Article
Biochemistry & Molecular Biology
Hun Ho Park, Junseong Park, Hye Joung Cho, Jin-Kyoung Shim, Ju Hyung Moon, Eui Hyun Kim, Jong Hee Chang, Soo Youl Kim, Seok-Gu Kang
Summary: This study demonstrates that combination therapy with the chemotherapeutic drug, gossypol, and phenformin can significantly reduce the stemness and invasiveness of GBM tumorspheres, enhancing therapeutic effects through multiple mechanisms of action.
Editorial Material
Biochemistry & Molecular Biology
Jolanta Floryszak-Wieczorek, Ewa Sobieszczuk-Nowicka, Magdalena Arasimowicz-Jelonek
Summary: Nitroxyl (HNO), a one-electron reduced and protonated congener of nitric oxide (NO), has been recently discovered in Arabidopsis thaliana. Due to its distinct chemical properties, further studies are needed to determine the impacts of HNO on physiological processes.
TRENDS IN BIOCHEMICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Che-Hong Chen, Benjamin R. Kraemer, Lucia Lee, Daria Mochly-Rosen
Summary: Human ALDH is a multigene family with 19 functional members involved in detoxification and biotransformation. Genetic mutations can lead to toxic aldehyde accumulation and human pathologies. The physiological functions and substrate specificity of many ALDH genes are still unknown.
Article
Cell Biology
Tatyana D. Larionova, Soniya Bastola, Tatiana E. Aksinina, Ksenia S. Anufrieva, Jia Wang, Victoria O. Shender, Dmitriy E. Andreev, Tatiana F. Kovalenko, Georgij P. Arapidi, Polina Shnaider, Anastasia N. Kazakova, Yaroslav A. Latyshev, Victor V. Tatarskiy, Alexander A. Shtil, Pascale Moreau, Francis Giraud, Chaoxi Li, Yichan Wang, Maria P. Rubtsova, Olga A. Dontsova, Michael Condro, Benjamin M. Ellingson, Mikhail Shakhparonov, Harley Kornblum, Ichiro Nakano, Marat S. Pavlyukov
Summary: Larionova et al. discover a mechanism by which acidification of the tumour microenvironment induces the generation of an alternative splice isoform of ribosomal protein RPL22L1, which regulates cell stemness and increases tumour heterogeneity. The acidic pH in the tumour core switches the RNA splicing of the ribosomal gene towards the RPL22L1b isoform, allowing cells to survive acidosis and promoting stemness. In the tumour edge region, RPL22L1a interacts with ribosomes and upregulates translation of multiple messenger RNAs including TP53. Targeting this mechanism may decrease GBM heterogeneity and facilitate therapy.
NATURE CELL BIOLOGY
(2022)
Article
Food Science & Technology
Hua Cao, Tuoyu Zhou, Haibo Tang, Pengya Feng, Gohar Ali, Pu Liu, Xiangkai Li
Summary: The genetically modified EcN has shown effectiveness in detoxifying ethanol metabolites in liver disease models, restoring liver function, inhibiting oxidative stress, lipid peroxidation, and inflammation, as well as promoting the recovery of gut microbiota homeostasis.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Chemistry, Applied
Yuguang Wang, Hengliang Liu, Donglin Cai, Jinqiu Zhou, Mengjing Wu, Huifang Zheng, Deming Xie
Summary: A high-performance and recyclable high valence oxides of ruthenium catalyst was successfully released from commercially available ruthenium carbon catalyst. It selectively oxidized C=C bonds and C equivalent to C bonds to yield corresponding aldehydes, ketones, and alpha-diketones with high yields. The catalyst, with its cheap availability, recyclability, safety, and low toxicity, shows great potential in industrial scale unsaturated bond oxidation cleavage applications.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Seonghee Jeon, Heewon Kang, Inhyung Cho, Sung-Il Cho
Summary: The alcohol flushing response is common among East Asians and may serve as an indicator of the health risks associated with alcohol intake. Current flushers are more likely to develop depression with a small dose of alcohol compared to never flushers.
SCIENTIFIC REPORTS
(2022)
Article
Agriculture, Multidisciplinary
Xiao Li, Jing-Nan Ren, Gang Fan, Lu-Lu Zhang, Si-Yi Pan
Summary: In this study, the enzyme involved in the (+)-valencene bioconversion by Y. lipolytica was isolated, purified, and identified. It was found to be aldehyde dehydrogenase (ALDH) with the highest activity at pH 6.0 and temperature of 30 degrees C. ALDH activity was stimulated by ferrous ions and inhibited by barium, calcium, and magnesium ions. This study provides a theoretical basis and reference for the biological synthesis of citrus flavor (+)-nootkatone.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Review
Agriculture, Multidisciplinary
Estelle Fischer, Nathalie Cayot, Remy Cachon
Summary: This review explores the potential of microorganisms to reduce the beany off-flavor in vegetable proteins. It identifies the volatile compounds contributing to the off-flavor and their formation pathways, and examines the role of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) in reducing the off-flavor. The presence of these enzymes in certain microorganisms is found to be linked to odor improvement. Strains with constitutive ADH or both ADH and ALDH show the best results in reducing the compounds involved in the off-flavor.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Review
Oncology
Zili Zhai, Takeshi Yamauchi, Sarah Shangraw, Vincent Hou, Akiko Matsumoto, Mayumi Fujita
Summary: Acetaldehyde (AcAH), a carcinogenic byproduct of ethanol metabolism, has been linked to the development of malignancies in the upper gastrointestinal tract as well as cutaneous melanoma. This review examines the sources of ethanol and AcAH in the skin, their metabolic pathways, and the role of dysfunctional ethanol and AcAH metabolizing enzymes in melanoma development and progression. Data analysis also shows reduced activity of alcohol and AcAH metabolizing enzymes in melanoma tissues.
Article
Food Science & Technology
Naila Boby, Eon-Bee Lee, Muhammad Aleem Abbas, Na-Hye Park, Sam-Pin Lee, Md. Sekendar Ali, Seung-Jin Lee, Seung-Chun Park
Summary: FSC pretreatment reduces blood alcohol and acetaldehyde concentrations, modulates liver enzyme activities, increases antioxidant enzyme expression, and decreases inflammatory cytokine gene expression in the liver. Additionally, it shows no acute oral toxicity in female rats and may be beneficial for reducing alcohol-induced damage.
Article
Biochemistry & Molecular Biology
Kuan-Fu Liao, Tsung-Lang Chiu, Shu-Fang Chang, Mei-Jen Wang, Sheng-Chun Chiu
Summary: Hispolon, a polyphenol compound from Phellinus linteus, exhibits strong antitumor effects on glioblastoma multiforme (GBM) cells by inhibiting proliferation, inducing apoptosis, causing G2/M phase arrest, and suppressing migration and invasion through modulation of epithelial-mesenchymal transition (EMT) markers. It also significantly reduces tumor growth in xenograft mice models, making it a potential candidate for GBM therapy.
Article
Immunology
Li-Ping Zhu, Wei-Lan Yin, Lei Peng, Xiao-Hong Zhou, Peng Zhou, Shu-Xia Xuan, Ying Luo, Chen Chen, Bin Cheng, Jin-Duan Lin, Yan-Mei Liu, Feng-Jun Tan, Wei-Guo Yin
Summary: The study revealed a correlation between the Glu504Lys polymorphism in the ALDH2 gene and myocardial infarction (MI), with the genotype GA/AA being an independent risk factor for MI. Alcohol consumption, high myoglobin levels, and low levels of high-density lipoprotein cholesterol were also significantly associated with a higher incidence of MI.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Carla Casadevall, Vlad Martin-Diaconescu, Wesley R. Browne, Sergio Fernandez, Federico Franco, Noemi Cabello, Jordi Benet-Buchholz, Benedikt Lassalle-Kaiser, Julio Lloret-Fillol
Summary: In this study, a Ru(IV) side-on peroxo complex is reported as a 'missing link' for species formed after the rate-determining O-O bond-forming step, confirming water nucleophilic attack as a viable mechanism for O-O bond formation.
Article
Biochemistry & Molecular Biology
Jiwon Kim, Hyeoncheol Francis Son, Sungmin Hwang, Gyeongtaek Gong, Ja Kyong Ko, Youngsoon Um, Sung Ok Han, Sun-Mi Lee
Summary: This study improved the furfural tolerance of Y. lipolytica by enhancing its endogenous detoxification mechanism, leading to increased efficiency in producing lipids and other chemicals from lignocellulosic biomass.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Inorganic & Nuclear
Angela Lis, Viorica Gladchi, Gheorghe Duca, Sergey Travin
Summary: This work presents studies on the photochemical transformations of TU and Cys with the addition of Cu(II) or Fe(III) ions. The results show that the oxidation rate of the thiols increases significantly when Cu(II) or Fe(III) ions are added to the system. It has also been found that TU and Cys can form stable complex compounds with the studied metal ions. The oxidation rates of the thiols are found to depend on the radiation intensity and emission spectrum of the irradiation sources.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Cristiane F. A. Teixeira, Estefane I. Teixeira, J. P. C. Nascimento, M. Amilcar Junior, L. M. C. Pinto, Anderson R. L. Caires, G. B. Alcantara, Ana C. Micheletti, Victor M. Deflon, Davi F. Back, Heveline Silva, Lucas Pizzuti, Gleison Antonio Casagrande
Summary: Novel binuclear heteroleptic copper(I) complexes based on mixed DPPE/thiocarbamoyl-pyrazoline ligands were synthesized and structurally characterized. These complexes exhibited similar structural behavior around the Copper(I) atoms and showed promising antimicrobial and anticancer activities.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Chen Chen, Li Liu, Xin-Xin Zhong, Fa-Bao Li, Hai-Mei Qin
Summary: Thermally activated delayed fluorescent (TADF) Cu(I) halide complexes with short lifetimes and intense emissions were synthesized and characterized. These complexes exhibit intense green to yellow-green delayed fluorescence and are suitable for OLED devices.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Tian-Yu Zhang, Xue-Qian Wu, Heng-Yu Ruan, Yi Yuan, Le Wang, Ya-Pan Wu, Qing-Wen Han, Ruan Chi, Dong-Sheng Li
Summary: In this study, a novel Ni(II)-based metal-organic framework with good electrocatalytic oxidation performance was successfully synthesized, showing potential for direct alcohol fuel cells.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Susanta Das Baishnab, R. N. Dutta Purkayastha, Waldemar Maniukiewicz, Rosa M. Gomila, Antonio Frontera
Summary: The synthesis, structure, and DNA binding ability of three decavanadate complexes containing cationic organic moieties were reported. The complexes were characterized by various techniques and their solid-state structures were analyzed. The complexes showed interesting assembly patterns and exhibited moderately strong intercalative binding with CTDNA. Additionally, their micellization behavior in the presence of the surfactant CTAB was studied.
INORGANICA CHIMICA ACTA
(2024)
Review
Chemistry, Inorganic & Nuclear
Jubaraj B. Baruah
Summary: Isomorphous series are generated by replacing atoms or molecules to form materials with similar compositions. They allow modulation of structure and properties, and generate equivalent compositions with novel material properties. The study of stereo-electronic aspects of different equivalent compositions can improve the utility of the original composition.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Kamelah S. Al-Rashdi, Bandar A. Babgi, Ehab M. M. Ali, Bambar Davaasuren, Abdul-Hamid M. Emwas, Mariusz Jaremko, Mark G. Humphrey, Mostafa A. Hussien
Summary: Tridentate ligands were used to synthesize a set of palladium complexes, which were characterized and found to have DNA and BSA binding abilities. The complexes also showed differences in anticancer activities.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Diane Isaacs, Chandler Cox, Mark A. Bezpalko, W. Scott Kassel, William G. Dougherty
Summary: The structure and electrochemical properties of zinc(II) complexes with a face-capping ligand have been investigated, revealing the effect of the ligand on bound semiquinonate (SQ) radicals. The substitution pattern of the SQ ring plays a crucial role in determining the fate of the bound SQ radicals. Additionally, the protective pocket formed by the ligand's phenyl substituents is unable to prevent decomposition of SQ radicals with minimal steric bulk, suggesting that substitution of the SQ ring is the main contributor to their stabilization.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Xingliang Chen, Zhiqiang Jiang
Summary: Here, a series of zinc tetrahedral tetrazolate frameworks (Zn-TTFs) are presented, and it is demonstrated that rotation of carboxyl group can generate structural diversity. Compound 3 exhibits a unique zeolite-like structure, while compound 4 shows both super acid and alkali resistance.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Ankita Puri, Allison Mcaninch, Sheng Shu, Khashayar Rajabimoghadam, Maxime A. Siegler, Marcel Swart, Isaac Garcia-Bosch
Summary: In this article, the synthesis and characterization of copper, nickel, and palladium complexes bound by bidentate ligands derived from ortho-phenylenediamine are described. The complexes contain tunable H-bond donors and their crystal structures reveal intramolecular H-bonding interactions between the ligand scaffolds. Variations in the coordination sphere led to the isolation of the complexes in square-planar or twisted pseudo-tetrahedral geometries. Structural analysis showed that intramolecular H-bonding interactions can be altered by disrupting the bonds between countercations, solvent of crystallization, and ligand scaffold, resulting in changes in the geometry of the complexes. DFT calculations confirmed that Cu complexes prefer twisted geometries while Ni and Pd complexes favor square-planar geometries.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Laiane dos Santos Oliveira, Pedro Henrique de Souza Guarda, Leticia Bazilio Rosa, Gustavo Clauss Rodrigues, Daniele Daiane Affonso, Joao Ernesto de Carvalho, Igor Andrade Santos, Mark Harris, Douglas Hideki Nakahata, Jose Ricardo Sabino, Danilo Ciccone Miguel, Ana Lucia Tasca Gois Ruiz, Ana Carolina Gomes Jardim, Camilla Abbehausen
Summary: Chalcones are chemical precursors of flavonoids that have various biological properties. In this study, novel copper(II)-2'-hydroxy-4-benzyloxychalcone complexes were synthesized and evaluated for their antileishmanial, antiproliferative, and antiviral activities. The results demonstrated that these complexes showed potential effects against tumor cells, leishmania parasites, and SARS-CoV-2 virus. The study also highlighted the influence of ligand structure on biological activity.
INORGANICA CHIMICA ACTA
(2024)
Review
Chemistry, Inorganic & Nuclear
Archana Thakur, Harpreet Kaur, Vishal Tyagi
Summary: This review article discusses the findings of research on the 13C NMR spectra of di- and tri-butyltin carboxylates, highlighting the importance of 13C NMR chemical shifts in determining the chemical surroundings of carbon nuclei and their role in structure elucidation.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Qiang Zhao, Qi-Yang Li, Zhi Shen, Guo Zang, Wen-Jun Lv
Summary: In this study, five metal complexes were synthesized using a solvothermal reaction and their structures were analyzed by single crystal X-ray diffraction. Fluorescence and magnetic properties of some complexes were also investigated.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Jeremy Erb, Darcy Setter, Jake Swavey, Frederick Willits, Shawn Swavey
Summary: Three BODIPY-Ru(II) complexes were synthesized by coordinating [Ru(bpy)2Cl]+ complexes to BODIPY ligands. The spectroscopic and electrochemical properties of the complexes were characterized. The complexes exhibited intense absorption peaks due to the pi pi* transitions localized on the BODIPY core, and additional charge transfer transitions associated with the metal center. The complexes showed significant singlet oxygen generation and were able to induce photo-nicking of DNA.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Sahin Reja, Dilip Sarkar, Kaushik Sarkar, Deboshmita Mukherjee, T. K. S. Fayaz, Palash Sanphui, Rajesh Kumar Das
Summary: A promising bioinspired metallocatalyst has been produced and characterized, showing high catalytic activity in oxygen dependant enzymatic radical pathway. The catalyst also exhibits inter and intra molecular H-bonding and C-H-pi interactions.
INORGANICA CHIMICA ACTA
(2024)