The diverse arsenal of type III CRISPR–Cas-associated CARF and SAVED effectors

CBASS phage defense and evolution of antiviral nucleotide signaling

(2022) Brianna Duncan-Lowey et al.   CURRENT OPINION IN IMMUNOLOGY

Structural basis of cyclic oligoadenylate binding to the transcription factor Csa3 outlines cross talk between type III and type I CRISPR systems

(2022) Pengjun Xia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure and the mode of activity of Lon proteases from diverse organisms

(2022) Alexander Wlodawer et al.   JOURNAL OF MOLECULAR BIOLOGY

Alternative functions of CRISPR–Cas systems in the evolutionary arms race

(2022) Prarthana Mohanraju et al.   NATURE REVIEWS MICROBIOLOGY

Short prokaryotic Argonaute systems trigger cell death upon detection of invading DNA

(2022) Balwina Koopal et al.   CELL

Cyclic nucleotide-induced helical structure activates a TIR immune effector

(2022) Gaëlle Hogrel et al.   NATURE

Shared TIR enzymatic functions regulate cell death and immunity across the tree of life

(2022) Kow Essuman et al.   SCIENCE

Phage defence by deaminase-mediated depletion of deoxynucleotides in bacteria

(2022) Brian Y. Hsueh et al.   Nature Microbiology

Craspase is a CRISPR RNA-guided, RNA-activated protease

(2022) Chunyi Hu et al.   SCIENCE

The Card1 nuclease provides defence during type-III CRISPR immunity

(2021) Jakob T. Rostøl et al.   NATURE

The CRISPR ancillary effector Can2 is a dual-specificity nuclease potentiating type III CRISPR defence

(2021) Wenlong Zhu et al.   NUCLEIC ACIDS RESEARCH

A type III-A CRISPR–Cas system mediates co-transcriptional DNA cleavage at the transcriptional bubbles in close proximity to active effectors

(2021) Jinzhong Lin et al.   NUCLEIC ACIDS RESEARCH

The gRAMP CRISPR-Cas effector is an RNA endonuclease complexed with a caspase-like peptidase

(2021) Sam P. B. van Beljouw et al.   SCIENCE

SCOPE enables type III CRISPR-Cas diagnostics using flexible targeting and stringent CARF ribonuclease activation

(2021) Jurre A. Steens et al.   Nature Communications

Cyclic CMP and cyclic UMP mediate bacterial immunity against phages

(2021) Nitzan Tal et al.   CELL

Effector-mediated membrane disruption controls cell death in CBASS antiphage defense

(2021) Brianna Duncan-Lowey et al.   MOLECULAR CELL

Antiviral activity of bacterial TIR domains via immune signalling molecules

(2021) Gal Ofir et al.   NATURE

Structural basis of cyclic oligoadenylate degradation by ancillary Type III CRISPR-Cas ring nucleases

(2021) Rafael Molina et al.   NUCLEIC ACIDS RESEARCH

CRISPR meets caspase

(2021) Megan L. Hochstrasser et al.   Nature Microbiology

Cyclic Tetra-Adenylate (cA4) Recognition by Csa3; Implications for an Integrated Class 1 CRISPR-Cas Immune Response in Saccharolobus solfataricus

(2021) Alexander A. Charbonneau et al.   Biomolecules

Structure and Mechanism of a Cyclic Trinucleotide-Activated Bacterial Endonuclease Mediating Bacteriophage Immunity

(2020) Rebecca K. Lau et al.   MOLECULAR CELL

Structure and mechanism of a Type III CRISPR defence DNA nuclease activated by cyclic oligoadenylate

(2020) Stephen A. McMahon et al.   Nature Communications

Insertions and Duplications in the Polyproline Region of the Hepatitis E Virus

(2020) Sébastien Lhomme et al.   Frontiers in Microbiology

Fuse to defuse: a self-limiting ribonuclease-ring nuclease fusion for type III CRISPR defence

(2020) Aleksei Samolygo et al.   NUCLEIC ACIDS RESEARCH

Regulation of the RNA and DNA nuclease activities required for Pyrococcus furiosus Type III-B CRISPR–Cas immunity

(2020) Kawanda Foster et al.   NUCLEIC ACIDS RESEARCH

Activation and self-inactivation mechanisms of the cyclic oligoadenylate-dependent CRISPR ribonuclease Csm6

(2020) Carmela Garcia-Doval et al.   Nature Communications

The dynamic interplay of host and viral enzymes in type III CRISPR-mediated cyclic nucleotide signalling

(2020) Januka S Athukoralage et al.   eLife

CBASS Immunity Uses CARF-Related Effectors to Sense 3′–5′- and 2′–5′-Linked Cyclic Oligonucleotide Signals and Protect Bacteria from Phage Infection

(2020) Brianna Lowey et al.   CELL

Bacteria SAVED from Viruses

(2020) Malcolm F. White   CELL

Evolutionary and functional classification of the CARF domain superfamily, key sensors in prokaryotic antivirus defense

(2020) Kira S Makarova et al.   NUCLEIC ACIDS RESEARCH

Type III-A CRISPR-associated protein Csm6 degrades cyclic hexa-adenylate activator using both CARF and HEPN domains

(2020) Dalia Smalakyte et al.   NUCLEIC ACIDS RESEARCH

Abortive Infection: Bacterial Suicide as an Antiviral Immune Strategy

(2020) Anna Lopatina et al.   Annual Review of Virology

CD-NTases and nucleotide second messenger signaling

(2020) Brianna Lowey et al.   CURRENT BIOLOGY

STING cyclic dinucleotide sensing originated in bacteria

(2020) Benjamin R. Morehouse et al.   NATURE

Diversity and classification of cyclic-oligonucleotide-based anti-phage signalling systems

(2020) Adi Millman et al.   Nature Microbiology

Non-specific degradation of transcripts promotes plasmid clearance during type III-A CRISPR–Cas immunity

(2019) Jakob T. Rostøl et al.   Nature Microbiology

Bacterial cGAS-like enzymes synthesize diverse nucleotide signals

(2019) Aaron T. Whiteley et al.   NATURE

A Type III CRISPR Ancillary Ribonuclease Degrades Its Cyclic Oligoadenylate Activator

(2019) Januka S. Athukoralage et al.   JOURNAL OF MOLECULAR BIOLOGY

Cas13-induced cellular dormancy prevents the rise of CRISPR-resistant bacteriophage

(2019) Alexander J. Meeske et al.   NATURE

CRISPR-Cas III-A Csm6 CARF Domain Is a Ring Nuclease Triggering Stepwise cA4 Cleavage with ApA>p Formation Terminating RNase Activity

(2019) Ning Jia et al.   MOLECULAR CELL

Cyclic GMP–AMP signalling protects bacteria against viral infection

(2019) Daniel Cohen et al.   NATURE

Cyclic oligoadenylate signalling mediates Mycobacterium tuberculosis CRISPR defence

(2019) Sabine Grüschow et al.   NUCLEIC ACIDS RESEARCH

TIR domains of plant immune receptors are NAD+-cleaving enzymes that promote cell death

(2019) Li Wan et al.   SCIENCE

Structure of Csx1-cOA4 complex reveals the basis of RNA decay in Type III-B CRISPR-Cas

(2019) Rafael Molina et al.   Nature Communications

Evolutionary classification of CRISPR–Cas systems: a burst of class 2 and derived variants

(2019) Kira S. Makarova et al.   NATURE REVIEWS MICROBIOLOGY

TIR Domain Proteins Are an Ancient Family of NAD + -Consuming Enzymes

(2018) Kow Essuman et al.   CURRENT BIOLOGY

Systematic prediction of genes functionally linked to CRISPR-Cas systems by gene neighborhood analysis

(2018) Sergey A. Shmakov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The ribonuclease activity of Csm6 is required for anti-plasmid immunity by Type III-A CRISPR-Cas systems

(2018) Kawanda Foster et al.   RNA Biology

Ring nucleases deactivate type III CRISPR ribonucleases by degrading cyclic oligoadenylate

(2018) Januka S. Athukoralage et al.   NATURE

Dynamics of Cas10 Govern Discrimination between Self and Non-self in Type III CRISPR-Cas Immunity

(2018) Ling Wang et al.   MOLECULAR CELL

Double-slit photoelectron interference in strong-field ionization of the neon dimer

(2018) Maksim Kunitski et al.   Nature Communications

Type III CRISPR–Cas systems produce cyclic oligoadenylate second messengers

(2017) Ole Niewoehner et al.   NATURE

Coupling transcriptional activation of CRISPR–Cas system and DNA repair genes by Csa3a in Sulfolobus islandicus

(2017) Tao Liu et al.   NUCLEIC ACIDS RESEARCH

A cyclic oligonucleotide signaling pathway in type III CRISPR-Cas systems

(2017) Migle Kazlauskiene et al.   SCIENCE

Assembly of a nucleus-like structure during viral replication in bacteria

(2017) Vorrapon Chaikeeratisak et al.   SCIENCE

Emerging role of Lon protease as a master regulator of mitochondrial functions

(2016) Marcello Pinti et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Degradation of Phage Transcripts by CRISPR-Associated RNases Enables Type III CRISPR-Cas Immunity

(2016) Wenyan Jiang et al.   CELL

Quorum Sensing Controls Adaptive Immunity through the Regulation of Multiple CRISPR-Cas Systems

(2016) Adrian G. Patterson et al.   MOLECULAR CELL

CRISPR-Cas type I-A Cascade complex couples viral infection surveillance to host transcriptional regulation in the dependence of Csa3b

(2016) Fei He et al.   NUCLEIC ACIDS RESEARCH

A type III-B CRISPR-Cas effector complex mediating massive target DNA destruction

(2016) Wenyuan Han et al.   NUCLEIC ACIDS RESEARCH

Quorum sensing controls thePseudomonas aeruginosaCRISPR-Cas adaptive immune system

(2016) Nina M. Høyland-Kroghsbo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for the endoribonuclease activity of the type III-A CRISPR-associated protein Csm6

(2016) Ole Niewoehner et al.   RNA

Co-transcriptional DNA and RNA Cleavage during Type III CRISPR-Cas Immunity

(2015) Poulami Samai et al.   CELL

Discovery and Functional Characterization of Diverse Class 2 CRISPR-Cas Systems

(2015) Sergey Shmakov et al.   MOLECULAR CELL

Comparative genomic analyses reveal a vast, novel network of nucleotide-centric systems in biological conflicts, immunity and signaling

(2015) A. Maxwell Burroughs et al.   NUCLEIC ACIDS RESEARCH

The CRISPR-associated Csx1 protein ofPyrococcus furiosusis an adenosine-specific endoribonuclease

(2015) Nolan F. Sheppard et al.   RNA

Structures of the CRISPR-Cmr complex reveal mode of RNA target positioning

(2015) D. W. Taylor et al.   SCIENCE

Structural Model of a CRISPR RNA-Silencing Complex Reveals the RNA-Target Cleavage Activity in Cmr4

(2014) Christian Benda et al.   MOLECULAR CELL

RNA Targeting by the Type III-A CRISPR-Cas Csm Complex of Thermus thermophilus

(2014) Raymond H.J. Staals et al.   MOLECULAR CELL

Programmable RNA Shredding by the Type III-A CRISPR-Cas System of Streptococcus thermophilus

(2014) Gintautas Tamulaitis et al.   MOLECULAR CELL

Evolution of suicide as a defence strategy against pathogens in a spatially structured environment

(2013) Thomas W. Berngruber et al.   ECOLOGY LETTERS

A Ruler Protein in a Complex for Antiviral Defense Determines the Length of Small Interfering CRISPR RNAs

(2013) Asma Hatoum-Aslan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure and Activity of the RNA-Targeting Type III-B CRISPR-Cas Complex of Thermus thermophilus

(2013) Raymond H.J. Staals et al.   MOLECULAR CELL

A novel interference mechanism by a type IIIB CRISPR-Cmr module inSulfolobus

(2013) Ling Deng et al.   MOLECULAR MICROBIOLOGY

Crystal structure and nucleic acid-binding activity of the CRISPR-associated protein Csx1 ofPyrococcus furiosus

(2013) Young Kwan Kim et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Unification of Cas protein families and a simple scenario for the origin and evolution of CRISPR-Cas systems

(2011) Kira S Makarova et al.   Biology Direct

The Structure of the CRISPR-Associated Protein Csa3 Provides Insight into the Regulation of the CRISPR/Cas System

(2010) Nathanael G. Lintner et al.   JOURNAL OF MOLECULAR BIOLOGY

Functional mechanics of the ATP-dependent Lon protease- lessons from endogenous protein and synthetic peptide substrates

(2008) Irene Lee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

MazF, an mRNA Interferase, Mediates Programmed Cell Death during Multicellular Myxococcus Development

(2008) Hirofumi Nariya et al.   CELL

Cas6 is an endoribonuclease that generates guide RNAs for invader defense in prokaryotes

(2008) J. Carte et al.   GENES & DEVELOPMENT

Prokaryotic silencing (psi)RNAs in Pyrococcus furiosus

(2008) C. Hale et al.   RNA