TLR7 Engagement on Dendritic Cells Enhances Autoreactive Th17 Responses via Activation of ERK

The MicroRNA-183-96-182 Cluster Promotes T Helper 17 Cell Pathogenicity by Negatively Regulating Transcription Factor Foxo1 Expression

(2016) Kenji Ichiyama et al.   IMMUNITY

RBPJ Controls Development of Pathogenic Th17 Cells by Regulating IL-23 Receptor Expression

(2016) Gerd Meyer zu Horste et al.   Cell Reports

Association Between Copy Number Variations of TLR7 and Ocular Behcet's Disease in a Chinese Han Population

(2015) J. Fang et al.   INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Retina-Specific T Regulatory Cells Bring About Resolution and Maintain Remission of Autoimmune Uveitis

(2015) Phyllis Silver et al.   JOURNAL OF IMMUNOLOGY

Targeting cell surface TLR7 for therapeutic intervention in autoimmune diseases

(2015) Atsuo Kanno et al.   Nature Communications

Phosphorylation status determines the opposing functions of Smad2/Smad3 as STAT3 cofactors in TH17 differentiation

(2015) Jeong-Hwan Yoon et al.   Nature Communications

Differential Adjuvant Activities of TLR7 and TLR9 Agonists Inversely Correlate with Nitric Oxide and PGE2 Production

(2015) Jinhee Lee et al.   PLoS One

Engagement of Toll-like receptor 2 enhances interleukin (IL)-17+autoreactive T cell responses via p38 mitogen-activated protein kinase signalling in dendritic cells

(2014) R. Wei et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Mechanism of pathogenesis of imiquimod-induced skin inflammation in the mouse: A role for interferon-alpha in dendritic cell activation by imiquimod

(2014) Azumi Ueyama et al.   JOURNAL OF DERMATOLOGY

TLR-Induced Cytokines Promote Effective Proinflammatory Natural Th17 Cell Responses

(2014) B. Massot et al.   JOURNAL OF IMMUNOLOGY

TLR7 induces anergy in human CD4+ T cells

(2014) Margarita Dominguez-Villar et al.   NATURE IMMUNOLOGY

The Co-Stimulatory Effects of MyD88-Dependent Toll-Like Receptor Signaling on Activation of Murine γδ T Cells

(2014) Jinping Zhang et al.   PLoS One

Protein kinase IKKβ-catalyzed phosphorylation of IRF5 at Ser462 induces its dimerization and nuclear translocation in myeloid cells

(2014) Marta Lopez-Pelaez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TLR8 on dendritic cells and TLR9 on B cells restrain TLR7-mediated spontaneous autoimmunity in C57BL/6 mice

(2014) B. Desnues et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A novel antagonist of Toll-like receptors 7, 8 and 9 suppresses lupus disease-associated parameters in NZBW/F1 mice

(2013) Fu-Gang Zhu et al.   AUTOIMMUNITY

Therapeutic Potential of Regulatory T cells in Autoimmune Disorders

(2013) Johannes Fessler et al.   BIODRUGS

Protein kinase inhibitors in the treatment of inflammatory and autoimmune diseases

(2013) H. Patterson et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

TLR7 signaling exacerbates CNS autoimmunity through downregulation of Foxp3+Treg cells

(2013) Patrice H. Lalive et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

ERK differentially regulates Th17- and Treg-cell development and contributes to the pathogenesis of colitis

(2013) Houpu Liu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IL-27p28 inhibits central nervous system autoimmunity by concurrently antagonizing Th1 and Th17 responses

(2013) Wai Po Chong et al.   JOURNAL OF AUTOIMMUNITY

Differential Involvement of Th1 and Th17 in Pathogenic Autoimmune Processes Triggered by Different TLR Ligands

(2013) G. Shi et al.   JOURNAL OF IMMUNOLOGY

A Toll-Like Receptor 7, 8, and 9 Antagonist Inhibits Th1 and Th17 Responses and Inflammasome Activation in a Model of IL-23-Induced Psoriasis

(2013) Weiwen Jiang et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1

(2013) Chuan Wu et al.   NATURE

Th17 Cells

(2012) Mohan S. Maddur et al.   AMERICAN JOURNAL OF PATHOLOGY

Regulation of TH17 cell differentiation by innate immune signals

(2012) Gonghua Huang et al.   Cellular & Molecular Immunology

Role of CD25+ Dendritic Cells in the Generation of Th17 Autoreactive T Cells in Autoimmune Experimental Uveitis

(2012) D. Liang et al.   JOURNAL OF IMMUNOLOGY

Signaling via the kinase p38α programs dendritic cells to drive TH17 differentiation and autoimmune inflammation

(2012) Gonghua Huang et al.   NATURE IMMUNOLOGY

Induction and molecular signature of pathogenic TH17 cells

(2012) Youjin Lee et al.   NATURE IMMUNOLOGY

TregLymphocytes in Autoimmune Uveitis

(2012) Simona Ruggieri et al.   OCULAR IMMUNOLOGY AND INFLAMMATION

Toll-like receptor 4 signaling in T cells promotes autoimmune inflammation

(2012) J. M. Reynolds et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toll-like receptor 7 stimulation promotes autoimmune diabetes in the NOD mouse

(2011) A. S. Lee et al.   DIABETOLOGIA

Mast cells promote Th1 and Th17 responses by modulating dendritic cell maturation and function

(2011) Anne Dudeck et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Activation of dendritic cells via TLR7 reduces Foxp3 expression and suppressive function in induced Tregs

(2011) Daniela Hackl et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The TLR7 Ligand 9-Benzyl-2-Butoxy-8-Hydroxy Adenine Inhibits IL-17 Response by Eliciting IL-10 and IL-10-Inducing Cytokines

(2011) A. Vultaggio et al.   JOURNAL OF IMMUNOLOGY

The encephalitogenicity of TH17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF

(2011) Mohamed El-Behi et al.   NATURE IMMUNOLOGY

MAPKs ERK and p38, but not JNK Phosphorylation, Modulate IL-6 and TNF-α Secretion Following OK-432 In Vitro Stimulation of Purified Human Monocytes

(2011) C. Olsnes et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

TLR7 promotes Th1 polarization in immune thrombocytopenia

(2011) Qing Yang et al.   THROMBOSIS RESEARCH

Induced Foxp3+ regulatory T cells: a potential new weapon to treat autoimmune and inflammatory diseases?

(2011) Q. Lan et al.   Journal of Molecular Cell Biology

zVAD-induced necroptosis in L929 cells depends on autocrine production of TNFα mediated by the PKC–MAPKs–AP-1 pathway

(2010) Y-T Wu et al.   CELL DEATH AND DIFFERENTIATION

Toll-like Receptor 2 Signaling in CD4+ T Lymphocytes Promotes T Helper 17 Responses and Regulates the Pathogenesis of Autoimmune Disease

(2010) Joseph M. Reynolds et al.   IMMUNITY

Pharmacologic Inhibition of MEK–ERK Signaling Enhances Th17 Differentiation

(2010) Andy Hee-Meng Tan et al.   JOURNAL OF IMMUNOLOGY

CD4+Foxp3+ T-Regulatory Cells in Noninfectious Uveitis

(2009) S. Yeh et al.   ARCHIVES OF OPHTHALMOLOGY

Toll-like receptors and innate immunity

(2009) Himanshu Kumar et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Targeting protein kinases for the development of anti-inflammatory drugs

(2009) Philip Cohen   CURRENT OPINION IN CELL BIOLOGY

Transcriptional regulatory networks in Th17 cell differentiation

(2009) Liang Zhou et al.   CURRENT OPINION IN IMMUNOLOGY

Regulation of JNK and p38 MAPK in the immune system: Signal integration, propagation and termination

(2009) Gonghua Huang et al.   CYTOKINE

Human Plasmacytoid Dendritic Cells Support Th17 Cell Effector Function in Response to TLR7 Ligation

(2009) C.-F. Yu et al.   JOURNAL OF IMMUNOLOGY

TLR-Stimulated CD34 Stem Cell-Derived Human Skin-Like and Monocyte-Derived Dendritic Cells Fail to Induce Th17 Polarization of Naive T Cells but Do Stimulate Th1 and Th17 Memory Responses

(2009) S. S. Duraisingham et al.   JOURNAL OF IMMUNOLOGY

Inhibition of ERK MAPK Suppresses IL-23- and IL-1-Driven IL-17 Production and Attenuates Autoimmune Disease

(2009) C. F. Brereton et al.   JOURNAL OF IMMUNOLOGY

The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17–producing effector T helper cells in vivo

(2009) Mandy J McGeachy et al.   NATURE IMMUNOLOGY

Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category

(2008) Dror Luger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

New perspectives on effector mechanisms in uveitis

(2008) Dror Luger et al.   Seminars in Immunopathology