Putative Neuroprotective and Neurotoxic Kynurenine Pathway Metabolites Are Associated with Hippocampal and Amygdalar Volumes in Subjects with Major Depressive Disorder

Epstein-Barr Virus Infection Induces Indoleamine 2,3-Dioxygenase Expression in Human Monocyte-Derived Macrophages through p38/Mitogen-Activated Protein Kinase and NF- B Pathways: Impairment in T Cell Functions

(2014) W.-l. Liu et al.   JOURNAL OF VIROLOGY

Stress-Induced Increase in Kynurenic Acid as a Potential Biomarker for Patients With Schizophrenia and Distress Intolerance

(2014) Joshua Chiappelli et al.   JAMA Psychiatry

Reduced Cortical Volume and Elevated Astrocyte Density in Rats Chronically Treated With Antipsychotic Drugs—Linking Magnetic Resonance Imaging Findings to Cellular Pathology

(2013) Anthony C. Vernon et al.   BIOLOGICAL PSYCHIATRY

Chemokines and the hippocampus: A new perspective on hippocampal plasticity and vulnerability

(2013) Lauren L. Williamson et al.   BRAIN BEHAVIOR AND IMMUNITY

The Ability of BDNF to Modify Neurogenesis and Depressive-Like Behaviors Is Dependent upon Phosphorylation of Tyrosine Residues 365/367 in the GABAA-Receptor  2 Subunit

(2013) M. Vithlani et al.   JOURNAL OF NEUROSCIENCE

Activation of kynurenine pathway in ex vivo fibroblasts from patients with bipolar disorder or schizophrenia: Cytokine challenge increases production of 3-hydroxykynurenine

(2013) Anne-Sofie Johansson et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Conceptual Confluence: The Kynurenine Pathway as a Common Target for Ketamine and the Convergence of the Inflammation and Glutamate Hypotheses of Depression

(2013) Andrew H Miller   NEUROPSYCHOPHARMACOLOGY

NMDA Receptor Blockade by Ketamine Abrogates Lipopolysaccharide-Induced Depressive-Like Behavior in C57BL/6J Mice

(2013) Adam K Walker et al.   NEUROPSYCHOPHARMACOLOGY

The kynurenine pathway: A missing piece in the puzzle of valproate action?

(2013) P. Maciejak et al.   NEUROSCIENCE

Cerebrospinal fluid kynurenic acid is associated with manic and psychotic features in patients with bipolar I disorder

(2012) Sara K Olsson et al.   BIPOLAR DISORDERS

Depression and sickness behavior are Janus-faced responses to shared inflammatory pathways

(2012) Michael Maes et al.   BMC Medicine

Brain indoleamine 2,3-dioxygenase contributes to the comorbidity of pain and depression

(2012) Hyangin Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

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(2012) Ciriana Orabona et al.   MOLECULAR MEDICINE

Kynurenines in the mammalian brain: when physiology meets pathology

(2012) Robert Schwarcz et al.   NATURE REVIEWS NEUROSCIENCE

Dynamic plasticity: The role of glucocorticoids, brain-derived neurotrophic factor and other trophic factors

(2012) J.D. Gray et al.   NEUROSCIENCE

Downregulated Kynurenine 3-Monooxygenase Gene Expression and Enzyme Activity in Schizophrenia and Genetic Association With Schizophrenia Endophenotypes

(2011) Ikwunga Wonodi   ARCHIVES OF GENERAL PSYCHIATRY

Reversal of imbalance between kynurenic acid and 3-hydroxykynurenine by antipsychotics in medication-naïve and medication-free schizophrenic patients

(2011) A.M. Myint et al.   BRAIN BEHAVIOR AND IMMUNITY

New insight into the antidepressants action: modulation of kynurenine pathway by increasing the kynurenic acid/3-hydroxykynurenine ratio

(2011) Tomasz Kocki et al.   JOURNAL OF NEURAL TRANSMISSION

Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: Evidence for an immune-modulated glutamatergic neurotransmission?

(2011) Johann Steiner et al.   Journal of Neuroinflammation

The neurogenesis hypothesis of affective and anxiety disorders: Are we mistaking the scaffolding for the building?

(2011) David Petrik et al.   NEUROPHARMACOLOGY

Psychoneuroimmunology Meets Neuropsychopharmacology: Translational Implications of the Impact of Inflammation on Behavior

(2011) Ebrahim Haroon et al.   NEUROPSYCHOPHARMACOLOGY

Interleukin-1β: A New Regulator of the Kynurenine Pathway Affecting Human Hippocampal Neurogenesis

(2011) Patricia A Zunszain et al.   NEUROPSYCHOPHARMACOLOGY

Bridging the gap between the immune and glutamate hypotheses of schizophrenia and major depression: Potential role of glial NMDA receptor modulators and impaired blood–brain barrier integrity

(2011) Johann Steiner et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

Immune modulation of learning, memory, neural plasticity and neurogenesis

(2010) Raz Yirmiya et al.   BRAIN BEHAVIOR AND IMMUNITY

The possible role of the kynurenine pathway in adolescent depression with melancholic features

(2010) Vilma Gabbay et al.   JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY

Hippocampal Volume Change in Schizophrenia

(2010) P. Cédric M. P. Koolschijn et al.   JOURNAL OF CLINICAL PSYCHIATRY

Evidence for a key role of the peripheral kynurenine pathway in the modulation of anxiety- and depression-like behaviours in mice: Focus on individual differences

(2010) Anthony Laugeray et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

The new ‘5-HT’ hypothesis of depression: Cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression

(2010) M. Maes et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Inflammation-associated depression: From serotonin to kynurenine

(2010) Robert Dantzer et al.   PSYCHONEUROENDOCRINOLOGY

A Meta-Analysis of Cytokines in Major Depression

(2009) Yekta Dowlati et al.   BIOLOGICAL PSYCHIATRY

Brain volume abnormalities in major depressive disorder: A meta-analysis of magnetic resonance imaging studies

(2009) P. Cédric M.P. Koolschijn et al.   HUMAN BRAIN MAPPING

CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-α: relationship to CNS immune responses and depression

(2009) C L Raison et al.   MOLECULAR PSYCHIATRY

Amygdala volume in depressed patients with bipolar disorder assessed using high resolution 3T MRI: The impact of medication

(2009) Jonathan Savitz et al.   NEUROIMAGE

Bipolar and major depressive disorder: Neuroimaging the developmental-degenerative divide

(2009) Jonathan Savitz et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Associations of Depression With C-Reactive Protein, IL-1, and IL-6: A Meta-Analysis

(2009) M Bryant Howren et al.   PSYCHOSOMATIC MEDICINE

Time course of hippocampal IL-1 β and memory consolidation impairments in aging rats following peripheral infection

(2008) Ruth M. Barrientos et al.   BRAIN BEHAVIOR AND IMMUNITY

Elevated levels of kynurenic acid change the dopaminergic response to amphetamine: implications for schizophrenia

(2008) Sara K. Olsson et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice

(2008) J C O'Connor et al.   MOLECULAR PSYCHIATRY

IL-1 is an essential mediator of the antineurogenic and anhedonic effects of stress

(2008) J. W. Koo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

From inflammation to sickness and depression: when the immune system subjugates the brain

(2007) Robert Dantzer et al.   NATURE REVIEWS NEUROSCIENCE

Immunological aspects in the neurobiology of suicide: Elevated microglial density in schizophrenia and depression is associated with suicide

(2006) Johann Steiner et al.   JOURNAL OF PSYCHIATRIC RESEARCH