C-Reactive protein and the kynurenic acid to quinolinic acid ratio are independently associated with white matter integrity in major depressive disorder

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Blood versus cerebrospinal fluid: Kynurenine pathway metabolites in depression

(2022) Jonathan Savitz   BRAIN BEHAVIOR AND IMMUNITY

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(2022) Elisabeth R. Paul et al.   BRAIN BEHAVIOR AND IMMUNITY

Real-time fMRI Neurofeedback Amygdala Training May Influence Kynurenine Pathway Metabolism in Major Depressive Disorder

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Elevated C-Reactive Protein in Patients With Depression, Independent of Genetic, Health, and Psychosocial Factors: Results From the UK Biobank

(2021) Maria C. Pitharouli et al.   AMERICAN JOURNAL OF PSYCHIATRY

Kynurenine metabolites and ratios differ between Chronic Fatigue Syndrome, Fibromyalgia, and healthy controls

(2021) Nina Groven et al.   PSYCHONEUROENDOCRINOLOGY

Kynurenines increase MRS metabolites in basal ganglia and decrease resting-state connectivity in frontostriatal reward circuitry in depression

(2021) Xiangchuan Chen et al.   Translational Psychiatry

Altered levels of interleukins and neurotrophic growth factors in mood disorders and suicidality: an analysis from periphery to central nervous system

(2021) Bharathi S. Gadad et al.   Translational Psychiatry

White Matter Alterations Associated with Pro-inflammatory Cytokines in Patients with Major Depressive Disorder

(2021) Jaehwa Lim et al.   Clinical Psychopharmacology and Neuroscience

The association between plasma tryptophan catabolites and depression: The role of symptom profiles and inflammation

(2021) Yuri Milaneschi et al.   BRAIN BEHAVIOR AND IMMUNITY

Selective association of cytokine levels and kynurenine/tryptophan ratio with alterations in white matter microstructure in bipolar but not in unipolar depression

(2021) Stefano Comai et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

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(2021) Fang-Cheng Yeh et al.   NEUROIMAGE

Elevated Systemic Inflammation Is Associated with Reduced Corticolimbic White Matter Integrity in Depression

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The Kynurenine Pathway in Traumatic Brain Injury: Implications for Psychiatric Outcomes

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Associations among peripheral and central kynurenine pathway metabolites and inflammation in depression

(2020) Ebrahim Haroon et al.   NEUROPSYCHOPHARMACOLOGY

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The kynurenine pathway in bipolar disorder: a meta-analysis on the peripheral blood levels of tryptophan and related metabolites

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Prevalence of low-grade inflammation in depression: a systematic review and meta-analysis of CRP levels

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White matter disturbances in major depressive disorder: a coordinated analysis across 20 international cohorts in the ENIGMA MDD working group

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A pilot resting-state functional connectivity study of the kynurenine pathway in adolescents with depression and healthy controls

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Alzheimer’s Disease: Recent Concepts on the Relation of Mitochondrial Disturbances, Excitotoxicity, Neuroinflammation, and Kynurenines

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Altered tryptophan catabolite concentrations in major depressive disorder and associated changes in hippocampal subfield volumes

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Relationship between white matter integrity and serum inflammatory cytokine levels in drug-naive patients with major depressive disorder: diffusion tensor imaging study using tract-based spatial statistics

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Inhibition of the kynurenine pathway protects against reactive microglial-associated reductions in the complexity of primary cortical neurons

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(2017) Jong-Min Lee et al.   NEUROPHARMACOLOGY

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Is the Enzyme ACMSD a Novel Therapeutic Target in Parkinson’s Disease?

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Voxel-Based Meta-Analytical Evidence of Structural Disconnectivity in Major Depression and Bipolar Disorder

(2016) Toby Wise et al.   BIOLOGICAL PSYCHIATRY

Relationship between neurotoxic kynurenine metabolites and reductions in right medial prefrontal cortical thickness in major depressive disorder

(2016) Timothy B. Meier et al.   BRAIN BEHAVIOR AND IMMUNITY

Kynurenine pathway and white matter microstructure in bipolar disorder

(2016) Sara Poletti et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

Inflammatory cytokines influence measures of white matter integrity in Bipolar Disorder

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Electroconvulsive therapy suppresses the neurotoxic branch of the kynurenine pathway in treatment-resistant depressed patients

(2016) Lilly Schwieler et al.   Journal of Neuroinflammation

Smaller Dentate Gyrus and CA2 and CA3 Volumes Are Associated with Kynurenine Metabolites in Collegiate Football Athletes

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Mast cells' involvement in inflammation pathways linked to depression: evidence in mastocytosis

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Conceptual convergence: increased inflammation is associated with increased basal ganglia glutamate in patients with major depression

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An integrated approach to correction for off-resonance effects and subject movement in diffusion MR imaging

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(2016) Fang-Cheng Yeh et al.   NEUROIMAGE

Incorporating outlier detection and replacement into a non-parametric framework for movement and distortion correction of diffusion MR images

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Tryptophan-2,3-dioxygenase (TDO) inhibition ameliorates neurodegeneration by modulation of kynurenine pathway metabolites

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Disorganization of white matter architecture in major depressive disorder: a meta-analysis of diffusion tensor imaging with tract-based spatial statistics

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Current Evidence for a Role of the Kynurenine Pathway of Tryptophan Metabolism in Multiple Sclerosis

(2016) Michael D. Lovelace et al.   Frontiers in Immunology

A role for inflammatory metabolites as modulators of the glutamate N-methyl-d-aspartate receptor in depression and suicidality

(2015) Cecilie Bay-Richter et al.   BRAIN BEHAVIOR AND IMMUNITY

Reduction of kynurenic acid to quinolinic acid ratio in both the depressed and remitted phases of major depressive disorder

(2015) Jonathan Savitz et al.   BRAIN BEHAVIOR AND IMMUNITY

Cumulative meta-analysis of interleukins 6 and 1β, tumour necrosis factor α and C-reactive protein in patients with major depressive disorder

(2015) Rita Haapakoski et al.   BRAIN BEHAVIOR AND IMMUNITY

Inflammation is associated with decreased functional connectivity within corticostriatal reward circuitry in depression

(2015) J C Felger et al.   MOLECULAR PSYCHIATRY

Neuroprotective kynurenine metabolite indices are abnormally reduced and positively associated with hippocampal and amygdalar volume in bipolar disorder

(2015) Jonathan Savitz et al.   PSYCHONEUROENDOCRINOLOGY

Activation of the kynurenine pathway is associated with striatal volume in major depressive disorder

(2015) Jonathan Savitz et al.   PSYCHONEUROENDOCRINOLOGY

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(2015) Dustin Tingley et al.   Journal of Statistical Software

Expression of the Kynurenine Pathway in Human Peripheral Blood Mononuclear Cells: Implications for Inflammatory and Neurodegenerative Disease

(2015) Simon P. Jones et al.   PLoS One

Putative Neuroprotective and Neurotoxic Kynurenine Pathway Metabolites Are Associated with Hippocampal and Amygdalar Volumes in Subjects with Major Depressive Disorder

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Anti-anhedonic effect of ketamine and its neural correlates in treatment-resistant bipolar depression

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Deterministic Diffusion Fiber Tracking Improved by Quantitative Anisotropy

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(2012) Gilles J. Guillemin   FEBS Journal

Kynurenine 3-Monooxygenase Inhibition in Blood Ameliorates Neurodegeneration

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The Kynurenine Pathway Modulates Neurodegeneration in a Drosophila Model of Huntington's Disease

(2011) Susanna Campesan et al.   CURRENT BIOLOGY

Changes in kynurenine pathway metabolism in the brain, liver and kidney of aged female Wistar rats

(2011) Nady Braidy et al.   FEBS Journal

Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: Evidence for an immune-modulated glutamatergic neurotransmission?

(2011) Johann Steiner et al.   Journal of Neuroinflammation

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(2011) Fang-Cheng Yeh et al.   NEUROIMAGE

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(2010) Fang-Cheng Yeh et al.   IEEE TRANSACTIONS ON MEDICAL IMAGING

Inflammation-associated depression: From serotonin to kynurenine

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Effect of quinolinic acid on human astrocytes morphology and functions: implications in Alzheimer's disease

(2009) Ka Ting et al.   Journal of Neuroinflammation

Bipolar and major depressive disorder: Neuroimaging the developmental-degenerative divide

(2009) Jonathan Savitz et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Metallothionein Treatment Attenuates Microglial Activation and Expression of Neurotoxic Quinolinic Acid Following Traumatic Brain Injury

(2009) R. S. Chung et al.   NEUROTOXICITY RESEARCH

Associations of Depression With C-Reactive Protein, IL-1, and IL-6: A Meta-Analysis

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From inflammation to sickness and depression: when the immune system subjugates the brain

(2007) Robert Dantzer et al.   NATURE REVIEWS NEUROSCIENCE