The macrophage senescence hypothesis: the role of poor heat shock response in pulmonary inflammation and endothelial dysfunction following chronic exposure to air pollution

HSP70 as a biomarker of the thin threshold between benefit and injury due to physical exercise when exposed to air pollution

(2021) Lílian Corrêa Costa-Beber et al.   CELL STRESS & CHAPERONES

Particulate matter causes telomere shortening and increase in cellular senescence markers in human lung epithelial cells

(2021) Ju Chang-Chien et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Long-term impacts of ambient fine particulate matter exposure on overweight or obesity in Chinese adults: The China-PAR project

(2021) Sihan Huang et al.   ENVIRONMENTAL RESEARCH

AMPK and TOR: The Yin and Yang of Cellular Nutrient Sensing and Growth Control

(2020) Asier González et al.   Cell Metabolism

Chaperone-Based Therapeutic Target Innovation: Heat Shock Protein 70 (HSP70) for Type 2 Diabetes Mellitus

(2020) W. Riski Widya Mulyani et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Chronic heat treatment positively impacts metabolic profile of ovariectomized rats: association with heat shock response pathways

(2020) Yana Picinin Sandri Lissarassa et al.   CELL STRESS & CHAPERONES

Targeting senescent cells to attenuate cardiovascular disease progression

(2020) Ping Song et al.   AGEING RESEARCH REVIEWS

SirT3 activates AMPK-related mitochondrial biogenesis and ameliorates sepsis-induced myocardial injury

(2020) Ting Xin et al.   Aging-US

Identification and validation of metformin protects against PM2.5-induced macrophages cytotoxicity by targeting toll like receptor pathway

(2020) Yanfeng Shi et al.   CHEMOSPHERE

The association of subchronic exposure to low concentration of PM2.5 and high-fat diet potentiates glucose intolerance development, by impairing adipose tissue antioxidant defense and eHSP72 levels

(2020) Lílian Corrêa Costa Beber et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Knockout of macrophage migration inhibitory factor accentuates side-stream smoke exposure-induced myocardial contractile dysfunction through dysregulated mitophagy

(2020) Shuyi Wang et al.   PHARMACOLOGICAL RESEARCH

In vivo and in vitro inflammatory responses to fine particulate matter (PM2.5) from China and California

(2020) Wanjun Yuan et al.   TOXICOLOGY LETTERS

Atmospheric fine particulate matter exposure exacerbates atherosclerosis in apolipoprotein E knockout mice by inhibiting autophagy in macrophages via the PI3K/Akt/mTOR signaling pathway

(2020) Qiang Wan et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Combined toxic effects of CBNPs and Pb on rat alveolar macrophage apoptosis and autophagy flux

(2020) Shuang Guan et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

IGF-1 receptor signaling regulates type II pneumocyte senescence and resulting macrophage polarization in lung fibrosis.

(2020) Eun Joo Chung et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Diesel Exhaust Particulates Induce Neutrophilic Lung Inflammation by Modulating Endoplasmic Reticulum Stress-Mediated CXCL1/KC Expression in Alveolar Macrophages

(2020) Dong Im Kim et al.   MOLECULES

HSF1 Attenuates LPS-Induced Acute Lung Injury in Mice by Suppressing Macrophage Infiltration

(2020) Tao Li et al.   Oxidative Medicine and Cellular Longevity

Ovariectomy enhances female rats' susceptibility to metabolic, oxidative, and heat shock response effects induced by a high-fat diet and fine particulate matter

(2020) Lílian Corrêa Costa-Beber et al.   EXPERIMENTAL GERONTOLOGY

Particulate matter with a diameter of ≤2.5 μm induces and enhances bleomycin-induced pulmonary fibrosis by stimulating endoplasmic reticulum stress in rat

(2019) Panfeng Xu et al.   Biochemistry and Cell Biology

Fine air pollution particles induce endothelial senescence via redox-sensitive activation of local angiotensin system

(2019) Kushal Sharma et al.   ENVIRONMENTAL POLLUTION

Repeat dose exposure of PM2.5 triggers the disseminated intravascular coagulation (DIC) in SD rats

(2019) Shuang Liang et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Exposure to Atmospheric Ultrafine Particles Induces Severe Lung Inflammatory Response and Tissue Remodeling in Mice

(2019) Yara Saleh et al.   International Journal of Environmental Research and Public Health

Senescence utilises inflammatory caspases to drive the SASP

(2019) Kimberley A. Wiggins et al.   Aging-US

Alveolar macrophage reaction to PM2.5 of hazy day in vitro: Evaluation methods and mitochondrial screening to determine mechanisms of biological effect

(2019) Haiying Wei et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

PM2.5 aggravates the lipid accumulation, mitochondrial damage and apoptosis in macrophage foam cells

(2019) Jiangyan Liu et al.   ENVIRONMENTAL POLLUTION

NF-κB Signaling in Macrophages: Dynamics, Crosstalk, and Signal Integration

(2019) Michael G. Dorrington et al.   Frontiers in Immunology

Prenatal and Childhood Traffic-Related Air Pollution Exposure and Telomere Length in European Children: The HELIX Project

(2019) Diana B.P. Clemente et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Protective effect of green tea catechin against urban fine dust particle-induced skin aging by regulation of NF-κB, AP-1, and MAPKs signaling pathways

(2019) Lei Wang et al.   ENVIRONMENTAL POLLUTION

Cellular response and extracellular vesicles characterization of human macrophages exposed to fine atmospheric particulate matter

(2019) Perrine J. Martin et al.   ENVIRONMENTAL POLLUTION

ER Stress Activates the NLRP3 Inflammasome: A Novel Mechanism of Atherosclerosis

(2019) Xinnong Chen et al.   Oxidative Medicine and Cellular Longevity

Acceleratory effects of ambient fine particulate matter on the development and progression of atherosclerosis in apolipoprotein E knockout mice by down-regulating CD4+CD25+Foxp3+ regulatory T cells

(2019) Qiang Wan et al.   TOXICOLOGY LETTERS

PM2.5 Exposure in the Respiratory System Induces Distinct Inflammatory Signaling in the Lung and the Liver of Mice

(2019) Soi Jeong et al.   Journal of Immunology Research

Heat shock response to exercise in pancreatic islets of obese mice

(2019) Aline Bittencourt et al.   BIOCHIMIE

Effective fraction of Bletilla striata reduces the inflammatory cytokine production induced by water and organic extracts of airborne fine particulate matter (PM2.5) in vitro

(2019) Yu-Yao Zu et al.   BMC Complementary and Alternative Medicine

Fine particulate matter from pig house induced immune response by activating TLR4/MAPK/NF-κB pathway and NLRP3 inflammasome in alveolar macrophages

(2019) Qian Tang et al.   CHEMOSPHERE

Salidroside ameliorates endothelial inflammation and oxidative stress by regulating the AMPK/NF-κB/NLRP3 signaling pathway in AGEs-induced HUVECs

(2019) Rong Hu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Metformin protects against PM2.5-induced lung injury and cardiac dysfunction independent of AMP-activated protein kinase α2

(2019) Junling Gao et al.   Redox Biology

Cellular senescence links aging and diabetes in cardiovascular disease

(2018) Hadis Shakeri et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

PM2.5 promotes abdominal aortic aneurysm formation in angiotensin Ⅱ-infused apoe-/- mice

(2018) Xie Jun et al.   BIOMEDICINE & PHARMACOTHERAPY

Subacute exposure to residual oil fly ash (ROFA) increases eHSP70 content and extracellular-to-intracellular HSP70 ratio: a relation with oxidative stress markers

(2018) Fernanda Giesel Baldissera et al.   CELL STRESS & CHAPERONES

Concentrated Ambient PM2.5-Induced Inflammation and Endothelial Dysfunction in a Murine Model of Neural IKK2 Deficiency

(2018) Minjie Chen et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Effects on IL-1β signaling activation induced by water and organic extracts of fine particulate matter (PM 2.5 ) in vitro

(2018) Fanfan Xu et al.   ENVIRONMENTAL POLLUTION

AMPKα2 deficiency exacerbates long-term PM 2.5 exposure-induced lung injury and cardiac dysfunction

(2018) Hongyun Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Long-term Persistent Organic Pollutants Exposure Induced Telomere Dysfunction and Senescence-Associated Secretary Phenotype

(2018) Jinghua Yuan et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Air pollution is associated with the development of atherosclerosis via the cooperation of CD36 and NLRP3 inflammasome in ApoE -/- mice

(2018) Xihao Du et al.   TOXICOLOGY LETTERS

Chronic whole-body heat treatment relieves atherosclerotic lesions, cardiovascular and metabolic abnormalities, and enhances survival time restoring the anti-inflammatory and anti-senescent heat shock response in mice

(2018) Maciel Alencar Bruxel et al.   BIOCHIMIE

Obese rats are more vulnerable to inflammation, genotoxicity and oxidative stress induced by coal dust inhalation than non-obese rats

(2018) Juciano Gasparotto et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Heat-induced extracellular HSP72 release is blunted in elderly diabetic people compared with healthy middle-aged and older adults, but it is partially restored by resistance training

(2018) Carlos Henrique de Lemos Muller et al.   EXPERIMENTAL GERONTOLOGY

Differential expression of HSPs and activation of MAPKs in A549 alveolar epithelial cells exposed to cigarette smoke extract

(2018) Anita Somborac-Bačura et al.   EXPERIMENTAL PHYSIOLOGY

Passive heat therapy protects against endothelial cell hypoxia-reoxygenation via effects of elevations in temperature and circulating factors

(2018) Vienna E. Brunt et al.   JOURNAL OF PHYSIOLOGY-LONDON

Microtubule destabilization caused by particulate matter contributes to lung endothelial barrier dysfunction and inflammation

(2018) Pratap Karki et al.   CELLULAR SIGNALLING

Genotoxic and epigenotoxic effects in mice exposed to concentrated ambient fine particulate matter (PM2.5) from São Paulo city, Brazil

(2018) Antonio Anax Falcão de Oliveira et al.   Particle and Fibre Toxicology

VCAM-1-mediated neutrophil infiltration exacerbates ambient fine particle-induced lung injury

(2018) Anfeng Cui et al.   TOXICOLOGY LETTERS

Diesel exhaust exposure intensifies inflammatory and structural changes associated with lung aging in mice

(2018) Gabriel Ribeiro Júnior et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Exposure scenario: Another important factor determining the toxic effects of PM2.5 and possible mechanisms involved

(2017) Wei Zhou et al.   ENVIRONMENTAL POLLUTION

Impact of probable interaction of low temperature and ambient fine particulate matter on the function of rats alveolar macrophages

(2017) Bin Luo et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Mitochondrial dysfunction and inflammatory response in the cytotoxicity of NR8383 macrophages induced by fine particulate matter

(2017) Qi Xiong et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

ROS-AKT-mTOR axis mediates autophagy of human umbilical vein endothelial cells induced by cooking oil fumes-derived fine particulate matters in vitro

(2017) Rui Ding et al.   FREE RADICAL BIOLOGY AND MEDICINE

Dual signaling evoked by oxidized LDLs in vascular cells

(2017) Anne Nègre-Salvayre et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nitric oxide-heat shock protein axis in menopausal hot flushes: neglected metabolic issues of chronic inflammatory diseases associated with deranged heat shock response

(2017) Antônio Azambuja Miragem et al.   HUMAN REPRODUCTION UPDATE

NLRP3 inflammasome: Its regulation and involvement in atherosclerosis

(2017) Zahra Hoseini et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Differential menopause- versus aging-induced changes in oxidative stress and circadian rhythm gene markers

(2017) Oriol A. Rangel-Zuñiga et al.   MECHANISMS OF AGEING AND DEVELOPMENT

mTOR signaling promotes foam cell formation and inhibits foam cell egress through suppressing the SIRT1 signaling pathway

(2017) Haixiang Zheng et al.   Molecular Medicine Reports

Exercise Training under Exposure to Low Levels of Fine Particulate Matter: Effects on Heart Oxidative Stress and Extra-to-Intracellular HSP70 Ratio

(2017) Aline Sfalcin Mai et al.   Oxidative Medicine and Cellular Longevity

Endothelial responses of the alveolar barrier in vitro in a dose-controlled exposure to diesel exhaust particulate matter

(2017) Sebastian G. Klein et al.   Particle and Fibre Toxicology

B vitamins attenuate the epigenetic effects of ambient fine particles in a pilot human intervention trial

(2017) Jia Zhong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Airborne nitro-PAHs induce Nrf2/ARE defense system against oxidative stress and promote inflammatory process by activating PI3K/Akt pathway in A549 cells

(2017) Yu Shang et al.   TOXICOLOGY IN VITRO

In Utero Particulate Matter Exposure Produces Heart Failure, Electrical Remodeling, and Epigenetic Changes at Adulthood

(2017) Vineeta Tanwar et al.   Journal of the American Heart Association

Urban particulate matter triggers lung inflammation via the ROS-MAPK-NF-κB signaling pathway

(2017) Jian Wang et al.   Journal of Thoracic Disease

Insulin sensitizers prevent fine particulate matter-induced vascular insulin resistance and changes in endothelial progenitor cell homeostasis

(2016) Petra Haberzettl et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Differential regulation of autophagy and mitophagy in pulmonary diseases

(2016) Saurabh Aggarwal et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Acute exposure to air pollution particulate matter aggravates experimental myocardial infarction in mice by potentiating cytokine secretion from lung macrophages

(2016) Timoteo Marchini et al.   BASIC RESEARCH IN CARDIOLOGY

Pre- and post-conditioning hormesis in elderly mice, rats, and humans: its loss and restoration

(2016) Edward J. Calabrese   BIOGERONTOLOGY

Amelioration of particulate matter-induced oxidative damage by vitamin c and quercetin in human bronchial epithelial cells

(2016) Xiaoting Jin et al.   CHEMOSPHERE

Exposure to Fine Particulate Air Pollution Causes Vascular Insulin Resistance by Inducing Pulmonary Oxidative Stress

(2016) Petra Haberzettl et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Acute exposure to Buenos Aires air particles (UAP-BA) induces local and systemic inflammatory response in middle-aged mice: A time course study

(2016) Nadia S. Orona et al.   ENVIRONMENTAL POLLUTION

Role of transition metals present in air particulate matter on lung oxygen metabolism

(2016) Natalia D. Magnani et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Fine particulate matter potentiates type 2 diabetes development in high-fat diet-treated mice: stress response and extracellular to intracellular HSP70 ratio analysis

(2016) Pauline Brendler Goettems-Fiorin et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Senescent intimal foam cells are deleterious at all stages of atherosclerosis

(2016) B. G. Childs et al.   SCIENCE

Ambient Air Pollution Is Associated With the Severity of Coronary Atherosclerosis and Incident Myocardial Infarction in Patients Undergoing Elective Cardiac Evaluation

(2016) Jaana Hartiala et al.   Journal of the American Heart Association

Exposure to concentrated ambient fine particulate matter disrupts vascular endothelial cell barrier function via the IL-6/HIF-1α signaling pathway

(2016) Jianwei Dai et al.   FEBS Open Bio

What is hormesis and its relevance to healthy aging and longevity?

(2015) Edward J. Calabrese et al.   BIOGERONTOLOGY

Effect of Ambient PM2.5 on Lung Mitochondrial Damage and Fusion/Fission Gene Expression in Rats

(2015) Ruijin Li et al.   CHEMICAL RESEARCH IN TOXICOLOGY

The regulatory roles of NADPH oxidase, intra- and extra-cellular HSP70 in pancreatic islet function, dysfunction and diabetes

(2015) Mauricio Krause et al.   CLINICAL SCIENCE

Oxidative stress, apoptosis, and cell cycle arrest are induced in primary fetal alveolar type II epithelial cells exposed to fine particulate matter from cooking oil fumes

(2015) Ying Liu et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

PM2.5-induced oxidative stress increases adhesion molecules expression in human endothelial cells through the ERK/AKT/NF-κB-dependent pathway

(2015) Wei Rui et al.   JOURNAL OF APPLIED TOXICOLOGY

Expression of the NLRP3 Inflammasome in Carotid Atherosclerosis

(2015) Xin Shi et al.   Journal of Stroke & Cerebrovascular Diseases

The Chaperone Balance Hypothesis: The Importance of the Extracellular to Intracellular HSP70 Ratio to Inflammation-Driven Type 2 Diabetes, the Effect of Exercise, and the Implications for Clinical Management

(2015) Mauricio Krause et al.   MEDIATORS OF INFLAMMATION

Expression of the NLRP3 Inflammasome in Carotid Atherosclerosis

(2015) Xin Shi et al.   Journal of Stroke & Cerebrovascular Diseases

Airborne fine particulate matter induces multiple cell death pathways in human lung epithelial cells

(2014) Xiaobei Deng et al.   APOPTOSIS

mTOR inhibition: A promising strategy for stabilization of atherosclerotic plaques

(2014) Wim Martinet et al.   ATHEROSCLEROSIS

Plasma membranes as heat stress sensors: From lipid-controlled molecular switches to therapeutic applications

(2014) Zsolt Török et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The fat cell senescence hypothesis

(2014) Philip Newsholme et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

A feasibility study of the association of exposure to biomass smoke with vascular function, inflammation, and cellular aging

(2014) Ming Shan et al.   ENVIRONMENTAL RESEARCH

Probing the impact of sex steroids and menopause-related sex steroid deprivation on modulation of immune senescence

(2014) Nikolaos Vrachnis et al.   MATURITAS

Silence of NLRP3 Suppresses Atherosclerosis and Stabilizes Plaques in Apolipoprotein E-Deficient Mice

(2014) Fei Zheng et al.   MEDIATORS OF INFLAMMATION

Obesity depresses the anti-inflammatory HSP70 pathway, contributing to NAFLD progression

(2014) Fábio Cangeri Di Naso et al.   Obesity

Metallic Nickel Nanoparticles May Exhibit Higher Carcinogenic Potential than Fine Particles in JB6 Cells

(2014) Ruth Magaye et al.   PLoS One

Health Risk Assessment for Air Pollutants: Alterations in Lung and Cardiac Gene Expression in Mice Exposed to Milano Winter Fine Particulate Matter (PM2.5)

(2014) Giulio Sancini et al.   PLoS One

HSF-1 is Involved in Attenuating the Release of Inflammatory Cytokines Induced by LPS Through Regulating Autophagy

(2014) Zhongyi Tong et al.   SHOCK

Activation of mTOR modulates SREBP-2 to induce foam cell formation through increased retinoblastoma protein phosphorylation

(2013) K. L. Ma et al.   CARDIOVASCULAR RESEARCH

Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders

(2013) Anu Kauppinen et al.   CELLULAR SIGNALLING

Air Pollution–Mediated Susceptibility to Inflammation and Insulin Resistance: Influence of CCR2 Pathways in Mice

(2013) Cuiqing Liu et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Heat shock transcription factor 1 attenuates TNFα-induced cardiomyocyte death through suppression of NFκB pathway

(2013) Lianpin Wu et al.   GENE

Difference in LDL Receptor Feedback Regulation in Macrophages and Vascular Smooth Muscle Cells: Foam Cell Transformation Under Inflammatory Stress

(2013) Qiang Ye et al.   INFLAMMATION

Diesel exhaust particulate increases the size and complexity of lesions in atherosclerotic mice

(2013) Mark R Miller et al.   Particle and Fibre Toxicology

Coal and tire burning mixtures containing ultrafine and nanoparticulate materials induce oxidative stress and inflammatory activation in macrophages

(2013) Juciano Gasparotto et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Reactive oxygen species produced by NADPH oxidase and mitochondrial dysfunction in lung after an acute exposure to Residual Oil Fly Ashes

(2013) Natalia D. Magnani et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Time course of systemic oxidative stress and inflammatory response induced by an acute exposure to Residual Oil Fly Ash

(2013) T. Marchini et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Beijing ambient particle exposure accelerates atherosclerosis in ApoE knockout mice

(2013) Tian Chen et al.   TOXICOLOGY LETTERS

Mycobacterial HBHA induces endoplasmic reticulum stress-mediated apoptosis through the generation of reactive oxygen species and cytosolic Ca2+ in murine macrophage RAW 264.7 cells

(2013) J-A Choi et al.   Cell Death & Disease

Sirt1 protects against thrombomodulin down-regulation and lung coagulation after particulate matter exposure

(2012) Z. Wu et al.   BLOOD

HSP90 inhibition by 17-DMAG attenuates oxidative stress in experimental atherosclerosis

(2012) Julio Madrigal-Matute et al.   CARDIOVASCULAR RESEARCH

Macrophage Autophagy Plays a Protective Role in Advanced Atherosclerosis

(2012) Xianghai Liao et al.   Cell Metabolism

Unhealthy diet and ultrafine carbon black particles induce senescence and disease associated phenotypic changes

(2012) Nicole Büchner et al.   EXPERIMENTAL GERONTOLOGY

Endothelial dysfunction in the pulmonary artery induced by concentrated fine particulate matter exposure is associated with local but not systemic inflammation

(2012) Ana Paula Davel et al.   TOXICOLOGY

Milan PM1 Induces Adverse Effects on Mice Lungs and Cardiovascular System

(2012) Francesca Farina et al.   Biomed Research International

Insufficient autophagy promotes bronchial epithelial cell senescence in chronic obstructive pulmonary disease

(2012) Satoko Fujii et al.   OncoImmunology

Anti-oxidative and inflammatory responses induced by fly ash particles and carbon black in lung epithelial cells

(2011) Silvia Diabaté et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Monoclonal antibodies targeting IL-1 beta reduce biomarkers of atherosclerosis in vitro and inhibit atherosclerotic plaque formation in Apolipoprotein E-deficient mice

(2011) Vinay Bhaskar et al.   ATHEROSCLEROSIS

Autophagy Regulates Cholesterol Efflux from Macrophage Foam Cells via Lysosomal Acid Lipase

(2011) Mireille Ouimet et al.   Cell Metabolism

Chronic Fine Particulate Matter Exposure Induces Systemic Vascular Dysfunction via NADPH Oxidase and TLR4 Pathways

(2011) Thomas Kampfrath et al.   CIRCULATION RESEARCH

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

(2011) Maria M. Mihaylova et al.   NATURE CELL BIOLOGY

The innate and adaptive immune response induced by alveolar macrophages exposed to ambient particulate matter

(2011) Ryohei Miyata et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Ambient particulate air pollution and acute lower respiratory infections: a systematic review and implications for estimating the global burden of disease

(2011) Sumi Mehta et al.   Air Quality Atmosphere and Health

Airborne particulate matter selectively activates endoplasmic reticulum stress response in the lung and liver tissues

(2010) Suzette Laing et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Particulate Matter Induces Translocation of IL-6 from the Lung to the Systemic Circulation

(2010) Takashi Kido et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Effect of Early Particulate Air Pollution Exposure on Obesity in Mice

(2010) Xiaohua Xu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Ovariectomy causes immunosenescence and oxi-inflamm-ageing in peritoneal leukocytes of aged female mice similar to that in aged males

(2010) Isabel Baeza et al.   BIOGERONTOLOGY

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

(2010) Gökhan S. Hotamisligil   CELL

Identification of an Autophagy Defect in Smokers' Alveolar Macrophages

(2010) M. M. Monick et al.   JOURNAL OF IMMUNOLOGY

Comparative acute lung inflammation induced by atmospheric PM and size-fractionated tire particles

(2010) Paride Mantecca et al.   TOXICOLOGY LETTERS

Inflammatory stress increases unmodified LDL uptake via LDL receptor: an alternative pathway for macrophage foam-cell formation

(2009) Qiang Ye et al.   INFLAMMATION RESEARCH

Senescence of Cultured Porcine Coronary Arterial Endothelial Cells Is Associated with Accelerated Oxidative Stress and Activation of NFĸB

(2009) Mary Y.K. Lee et al.   JOURNAL OF VASCULAR RESEARCH

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

Stress-Inducible Regulation of Heat Shock Factor 1 by the Deacetylase SIRT1

(2009) S. D. Westerheide et al.   SCIENCE

Urban Particulate Matter Causes ER Stress and the Unfolded Protein Response in Human Lung Cells

(2009) Todd L. Watterson et al.   TOXICOLOGICAL SCIENCES

Airborne particulate matter PM2.5 from Mexico City affects the generation of reactive oxygen species by blood neutrophils from asthmatics: an in vitro approach

(2009) Martha Sierra-Vargas et al.   Journal of Occupational Medicine and Toxicology

Extrapulmonary translocation of intratracheally instilled fine and ultrafine particles via direct and alveolar macrophage-associated routes

(2008) Akiko Furuyama et al.   ARCHIVES OF TOXICOLOGY

hsp70 genes in the human genome: Conservation and differentiation patterns predict a wide array of overlapping and specialized functions

(2008) Luciano Brocchieri et al.   BMC EVOLUTIONARY BIOLOGY

SIRT1 Modulation of the Acetylation Status, Cytosolic Localization, and Activity of LKB1

(2008) Fan Lan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HSP72 protects against obesity-induced insulin resistance

(2008) J. Chung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA