Investigation of the causal relationship between ALS and autoimmune disorders: a Mendelian randomization study

Genome-wide genetic links between amyotrophic lateral sclerosis and autoimmune diseases

(2021) Chun Yu Li et al.   BMC Medicine

An international genome-wide meta-analysis of primary biliary cholangitis: Novel risk loci and candidate drugs

(2021) Heather J. Cordell et al.   JOURNAL OF HEPATOLOGY

Prioritization of candidate causal genes for asthma in susceptibility loci derived from UK Biobank

(2021) Kim Valette et al.   Communications Biology

Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders

(2021) Chris Eijsbouts et al.   NATURE GENETICS

Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

(2021) Wouter van Rheenen et al.   NATURE GENETICS

Rare Genetic Variants of Large Effect Influence Risk of Type 1 Diabetes.

(2020) Vincenzo Forgetta et al.   DIABETES

Lifetime Risk and Heritability of Amyotrophic Lateral Sclerosis

(2019) Marie Ryan et al.   JAMA Neurology

Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility

(2019)   SCIENCE

Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases

(2018) Marie Verbanck et al.   NATURE GENETICS

Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians

(2018) Neil M Davies et al.   BMJ-British Medical Journal

Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians

(2018) Neil M Davies et al.   BMJ-British Medical Journal

The MR-Base platform supports systematic causal inference across the human phenome

(2018) Gibran Hemani et al.   eLife

The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019

(2018) Annalisa Buniello et al.   NUCLEIC ACIDS RESEARCH

Sensitivity Analyses for Robust Causal Inference from Mendelian Randomization Analyses with Multiple Genetic Variants

(2017) Stephen Burgess et al.   EPIDEMIOLOGY

Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease

(2017) Katrina M de Lange et al.   NATURE GENETICS

The role of peripheral immune cells in the CNS in steady state and disease

(2017) Marco Prinz et al.   NATURE NEUROSCIENCE

Amyotrophic Lateral Sclerosis

(2017) Robert H. Brown et al.   NEW ENGLAND JOURNAL OF MEDICINE

Orienting the causal relationship between imprecisely measured traits using GWAS summary data

(2017) Gibran Hemani et al.   PLoS Genetics

Correlation of Peripheral Immunity With Rapid Amyotrophic Lateral Sclerosis Progression

(2017) Benjamin J. Murdock et al.   JAMA Neurology

Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator

(2016) Jack Bowden et al.   GENETIC EPIDEMIOLOGY

Decoding ALS: from genes to mechanism

(2016) J. Paul Taylor et al.   NATURE

Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease

(2016) Sun-Gou Ji et al.   NATURE GENETICS

Multivariable Mendelian Randomization: The Use of Pleiotropic Genetic Variants to Estimate Causal Effects

(2015) S. Burgess et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression

(2015) J. Bowden et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus

(2015) James Bentham et al.   NATURE GENETICS

The economic impact of amyotrophic lateral sclerosis: a systematic review

(2015) Matthew Gladman et al.   Expert Review of Pharmacoeconomics & Outcomes Research

Sample size and power calculations in Mendelian randomization with a single instrumental variable and a binary outcome

(2014) S. Burgess   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Mendelian Randomization Analysis With Multiple Genetic Variants Using Summarized Data

(2013) Stephen Burgess et al.   GENETIC EPIDEMIOLOGY

Genetics of rheumatoid arthritis contributes to biology and drug discovery

(2013) Yukinori Okada et al.   NATURE

Autoimmune disease preceding amyotrophic lateral sclerosis: An epidemiologic study

(2013) M. R. Turner et al.   NEUROLOGY

Regulatory T-lymphocytes mediate amyotrophic lateral sclerosis progression and survival

(2012) Jenny S. Henkel et al.   EMBO Molecular Medicine

Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity

(2012) Lam C Tsoi et al.   NATURE GENETICS

The Role of Immune and Inflammatory Mechanisms in ALS

(2011) P. A. McCombe et al.   CURRENT MOLECULAR MEDICINE

Avoiding bias from weak instruments in Mendelian randomization studies

(2011) Stephen Burgess et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease

(2011) Gosia Trynka et al.   NATURE GENETICS

Gene expression profiling in peripheral blood mononuclear cells from patients with sporadic amyotrophic lateral sclerosis (sALS)

(2010) Rongzhen Zhang et al.   JOURNAL OF NEUROIMMUNOLOGY

Genome-wide association identifies multiple ulcerative colitis susceptibility loci

(2010) Dermot P B McGovern et al.   NATURE GENETICS

Prognostic factors in ALS: A critical review

(2009) Adriano Chiò et al.   Amyotrophic Lateral Sclerosis