X-linked ubiquitin-specific peptidase 11 increases tauopathy vulnerability in women

Lysine 63-linked ubiquitination of tau oligomers contributes to the pathogenesis of Alzheimer’s disease

(2022) Nicha Puangmalai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gene regulation in time and space during X-chromosome inactivation

(2022) Agnese Loda et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019

(2022) Emma Nichols et al.   Lancet Public Health

FSH blockade improves cognition in mice with Alzheimer’s disease

(2022) Jing Xiong et al.   NATURE

Endogenous and Exogenous Estrogen Exposures: How Women’s Reproductive Health Can Drive Brain Aging and Inform Alzheimer’s Prevention

(2022) Steven Jett et al.   Frontiers in Aging Neuroscience

A pro-inflammatory mediator USP11 enhances the stability of p53 and inhibits KLF2 in intracerebral hemorrhage

(2021) Xiuqing Zhang et al.   Molecular Therapy-Methods & Clinical Development

Usp11 controls cortical neurogenesis and neuronal migration through Sox11 stabilization

(2021) Shang-Yin Chiang et al.   Science Advances

Reducing acetylated tau is neuroprotective in brain injury

(2021) Min-Kyoo Shin et al.   CELL

Methylation as a key regulator of Tau aggregation and neuronal health in Alzheimer’s disease

(2021) Abhishek Ankur Balmik et al.   Cell Communication and Signaling

Population estimate of people with clinical Alzheimer's disease and mild cognitive impairment in the United States (2020–2060)

(2021) Kumar B. Rajan et al.   Alzheimers & Dementia

Sex differences in in vivo tau neuropathology in a multiethnic sample of late middle-aged adults

(2021) Priya Palta et al.   NEUROBIOLOGY OF AGING

Female specific risk factors for the development of Alzheimer’s disease neuropathology and cognitive impairment: Call for a precision medicine approach

(2021) Chinedu Udeh-Momoh et al.   AGEING RESEARCH REVIEWS

USP11 regulates autophagy-dependent ferroptosis after spinal cord ischemia-reperfusion injury by deubiquitinating Beclin 1

(2021) Yuluo Rong et al.   CELL DEATH AND DIFFERENTIATION

The deubiquitinase USP11 is a versatile and conserved regulator of autophagy

(2021) Mila Basic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Posttranslational Modifications Mediate the Structural Diversity of Tauopathy Strains

(2020) Tamta Arakhamia et al.   CELL

The behavioural and neuropathologic sexual dimorphism and absence of MIP-3α in tau P301S mouse model of Alzheimer’s disease

(2020) Yao Sun et al.   Journal of Neuroinflammation

β-Arrestin2 oligomers impair the clearance of pathological tau and increase tau aggregates

(2020) Jung-A A. Woo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sex Differences in in vivo Alzheimer’s Disease Neuropathology in Late Middle-Aged Hispanics

(2020) José A. Luchsinger et al.   JOURNAL OF ALZHEIMERS DISEASE

Sex differences in CSF biomarkers vary by Alzheimer’s disease stage and APOE ε4 genotype

(2020) Rosha Babapour Mofrad et al.   NEUROLOGY

Sex Mediates Relationships Between Regional Tau Pathology and Cognitive Decline

(2020) Rachel F. Buckley et al.   ANNALS OF NEUROLOGY

SSH1 impedes SQSTM1/p62 flux and MAPT/Tau clearance independent of CFL (cofilin) activation

(2020) Cenxiao Fang et al.   Autophagy

Sex differences in dementia: on the potentially mediating effects of educational attainment and experiences of psychological distress

(2020) Caroline Hasselgren et al.   BMC Psychiatry

A functional genomic screen identifies the deubiquitinase USP11 as a novel transcriptional regulator of ERα in breast cancer

(2020) Lisa Dwane et al.   CANCER RESEARCH

Sex differences in behavioral and metabolic effects of gene inactivation: The neuropeptide Y and Y receptors in the brain

(2020) Carola Eva et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Tau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer’s Disease

(2020) Hendrik Wesseling et al.   CELL

Sex Differences in the Association of Global Amyloid and Regional Tau Deposition Measured By Positron Emission Tomography in Clinically Normal Older Adults

(2019) Rachel F. Buckley et al.   JAMA Neurology

An acetylation mimicking mutation, K274Q, in tau imparts neurotoxicity by enhancing tau aggregation and inhibiting tubulin polymerization

(2019) Jitendra S. Rane et al.   BIOCHEMICAL JOURNAL

Early neuronal accumulation of DNA double strand breaks in Alzheimer’s disease

(2019) Niraj M. Shanbhag et al.   Acta Neuropathologica Communications

USP11 acts as a histone deubiquitinase functioning in chromatin reorganization during DNA repair

(2019) Xia Ting et al.   NUCLEIC ACIDS RESEARCH

Quantification of Tau Protein Lysine Methylation in Aging and Alzheimer’s Disease

(2019) Carol J. Huseby et al.   JOURNAL OF ALZHEIMERS DISEASE

Ubiquitin Specific Protease 13 Regulates Tau Accumulation and Clearance in Models of Alzheimer’s Disease

(2019) Xiaoguang Liu et al.   JOURNAL OF ALZHEIMERS DISEASE

Microglial microRNAs mediate sex-specific responses to tau pathology

(2019) Lay Kodama et al.   NATURE NEUROSCIENCE

Dual Function of USP14 Deubiquitinase in Cellular Proteasomal Activity and Autophagic Flux

(2018) Eunkyoung Kim et al.   Cell Reports

S-Trap, an Ultrafast Sample-Preparation Approach for Shotgun Proteomics

(2018) Milkessa HaileMariam et al.   JOURNAL OF PROTEOME RESEARCH

Sex differences in Alzheimer’s disease and common neuropathologies of aging

(2018) Shahram Oveisgharan et al.   ACTA NEUROPATHOLOGICA

The cargo receptor SQSTM1 ameliorates neurofibrillary tangle pathology and spreading through selective targeting of pathological MAPT (microtubule associated protein tau)

(2018) Yin Xu et al.   Autophagy

Acetylation as a major determinant to microtubule-dependent autophagy: Relevance to Alzheimer's and Parkinson disease pathology

(2018) A.R. Esteves et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Phosphorylation of nuclear Tau is modulated by distinct cellular pathways

(2018) Giorgio Ulrich et al.   Scientific Reports

Sexually Dimorphic Effects of Aromatase on Neurobehavioral Responses

(2018) Dusti A. Shay et al.   Frontiers in Molecular Neuroscience

Enhanced tau pathology via RanBP9 and Hsp90/Hsc70 chaperone complexes

(2017) Jung A Woo et al.   HUMAN MOLECULAR GENETICS

Landscape of X chromosome inactivation across human tissues

(2017) Taru Tukiainen et al.   NATURE

Synaptic integrative mechanisms for spatial cognition

(2017) Christoph Schmidt-Hieber et al.   NATURE NEUROSCIENCE

Hsp90 activator Aha1 drives production of pathological tau aggregates

(2017) Lindsey B. Shelton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic compensation: A phenomenon in search of mechanisms

(2017) Mohamed A. El-Brolosy et al.   PLoS Genetics

A Dual Pathogenic Mechanism Links Tau Acetylation to Sporadic Tauopathy

(2017) Hanna Trzeciakiewicz et al.   Scientific Reports

Generation and Application of Mouse-Rat Allodiploid Embryonic Stem Cells

(2016) Xin Li et al.   CELL

Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment

(2016) Peter Dongmin Sohn et al.   Molecular Neurodegeneration

Fluorescent Filter-Trap Assay for Amyloid Fibril Formation Kinetics in Complex Solutions

(2015) Irem Nasir et al.   ACS Chemical Neuroscience

Erratum: Slingshot-Cofilin activation mediates mitochondrial and synaptic dysfunction via Aβ ligation to β1-integrin conformers

(2015) J A Woo et al.   CELL DEATH AND DIFFERENTIATION

Ubiquitin-specific Protease 11 (USP11) Deubiquitinates Hybrid Small Ubiquitin-like Modifier (SUMO)-Ubiquitin Chains to Counteract RING Finger Protein 4 (RNF4)

(2015) Ivo A. Hendriks et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

USP11 Is a Negative Regulator to γH2AX Ubiquitylation by RNF8/RNF168

(2015) Miao Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A mechanism for the suppression of homologous recombination in G1 cells

(2015) Alexandre Orthwein et al.   NATURE

Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits

(2015) Sang-Won Min et al.   NATURE MEDICINE

Tau post-translational modifications in wild-type and human amyloid precursor protein transgenic mice

(2015) Meaghan Morris et al.   NATURE NEUROSCIENCE

Critical window hypothesis of hormone therapy and cognition

(2015) Pauline M. Maki   MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY

Sex modifies theAPOE-related risk of developing Alzheimer disease

(2014) Andre Altmann et al.   ANNALS OF NEUROLOGY

Axotrophin/MARCH7 acts as an E3 ubiquitin ligase and ubiquitinates tau protein in vitro impairing microtubule binding

(2014) Katharina Flach et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Accurate Proteome-wide Label-free Quantification by Delayed Normalization and Maximal Peptide Ratio Extraction, Termed MaxLFQ

(2014) Jürgen Cox et al.   MOLECULAR & CELLULAR PROTEOMICS

Suspension trapping (STrap) sample preparation method for bottom-up proteomics analysis

(2014) Alexandre Zougman et al.   PROTEOMICS

USP11 regulates PML stability to control Notch-induced malignancy in brain tumours

(2014) Hsin-Chieh Wu et al.   Nature Communications

An optimal ubiquitin-proteasome pathway in the nervous system: the role of deubiquitinating enzymes

(2014) Gorica Ristic et al.   Frontiers in Molecular Neuroscience

Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes?

(2013) James A Nathan et al.   EMBO JOURNAL

Deubiquitylases From Genes to Organism

(2013) Michael J. Clague et al.   PHYSIOLOGICAL REVIEWS

Tau degradation: The ubiquitin–proteasome system versus the autophagy-lysosome system

(2013) Min Jae Lee et al.   PROGRESS IN NEUROBIOLOGY

The Ubiquitin-Proteasome System and the Autophagic-Lysosomal System in Alzheimer Disease

(2013) Y. Ihara et al.   Cold Spring Harbor Perspectives in Medicine

Usp14 Deficiency Increases Tau Phosphorylation without Altering Tau Degradation or Causing Tau-Dependent Deficits

(2012) Youngnam N. Jin et al.   PLoS One

Dual modification of Alzheimer’s disease PHF-tau protein by lysine methylation and ubiquitylation: a mass spectrometry approach

(2011) Stefani N. Thomas et al.   ACTA NEUROPATHOLOGICA

National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach

(2011) Thomas J. Montine et al.   ACTA NEUROPATHOLOGICA

A conditional knockout resource for the genome-wide study of mouse gene function

(2011) William C. Skarnes et al.   NATURE

P301S Mutant Human Tau Transgenic Mice Manifest Early Symptoms of Human Tauopathies with Dementia and Altered Sensorimotor Gating

(2011) Hiroki Takeuchi et al.   PLoS One

The acetylation of tau inhibits its function and promotes pathological tau aggregation

(2011) Todd J. Cohen et al.   Nature Communications

Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor

(2010) Goedele N Maertens et al.   EMBO JOURNAL

Sensitivity to Poly(ADP-ribose) Polymerase (PARP) Inhibition Identifies Ubiquitin-specific Peptidase 11 (USP11) as a Regulator of DNA Double-strand Break Repair

(2010) Timothy D. Wiltshire et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy

(2010) Sang-Won Min et al.   NEURON

ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS

(2010) S.-C. Ling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Breaking the chains: structure and function of the deubiquitinases

(2009) David Komander et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular Dissection of the Mechanisms of Substrate Recognition and F-actin-mediated Activation of Cofilin-phosphatase Slingshot-1

(2008) Souichi Kurita et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic inactivation of p62 leads to accumulation of hyperphosphorylated tau and neurodegeneration

(2008) J. Ramesh Babu et al.   JOURNAL OF NEUROCHEMISTRY

Analyzing real-time PCR data by the comparative CT method

(2008) Thomas D Schmittgen et al.   Nature Protocols

Akt and CHIP coregulate tau degradation through coordinated interactions

(2008) C. A. Dickey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA