Journal
FRONTIERS IN ONCOLOGY
Volume 11, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2021.778492
Keywords
iron; cancer; ferroptosis; ferritinophagy; prognostic; therapy
Categories
Funding
- National Natural Science Foundation of China [81903857]
- Science and Technology Research Project of Henan Province [202102310158]
- Medical Science and Technology Research Project of Henan Province [SBGJ202003010, LHGJ20190675]
- 2019 Ningbo Natural Science Foundation [2019A610311]
- Doctoral Research Start-up Foundation of Henan Cancer Hospital
- Priority Academic Program Development (PAPD) of Jiangsu Higher Education Institutions
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Iron is closely related to the occurrence and development of tumors, playing a crucial role in cell death. Research on iron metabolism disorders and the use of iron in tumor treatment is important for the prevention and treatment of tumors.
Iron is an essential trace element for the human body, and its deficiency or excess can induce a variety of biological processes. Plenty of evidences have shown that iron metabolism is closely related to the occurrence and development of tumors. In addition, iron plays an important role in cell death, which is very important for the development of potential strategies for tumor treatment. Here, we reviewed the latest research about iron metabolism disorders in various types of tumors, the functions and properties of iron in ferroptosis and ferritinophagy, and new opportunities for iron-based on treatment methods for tumors, providing more information regarding the prevention and treatment of tumors.
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