The Pleiotropy of PAX5 Gene Products and Function

Paired box 5 increases the chemosensitivity of esophageal squamous cell cancer cells by promoting p53 signaling activity

(2022) Weiwei Zhang et al.   CHINESE MEDICAL JOURNAL

EBF1 drives hallmark B cell gene expression by enabling the interaction of PAX5 with the MLL H3K4 methyltransferase complex

(2021) Charles E. Bullerwell et al.   Scientific Reports

Insights Into the Role of CircRNAs: Biogenesis, Characterization, Functional, and Clinical Impact in Human Malignancies

(2021) Sabah Nisar et al.   Frontiers in Cell and Developmental Biology

Enhancing B-Cell Malignancies—On Repurposing Enhancer Activity towards Cancer

(2021) Marta Elżbieta Kasprzyk et al.   Cancers

New Molecular Mechanisms and Clinical Impact of circRNAs in Human Cancer

(2021) Giulia Fontemaggi et al.   Cancers

Cyclophosphamide inhibits Pax5 methylation to regulate the growth of retinoblastoma via the Notch1 pathway

(2021) Lan Jin et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Pax-5 Protein Expression Is Regulated by Transcriptional 3′UTR Editing

(2021) Annie-Pier Beauregard et al.   Cells

Overview of PAX gene family: analysis of human tissue-specific variant expression and involvement in human disease

(2020) Brian Thompson et al.   HUMAN GENETICS

Repression of the B cell identity factor Pax5 is not required for plasma cell development

(2020) Grace J. Liu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Metabolic Gatekeepers of Pathological B Cell Activation

(2020) Teresa Sadras et al.   Annual Review of Pathology-Mechanisms of Disease

Genome-wide discovery of somatic coding and non-coding mutations in pediatric endemic and sporadic Burkitt lymphoma

(2019) Bruno M. Grande et al.   BLOOD

Combined Transcriptome and Proteome Analysis of Immortalized Human Keratinocytes Expressing Human Papillomavirus 16 (HPV16) Oncogenes Reveals Novel Key Factors and Networks in HPV-Induced Carcinogenesis

(2019) Ruwen Yang et al.   mSphere

Circular RNAs: A Novel Class of Functional RNA Molecules with a Therapeutic Perspective

(2019) Laura Santer et al.   MOLECULAR THERAPY

PAX5 is part of a functional transcription factor network targeted in lymphoid leukemia

(2019) Kazuki Okuyama et al.   PLoS Genetics

Circular RNA differential expression in blood cell populations and exploration of circRNA deregulation in pediatric acute lymphoblastic leukemia

(2019) Enrico Gaffo et al.   Scientific Reports

Transactivation of PTGS2 by PAX5 signaling potentiates cisplatin resistance in muscle-invasive bladder cancer cells

(2018) Bing-wei Dong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Epigenetic regulation in B-cell maturation and its dysregulation in autoimmunity

(2018) Haijing Wu et al.   Cellular & Molecular Immunology

Pax-5 Inhibits NF-κB Activity in Breast Cancer Cells Through IKKε and miRNA-155 Effectors

(2018) Jason Harquail et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Nuclear functions of mammalian MicroRNAs in gene regulation, immunity and cancer

(2018) Hongyu Liu et al.   Molecular Cancer

PU.1 Is Required for the Developmental Progression of Multipotent Progenitors to Common Lymphoid Progenitors

(2018) Swee Heng Milon Pang et al.   Frontiers in Immunology

Direct role of FLT3 in regulation of early lymphoid progenitors

(2018) Alya Zriwil et al.   BRITISH JOURNAL OF HAEMATOLOGY

PAX5-ELN oncoprotein promotes multistep B-cell acute lymphoblastic leukemia in mice

(2018) Laura Jamrog et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-wide discovery of somatic regulatory variants in diffuse large B-cell lymphoma

(2018) Sarah E. Arthur et al.   Nature Communications

PAX5A and PAX5B isoforms are both efficient to drive B cell differentiation

(2018) Charlotte Cresson et al.   Oncotarget

MiRNAs 484 and 210 Regulate Pax-5 Expression and Function in Breast Cancer Cells

(2018) Jason Harquail et al.   CARCINOGENESIS

PAX5 gene as a novel methylation marker that predicts both clinical outcome and cisplatin sensitivity in esophageal squamous cell carcinoma

(2017) Keisuke Kurimoto et al.   Epigenetics

Metabolic gatekeeper function of B-lymphoid transcription factors

(2017) Lai N. Chan et al.   NATURE

Pax-5 is a potent regulator of E-cadherin and breast cancer malignant processes

(2017) Sami Benzina et al.   Oncotarget

PAX5 tyrosine phosphorylation by SYK co-operatively functions with its serine phosphorylation to cancel the PAX5-dependent repression of BLIMP1: A mechanism for antigen-triggered plasma cell differentiation

(2016) Yuichiro Inagaki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Aberrant methylation of tumour suppressor genes WT1, GATA5 and PAX5 in hepatocellular carcinoma

(2016) Martin Mžik et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Non-coding RNAs as regulators in epigenetics

(2016) Jian-Wei Wei et al.   ONCOLOGY REPORTS

Regulatory RNAs and control of epigenetic mechanisms: expectations for cognition and cognitive dysfunction

(2016) Anderson A Butler et al.   Epigenomics

Regulation of B-cell development and tolerance by different members of the miR-17∼92 family microRNAs

(2016) Maoyi Lai et al.   Nature Communications

Transcription-coupled genetic instability marks acute lymphoblastic leukemia structural variation hotspots

(2016) Merja Heinäniemi et al.   eLife

Tet2 and Tet3 cooperate with B-lineage transcription factors to regulate DNA modification and chromatin accessibility

(2016) Chan-Wang Lio et al.   eLife

Breast Cancer Malignant Processes are Regulated by Pax-5 Through the Disruption of FAK Signaling Pathways

(2016) Sami Benzina et al.   Journal of Cancer

Epigenetic Control of B Cell Development and B-Cell-Related Immune Disorders

(2015) Yan Bao et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

The FOXO1 Transcription Factor Instructs the Germinal Center Dark Zone Program

(2015) David Dominguez-Sola et al.   IMMUNITY

Paired box gene 5 isoforms A and B have different functions in transcriptional regulation of B cell development-related genes in immature B cells

(2015) Hidehiko Kikuchi et al.   MICROBIOLOGY AND IMMUNOLOGY

Non-coding recurrent mutations in chronic lymphocytic leukaemia

(2015) Xose S. Puente et al.   NATURE

RNA-mediated epigenetic regulation of gene expression

(2015) Daniel Holoch et al.   NATURE REVIEWS GENETICS

The MYC/miR-17-92 axis in lymphoproliferative disorders: A common pathway with therapeutic potential

(2015) Michele Dal Bo et al.   Oncotarget

DNA methylation-based subtype prediction for pediatric acute lymphoblastic leukemia

(2015) Jessica Nordlund et al.   Clinical Epigenetics

Applicability of the methylated CpG sites of paired box 5 (PAX5) promoter for prediction the prognosis of gastric cancer

(2015) Jingyu Deng et al.   Oncotarget

Interpreting the language of histone and DNA modifications

(2014) Scott B. Rothbart et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Key tumor suppressor genes inactivated by “greater promoter” methylation and somatic mutations in head and neck cancer

(2014) Rafael Guerrero-Preston et al.   Epigenetics

Pax5 loss imposes a reversible differentiation block in B-progenitor acute lymphoblastic leukemia

(2014) G. J. Liu et al.   GENES & DEVELOPMENT

Three novel fusion transcripts of the paired box 5 gene in B-cell precursor acute lymphoblastic leukemia

(2014) G. Fazio et al.   HAEMATOLOGICA

Multiple functions of hypoxia-regulated miR-210 in cancer

(2014) Qin Qin et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The miR-155–PU.1 axis acts on Pax5 to enable efficient terminal B cell differentiation

(2014) Dong Lu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Identification of Pax5 Target Genes in Early B Cell Differentiation

(2014) C. Pridans et al.   JOURNAL OF IMMUNOLOGY

The role of Pax5 in leukemia: diagnosis and prognosis significance

(2014) Mohammad Shahjahani et al.   MEDICAL ONCOLOGY

Epigenetic Function of Activation-Induced Cytidine Deaminase and Its Link to Lymphomagenesis

(2014) Pilar M. Dominguez et al.   Frontiers in Immunology

The Interplay between Chromatin and Transcription Factor Networks during B Cell Development: Who Pulls the Trigger First?

(2014) Mohamed Amin Choukrallah et al.   Frontiers in Immunology

The Myc-miR-17-92 axis amplifies B-cell receptor signaling via inhibition of ITIM proteins: a novel lymphomagenic feed-forward loop

(2013) J. N. Psathas et al.   BLOOD

Alternative splicing of the trout Pax5 gene and identification of novel B cell populations using Pax5 signatures

(2013) Elizabeth MacMurray et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

A recurrent germline PAX5 mutation confers susceptibility to pre-B cell acute lymphoblastic leukemia

(2013) Sohela Shah et al.   NATURE GENETICS

Epigenetics of the antibody response

(2013) Guideng Li et al.   TRENDS IN IMMUNOLOGY

Coordinated Expression of Pax-5 and FAK1 in Metastasis

(2012) Nicolas Crapoulet et al.   Anti-Cancer Agents in Medicinal Chemistry

Expression of glucose transporters in cancers

(2012) Leszek Szablewski   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Genetic Alterations Activating Kinase and Cytokine Receptor Signaling in High-Risk Acute Lymphoblastic Leukemia

(2012) Kathryn G. Roberts et al.   CANCER CELL

PAX Proteins and Fables of Their Reconstruction

(2012) Darrell Alan Underhill   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

The B-cell identity factor Pax5 regulates distinct transcriptional programmes in early and late B lymphopoiesis

(2012) Roger Revilla-i-Domingo et al.   EMBO JOURNAL

B Cell Receptor-ERK1/2 Signal Cancels PAX5-Dependent Repression of BLIMP1 through PAX5 Phosphorylation: A Mechanism of Antigen-Triggering Plasma Cell Differentiation

(2012) T. Yasuda et al.   JOURNAL OF IMMUNOLOGY

PAX5/ETV6 alters the gene expression profile of precursor B cells with opposite dominant effect on endogenous PAX5

(2012) G Fazio et al.   LEUKEMIA

A Methyl-Deficient Diet Modifies Early B Cell Development

(2012) Toshiaki Kurogi et al.   PATHOBIOLOGY

Epigenetic and Copy Number Variation Analysis in Retinoblastoma by MS-MLPA

(2012) Gabriella Livide et al.   PATHOLOGY & ONCOLOGY RESEARCH

Circular RNAs Are the Predominant Transcript Isoform from Hundreds of Human Genes in Diverse Cell Types

(2012) Julia Salzman et al.   PLoS One

PAX5 deletion is common and concurrently occurs with CDKN2A deletion in B-lineage acute lymphoblastic leukemia

(2011) Miyoung Kim et al.   BLOOD CELLS MOLECULES AND DISEASES

The Pax-5 Gene: A Pluripotent Regulator of B-cell Differentiation and Cancer Disease

(2011) P. O'Brien et al.   CANCER RESEARCH

The transcription factor Pax5 regulates its target genes by recruiting chromatin-modifying proteins in committed B cells

(2011) Shane McManus et al.   EMBO JOURNAL

miR-210: More than a silent player in hypoxia

(2011) Cecilia Devlin et al.   IUBMB LIFE

Histone Acetyltransferase p300 Acetylates Pax5 and Strongly Enhances Pax5-mediated Transcriptional Activity

(2011) Ti He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ebf1orPax5haploinsufficiency synergizes with STAT5 activation to initiate acute lymphoblastic leukemia

(2011) Lynn M. Heltemes-Harris et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Frequent promoter hypermethylation of BRCA2, CDH13, MSH6, PAX5, PAX6 and WT1 in ductal carcinoma in situ and invasive breast cancer

(2011) Cathy B Moelans et al.   JOURNAL OF PATHOLOGY

Epigenetic inactivation of paired box gene 5, a novel tumor suppressor gene, through direct upregulation of p53 is associated with prognosis in gastric cancer patients

(2011) X Li et al.   ONCOGENE

PAX5–PML acts as a dual dominant-negative form of both PAX5 and PML

(2011) S Kurahashi et al.   ONCOGENE

Dominant-negative mechanism of leukemogenic PAX5 fusions

(2011) N Kawamata et al.   ONCOGENE

Global MicroRNA Expression Profiling Identifies MiR-210 Associated with Tumor Proliferation, Invasion and Poor Clinical Outcome in Breast Cancer

(2011) Françoise Rothé et al.   PLoS One

Wide diversity of PAX5 alterations in B-ALL: a Groupe Francophone de Cytogenetique Hematologique study

(2010) E. Coyaud et al.   BLOOD

Structure and Function of Mammalian DNA Methyltransferases

(2010) Renata Zofia Jurkowska et al.   CHEMBIOCHEM

TET Genes: new players in DNA demethylation and important determinants for stemness

(2010) Fabian Mohr et al.   EXPERIMENTAL HEMATOLOGY

Paired box gene 5is a novel tumor suppressor in hepatocellular carcinoma through interaction with p53 signaling pathway

(2010) Weili Liu et al.   HEPATOLOGY

Epigenetics and gene expression

(2010) E R Gibney et al.   HEREDITY

Overexpression of PAX5 induces apoptosis in multiple myeloma cells

(2010) Maryse Proulx et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Epithelial-Mesenchymal Transition in Cancer: Parallels Between Normal Development and Tumor Progression

(2010) Douglas S. Micalizzi et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Epigenetic regulation of PAX5 expression in acute T-cell lymphoblastic leukemia

(2010) Gero Hütter et al.   LEUKEMIA RESEARCH

Breast carcinoma cells re-express E-cadherin during mesenchymal to epithelial reverting transition

(2010) Yvonne L Chao et al.   Molecular Cancer

PAX5  Enhances the Epithelial Behavior of Human Mammary Carcinoma Cells

(2010) L. J-P Vidal et al.   MOLECULAR CANCER RESEARCH

A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate

(2010) Yin C Lin et al.   NATURE IMMUNOLOGY

MiR-210 – micromanager of the hypoxia pathway

(2010) Xin Huang et al.   TRENDS IN MOLECULAR MEDICINE

Molecular mechanisms controlling E-cadherin expression in breast cancer

(2009) Somesh Baranwal et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Multiple isoforms ofPAX5are expressed in both lymphomas and normal B-cells

(2009) Jean-René Arseneau et al.   BRITISH JOURNAL OF HAEMATOLOGY

Widespread Shortening of 3′UTRs by Alternative Cleavage and Polyadenylation Activates Oncogenes in Cancer Cells

(2009) Christine Mayr et al.   CELL

A gene expression signature that defines breast cancer metastases

(2009) Rachel E. Ellsworth et al.   CLINICAL & EXPERIMENTAL METASTASIS

PAX5 is expressed in small-cell lung cancer and positively regulates c-Met transcription

(2009) Rajani Kanteti et al.   LABORATORY INVESTIGATION

Genome-wide profiling of genetic alterations in acute lymphoblastic leukemia: recent insights and future directions

(2009) C G Mullighan et al.   LEUKEMIA

PAX5 mutations occur frequently in adult B-cell progenitor acute lymphoblastic leukemia and PAX5 haploinsufficiency is associated with BCR-ABL1 and TCF3-PBX1 fusion genes: a GRAALL study

(2009) J Familiades et al.   LEUKEMIA

Hypoxia-Inducible mir-210 Regulates Normoxic Gene Expression Involved in Tumor Initiation

(2009) Xin Huang et al.   MOLECULAR CELL

Opposing effects of SWI/SNF and Mi-2/NuRD chromatin remodeling complexes on epigenetic reprogramming by EBF and Pax5

(2009) H. Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

To localize or not to localize: mRNA fate is in 3′UTR ends

(2009) Catia Andreassi et al.   TRENDS IN CELL BIOLOGY

E-cadherin as an indicator of mesenchymal to epithelial reverting transitions during the metastatic seeding of disseminated carcinomas

(2008) Alan Wells et al.   CLINICAL & EXPERIMENTAL METASTASIS

Paxgenes in embryogenesis and oncogenesis

(2008) Qiuyu Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Acute lymphoblastic leukaemia

(2008) Ching-Hon Pui et al.   LANCET

Incidence and diversity of PAX5 fusion genes in childhood acute lymphoblastic leukemia

(2008) K Nebral et al.   LEUKEMIA

BCR–ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros

(2008) Charles G. Mullighan et al.   NATURE

Development of an isoform-specific gene suppression system: the study of the human Pax-5B transcriptional element

(2008) G. A. Robichaud et al.   NUCLEIC ACIDS RESEARCH

Variable breakpoints target PAX5 in patients with dicentric chromosomes: A model for the basis of unbalanced translocations in cancer

(2008) Q. An et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cloning of genes involved in chromosomal translocations by high-resolution single nucleotide polymorphism genomic microarray

(2008) N. Kawamata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proliferating Cells Express mRNAs with Shortened 3' Untranslated Regions and Fewer MicroRNA Target Sites

(2008) R. Sandberg et al.   SCIENCE

Global Genomic Characterization of Acute Lymphoblastic Leukemia

(2008) Charles G. Mullighan et al.   SEMINARS IN HEMATOLOGY