Review
Immunology
Hideaki Fujiwara
Summary: This article discusses the impact of allo-HSCT on intestinal microbiota and metabolites, as well as the mechanisms for regulating experimental GVHD through dietary intervention or metabolites produced by intestinal bacteria post-allo-HSCT. It also summarizes the major findings of microbiome-based immunotherapeutic approaches for tissue protection against experimental GVHD. Understanding the complex relationships within the gut microbiota-metabolites-host tissues axis is crucial for insight into GVHD pathogenesis and the development of new therapeutic strategies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Zhenyang Gu, Qian Xiong, Lu Wang, Lili Wang, Fei Li, Cheng Hou, Liping Dou, Baoli Zhu, Daihong Liu
Summary: This study indicates that gut dysbiosis in platforms of ATG-based myeloablative allo-HCT features loss of bacterial diversity. The diversity of the intestinal flora at the engraftment period is an independent predictor of longer survival.
Review
Immunology
Tao Hong, Rui Wang, Xiaoqi Wang, Shijie Yang, Weihao Wang, Qiangguo Gao, Xi Zhang
Summary: Allogeneic hematopoietic stem cell transplantation is an effective therapy for hematological disorders, but acute graft-versus-host disease remains a major obstacle with potentially high mortality rates. Imbalance in intestinal microbiota is associated with the development and severity of aGVHD, impacting clinical outcomes following allo-HSCT. Monitoring and modifying the intestinal microecology post allo-HSCT may offer promising approaches for diagnosing, preventing, or treating aGVHD in clinical settings.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Hematology
Lijie Han, Haiyan Zhang, Ping Ma, Jie Peng, Yilu Li, Jiaying Wu, Yuanyuan Li, Jifeng Yu, Wei Li, Mengmeng Zhang, Jia Bao He, Zhiping Fan, Weimin Wang, Li'na Sang, Hui Sun, Qifa Liu, Yang Liu, Zhongxing Jiang
Summary: The intestinal microbiota score at neutrophil recovery could predict survival following allo-HSCT. A low score was associated with better 3-year cumulative overall survival and lower mortality. High score was found to be an independent risk factor for poor survival.
ANNALS OF HEMATOLOGY
(2022)
Article
Medicine, Research & Experimental
Erika S. Varady, L. Angel Ayala, Pauline U. Nguyen, Vanessa M. Scarfone, Alborz Karimzadeh, Cuiwen Zhou, Xiyu Chen, Scott A. Greilach, Craig M. Walsh, Matthew A. Inlay
Summary: Donor cell conditioning with the glucocorticoid fluticasone propionate (FLU) prior to transplantation increases HSC engraftment and reduces the severity and incidence of graft-versus-host disease (GvHD) in allogeneic hosts.
EMBO MOLECULAR MEDICINE
(2023)
Review
Health Care Sciences & Services
Andrea Pession, Daniele Zama, Edoardo Muratore, Davide Leardini, Davide Gori, Federica Guaraldi, Arcangelo Prete, Silvia Turroni, Patrizia Brigidi, Riccardo Masetti
Summary: FMT has been used in allo-HSCT patients for therapeutic and preventive purposes, but further research on the biological mechanisms is needed. Concerns exist regarding the safety and efficacy of administering microbial consortia in immune-compromised patients.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Oncology
Siddika Songul Yalcin, Tekin Aksu, Baris Kuskonmaz, Namik Yasar Ozbek, Vicente Perez-Brocal, Melda Celik, Duygu Uckan Cetinkaya, Andres Moya, Ener Cagri Dinleyici
Summary: This study evaluated the mycobiota composition pre- and post-HSCT in children with thalassemia, revealing a decrease in diversity following transplantation. Particularly, there was a predominance of Malassezia in children with GVHD. Further research is needed to understand this phenomenon in children with GVHD.
PEDIATRIC BLOOD & CANCER
(2022)
Review
Biochemistry & Molecular Biology
Riccardo Masetti, Daniele Zama, Davide Leardini, Edoardo Muratore, Silvia Turroni, Patrizia Brigidi, Andrea Pession
Summary: The gut microbiome plays a significant role in hematopoietic stem cell transplantation, with its metabolites mediating interactions between intestinal microbial communities and the host. New data offer a fresh perspective on the role of microbiome-derived metabolites in transplant settings.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Yosuke Okada, Hideki Nakasone, Yuhei Nakamura, Masakatsu Kawamura, Shunto Kawamura, Junko Takeshita, Nozomu Yoshino, Yukiko Misaki, Kazuki Yoshimura, Shimpei Matsumi, Ayumi Gomyo, Aki Tanihara, Masaharu Tamaki, Machiko Kusuda, Kazuaki Kameda, Shun-Ichi Kimura, Shinichi Kako, Noriko Oyama-Manabe, Yoshinobu Kanda
Summary: Pancreatic atrophy is associated with chronic graft-versus-host disease after allogeneic hematopoietic cell transplantation. The recovery of pancreatic thickness plays a crucial role in body weight recovery, but pancreatic atrophy may have a negative impact on prognosis.
JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Immunology
Thomas Krueger, Rebekka Wehner, Maik Herbig, Martin Kraeter, Michael Kramer, Jan Moritz Middeke, Friedrich Stoelzel, Catrin List, Katharina Egger-Heidrich, Raphael Teipel, Uta Oelschlaegel, Martin Wermke, Helena Jambor, Manja Wobus, Johannes Schetelig, Korinna Joehrens, Torsten Tonn, Julien Subburayalu, Marc Schmitz, Martin Bornhauser, Malte von Bonin
Summary: Functional impairment of the bone marrow niche, particularly a decrease in mesenchymal stromal cells (MSCs), is associated with cytopenia and graft failure after hematopoietic cell transplantation. Acute graft-versus-host disease (aGvHD) is shown to significantly reduce MSC numbers, and this reduction can be observed before clinical onset of aGvHD. The different phenotypic and functional characteristics of MSCs depending on the occurrence of aGvHD suggest that they may contribute to alloreactivity after transplantation.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Gastroenterology & Hepatology
Fei Gao, Hengwei Wu, Limengmeng Wang, Yanmin Zhao, He Huang
Summary: Despite advancements in HSCT, GVHD, especially intestinal GVHD, still poses a significant challenge to the procedure. Traditionally, GVHD has been seen as an immune response, with the intestine as a target. However, factors such as altered intestinal microbiome and epithelial damage contribute to intestinal damage after transplantation. This review summarizes these factors and explores the potential of remodeling intestinal homeostasis in GVHD management.
Article
Hematology
Oriana Miltiadous, Nicholas R. Waters, Hana Andrlova, Anqi Dai, Chi L. Nguyen, Marina Burgos da Silva, Sarah Lindner, John Slingerland, Paul Giardina, Annelie Clurman, Gabriel K. Armijo, Antonio L. C. Gomes, Madhavi Lakkaraja, Peter Maslak, Michael Scordo, Roni Shouval, Anna Staffas, Richard O'Reilly, Ying Taur, Susan Prockop, Jaap Jan Boelens, Sergio Giralt, Miguel-Angel Perales, Sean M. Devlin, Jonathan U. Peled, Kate A. Markey, Marcel R. M. van den Brink
Summary: This study analyzed stool samples and peripheral blood samples from patients undergoing allogeneic hematopoietic cell transplantation, and found that the diversity of intestinal microbiota and the relative abundance of specific bacterial genera were associated with the recovery of immune cells.
Article
Oncology
Ana Claudia Scaraficci, Patricia Maria Fernandes, Fabio Abreu Alves, Jayr Schmidt Filho, Graziella Chagas Jaguar
Summary: The study revealed that the mean time for oral GVHD to develop after AHCT was 229 days, with pain and xerostomia being the main symptoms, and ulcers being the most common oral manifestation. Patients who received myeloablative conditioning regimen had a higher survival rate.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Microbiology
Ashley N. Gray, Nicole H. Tobin, Theodore B. Moore, Fan Li, Grace M. Aldrovandi
Summary: Allogeneic Hematopoietic Cell Transplantation (HCT) offers a chance of survival to children with life-threatening diseases, but complications from graft-versus-host disease (GVHD) have been identified as a significant cause of morbidity and mortality. Recent research has found that gut dysbiosis is associated with GVHD in adult HCT patients. In this study, a longitudinal analysis of the gut microbiota in nine pediatric allogeneic HCT participants revealed that HCT and antibiotic therapy caused acute shifts in gut microbiota diversity, with those experiencing stages 3-4 gut GVHD having greater microbiota variation over time. Pre-HCT microbiota diversity showed a trend towards an inverse relationship with gut microbiota stability over time. Further large-scale prospective studies are needed to understand the mechanisms underlying these dynamic changes in the gut microbiota after pediatric allogeneic HCT.
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Chia-Chi Chang, Eiko Hayase, Robert R. Jenq
Summary: This article reviews the impact of the microbiota on allo-HSCT outcomes, including effects of microbiota-derived metabolites, crosstalk between commensals and the allogeneic immune response, and the effects of HSCT and transplant-related procedures on the microbiota. The study indicates that the composition of the intestinal microbiota may serve as a predictive biomarker for assessing the risk and severity of acute GVHD in patients undergoing allo-HSCT.
EXPERT OPINION ON BIOLOGICAL THERAPY
(2021)
Article
Plant Sciences
Yanping Wang, Jinzhu Li, Li Yang, Zhulong Chan
Summary: This study reveals that melatonin can promote primary root growth in plants by regulating auxin transport and modulating cytokinin signaling pathway.
JOURNAL OF PLANT GROWTH REGULATION
(2023)
Article
Chemistry, Applied
Fan Yang, Jia Li, Xin-Lei Du, Shi-Jun Wang, Xiang-Hao Xu, Yong-Qing Zhang, Ran Yang
Summary: Two new constituents, salignan A and salside A, along with two known compounds, have been isolated from the aerial parts of Salvia miltiorrhiza Bge. Compound salignan A and salside A showed moderate inhibitory effects on NO production, while compound 4 exhibited moderate antioxidant activity.
NATURAL PRODUCT RESEARCH
(2023)
Article
Oncology
Yue Ning, Yang Yang, Hongmei Zheng, Yuting Zhan, Hongjing Zang, Qiuyuan Wen, Jinwu Peng, Songqing Fan
Summary: This study reveals that FAT4 is downregulated in non-small cell lung cancer and is associated with poor prognosis. Overexpression or knockdown of FAT4 regulates the metastasis of lung adenocarcinoma and promotes an immunosuppressive tumor microenvironment. Additionally, DNA methylation of specific CpG sites is strongly associated with FAT4 expression.
Article
Oncology
Yiding Li, Guiling Wu, Yujie Zhang, Wanli Yang, Xiaoqian Wang, Lili Duan, Liaoran Niu, Junfeng Chen, Wei Zhou, Jinqiang Liu, Daiming Fan, Liu Hong
Summary: Marital status affects the survival rate of retroperitoneal liposarcoma patients, with divorced, separated, or widowed patients having lower survival rates and being diagnosed at a later stage with less surgical treatment. This effect is more pronounced in older and female patients.
Article
Chemistry, Physical
Bao Zhang, Yannan Zhang, Jianguo Duan, Xue Li, Xiaoyuan Zeng, Kai Zhou, Zhengwu Wang, Zheng Lian, Peng Dong, Yingjie Zhang
Summary: Lithium manganate cathode materials are attractive for cobalt-free lithium ion batteries due to their low-cost and low toxicity. However, they suffer from capacity fading caused by transition metal dissolution. Coating the surface with Gd2O3 can effectively reduce side reactions and the dissolution of manganese, resulting in improved electrochemical performance.
Article
Nanoscience & Nanotechnology
Jin-Hua Peng, Zhen Zhang, Huan-huan Chen, Qian-Hao Zang, Liang-Yu Chen, Ting-Ting Guo, Sheng Lu
Summary: Ambient extrusion was used to introduce different pre-strains in billets of AZ31 magnesium alloy. The results showed that the pre-strain had a significant effect on tension-compression asymmetry and Bauschinger-like effect, with the strongest effect observed at a pre-strain of approximately 11%.
MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING
(2023)
Article
Engineering, Mechanical
Jie Huang, Chaoshun Li, Xiangqu Xiao, Tian Yu, Xiaohui Yuan, Yongchuan Zhang
Summary: This study proposes a novel method, called adaptive multivariate chirp mode decomposition (AMCMD), to address the challenges of prior knowledge requirement, narrowband limitation, and mode mixing in existing multivariate signal decomposition methods. The method captures time-varying joint modes in a recursive framework and uses demodulation techniques to convert wideband signals into narrowband characteristics. The effectiveness and superiority of the method are demonstrated through numerical examples and real-world time-varying vibration signal analysis.
MECHANICAL SYSTEMS AND SIGNAL PROCESSING
(2023)
Review
Clinical Neurology
Xiaoqing Zhong, Miaomiao Wang, Qingxia Meng, Xuebin Jiang, Zhendong Guo, Yunzhou Zhang, Daiquan Gao
Summary: We reported a rare case of meningitis caused by infection of oral anaerobes in a middle-aged woman. The metagenomic next-generation sequencing (mNGS) accurately detected the pathogens of infectious diseases.
Article
Environmental Sciences
Chenbin Cui, Xinru Wang, Yao Zheng, Lindeng Li, Fangke Wang, Hongkui Wei, Jian Peng
Summary: A study found that treatment with deoxynivalenol (DON) reduced the number of Paneth cells in mouse intestines. However, disrupting Paneth cells using dithizone worsened intestinal injury and affected intestinal stem cells and microbiota in DON-treated mice. Surprisingly, the number of goblet cells and proliferative cells increased after treatment with dithizone and DON.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Thermodynamics
Wei Gao, Ming Liu, Junjie Yin, Yongliang Zhao, Weixiong Chen, Junjie Yan
Summary: In this study, a dynamic model of a coal-fired power plant is developed to evaluate the characteristics of a denitrification system during load cycling transient processes. An improved control strategy for the denitrification system is proposed, which effectively controls the NOx outlet concentration and NH3 slip.
Article
Chemistry, Analytical
Jian-Peng Hu, Qi Lin, Hong Yao, You-Ming Zhang, Tai-Bao Wei
Summary: In this paper, selective sensing materials for biogenic amine detection were designed and synthesized. The materials exhibited a transition from microsphere structure to supramolecular polymer gel, with fluorescence emission enhancement in the gel state. The supramolecular polymer gel material showed sensitive stimulus-response behavior and could be applied to detect food spoilage.
MICROCHEMICAL JOURNAL
(2023)
Review
Medicine, General & Internal
Xingxing Sun, Yanling Teng, Shengnan Mu, Yilian Wang, Hongwu Chen
Summary: ECG-based algorithms exhibit high sensitivity and moderate specificity in diagnosing wide QRS complex tachycardia (WCT). Combining the Brugada or Vereckei-aVR algorithm with RWPT-II could be considered for diagnosing WCT.
Article
Astronomy & Astrophysics
Z. P. Ye, F. Hu, W. Tian, Q. C. Chang, Y. L. Chang, Z. S. Cheng, J. Gao, T. Ge, G. H. Gong, J. Guo, X. X. Guo, X. G. He, J. T. Huang, K. Jiang, P. K. Jiang, Y. P. Jing, H. L. Li, J. L. Li, L. Li, W. L. Li, Z. Li, N. Y. Liao, Q. Lin, J. Lin, F. Liu, J. L. Liu, X. H. Liu, P. Miao, C. Mo, I. Morton-Blake, T. Peng, Z. Y. Sun, J. N. Tang, Z. B. Tang, C. H. Tao, X. L. Tian, M. X. Wang, Y. Wang, Y. Wang, H. D. Wei, Z. Y. Wei, W. H. Wu, S. S. Xian, D. Xiang, D. L. Xu, Q. Xue, J. H. Yang, J. M. Yang, W. B. Yu, C. Zeng, F. Y. D. Zhang, T. Zhang, X. T. Zhang, Y. Y. Zhang, W. Zhi, Y. S. Zhong, M. Zhou, X. H. Zhu, G. J. Zhuang
Summary: The finding of a suitable site for a neutrino telescope in the northeastern region of the South China Sea is presented, along with the design and expected performance of a next-generation neutrino telescope called TRIDENT. This telescope, with its advanced technology and large dimensions, aims to observe the IceCube steady source candidate NGC 1068 with significant significance within one year of operation. It is hoped that this level of sensitivity will shed light on the origin of cosmic rays and contribute to fundamental physics research.
Article
Pharmacology & Pharmacy
H. -L. Chen, J. -P. Hu, J. -F. Li, Q. Li, L. Lan
Summary: This study investigates the possible pathways by which zoledronic acid regulates osteogenesis when blood glucose levels are high. The study found that zoledronic acid can modulate the expression of the RUNX2 transcription factor through epigenetic regulation under a high-glucose environment.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Materials Science, Multidisciplinary
Tao Yang, Xiangyuan Chen, Tingting Liu, Zhiguang Zhu, Huiliang Wei, Yulei Du, Changdong Zhang, Wenhe Liao
Summary: The inclusion of 2 wt% Zr50.7Cu28Al12.3Ni9 metallic glass powders successfully eliminated hot cracks in AA-7075 specimens fabricated by laser powder bed fusion. Microstructure analysis revealed significant grain refinement in the AA-7075/MG specimen due to the formation of Al3Zr precipitates. The average grain size reduced from 9.26 μm to 1.6 μm, and the previously coarser columnar grains transformed into finer equiaxed grains with random orientation.
