Article
Psychology, Clinical
Jonathan Savitz, Bart N. Ford, Hung-Wen Yeh, Elisabeth Akeman, Kelly Cosgrove, Ashley N. Clausen, Christopher Martell, Namik Kirlic, Jessica Santiago, T. Kent Teague, Michael R. Irwin, Martin P. Paulus, Robin L. Aupperle
Summary: The current study found that behavioral activation therapy can effectively reduce depression and disability scores in individuals with major depressive disorder. The therapy also affects the kynurenine pathway metabolites, but these changes are not associated with the response to therapy.
PSYCHOLOGICAL MEDICINE
(2022)
Review
Immunology
Kaat Hebbrecht, Katrien Skorobogatov, Erik J. Giltay, Violette Coppens, Livia De Picker, Manuel Morrens
Summary: The TRYCAT pathway is downregulated in BD patients, with lower levels of TRP and KYN in peripheral blood compared to healthy controls, while no difference was found in cerebrospinal fluid. The quality of the studies was rated as moderate.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Claudia Pisanu, Alessio Squassina, Pasquale Paribello, Stefano Dall'Acqua, Stefania Sut, Sofia Nasini, Antonella Bertazzo, Donatella Congiu, Anna Meloni, Mario Garzilli, Beatrice Guiso, Federico Suprani, Vittoria Pulcinelli, Maria Novella Iaselli, Ilaria Pinna, Giulia Somaini, Laura Arru, Carolina Corrias, Federica Pinna, Bernardo Carpiniello, Stefano Comai, Mirko Manchia
Summary: The study identified significant associations between TRP metabolites via the 5-HT and KYN pathways and genetic variants at the genome-wide level. Penalized regression models incorporating clinical, genetic, and metabolic predictors showed discriminative performance for potential impact of tryptophan metabolism abnormalities.
Article
Genetics & Heredity
Per G. Farup, Helge Rootwelt, Knut Hestad
Summary: The study found associations between APOE polymorphism and metabolites in the Kynurenine pathway, indicating a potential link between APOE and disease occurrence. Inflammation may play a key role in the relationship between APOE and the Kynurenine pathway.
Review
Immunology
Arduino A. Mangoni, Angelo Zinellu
Summary: There is a growing interest in the role of the kynurenine pathway in regulating immune function and inflammation in rheumatic diseases (RD). This study conducted a systematic review and meta-analysis to explore the link between this pathway and RD by examining the levels of tryptophan, kynurenine, and other relevant metabolites in RD patients and healthy controls. The analysis of selected studies revealed significantly lower tryptophan levels and higher kynurenine levels, kynurenine to tryptophan ratios, 3-hydroxykynurenine levels, and quinolinic acid concentrations in RD patients compared to controls. However, the levels of kynurenic acid, 3-hydroxyanthranilic acid, kynurenic acid to kynurenine ratio, and quinolinic acid to kynurenine acid ratio did not show significant differences. Subgroup analysis showed consistent results across different types of RD, except for rheumatoid arthritis. Further research is needed to determine the potential diagnostic and management utility of these biomarkers in RD patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Mobina Fathi, Kimia Vakili, Shirin Yaghoobpoor, Arian Tavasol, Kimia Jazi, Ashraf Mohamadkhani, Andis Klegeris, Alyssa McElhinney, Zahedeh Mafi, Mohammadreza Hajiesmaeili, Fatemeh Sayehmiri
Summary: This systematic review investigates the dysregulation of the kynurenine pathway (KP) and differences in its metabolites and enzymes in multiple sclerosis (MS) patients compared to healthy control subjects. The results suggest that alterations in KP metabolites and enzymes may be linked to MS and that certain metabolite and enzyme levels could potentially be used to differentiate between MS patients and control subjects.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Clinical Neurology
Mona Dehhaghi, Benjamin Heng, Gilles J. Guillemin
Summary: Up to 10 million people per annum experience traumatic brain injury (TBI), 80-90% of which are mild. TBI can cause secondary brain injuries through mechanisms that are not yet fully understood but likely involve neurochemical changes triggered by inflammation, excitotoxicity, and reactive oxygen species. The kynurenine pathway (KP) is an important pathway that is overactivated during inflammation and its metabolites, such as QUIN, may have neurotoxic effects, suggesting a possible mechanism for secondary brain injury. Understanding the changes in KP metabolites during TBI is crucial to prevent or attenuate the severity of secondary brain injuries and develop biomarkers for TBI severity and risk of secondary brain injuries. This review aims to address the knowledge gap regarding the role of KP in TBI and highlight areas for future study.
FRONTIERS IN NEUROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ping Chen, Xiaofei Geng
Summary: Parkinson's disease (PD) is characterized by the death of dopamine (DA) neurons and the accumulation of α-synuclein fibrils in the substantia nigra pars compacta (SNpc), along with central nervous system inflammation. Elevated levels of central inflammatory factors disrupt the kynurenine pathway (KP) in PD, leading to reduced neuroprotective metabolite KYNA and increased neurotoxic metabolite QUIN, exacerbating excitotoxicity and inflammation. KYNA analogs, precursor drugs, and KP enzyme modulators may offer potential therapeutic strategies for PD.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2023)
Article
Clinical Neurology
David J. Bond, Ana C. Andreazza, Ivan J. Torres, William G. Honer, Raymond W. Lam, Lakshmi N. Yatham
Summary: This study found that inflammation, measured by a composite measure of total peripheral inflammation, is associated with lower white matter volumes in the frontal and temporal lobes of patients with early-stage BD. Total inflammation is a stronger predictor of lower white matter volumes than individual cytokines.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Rodrigo B. Mansur, Mehala Subramaniapillai, Yena Lee, Zihang Pan, Nicole E. Carmona, Margarita Shekotikhina, Michelle Iacobucci, Nelson Rodrigues, Flora Nasri, Joshua D. Rosenblat, Elisa Brietzke, Victoria E. Cosgrove, Nicole E. Kramer, Trisha Suppes, Jason Newport, Tomas Hajek, Roger S. McIntyre
Summary: The study found that treatment with infliximab did not significantly affect prefrontal NAA concentration in adults with BD. However, there was a significant effect on Glx levels, with an interaction between treatment and time indicating a decrease in Glx levels in infliximab-treated patients. Furthermore, the reduction in Glx levels in infliximab-treated participants was associated with cognitive improvement, as measured by neurocognitive tests.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Clinical Neurology
Wenwen Ou, Yihua Chen, Yumeng Ju, Mohan Ma, Yaqi Qin, Ying Bi, Mei Liao, Bangshan Liu, Jin Liu, Yan Zhang, Lingjiang Li
Summary: This meta-analysis examined the differences in kynurenine (KYN) metabolites between patients with major depressive disorder (MDD) in the current episode and patients in remission, as well as the changes after treatments. The findings showed that during the depressive episode, patients had lower concentrations of tryptophan (TRP), KYN, kynurenic acid (KYNA), KYNA/quinolinic acid (QA), KYNA/3-hydroxykynurenine (3-HK), and KYNA/KYN, while KYN/TRP was higher. These changes were more pronounced in medication-free patients. There were no significant differences between patients in remission and healthy controls. Additionally, KYNA levels were negatively correlated with depression severity and increased significantly after treatments.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Medical Laboratory Technology
Simon Michaelis, Sieglinde Zelzer, Christopher Schneider, Wolfgang J. Schnedl, Andreas Baranyi, Andreas Meinitzer, Markus Herrmann, Dietmar Enko
Summary: This study investigated the role of quinolinic acid (QA) in patients infected with SARS-CoV-2 and found that QA may serve as a prognostic marker for survival. Repeated measurements during the early stages of the disease may enhance the predictive accuracy.
CLINICA CHIMICA ACTA
(2023)
Review
Dermatology
A. Stepaniuk, A. Baran, I. Flisiak
Summary: Psoriasis is a common dermatosis that affects the patient's skin and overall well-being, with potential links to diseases such as depression, kidney disease, and metabolic syndrome. The exact causes and effective treatments for psoriasis are still unknown. However, recent studies have found abnormal activation of the kynurenine pathway, which may play a role in the development of psoriasis and its associated comorbidities.
DERMATOLOGY AND THERAPY
(2023)
Article
Psychiatry
Naomichi Okamoto, Tomoya Natsuyama, Ryohei Igata, Yuki Konishi, Hirofumi Tesen, Atsuko Ikenouchi, Reiji Yoshimura
Summary: Patients with schizophrenia and healthy controls did not show significant differences in the levels of Kyn and its metabolites, proinflammatory cytokines, and BDNF. In the schizophrenia group, there was a significant positive correlation between TNF-alpha levels and Kyn as well as the Kyn/Trp value, which was not observed in the healthy control group. Associations between the Kyn pathway and proinflammatory cytokines, BDNF, or psychotic symptoms in hospitalized patients with chronic schizophrenia may be complex.
FRONTIERS IN PSYCHIATRY
(2021)
Review
Endocrinology & Metabolism
Gregory H. Jones, Omar F. Pinjari, Courtney M. Vecera, Kacy Smith, Anita Barrera, Rodrigo Machado-Vieira
Summary: Bipolar disorder is a complex disease with significant burden. Understanding the role of gut-microbial homeostasis in this disorder and its impacts on relevant pathways is crucial for developing novel therapeutics. However, there are still obstacles to overcome before microbiome-related findings can be applied clinically. This review provides an overview of the current understanding and suggests areas for future research.
FRONTIERS IN NEUROENDOCRINOLOGY
(2023)
Article
Neuroimaging
Namik Kirlic, Rayus Kuplicki, James Touthang, Zsofia P. Cohen, Jennifer L. Stewart, Martin P. Paulus, Robin L. Aupperle
Summary: This study aimed to investigate the neural substrates and behavioral responses during fear learning in a large sample with depressive and/or anxious dysfunction. The results revealed that fear learning recruits a distributed network of brain regions and there are distinct subjective and neural response patterns. However, there were no robust relationships to demographic or cognitive-affective variables.
NEUROIMAGE-CLINICAL
(2022)
Review
Geriatrics & Gerontology
Bart N. Ford, Jonathan Savitz
Summary: The aging process can weaken the immune system and make the elderly more vulnerable to infections and less responsive to vaccines. Major depressive disorder has characteristics of accelerated biological aging, suggesting that individuals with depression may have similar immune response to infections and vaccines as elderly populations. Available data suggest that depression is a risk factor for adverse outcomes following COVID-19 infection and reduced effectiveness of COVID-19 vaccines. Therefore, individuals with MDD (and other major psychiatric disorders) should be considered as vulnerable populations and given priority for vaccination.
Article
Psychiatry
Leandra K. Figueroa-Hall, Bohan Xu, Rayus Kuplicki, Bart N. Ford, Kaiping Burrows, T. Kent Teague, Sandip Sen, Hung-Wen Yeh, Michael R. Irwin, Jonathan Savitz, Martin P. Paulus
Summary: Elevated levels of C-reactive protein (CRP) in the blood are associated with inflammation and an increased risk of cardiovascular disease. In psychiatric populations, higher levels of CRP have been found in individuals with depression. However, the association between CRP and depression is attenuated after controlling for confounding variables. There is also emerging research linking inflammation to symptoms of anxiety and substance abuse.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Psychiatry
Cynthia H. Y. Fu, Guray Erus, Yong Fan, Mathilde Antoniades, Danilo Arnone, Stephen R. Arnott, Taolin Chen, Ki Sueng Choi, Cherise Chin Fatt, Benicio N. Frey, Vibe G. Frokjaer, Melanie Ganz, Jose Garcia, Beata R. Godlewska, Stefanie Hassel, Keith Ho, Andrew M. McIntosh, Kun Qin, Susan Rotzinger, Matthew D. Sacchet, Jonathan Savitz, Haochang Shou, Ashish Singh, Aleks Stolicyn, Irina Strigo, Stephen C. Strother, Duygu Tosun, Teresa A. Victor, Dongtao Wei, Toby Wise, Rachel D. Woodham, Roland Zahn, Ian M. Anderson, J. F. William Deakin, Boadie W. Dunlop, Rebecca Elliott, Qiyong Gong, Ian H. Gotlib, Catherine J. Harmer, Sidney H. Kennedy, Gitte M. Knudsen, Helen S. Mayberg, Martin P. Paulus, Jiang Qiu, Madhukar H. Trivedi, Heather C. Whalley, Chao-Gan Yan, Allan H. Young, Christos Davatzikos
Summary: In this study, a consortium called "COORDINATE-MDD" was established to define patterns of brain alteration in major depressive disorder (MDD) using neuroanatomical and neurofunctional heterogeneity as dimensions. By harmonizing imaging data and using machine learning methods, the project aims to predict treatment response at the individual level. International datasets from various MDD populations are being shared, and novel predictors of treatment response are being identified and validated externally.
Article
Physiology
Emily M. Rogers, Nile F. Banks, Patrick M. Tomko, Christina M. Sciarrillo, Sam R. Emerson, Emily B. K. Thomas, Ashlee Taylor, T. Kent Teague, Nathaniel D. M. Jenkins
Summary: This study aimed to investigate the effects of aerobic and resistance exercise training on mental health and cardiovascular disease risk in young women with adverse childhood experiences. The results showed that exercise can lower ET-1 levels, improve positive psychological coping, and potentially improve systolic blood pressure.
JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Behavioral Sciences
Kiersten Scott, Nabila Boukelmoune, Cullen Taniguchi, A. Phillip West, Cobi J. Heijnen, Robert Dantzer
Summary: Based on previous studies, this experiment aimed to investigate the role of endogenous interleukin-10 (IL-10) in the recovery from cisplatin-induced fatigue in male mice. The mice were treated with cisplatin and a monoclonal neutralizing antibody (IL-10na) to neutralize IL-10. The results showed that IL-10 was not necessary for the recovery from cisplatin-induced decrease in voluntary wheel running, contrary to its role in the recovery from cisplatin-induced peripheral neuropathy.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Clinical Neurology
Jonathan Savitz, Bryna D. Goeckner, Bart N. Ford, T. Kent Teague, Haixia Zheng, Jaroslaw Harezlak, Rebekah Mannix, L. Tugan Muftuler, Benjamin L. Brett, Michael A. McCrea, Timothy B. Meier
Summary: This study suggests that cytomegalovirus infection may contribute to structural brain abnormalities in individuals with concussion. The researchers evaluated the effect of cytomegalovirus serostatus on brain structure in athletes with concussion, finding significant differences in white and grey matter structure between athletes with and without cytomegalovirus infection.
Article
Psychology, Clinical
Sean R. McWhinney, Christoph Abe, Martin Alda, Francesco Benedetti, Erlend Boen, Caterina del Mar Bonnin, Tiana Borgers, Katharina Brosch, Erick J. Canales-Rodriguez, Dara M. Cannon, Udo Dannlowski, Ana M. Diaz-Zuluaga, Lorielle M. F. Dietze, Torbjorn Elvsashagen, Lisa T. Eyler, Janice M. Fullerton, Jose M. Goikolea, Janik Goltermann, Dominik Grotegerd, Bartholomeus C. M. Haarman, Tim Hahn, Fleur M. Howells, Martin Ingvar, Neda Jahanshad, Tilo T. J. Kircher, Axel Krug, Rayus T. Kuplicki, Mikael Landen, Hannah Lemke, Benny Liberg, Carlos Lopez-Jaramillo, Ulrik F. Malt, Fiona M. Martyn, Elena Mazza, Colm McDonald, Genevieve McPhilemy, Sandra Meier, Susanne Meinert, Tina Meller, Elisa M. T. Melloni, Philip B. Mitchell, Leila Nabulsi, Igor Nenadic, Nils Opel, Roel A. Ophoff, Bronwyn J. Overs, Julia-Katharina Pfarr, Julian A. Pineda-Zapata, Edith Pomarol-Clotet, Joaquim Radua, Jonathan Repple, Maike Richter, Kai G. Ringwald, Gloria Roberts, Alex Ross, Raymond Salvador, Jonathan Savitz, Simon Schmitt, Peter R. Schofield, Kang Sim, Dan J. Stein, Frederike Stein, Henk S. Temmingh, Katharina Thiel, Sophia I. Thomopoulos, Neeltje E. M. van Haren, Cristian Vargas, Eduard Vieta, Annabel Vreeker, Lena Waltemate, Lakshmi N. Yatham, Christopher R. K. Ching, Ole A. Andreassen, Paul M. Thompson, Tomas Hajek
Summary: This study found that body mass index (BMI) and bipolar disorder (BD) have an impact on brain structure, particularly in cortical thickness. Both BMI and BD negatively affect the same brain regions, and BMI has a greater effect on brain alterations in individuals with BD. It is important to assess the neuroanatomical changes in BD caused by BMI and the effects of psychiatric medications on the brain.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Clinical Neurology
David M. Raizen, Janet Mullington, Christelle Anaclet, Gerard Clarke, Hugo Critchley, Robert Dantzer, Ronald Davis, Kelly L. Drew, Josh Fessel, Patrick M. Fuller, Erin M. Gibson, Mary Harrington, W. Ian Lipkin, Elizabeth B. Klerman, Nancy Klimas, Anthony L. Komaroff, Walter Koroshetz, Lauren Krupp, Anna Kuppuswamy, Julie Lasselin, Laura D. Lewis, Pierre J. Magistretti, Heidi Y. Matos, Christine Miaskowski, Andrew H. Miller, Avindra Nath, Maiken Nedergaard, Mark R. Opp, Marylyn D. Ritchie, Dragana Rogulja, Asya Rolls, John D. Salamone, Clifford Saper, Vicky Whittemore, Glenn Wylie, Jarred Younger, Phyllis C. Zee, H. Craig Heller
Summary: The workshop "Beyond the Symptom: The Biology of Fatigue" was a virtual event held on September 27-28, 2021. It aimed to bring together clinicians and scientists using different research approaches to understand fatigue in various conditions and identify gaps in our understanding of its biology. This workshop summary highlights key issues discussed and provides a list of promising future research directions, without aiming to comprehensively review the state of understanding or reprise all the presentations.
Article
Immunology
Kaiping Burrows, Leandra K. Figueroa-Hall, Ahlam M. Alarbi, Jennifer L. Stewart, Rayus Kuplicki, Chibing Tan, Bethany N. Hannafon, Rajagopal Ramesh, Jonathan Savitz, Sahib Khalsa, T. Kent Teague, Victoria B. Risbrough, Martin P. Paulus
Summary: This study examines the effects of ibuprofen on extracellular vesicles (AEEVs) miRNA and finds that ibuprofen dose-dependently increases the expression of AEEV miR-23b-3p. Individuals with higher miR-23b-3p expression show increased striatal brain activation during reward anticipation, suggesting that ibuprofen alters the composition of AEEV miRNA and may have implications for mental health.
BRAIN, BEHAVIOR, & IMMUNITY - HEALTH
(2023)
Article
Biochemistry & Molecular Biology
Haixia Zheng, Maree J. J. Webster, Cynthia Shannon Weickert, Clare L. L. Beasley, Martin P. P. Paulus, Robert H. H. Yolken, Jonathan Savitz
Summary: CMV reactivation may contribute to the neuroinflammation underlying some psychiatric disorders by exacerbating inflammation and translating peripheral inflammation into neuroinflammation. The study found significant associations between CMV infection and mood disorders, suicide, neuroinflammation, and microglial density in the dorsolateral prefrontal cortex.
MOLECULAR PSYCHIATRY
(2023)
Editorial Material
Neurosciences
Haixia Zheng, Jonathan Savitz
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Psychology, Biological
Bryant H. Keirns, Natalie G. Keirns, Cindy E. Tsotsoros, Harley M. Layman, Madison E. Stout, Austin R. Medlin, Christina M. Sciarrillo, T. Kent Teague, Sam R. Emerson, Misty A. W. Hawkins
Summary: Gut permeability may contribute to cardiovascular disease risk and chronic inflammation, but the relationship with adverse childhood experiences (ACEs) and obesity is unknown. This study found that ACE status and obesity were independently associated with gut permeability and systemic inflammation, but there was no interaction between the two factors.
PHYSIOLOGY & BEHAVIOR
(2023)
Article
Multidisciplinary Sciences
Kaiping Burrows, Breanna A. McNaughton, Leandra K. Figueroa-Hall, Philip A. Spechler, Rayus Kuplicki, Teresa A. Victor, Robin Aupperle, Sahib S. Khalsa, Jonathan B. Savitz, T. Kent Teague, Martin P. Paulus, Jennifer L. Stewart
Summary: This study examined the associations between inflammation, metabolic hormones, and reward-related brain processing in MDD patients with high and low CRP levels compared to healthy individuals. The results demonstrated that both MDD-High and MDD-Low patients had higher leptin concentrations than healthy controls, and higher leptin levels were associated with decreased brain activation during reward anticipation in MDD patients but increased activation in healthy controls.
SCIENTIFIC REPORTS
(2023)
Article
Endocrinology & Metabolism
Shanshan Xiao, Natalie C. Ebner, Amirhossein Manzouri, Tie-Qiang Li, Diana S. Cortes, Kristoffer N. T. Mansson, Hakan Fischer
Summary: The mechanisms through which intranasal oxytocin affects the brain are not fully understood, but recent research suggests that brain regions with a higher density of oxytocin receptors may play a key role. This study used resting-state fMRI to investigate the effects of intranasal oxytocin administration on connectivity between these receptor-enriched regions and other regions in the brain, and found that the effects varied depending on the age of the participants.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Lisa Haase, Antonia Vehlen, Julia Strojny, Gregor Domes
Summary: This study found no significant changes in the cortisol awakening response (CAR) over the menstrual cycle, and no significant association with variations in estradiol and progesterone. These results suggest that CAR is largely robust against hormonal variations across the menstrual cycle.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Derek Schaeuble, Tyler Wallace, Sebastian A. Pace, Shane T. Hentges, Brent Myers
Summary: Depression and cardiovascular disease are influenced by daily life stress, but the biological mechanisms behind this connection are not well understood. This study shows that the ventromedial prefrontal cortex (vmPFC) plays a role in regulating stress responses and behavior, with sex-specific effects. In males, the vmPFC-PH circuitry promotes positive motivation and reduces stress responses, while in females it elevates stress responses. This suggests that cortical regulation of stress reactivity and behavior is mediated by projections to the hypothalamus in a sex-specific manner.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Jose M. Guzman, Montana H. Boone, Gabriela L. Suarez, Colter Mitchell, Christopher S. Monk, Luke W. Hyde, Nestor L. Lopez-Duran
Summary: The COVID-19 pandemic has led to increased life stress and internalizing disorders, with a disproportionate impact on women. This study focused on the neuroendocrinology of stress-related disorders and found that women have lower cortisol responses and higher DHEA responses to stress. However, lower cortisol and higher DHEA are associated with internalizing disorders in women, while the opposite is true in men. The study also examined the relationship between COVID-related stress and internalizing symptoms and found gender differences in the association between DHEA and cortisol and internalizing outcomes. These findings suggest distinct neuroendocrine pathways for stress-related disorders in young men and women.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Meriah L. Dejoseph, Keira B. Leneman, Alyssa R. Palmer, Emily R. Padrutt, Otiti A. Mayo, Daniel Berry
Summary: Childhood and adolescence are critical periods for the development of the stress response system. This study found a modest positive relation between the adrenocortical and sympathetic systems, as well as between the adrenocortical and parasympathetic systems. The strength of these associations varied based on methodological and sociodemographic characteristics.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Qiong Xiang, Jia-Sheng Tao, Shuai Dong, Xiao-Lin Liu, Liang Yang, Li-Ni Liu, Jing Deng, Xian-Hui Li
Summary: Chronic hyperglycemia accelerates the pathological process of cognitive dysfunction, but the heterogeneity of hippocampal cells under long-term high glucose conditions is not well known. In this study, single-cell RNA sequencing was performed on diabetic mice, and distinct cell sub-clusters and important genes involved in neuroplasticity regulation were identified.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Roger Mcintosh, Hannah Hoogerwoerd, Salman S. Ahmad, Cassandra Michel, Kaitlyn Dillon, Mahendra Kumar, Gail Ironson
Summary: The study found that a 4-session guided written emotional disclosure intervention led to significant reductions in total output and concentration of epinephrine in urine for up to 6 months in individuals living with HIV. This effect was especially pronounced in women. However, there were no significant changes in norepinephrine output in urine.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Meredith Gruhn, Adam Bryant Miller, Tory A. Eisenlohr-Moul, Sophia Martin, Matthew G. Clayton, Matteo Giletta, Paul D. Hastings, Matthew K. Nock, Karen D. Rudolph, George M. Slavich, Mitchell J. Prinstein, Margaret A. Sheridan
Summary: This study investigates how early life adversity characterized by threat impacts the association between neural activity and cortisol production during emotion processing. The results suggest that threat exposure may moderate the relationship between neural activation and cortisol response.
PSYCHONEUROENDOCRINOLOGY
(2024)