Journal
NEUROCHEMISTRY INTERNATIONAL
Volume 62, Issue 5, Pages 757-763Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuint.2013.01.012
Keywords
Mitochondria; Reactive oxygen species; Dehydrogenases; Oxidative stress; Alpha-ketoglutarate dehydrogenase; Alpha-glycerophosphate dehydrogenase
Categories
Funding
- OTKA [NK 81983]
- TAMOP [4.2.2./B-09/1]
- Hungarian Academy of Sciences
Ask authors/readers for more resources
In addition to complexes in the respiratory chain, few dehydrogenases playing key roles in the physiological metabolism in neurons, are able to generate reactive oxygen species (ROS) in mitochondria. One of them is the Krebs cycle enzyme, alpha-ketoglutarate dehydrogenase (alpha-KGDH), which is capable of producing superoxide and hydrogen peroxide by the E3 subunit of the enzyme regulated by changes in the NADH/NAD(+) ratio. Mutations in the E3 subunit known to be related to diseases in humans were shown to have increased ROS-forming ability. alpha-Glycerophosphate dehydrogenase (alpha-GPDH) located on the outer surface of the inner membrane can also generate ROS, which is stimulated by Ca2+. ROS production by alpha-GPDH is unique as it does not require Ca2+ uptake and it is observed in respiring as well as damaged, bioenergetically incompetent mitochondria. The possible role of ROS generation by these dehydrogenases in brain pathology is discussed in this review. (C) 2013 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available