Angiotensin II induces podocyte metabolic reprogramming from glycolysis to glycerol-3-phosphate biosynthesis

ManNAc protects against podocyte pyroptosis via inhibiting mitochondrial damage and ROS/NLRP3 signaling pathway in diabetic kidney injury model

(2022) Yanmin Gao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Role of mitochondrial quality surveillance in myocardial infarction: From bench to bedside

(2021) Hao Zhou et al.   AGEING RESEARCH REVIEWS

Deficiency of mitochondrial glycerol 3-phosphate dehydrogenase exacerbates podocyte injury and the progression of diabetic kidney disease

(2021) Hua Qu et al.   DIABETES

Faster lipid β‐oxidation rate by acetyl‐CoA carboxylase 2 inhibition alleviates high‐glucose‐induced insulin resistance via SIRT1/PGC‐1α in human podocytes

(2021) Qinglian Wang et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Neutrophil HIF-1α stabilisation is augmented by mitochondrial ROS produced via the glycerol 3-phosphate shuttle

(2021) Joseph Alexander Willson et al.   BLOOD

Glycerol-3-phosphate biosynthesis regenerates cytosolic NAD+ to alleviate mitochondrial disease

(2021) Shanshan Liu et al.   Cell Metabolism

A HIF1α-GPD1 feedforward loop inhibits the progression of renal clear cell carcinoma via mitochondrial function and lipid metabolism

(2021) Ren Liu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Sp1-mediated upregulation of Prdx6 expression prevents podocyte injury in diabetic nephropathy via mitigation of oxidative stress and ferroptosis

(2021) Qianjin Zhang et al.   LIFE SCIENCES

Renin-angiotensin system inhibition reverses the altered triacylglycerol metabolic network in diabetic kidney disease

(2021) Kelli M. Sas et al.   Metabolomics

LPL/AQP7/GPD2 promotes glycerol metabolism under hypoxia and prevents cardiac dysfunction during ischemia

(2021) Sohta Ishihama et al.   FASEB JOURNAL

Lipidomic approaches to dissect dysregulated lipid metabolism in kidney disease

(2021) Judy Baek et al.   Nature Reviews Nephrology

AGPAT2 interaction with CDP-diacylglycerol synthases promotes the flux of fatty acids through the CDP-diacylglycerol pathway

(2021) Hoi Yin Mak et al.   Nature Communications

Delayed metabolic dysfunction in myocardium following exertional heat stroke in mice

(2020) Orlando Laitano et al.   JOURNAL OF PHYSIOLOGY-LONDON

GPD1 enhances the anti-cancer effects of metformin by synergistically increasing total cellular glycerol-3-phosphate

(2020) Jianjiang Xie et al.   CANCER RESEARCH

Role of pyruvate kinase M2-mediated metabolic reprogramming during podocyte differentiation

(2020) Qi Yuan et al.   Cell Death & Disease

Mitochondrial quality control mechanisms as molecular targets in cardiac ischemia-reperfusion injury

(2020) Jin Wang et al.   Acta Pharmaceutica Sinica B

Podocytopathies

(2020) Jeffrey B. Kopp et al.   Nature Reviews Disease Primers

Characterization of Glycolytic Enzymes and Pyruvate Kinase M2 in Type 1 and 2 Diabetic Nephropathy

(2019) Daniel Gordin et al.   DIABETES CARE

Anaerobic Glycolysis Maintains the Glomerular Filtration Barrier Independent of Mitochondrial Metabolism and Dynamics

(2019) Paul T. Brinkkoetter et al.   Cell Reports

GPD1 Specifically Marks Dormant Glioma Stem Cells with a Distinct Metabolic Profile

(2019) Patricia Rusu et al.   Cell Stem Cell

Crosstalk Between Lipids and Mitochondria in Diabetic Kidney Disease

(2019) G. Michelle Ducasa et al.   Current Diabetes Reports

Mitochondrial dysfunction in diabetic kidney disease

(2018) Josephine M. Forbes et al.   Nature Reviews Nephrology

Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology

(2018) Steven J. Forrester et al.   PHYSIOLOGICAL REVIEWS

Role of c-Abl and nephrin in podocyte cytoskeletal remodeling induced by angiotensin II

(2018) Yiqiong Ma et al.   Cell Death & Disease

Angiotensin II Modulates Podocyte Glucose Transport

(2018) Barbara Lewko et al.   Frontiers in Endocrinology

Mitochondrial glycerol 3‐phosphate dehydrogenase promotes skeletal muscle regeneration

(2018) Xiufei Liu et al.   EMBO Molecular Medicine

Mitochondrial energetics in the kidney

(2017) Pallavi Bhargava et al.   Nature Reviews Nephrology

Angiotensin II induces cholesterol accumulation and injury in podocytes

(2017) Yingjie Yang et al.   Scientific Reports

Csk regulates angiotensin II-induced podocyte apoptosis

(2016) Lu Zhang et al.   APOPTOSIS

Glycerol 3-phosphate dehydrogenase 1 deficiency enhances exercise capacity due to increased lipid oxidation during strenuous exercise

(2015) Tomoki Sato et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Glycolysis, but not Mitochondria, responsible for intracellular ATP distribution in cortical area of podocytes

(2015) Shota Ozawa et al.   Scientific Reports

The role of glycerol-3-phosphate dehydrogenase 1 in the progression of fatty liver after acute ethanol administration in mice

(2014) Tomoki Sato et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A compound heterozygous mutation in GPD1 causes hepatomegaly, steatohepatitis and hypertriglyceridemia

(2014) Mugdha Joshi et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

(2014) Anila K. Madiraju et al.   NATURE

Lipid biology of the podocyte—new perspectives offer new opportunities

(2014) Alessia Fornoni et al.   Nature Reviews Nephrology

The role of mitochondrial dehydrogenases in the generation of oxidative stress

(2013) Vera Adam-Vizi et al.   NEUROCHEMISTRY INTERNATIONAL

Sites of reactive oxygen species generation by mitochondria oxidizing different substrates

(2013) Casey L. Quinlan et al.   Redox Biology

Angiotensinogen Gene Silencing Reduces Markers of Lipid Accumulation and Inflammation in Cultured Adipocytes

(2013) Wenting X. Carroll et al.   Frontiers in Endocrinology

Transient Infantile Hypertriglyceridemia, Fatty Liver, and Hepatic Fibrosis Caused by Mutated GPD1, Encoding Glycerol-3-Phosphate Dehydrogenase 1

(2012) Lina Basel-Vanagaite et al.   AMERICAN JOURNAL OF HUMAN GENETICS

T cell Activation Is Driven by an ADP-Dependent Glucokinase Linking Enhanced Glycolysis with Mitochondrial Reactive Oxygen Species Generation

(2012) Marcin M. Kamiński et al.   Cell Reports

Involvement of the G3P shuttle and β-oxidation pathway in the control of TAG synthesis and lipid accumulation in Yarrowia lipolytica

(2011) Thierry Dulermo et al.   METABOLIC ENGINEERING