Faster lipid β‐oxidation rate by acetyl‐CoA carboxylase 2 inhibition alleviates high‐glucose‐induced insulin resistance via SIRT1/PGC‐1α in human podocytes

A Novel Acetyl-CoA Carboxylase 2 Selective Inhibitor Improves Whole-Body Insulin Resistance and Hyperglycemia in Diabetic Mice through Target-Dependent Pathways

(2020) Hiroyuki Takagi et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Tectorigenin attenuates diabetic nephropathy by improving vascular endothelium dysfunction through activating AdipoR1/2 pathway

(2020) Shu Yang et al.   PHARMACOLOGICAL RESEARCH

Metformin overcomes high glucose-induced insulin resistance of podocytes by pleiotropic effects on SIRT1 and AMPK

(2018) Dorota Rogacka et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Acetyl-CoA Carboxylase Inhibition Reverses NAFLD and Hepatic Insulin Resistance but Promotes Hypertriglyceridemia in Rodents

(2018) Leigh Goedeke et al.   HEPATOLOGY

Advanced glycation end-products suppress autophagic flux in podocytes by activating mammalian target of rapamycin and inhibiting nuclear translocation of transcription factor EB

(2018) Xingchen Zhao et al.   JOURNAL OF PATHOLOGY

Global kidney health 2017 and beyond: a roadmap for closing gaps in care, research, and policy

(2017) Adeera Levin et al.   LANCET

Lipid toxicity drives renal disease

(2017) Liesbet Lieben   Nature Reviews Nephrology

Research Progress on Mechanism of Podocyte Depletion in Diabetic Nephropathy

(2017) Haoran Dai et al.   Journal of Diabetes Research

Autophagy protects human podocytes from high glucose-induced injury by preventing insulin resistance

(2016) Wei Xin et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Involvement of the AMPK–PTEN pathway in insulin resistance induced by high glucose in cultured rat podocytes

(2014) Dorota Rogacka et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Lipid accumulation is ahead of epithelial-to-mesenchymal transition and therapeutic intervention by acetyl-CoA carboxylase 2 silence in diabetic nephropathy

(2014) Ying Xu et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Lipid Droplet Accumulation Is Associated with an Increase in Hyperglycemia-Induced Renal Damage

(2013) Eva Kiss et al.   AMERICAN JOURNAL OF PATHOLOGY

Cyclodextrin Protects Podocytes in Diabetic Kidney Disease

(2013) S. Merscher-Gomez et al.   DIABETES

NOD2 promotes renal injury by exacerbating inflammation and podocyte insulin resistance in diabetic nephropathy

(2013) Pengchao Du et al.   KIDNEY INTERNATIONAL

Accelerated renal disease is associated with the development of metabolic syndrome in a glucolipotoxic mouse model

(2012) C. Martinez-Garcia et al.   Disease Models & Mechanisms

Activation of Liver X Receptor Inhibits Osteopontin and Ameliorates Diabetic Nephropathy

(2012) H. Tachibana et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Insulin Signaling to the Glomerular Podocyte Is Critical for Normal Kidney Function

(2010) Gavin I. Welsh et al.   Cell Metabolism

Renal lipid metabolism and lipotoxicity

(2010) Ion Alexandru Bobulescu   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Diabetic Nephropathy Is Accelerated by Farnesoid X Receptor Deficiency and Inhibited by Farnesoid X Receptor Activation in a Type 1 Diabetes Model

(2010) X. X. Wang et al.   DIABETES

Podocytes lose their footing

(2010) Christian Rask-Madsen et al.   NATURE

Role of altered insulin signaling pathways in the pathogenesis of podocyte malfunction and microalbuminuria

(2009) Alexandra Jauregui et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Myocardial lipid accumulation in patients with pressure-overloaded heart and metabolic syndrome

(2009) Raffaele Marfella et al.   JOURNAL OF LIPID RESEARCH

Myocardial lipid accumulation and lipotoxicity in heart failure

(2009) P. Christian Schulze   JOURNAL OF LIPID RESEARCH

Fatty acid metabolism: target for metabolic syndrome

(2008) Salih J. Wakil et al.   JOURNAL OF LIPID RESEARCH

Failure to phosphorylate AKT in podocytes from mice with early diabetic nephropathy promotes cell death

(2008) T. Tejada et al.   KIDNEY INTERNATIONAL

Effect of a Multifactorial Intervention on Mortality in Type 2 Diabetes

(2008) Peter Gæde et al.   NEW ENGLAND JOURNAL OF MEDICINE