ameliorate Acute Colitis

(2015) Qi Ying Lean et al.   PLoS One

Targeting P-Selectin by Gallium-68–Labeled Fucoidan Positron Emission Tomography for Noninvasive Characterization of Vulnerable Plaques

(2014) Xiang Li et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Fucoidan/FGF-2 induces angiogenesis through JNK- and p38-mediated activation of AKT/MMP-2 signalling

(2014) Beom Su Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Endothelial cells translate pathogen signals into G-CSF-driven emergency granulopoiesis

(2014) S. Boettcher et al.   BLOOD

A Pilot Trial Using Lymphocytes Genetically Engineered with an NY-ESO-1-Reactive T-cell Receptor: Long-term Follow-up and Correlates with Response

(2014) P. F. Robbins et al.   CLINICAL CANCER RESEARCH

Seaweed-microbial interactions: key functions of seaweed-associated bacteria

(2014) Ravindra Pal Singh et al.   FEMS MICROBIOLOGY ECOLOGY

Fucoidans: Pro- or antiangiogenic agents?

(2014) N. E. Ustyuzhanina et al.   GLYCOBIOLOGY

Preparation and Characterization of Fucoidan-Chitosan Nanospheres by the Sonification Method

(2014) Yuangang Liu et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

Gram-Negative Marine Bacteria: Structural Features of Lipopolysaccharides and Their Relevance for Economically Important Diseases

(2014) Muhammad Anwar et al.   Marine Drugs

Fucoidan Inhibits the Proliferation of Human Urinary Bladder Cancer T24 Cells by Blocking Cell Cycle Progression and Inducing Apoptosis

(2014) Hye Park et al.   MOLECULES

Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR–S6K pathway

(2014) J Park et al.   Mucosal Immunology

Fucoidan Can Function as an Adjuvant In Vivo to Enhance Dendritic Cell Maturation and Function and Promote Antigen-Specific T Cell Immune Responses

(2014) Jun-O Jin et al.   PLoS One

Fucoidans as a platform for new anticoagulant drugs discovery

(2014) Nadezhda E. Ustyuzhanina et al.   PURE AND APPLIED CHEMISTRY

Preliminary investigation of a highly sulfated galactofucan fraction isolated from the brown alga Sargassum polycystum

(2013) Maria I. Bilan et al.   CARBOHYDRATE RESEARCH

Fucoidan Extract Enhances the Anti-Cancer Activity of Chemotherapeutic Agents in MDA-MB-231 and MCF-7 Breast Cancer Cells

(2013) Zhongyuan Zhang et al.   Marine Drugs

Fucoidan induces caspase-dependent apoptosis in MC3 human mucoepidermoid carcinoma cells

(2013) HANG-EUN LEE et al.   Experimental and Therapeutic Medicine

Roles of toll-like receptors in Cancer: A double-edged sword for defense and offense

(2012) Shaherin Basith et al.   ARCHIVES OF PHARMACAL RESEARCH

Fucoidan induces changes in the epithelial to mesenchymal transition and decreases metastasis by enhancing ubiquitin-dependent TGF  receptor degradation in breast cancer

(2012) H.-Y. Hsu et al.   CARCINOGENESIS

Anticancer Properties and Mechanisms of Fucoidan on Mouse Breast Cancer In Vitro and In Vivo

(2012) Meilan Xue et al.   PLoS One

Fucoidan from Seaweed Fucus vesiculosus Inhibits Migration and Invasion of Human Lung Cancer Cell via PI3K-Akt-mTOR Pathways

(2012) Hyunkyoung Lee et al.   PLoS One

Acid-promoted synthesis of per-O-sulfated fucooligosaccharides related to fucoidan fragments

(2011) Vadim B. Krylov et al.   CARBOHYDRATE RESEARCH

Antiproliferative Activity of Fucoidan Was Associated with the Induction of Apoptosis and Autophagy in AGS Human Gastric Cancer Cells

(2011) Hyun Soo Park et al.   JOURNAL OF FOOD SCIENCE

Management of venous thromboembolism in patients with cancer

(2011) G. AGNELLI et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Fucose-Containing Sulfated Polysaccharides from Brown Seaweeds Inhibit Proliferation of Melanoma Cells and Induce Apoptosis by Activation of Caspase-3 in Vitro

(2011) Marcel Tutor Ale et al.   Marine Drugs

Important Determinants for Fucoidan Bioactivity: A Critical Review of Structure-Function Relations and Extraction Methods for Fucose-Containing Sulfated Polysaccharides from Brown Seaweeds

(2011) Marcel Tutor Ale et al.   Marine Drugs

Fucans, but Not Fucomannoglucuronans, Determine the Biological Activities of Sulfated Polysaccharides from Laminaria saccharina Brown Seaweed

(2011) Diego O. Croci et al.   PLoS One

Chitooligosaccharides: Synthesis, characterization and applications

(2011) V. K. Mourya et al.   POLYMER SCIENCE SERIES A

Fucoidan reduces the toxicities of chemotherapy for patients with unresectable advanced or recurrent colorectal cancer

(2011) MASAHIDE IKEGUCHI et al.   Oncology Letters

Further studies on the composition and structure of a fucoidan preparation from the brown alga Saccharina latissima

(2010) Maria I. Bilan et al.   CARBOHYDRATE RESEARCH

Immunomodulatory activity of fucoidan against aspirin-induced gastric mucosal damage in rats

(2010) Hanumantha Rao Balaji Raghavendran et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The mechanism of fucoidan-induced apoptosis in leukemic cells: Involvement of ERK1/2, JNK, glutathione, and nitric oxide

(2010) Jun-O Jin et al.   MOLECULAR CARCINOGENESIS

Pilot clinical study to evaluate the anticoagulant activity of fucoidan

(2009) Mohammad R Irhimeh et al.   BLOOD COAGULATION & FIBRINOLYSIS

Inhibition of thrombin and factor Xa by Fucus evanescens fucoidan and its modified analogs

(2009) E. S. Lapikova et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Fucoidans — sulfated polysaccharides of brown algae

(2009) Anatolii I Usov et al.   RUSSIAN CHEMICAL REVIEWS

Radiation-Guided P-Selectin Antibody Targeted to Lung Cancer

(2008) G. Hariri et al.   ANNALS OF BIOMEDICAL ENGINEERING

A sulfated glucuronofucan containing both fucofuranose and fucopyranose residues from the brown alga Chordaria flagelliformis

(2008) Maria I. Bilan et al.   CARBOHYDRATE RESEARCH

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE

TLR signaling by tumor and immune cells: a double-edged sword

(2008) B Huang et al.   ONCOGENE