Single cell analysis of PANoptosome cell death complexes through an expansion microscopy method

Dickkopf-1 exerts protective effects by inhibiting PANoptosis and retinal neovascularization in diabetic retinopathy

(2022) Xiaoling Xu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mosaic composition of RIP1–RIP3 signalling hub and its role in regulating cell death

(2022) Xin Chen et al.   NATURE CELL BIOLOGY

STING agonist diABZI induces PANoptosis and DNA mediated acute respiratory distress syndrome (ARDS)

(2022) Yasmine Messaoud-Nacer et al.   Cell Death & Disease

It’s All in the PAN: Crosstalk, Plasticity, Redundancies, Switches, and Interconnectedness Encompassed by PANoptosis Underlying the Totality of Cell Death-Associated Biological Effects

(2022) Jessica M. Gullett et al.   Cells

ZBP1-dependent inflammatory cell death, PANoptosis, and cytokine storm disrupt IFN therapeutic efficacy during coronavirus infection

(2022) Rajendra Karki et al.   Science Immunology

Nanobody: a promising toolkit for molecular imaging and disease therapy

(2021) Guangfa Bao et al.   EJNMMI Research

A toolbox for imaging RIPK1, RIPK3, and MLKL in mouse and human cells

(2021) André L. Samson et al.   CELL DEATH AND DIFFERENTIATION

AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence

(2021) SangJoon Lee et al.   NATURE

Real-Time Induction of Macrophage Apoptosis, Pyroptosis, and Necroptosis by Enterococcus faecalis OG1RF and Two Root Canal Isolated Strains

(2021) Danlu Chi et al.   Frontiers in Cellular and Infection Microbiology

Cutting Edge: Caspase-8 Is a Linchpin in Caspase-3 and Gasdermin D Activation to Control Cell Death, Cytokine Release, and Host Defense during Influenza A Virus Infection

(2021) Yaqiu Wang et al.   JOURNAL OF IMMUNOLOGY

ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis

(2021) Rajendra Karki et al.   Cell Reports

Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense

(2020) Min Zheng et al.   CELL

The Zα2 domain of ZBP1 is a molecular switch regulating influenza-induced PANoptosis and perinatal lethality during development

(2020) Sannula Kesavardhana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of the PANoptosome: A Molecular Platform Triggering Pyroptosis, Apoptosis, and Necroptosis (PANoptosis)

(2020) Shelbi Christgen et al.   Frontiers in Cellular and Infection Microbiology

Impaired NLRP3 inflammasome activation/pyroptosis leads to robust inflammatory cell death via caspase-8/RIPK3 during coronavirus infection

(2020) Min Zheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interferon regulatory factor 1 regulates PANoptosis to prevent colorectal cancer

(2020) Rajendra Karki et al.   JCI Insight

Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes

(2020) Rajendra Karki et al.   CELL

ZBP1 promotes fungi-induced inflammasome activation and pyroptosis, apoptosis, and necroptosis (PANoptosis)

(2020) Balaji Banoth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of necroptosis in cancer biology and therapy

(2019) Yitao Gong et al.   Molecular Cancer

Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis

(2019) Kim Newton et al.   NATURE

Innate immune priming in the absence of TAK1 drives RIPK1 kinase activity–independent pyroptosis, apoptosis, necroptosis, and inflammatory disease

(2019) R.K. Subbarao Malireddi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TAK1 restricts spontaneous NLRP3 activation and cell death to control myeloid proliferation

(2018) R.K. Subbarao Malireddi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Necroptosis: a regulated inflammatory mode of cell death

(2018) Yogesh K. Dhuriya et al.   Journal of Neuroinflammation

Necroptosis in anti-viral inflammation

(2018) Himani Nailwal et al.   CELL DEATH AND DIFFERENTIATION

ZBP1/DAI ubiquitination and sensing of influenza vRNPs activate programmed cell death

(2017) Sannula Kesavardhana et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Expansion microscopy

(2015) F. Chen et al.   SCIENCE

Inflammasome activation causes dual recruitment of NLRC4 and NLRP3 to the same macromolecular complex

(2014) S. M. Man et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC

(2013) V Sagulenko et al.   CELL DEATH AND DIFFERENTIATION

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

(2013) James M. Murphy et al.   IMMUNITY

Salmonella Infection Induces Recruitment of Caspase-8 to the Inflammasome To Modulate IL-1  Production

(2013) S. M. Man et al.   JOURNAL OF IMMUNOLOGY

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

AIM2/ASC triggers caspase-8-dependent apoptosis in Francisella-infected caspase-1-deficient macrophages

(2012) R Pierini et al.   CELL DEATH AND DIFFERENTIATION

Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis

(2012) J. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis

(2011) Andrew Oberst et al.   NATURE

Cutting Edge: Proteolytic Inactivation of Poly(ADP-Ribose) Polymerase 1 by the Nlrp3 and Nlrc4 Inflammasomes

(2010) R. K. S. Malireddi et al.   JOURNAL OF IMMUNOLOGY

Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis

(2010) J. W. Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines

(2008) Ken J. Ishii et al.   NATURE