Current Evidence for a Role of the Kynurenine Pathway of Tryptophan Metabolism in Multiple Sclerosis

Recent evidence for an expanded role of the kynurenine pathway of tryptophan metabolism in neurological diseases

(2017) Michael D. Lovelace et al.   NEUROPHARMACOLOGY

Immune cell trafficking across the barriers of the central nervous system in multiple sclerosis and stroke

(2016) Melissa A. Lopes Pinheiro et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Regulation of cerebrospinal fluid (CSF) flow in neurodegenerative, neurovascular and neuroinflammatory disease

(2016) Matthew J. Simon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Cerebrospinal fluid kynurenines in multiple sclerosis; relation to disease course and neurocognitive symptoms

(2016) Shahin Aeinehband et al.   BRAIN BEHAVIOR AND IMMUNITY

Brain Aging and Disorders of the Central Nervous System: Kynurenines and Drug Metabolism

(2016) Nóra Török et al.   CURRENT DRUG METABOLISM

Tryptophan Catabolites and Their Impact on Multiple Sclerosis Progression

(2016) Jens O. Watzlawik et al.   CURRENT PHARMACEUTICAL DESIGN

Therapeutic depletion of monocyte-derived cells protects from long-term axonal loss in experimental autoimmune encephalomyelitis

(2016) Monica A. Moreno et al.   JOURNAL OF NEUROIMMUNOLOGY

Cerebrospinal fluid markers reveal intrathecal inflammation in progressive multiple sclerosis

(2015) Mika Komori et al.   ANNALS OF NEUROLOGY

Permeability of the blood–brain barrier predicts conversion from optic neuritis to multiple sclerosis

(2015) Stig P. Cramer et al.   BRAIN

Kynurenines and Multiple Sclerosis: The Dialogue between the Immune System and the Central Nervous System

(2015) Cecilia Rajda et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effects of endogenous neurotoxin quinolinic acid on reactive oxygen species production by Fenton reaction catalyzed by iron or copper

(2015) Lenka Kubicova et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Cerebrospinal fluid levels of chitinase 3-like 1 and neurofilament light chain predict multiple sclerosis development and disability after optic neuritis

(2015) S Modvig et al.   Multiple Sclerosis Journal

The choroid plexus is modulated by various peripheral stimuli: implications to diseases of the central nervous system

(2015) Fernanda Marques et al.   Frontiers in Cellular Neuroscience

Cerebrospinal fluid levels of chitinase 3-like 1 and neurofilament light chain predict multiple sclerosis development and disability after optic neuritis

(2015) S Modvig et al.   Multiple Sclerosis Journal

Laquinimod (ABR-215062) for the treatment of relapsing multiple sclerosis

(2015) Simona E Constantinescu et al.   Expert Review of Clinical Pharmacology

Stage-Specific Role of Interferon-Gamma in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis

(2015) Gabriel Arellano et al.   Frontiers in Immunology

Cancer Immunotherapy by Targeting IDO1/TDO and Their Downstream Effectors

(2015) Michael Platten et al.   Frontiers in Immunology

Amino acids inhibit kynurenic acid formation via suppression of kynurenine uptake or kynurenic acid synthesis in rat brain in vitro

(2015) Airi Sekine et al.   SpringerPlus

Expression of the Kynurenine Pathway in Human Peripheral Blood Mononuclear Cells: Implications for Inflammatory and Neurodegenerative Disease

(2015) Simon P. Jones et al.   PLoS One

Indoleamine 2,3 Dioxygenase (IDO) Expression and Activity in Relapsing- Remitting Multiple Sclerosis

(2015) Roberta Mancuso et al.   PLoS One

Monocyte homeostasis and the plasticity of inflammatory monocytes

(2014) Andrew J. Mitchell et al.   CELLULAR IMMUNOLOGY

Cerebrospinal fluid immunological biomarkers associated with axonal damage in multiple sclerosis

(2014) L. M. Villar et al.   EUROPEAN JOURNAL OF NEUROLOGY

The phosphorylation status and cytoskeletal remodeling of striatal astrocytes treated with quinolinic acid

(2014) Paula Pierozan et al.   EXPERIMENTAL CELL RESEARCH

Differential roles of microglia and monocytes in the inflamed central nervous system

(2014) Ryo Yamasaki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Quinolinic acid toxicity on oligodendroglial cells: relevance for multiple sclerosis and therapeutic strategies

(2014) Gayathri Sundaram et al.   Journal of Neuroinflammation

A randomized placebo-controlled phase III trial of oral laquinimod for multiple sclerosis

(2014) T. L. Vollmer et al.   JOURNAL OF NEUROLOGY

Quinolinic acid induces disrupts cytoskeletal homeostasis in striatal neurons. Protective role of astrocyte-neuron interaction

(2014) Paula Pierozan et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Real-Time Imaging Reveals the Dynamics of Leukocyte Behaviour during Experimental Cerebral Malaria Pathogenesis

(2014) Saparna Pai et al.   PLoS Pathogens

IDO2 in Immunomodulation and Autoimmune Disease

(2014) George C. Prendergast et al.   Frontiers in Immunology

The kynurenine pathway as a therapeutic target in cognitive and neurodegenerative disorders

(2013) Trevor W Stone et al.   BRITISH JOURNAL OF PHARMACOLOGY

Quinolinic Acid: Neurotoxin or Oxidative Stress Modulator?

(2013) Lenka Kubicova et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

2-photon imaging of phagocyte-mediated T cell activation in the CNS

(2013) Marija Pesic et al.   JOURNAL OF CLINICAL INVESTIGATION

Oxidative modification of blood serum proteins in multiple sclerosis after interferon or mitoxantrone treatment

(2013) Izabela Sadowska-Bartosz et al.   JOURNAL OF NEUROIMMUNOLOGY

Perivascular macrophages mediate neutrophil recruitment during bacterial skin infection

(2013) Arby Abtin et al.   NATURE IMMUNOLOGY

Cutaneous immunosurveillance and regulation of inflammation by group 2 innate lymphoid cells

(2013) Ben Roediger et al.   NATURE IMMUNOLOGY

Quinolinic Acid: An Endogenous Neurotoxin with Multiple Targets

(2013) Rafael Lugo-Huitrón et al.   Oxidative Medicine and Cellular Longevity

Expression of Tryptophan 2,3-Dioxygenase and Production of Kynurenine Pathway Metabolites in Triple Transgenic Mice and Human Alzheimer's Disease Brain

(2013) Wei Wu et al.   PLoS One

Therapies for multiple sclerosis: translational achievements and outstanding needs

(2013) Aiden Haghikia et al.   TRENDS IN MOLECULAR MEDICINE

Visualizing leukocyte trafficking in the living brain with 2-photon intravital microscopy

(2013) Saparna Pai et al.   Frontiers in Cellular Neuroscience

Type I Interferon Programs Innate Myeloid Dynamics and Gene Expression in the Virally Infected Nervous System

(2013) Debasis Nayak et al.   PLoS Pathogens

Abnormal blood–brain barrier permeability in normal appearing white matter in multiple sclerosis investigated by MRI

(2013) S.P. Cramer et al.   NeuroImage-Clinical

Kinetics of Proinflammatory Monocytes in a Model of Multiple Sclerosis and Its Perturbation by Laquinimod

(2012) Manoj K. Mishra et al.   AMERICAN JOURNAL OF PATHOLOGY

Excitotoxicity: Bridge to various triggers in neurodegenerative disorders

(2012) Ankita Mehta et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Quinolinic acid: neurotoxicity

(2012) Gilles J. Guillemin   FEBS Journal

Quinolinic acid, the inescapable neurotoxin

(2012) Gilles J. Guillemin   FEBS Journal

Quantification of Perfusion and Permeability in Multiple Sclerosis

(2012) Michael Ingrisch et al.   INVESTIGATIVE RADIOLOGY

Generalized Lévy walks and the role of chemokines in migration of effector CD8+ T cells

(2012) Tajie H. Harris et al.   NATURE

Intravital multiphoton imaging of immune responses in the mouse ear skin

(2012) Jackson LiangYao Li et al.   Nature Protocols

Kynurenines in the CNS: recent advances and new questions

(2012) László Vécsei et al.   NATURE REVIEWS DRUG DISCOVERY

Neuroprotection and repair in multiple sclerosis

(2012) Robin J. M. Franklin et al.   Nature Reviews Neurology

Kynurenines in the mammalian brain: when physiology meets pathology

(2012) Robert Schwarcz et al.   NATURE REVIEWS NEUROSCIENCE

Will the real multiple sclerosis please stand up?

(2012) Peter K. Stys et al.   NATURE REVIEWS NEUROSCIENCE

3-Hydroxykynurenine: An intriguing molecule exerting dual actions in the Central Nervous System

(2012) Ana Laura Colín-González et al.   NEUROTOXICOLOGY

Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation

(2012) Dimitrios Davalos et al.   Nature Communications

Suppression of human CD4+ T cell activation by 3,4-dimethoxycinnamonyl-anthranilic acid (tranilast) is mediated by CXCL9 and CXCL10

(2011) Anne Hertenstein et al.   BIOCHEMICAL PHARMACOLOGY

Oxidative damage in multiple sclerosis lesions

(2011) L. Haider et al.   BRAIN

How do immune cells overcome the blood-brain barrier in multiple sclerosis?

(2011) Catherine Larochelle et al.   FEBS LETTERS

The kynurenine system and immunoregulation

(2011) Yvette Mándi et al.   JOURNAL OF NEURAL TRANSMISSION

Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells

(2011) Maria T Pallotta et al.   NATURE IMMUNOLOGY

A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis

(2011) Ivana Nikić et al.   NATURE MEDICINE

Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool

(2011) Bahareh Ajami et al.   NATURE NEUROSCIENCE

Interleukin-1β: A New Regulator of the Kynurenine Pathway Affecting Human Hippocampal Neurogenesis

(2011) Patricia A Zunszain et al.   NEUROPSYCHOPHARMACOLOGY

Intracerebral Human Regulatory T Cells: Analysis of CD4+CD25+FOXP3+ T Cells in Brain Lesions and Cerebrospinal Fluid of Multiple Sclerosis Patients

(2011) Benedikt Fritzsching et al.   PLoS One

Interferon-γ Regulates the Proliferation and Differentiation of Mesenchymal Stem Cells via Activation of Indoleamine 2,3 Dioxygenase (IDO)

(2011) Juliana Croitoru-Lamoury et al.   PLoS One

Acute intrastriatal administration of quinolinic acid provokes hyperphosphorylation of cytoskeletal intermediate filament proteins in astrocytes and neurons of rats

(2010) Paula Pierozan et al.   EXPERIMENTAL NEUROLOGY

In Vivo Imaging of Partially Reversible Th17 Cell-Induced Neuronal Dysfunction in the Course of Encephalomyelitis

(2010) Volker Siffrin et al.   IMMUNITY

Control of immune response by amino acid metabolism

(2010) Ursula Grohmann et al.   IMMUNOLOGICAL REVIEWS

Trafficking of immune cells in the central nervous system

(2010) Emma H. Wilson et al.   JOURNAL OF CLINICAL INVESTIGATION

IDO Upregulates Regulatory T Cells via Tryptophan Catabolite and Suppresses Encephalitogenic T Cell Responses in Experimental Autoimmune Encephalomyelitis

(2010) Y. Yan et al.   JOURNAL OF IMMUNOLOGY

Characterization of the kynurenine pathway in NSC-34 cell line: implications for amyotrophic lateral sclerosis

(2010) Yiquan Chen et al.   JOURNAL OF NEUROCHEMISTRY

Knocking at the brain’s door: intravital two-photon imaging of autoreactive T cell interactions with CNS structures

(2010) Naoto Kawakami et al.   Seminars in Immunopathology

Intravital Microscopy of the Mouse Brain Microcirculation using a Closed Cranial Window

(2010) Pedro Cabrales et al.   Jove-Journal of Visualized Experiments

The effects of blood–brain barrier disruption on glial cell function in multiple sclerosis: Figure 1

(2009) Stephen McQuaid et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Circulating Ly-6C+ myeloid precursors migrate to the CNS and play a pathogenic role during autoimmune demyelinating disease

(2009) I. L. King et al.   BLOOD

Differential immune cell dynamics in the CNS cause CD4+ T cell compartmentalization

(2009) Volker Siffrin et al.   BRAIN

Enzymes in the NAD+Salvage Pathway Regulate SIRT1 Activity at Target Gene Promoters

(2009) Tong Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of quinolinic acid on human astrocytes morphology and functions: implications in Alzheimer's disease

(2009) Ka Ting et al.   Journal of Neuroinflammation

The role of kynurenines in disorders of the central nervous system: Possibilities for neuroprotection

(2009) Eniko Vamos et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Grey matter pathology in clinically early multiple sclerosis: Evidence from magnetic resonance imaging

(2009) Declan Chard et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions

(2009) Ingo Bartholomäus et al.   NATURE

Long-term, high-resolution imaging in the mouse neocortex through a chronic cranial window

(2009) Anthony Holtmaat et al.   Nature Protocols

Protective Effect of Tert-Butylhydroquinone on the Quinolinic-Acid-Induced Toxicity in Rat Striatal Slices: Role of the Nrf2-Antioxidant Response Element Pathway

(2009) Inmaculada Tasset et al.   NEUROSIGNALS

5-Hydroxyanthranilic Acid, a Tryptophan Metabolite, Generates Oxidative Stress and Neuronal Death via p38 Activation in Cultured Cerebellar Granule Neurones

(2009) Andrew J. Smith et al.   NEUROTOXICITY RESEARCH

Atorvastatin Prevents Hippocampal Cell Death due to Quinolinic Acid-Induced Seizures in Mice by Increasing Akt Phosphorylation and Glutamate Uptake

(2009) Tetsadê C. B. Piermartiri et al.   NEUROTOXICITY RESEARCH

Mechanism for Quinolinic Acid Cytotoxicity in Human Astrocytes and Neurons

(2009) Nady Braidy et al.   NEUROTOXICITY RESEARCH

The Kynurenine Pathway and Inflammation in Amyotrophic Lateral Sclerosis

(2009) Yiquan Chen et al.   NEUROTOXICITY RESEARCH

The Excitotoxin Quinolinic Acid Induces Tau Phosphorylation in Human Neurons

(2009) Abdur Rahman et al.   PLoS One

Of mice, rats and men: Revisiting the quinolinic acid hypothesis of Huntington's disease

(2009) Robert Schwarcz et al.   PROGRESS IN NEUROBIOLOGY

Adipose-Derived Mesenchymal Stem Cells Ameliorate Chronic Experimental Autoimmune Encephalomyelitis

(2009) Gabriela Constantin et al.   STEM CELLS

Abnormally phosphorylated tau is associated with neuronal and axonal loss in experimental autoimmune encephalomyelitis and multiple sclerosis

(2008) J. M. Anderson et al.   BRAIN

Mechanisms and Functional Implications of Adult Neurogenesis

(2008) Chunmei Zhao et al.   CELL

Visualizing dendritic cell migration within the skin

(2008) Ben Roediger et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Autoantibodies to myelin basic protein (MBP) in healthy individuals and in patients with multiple sclerosis: a role in regulating cytokine responses to MBP

(2008) Chris J. Hedegaard et al.   IMMUNOLOGY

Kynurenine pathway metabolism in human blood–brain–barrier cells: implications for immune tolerance & neurotoxicity

(2008) Robert Owe-Young et al.   JOURNAL OF NEUROCHEMISTRY

Perivascular Spaces and the Two Steps to Neuroinflammation

(2008) Trevor Owens et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

A role for leukocyte-endothelial adhesion mechanisms in epilepsy

(2008) Paolo F Fabene et al.   NATURE MEDICINE

Quinolinate-induced Rat Striatal Excitotoxicity Impairs Endoplasmic Reticulum Ca2+-ATPase Function

(2008) Anna M. A. P. Fernandes et al.   NEUROCHEMICAL RESEARCH

Cerebrospinal Fluid B Cells Correlate with Early Brain Inflammation in Multiple Sclerosis

(2008) Bettina Kuenz et al.   PLoS One

Th17 Cells and Autoimmune Encephalomyelitis (EAE/MS)

(2008) Toshimasa Aranami et al.   ALLERGOLOGY INTERNATIONAL