Metabolic gatekeeper function of B-lymphoid transcription factors

Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex

(2015) Silvana Konermann et al.   NATURE

Mechanisms of clonal evolution in childhood acute lymphoblastic leukemia

(2015) Srividya Swaminathan et al.   NATURE IMMUNOLOGY

Infection Exposure Is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of Pax5-Inherited Susceptibility

(2015) A. Martin-Lorenzo et al.   Cancer Discovery

Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation

(2014) Luke A. Gilbert et al.   CELL

Adenovirus E4ORF1-Induced MYC Activation Promotes Host Cell Anabolic Glucose Metabolism and Virus Replication

(2014) Minh Thai et al.   Cell Metabolism

Pax5 loss imposes a reversible differentiation block in B-progenitor acute lymphoblastic leukemia

(2014) G. J. Liu et al.   GENES & DEVELOPMENT

RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia

(2014) Elli Papaemmanuil et al.   NATURE GENETICS

Acquired Initiating Mutations in Early Hematopoietic Cells of CLL Patients

(2014) F. Damm et al.   Cancer Discovery

AMPK-Dependent Degradation of TXNIP upon Energy Stress Leads to Enhanced Glucose Uptake via GLUT1

(2013) Ning Wu et al.   MOLECULAR CELL

The genomic landscape of hypodiploid acute lymphoblastic leukemia

(2013) Linda Holmfeldt et al.   NATURE GENETICS

Expression of BCR/ABL p210 from a Knockin Allele Enhances Bone Marrow Engraftment without Inducing Neoplasia

(2013) Samantha B. Foley et al.   Cell Reports

AMPK Is a Negative Regulator of the Warburg Effect and Suppresses Tumor Growth In Vivo

(2012) Brandon Faubert et al.   Cell Metabolism

Osteoblasts mediate the adverse effects of glucocorticoids on fuel metabolism

(2012) Tara C. Brennan-Speranza et al.   JOURNAL OF CLINICAL INVESTIGATION

A self-reinforcing regulatory network triggered by limiting IL-7 activates pre-BCR signaling and differentiation

(2012) Kyoko Ochiai et al.   NATURE IMMUNOLOGY

Developmental origins and impact of BCR-ABL1 fusion and IKZF1 deletions in monozygotic twins with Ph+ acute lymphoblastic leukemia

(2011) G. Cazzaniga et al.   BLOOD

MondoA Senses Non-glucose Sugars

(2011) Carrie A. Stoltzman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CCAAT/enhancer binding protein   (C/EBP )-induced transdifferentiation of pre-B cells into macrophages involves no overt retrodifferentiation

(2011) A. Di Tullio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of novel cluster groups in pediatric high-risk B-precursor acute lymphoblastic leukemia with gene expression profiling: correlation with genome-wide DNA copy number alterations, clinical characteristics, and outcome

(2010) R. C. Harvey et al.   BLOOD

Altered Metabolism and Lipodystrophy in the Early B-Cell Factor 1-Deficient Mouse

(2010) Jackie A. Fretz et al.   ENDOCRINOLOGY

Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells

(2010) Daisuke Nakada et al.   NATURE

The Lkb1 metabolic sensor maintains haematopoietic stem cell survival

(2010) Sushma Gurumurthy et al.   NATURE

Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells

(2010) Boyi Gan et al.   NATURE

Gene expression classifiers for relapse-free survival and minimal residual disease improve risk classification and outcome prediction in pediatric B-precursor acute lymphoblastic leukemia

(2009) H. Kang et al.   BLOOD

The endocannabinoid system: Role in glucose and energy metabolism

(2009) Ruben Nogueiras et al.   PHARMACOLOGICAL RESEARCH

BCR–ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros

(2008) Charles G. Mullighan et al.   NATURE