Multimodal detection of flap endonuclease 1 activity through CRISPR/Cas12a trans-cleavage of single-strand DNA oligonucleotides

Label-free and homogeneous detection of flap endonuclease 1 by ligation-promoted hyperbranched rolling circle amplification platform

(2022) Xue-ru Wei et al.   TALANTA

Dual-Mode FEN1 Activity Detection Based on Nt.BstNBI-Induced Tandem Signal Amplification

(2021) Haitang Yang et al.   ANALYTICAL CHEMISTRY

Ultrasensitive detection of gene-PIK3CAH1047R mutation based on cascaded strand displacement amplification and trans-cleavage ability of CRISPR/Cas12a

(2021) Yuanyi Deng et al.   TALANTA

CRISPR-cas12a mediated SERS lateral flow assay for amplification-free detection of double-stranded DNA and single-base mutation

(2021) Yuanfeng Pang et al.   CHEMICAL ENGINEERING JOURNAL

Exponential amplification reaction-based fluorescent sensor for the sensitive detection of tumor biomarker flap endonuclease 1

(2021) Bin Zhou et al.   SENSORS AND ACTUATORS B-CHEMICAL

CRISPR/Cas12a-regulated homogeneous electrochemical aptasensor for amplified detection of protein

(2021) Min Qing et al.   SENSORS AND ACTUATORS B-CHEMICAL

CRISPR–Cas12-based detection of SARS-CoV-2

(2020) James P. Broughton et al.   NATURE BIOTECHNOLOGY

Exploring the Trans-Cleavage Activity of CRISPR-Cas12a (cpf1) for the Development of a Universal Electrochemical Biosensor

(2019) Yifan Dai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cas12a-Based On-Site and Rapid Nucleic Acid Detection of African Swine Fever

(2019) Jing Bai et al.   Frontiers in Microbiology

CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity

(2018) Janice S. Chen et al.   SCIENCE

CRISPR-Cas12a-assisted nucleic acid detection

(2018) Shi-Yuan Li et al.   Cell Discovery

FEN1 promotes tumor progression and confers cisplatin resistance in non-small-cell lung cancer

(2017) Lingfeng He et al.   Molecular Oncology

The Overexpression of FEN1 and RAD54B May Act as Independent Prognostic Factors of Lung Adenocarcinoma

(2015) Jau-Chung Hwang et al.   PLoS One

Flap endonuclease 1 is a promising candidate biomarker in gastric cancer and is involved in cell proliferation and apoptosis

(2014) KEJIA WANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Genomic and protein expression analysis reveals flap endonuclease 1 (FEN1) as a key biomarker in breast and ovarian cancer

(2014) Tarek M.A. Abdel-Fatah et al.   Molecular Oncology

Human Flap Endonuclease Structures, DNA Double-Base Flipping, and a Unified Understanding of the FEN1 Superfamily

(2011) Susan E. Tsutakawa et al.   CELL

NUPACK: Analysis and design of nucleic acid systems

(2010) Joseph N. Zadeh et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Functional regulation of FEN1 nuclease and its link to cancer

(2010) L. Zheng et al.   NUCLEIC ACIDS RESEARCH