Microbiota-derived short-chain fatty acids: Implications for cardiovascular and metabolic disease

Microbiota-derived tryptophan metabolites in vascular inflammation and cardiovascular disease

(2022) Nadja Paeslack et al.   AMINO ACIDS

Mechanistic Insights into Inorganic Nitrite-Mediated Vasodilation of Isolated Aortic Rings under Oxidative/Hypertensive Conditions and S-Nitros(yl)ation of Proteins in Germ-Free Mice

(2022) Paul Stamm et al.   Biomedicines

Short Chain Fatty Acid Acetate Increases TNFα-Induced MCP-1 Production in Monocytic Cells via ACSL1/MAPK/NF-κB Axis

(2021) Areej Al-Roub et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Propionate attenuates atherosclerosis by immune-dependent regulation of intestinal cholesterol metabolism

(2021) Arash Haghikia et al.   EUROPEAN HEART JOURNAL

Adherence to the Dietary Approaches to Stop Hypertension (DASH) and hypertension risk: results of the Longitudinal Study of Adult Health (ELSA-Brasil)

(2020) S. C. Francisco et al.   BRITISH JOURNAL OF NUTRITION

Butyrate improves cardiac function and sympathetic neural remodeling following myocardial infarction in rats

(2020) Xiaojie Jiang et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

The Association of Post-Stroke Cognitive Impairment and Gut Microbiota and its Corresponding Metabolites

(2020) Yongqiang Liu et al.   JOURNAL OF ALZHEIMERS DISEASE

Dietary cellulose prevents gut inflammation by modulating lipid metabolism and gut microbiota

(2020) Yeji Kim et al.   Gut Microbes

Composite probiotics alleviate type 2 diabetes by regulating intestinal microbiota and inducing GLP-1 secretion in db/db mice

(2020) Yanming Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Deficiency of Prebiotic Fiber and Insufficient Signaling Through Gut Metabolite-Sensing Receptors Leads to Cardiovascular Disease

(2020) David M. Kaye et al.   CIRCULATION

Gut metagenomic and short chain fatty acids signature in hypertension: a cross-sectional study

(2020) Lorena Calderón-Pérez et al.   Scientific Reports

Modest Sodium Reduction Increases Circulating Short-Chain Fatty Acids in Untreated Hypertensives

(2020) Li Chen et al.   HYPERTENSION

Short-Chain Fatty Acids (Except Hexanoic Acid) Lower NF-kB Transactivation, Which Rescues Inflammation-Induced Decreased Apolipoprotein A-I Transcription in HepG2 Cells

(2020) Jehad Z. Tayyeb et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Germ-free housing conditions do not affect aortic root and aortic arch lesion size of late atherosclerotic low-density lipoprotein receptor-deficient mice

(2020) Klytaimnistra Kiouptsi et al.   Gut Microbes

The Commensal Microbiota Enhances ADP-Triggered Integrin αIIbβ3 Activation and von Willebrand Factor-Mediated Platelet Deposition to Type I Collagen

(2020) Klytaimnistra Kiouptsi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Short-Chain Fatty Acid Propionate Protects from Hypertensive Cardiovascular Damage

(2019) Hendrik Bartolomaeus et al.   CIRCULATION

Loss of Gut Microbiota Alters Immune System Composition and Cripples Post-Infarction Cardiac Repair

(2019) Tony WH Tang et al.   CIRCULATION

A Proinflammatory Gut Microbiota Increases Systemic Inflammation and Accelerates Atherosclerosis

(2019) Eelke Brandsma et al.   CIRCULATION RESEARCH

Gut Microbiota Involvement in Ventricular Remodeling Post–Myocardial Infarction

(2019) Amy McMillan et al.   CIRCULATION

Gut Microbial Associations to Plasma Metabolites Linked to Cardiovascular Phenotypes and Risk: A Cross-Sectional Study

(2019) Alexander Kurilshikov et al.   CIRCULATION RESEARCH

Influence of a 3-month low-calorie Mediterranean diet compared to the vegetarian diet on human gut microbiota and SCFA: the CARDIVEG Study

(2019) Giuditta Pagliai et al.   EUROPEAN JOURNAL OF NUTRITION

Gut Microbiota and Fecal Levels of Short-Chain Fatty Acids Differ Upon 24-Hour Blood Pressure Levels in Men

(2019) Justine Huart et al.   HYPERTENSION

Involvement of circulating inflammatory factors in prognosis and risk of cardiovascular disease

(2019) Habib Haybar et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mortality, morbidity, and risk factors in China and its provinces, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

(2019) Maigeng Zhou et al.   LANCET

Xiao-Qing-Long Tang Prevents Cardiomyocyte Hypertrophy, Fibrosis, and the Development of Heart Failure with Preserved Ejection Faction in Rats by Modulating the Composition of the Gut Microbiota

(2019) Guo-Feng Zhou et al.   Biomed Research International

Gut microbiota regulates cardiac ischemic tolerance and aortic stiffness in obesity

(2019) Micah L. Battson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Sodium butyrate attenuates angiotensin II‐induced cardiac hypertrophy by inhibiting COX2/PGE2 pathway via a HDAC5/HDAC6‐dependent mechanism

(2019) Linlin Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Xiexin Tang ameliorates dyslipidemia in high-fat diet-induced obese rats via elevating gut microbiota-derived short chain fatty acids production and adjusting energy metabolism

(2019) Suwei Xiao et al.   JOURNAL OF ETHNOPHARMACOLOGY

Butyrate protects against high‐fat diet‐induced atherosclerosis via up‐regulating ABCA1 expression in apolipoprotein E‐deficiency mice

(2019) Yu Du et al.   BRITISH JOURNAL OF PHARMACOLOGY

Butyric acid, a gut bacteria metabolite, lowers arterial blood pressure via colon-vagus nerve signaling and GPR41/43 receptors

(2019) Maksymilian Onyszkiewicz et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Transplantation of fecal microbiota rich in short chain fatty acids and butyric acid treat cerebral ischemic stroke by regulating gut microbiota

(2019) Runzhi Chen et al.   PHARMACOLOGICAL RESEARCH

The Microbiota Promotes Arterial Thrombosis in Low-Density Lipoprotein Receptor-Deficient Mice

(2019) Klytaimnistra Kiouptsi et al.   mBio

Baicalin Protects Against Hypertension-Associated Intestinal Barrier Impairment in Part Through Enhanced Microbial Production of Short-Chain Fatty Acids

(2019) Dandan Wu et al.   Frontiers in Pharmacology

Anti-Oxidized LDL Antibodies and Coronary Artery Disease: A Systematic Review

(2019) Victor J. van den Berg et al.   Antioxidants

Inflammation and atherosclerosis: Cardiovascular evaluation in patients with autoimmune diseases

(2018) Ricardo O. Escárcega et al.   AUTOIMMUNITY REVIEWS

Role of PCSK9 in lipid metabolism and atherosclerosis

(2018) Xiao-Long Lin et al.   BIOMEDICINE & PHARMACOTHERAPY

Imbalance of gut microbiome and intestinal epithelial barrier dysfunction in cardiovascular disease

(2018) Judith N. Lezutekong et al.   CLINICAL SCIENCE

Atherosclerosis and inflammation: overview and updates

(2018) Glaucylara Reis Geovanini et al.   CLINICAL SCIENCE

Effects of a homogeneous polysaccharide from Sijunzi decoction on human intestinal microbes and short chain fatty acids in vitro

(2018) Beibei Gao et al.   JOURNAL OF ETHNOPHARMACOLOGY

Butyrate from pectin fermentation inhibits intestinal cholesterol absorption and attenuates atherosclerosis in apolipoprotein E-deficient mice

(2018) Ying Chen et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Oral hydroxysafflor yellow A reduces obesity in mice by modulating the gut microbiota and serum metabolism

(2018) Juan Liu et al.   PHARMACOLOGICAL RESEARCH

Ethanol extract of Ganoderma lucidum ameliorates lipid metabolic disorders and modulates the gut microbiota composition in high-fat diet fed rats

(2018) Wei-Ling Guo et al.   Food & Function

Mediterranean Diet and Other Dietary Patterns in Primary Prevention of Heart Failure and Changes in Cardiac Function Markers: A Systematic Review

(2018) Karina Sanches Machado d’Almeida et al.   Nutrients

Time and Concentration Dependent Effects of Short Chain Fatty Acids on Lipopolysaccharide- or Tumor Necrosis Factor α-Induced Endothelial Activation

(2018) Meng Li et al.   Frontiers in Pharmacology

Differential effects of short chain fatty acids on endothelial Nlrp3 inflammasome activation and neointima formation: Antioxidant action of butyrate

(2018) Xinxu Yuan et al.   Redox Biology

Role of inflammation in the pathogenesis of atherosclerosis and therapeutic interventions

(2018) Paolo Raggi et al.   ATHEROSCLEROSIS

Short-Chain Fatty Acids Manifest Stimulative and Protective Effects on Intestinal Barrier Function Through the Inhibition of NLRP3 Inflammasome and Autophagy

(2018) Yanhai Feng et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

A High Salt Diet Modulates the Gut Microbiota and Short Chain Fatty Acids Production in a Salt-Sensitive Hypertension Rat Model

(2018) Ariel Bier et al.   Nutrients

Xiexin Tang improves the symptom of type 2 diabetic rats by modulation of the gut microbiota

(2018) Xiaoyan Wei et al.   Scientific Reports

Lactobacillus plantarum 299v Supplementation Improves Vascular Endothelial Function and Reduces Inflammatory Biomarkers in Men With Stable Coronary Artery Disease

(2018) Mobin Malik et al.   CIRCULATION RESEARCH

Prebiotics, Probiotics, and Acetate Supplementation Prevent Hypertension in a Model of Obstructive Sleep Apnea

(2018) Bhanu P. Ganesh et al.   HYPERTENSION

Attenuation of Microbiotal Dysbiosis and Hypertension in a CRISPR/Cas9 Gene Ablation Rat Model of GPER1

(2018) Harshal Waghulde et al.   HYPERTENSION

Epidemiology of cardiovascular disease in China: current features and implications

(2018) Dong Zhao et al.   Nature Reviews Cardiology

Higher Fecal Short-Chain Fatty Acid Levels Are Associated with Gut Microbiome Dysbiosis, Obesity, Hypertension and Cardiometabolic Disease Risk Factors

(2018) Jacobo de la Cuesta-Zuluaga et al.   Nutrients

Interactions between Roseburia intestinalis and diet modulate atherogenesis in a murine model

(2018) Kazuyuki Kasahara et al.   Nature Microbiology

Polysaccharide from Plantago asiatica L. attenuates hyperglycemia, hyperlipidemia and affects colon microbiota in type 2 diabetic rats

(2017) Qixing Nie et al.   FOOD HYDROCOLLOIDS

Global Burden of Hypertension and Systolic Blood Pressure of at Least 110 to 115 mm Hg, 1990-2015

(2017) Mohammad H. Forouzanfar et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Sodium Butyrate Protects ­Against High Fat Diet-Induced Cardiac Dysfunction and Metabolic Disorders in Type II Diabetic Mice

(2017) Ling Zhang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Effects of dyslipidaemia on monocyte production and function in cardiovascular disease

(2017) Mohammed Shamim Rahman et al.   Nature Reviews Cardiology

Intake of total saponins and polysaccharides from Polygonatum kingianum affects the gut microbiota in diabetic rats

(2017) Hongli Yan et al.   PHYTOMEDICINE

Gut microbiota dysbiosis contributes to the development of hypertension

(2017) Jing Li et al.   Microbiome

Microbiome and metabolome modifying effects of several cardiovascular disease interventions in apo-E−/− mice

(2017) Paul M. Ryan et al.   Microbiome

Gut dysbiosis is associated with metabolism and systemic inflammation in patients with ischemic stroke

(2017) Kazuo Yamashiro et al.   PLoS One

Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk

(2016) Weifei Zhu et al.   CELL

Correction to: 2016 ACC/AHA/HFSA Focused Update on New Pharmacological Therapy for Heart Failure: An Update of the 2013 ACCF/AHA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Failure Society of America

(2016)   CIRCULATION

High-Fiber Diet and Acetate Supplementation Change the Gut Microbiota and Prevent the Development of Hypertension and Heart Failure in Hypertensive MiceClinical Perspective

(2016) Francine Z. Marques et al.   CIRCULATION

Role of Inflammation and Immunity in Hypertension: Recent Epidemiological, Laboratory, and Clinical Evidence

(2016) Antoine Caillon et al.   CURRENT HYPERTENSION REPORTS

Increased Systolic and Diastolic Blood Pressure Is Associated With Altered Gut Microbiota Composition and Butyrate Production in Early PregnancyNovelty and Significance

(2016) Luisa F. Gomez-Arango et al.   HYPERTENSION

Oral butyrate reduces oxidative stress in atherosclerotic lesion sites by a mechanism involving NADPH oxidase down-regulation in endothelial cells

(2016) Edenil C. Aguilar et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Experimental support for the effects of a probiotic/digestive enzyme supplement on serum cholesterol concentrations and the intestinal microbiome

(2016) Thomas E. Ichim et al.   Journal of Translational Medicine

Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015

(2016) Theo Vos et al.   LANCET

Commensal microbiota affects ischemic stroke outcome by regulating intestinal γδ T cells

(2016) Corinne Benakis et al.   NATURE MEDICINE

Clostridium butyricum pretreatment attenuates cerebral ischemia/reperfusion injury in mice via anti-oxidation and anti-apoptosis

(2016) Jing Sun et al.   NEUROSCIENCE LETTERS

Retinoic acid and sodium butyrate suppress the cardiac expression of hypertrophic markers and proinflammatory mediators in Npr1 gene-disrupted haplotype mice

(2016) Umadevi Subramanian et al.   PHYSIOLOGICAL GENOMICS

Microbial short chain fatty acid metabolites lower blood pressure via endothelial G protein-coupled receptor 41

(2016) Niranjana Natarajan et al.   PHYSIOLOGICAL GENOMICS

PLGA-PNIPAM Microspheres Loaded with the Gastrointestinal Nutrient NaB Ameliorate Cardiac Dysfunction by Activating Sirt3 in Acute Myocardial Infarction

(2016) Panke Cheng et al.   Advanced Science

Pathogenic Gut Flora in Patients With Chronic Heart Failure

(2016) Evasio Pasini et al.   JACC-Heart Failure

Homeostasis and its disruption in the lung microbiome

(2015) Robert P. Dickson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Total, insoluble and soluble dietary fibre intake in relation to blood pressure: the INTERMAP Study

(2015) Ghadeer S. Aljuraiban et al.   BRITISH JOURNAL OF NUTRITION

Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis

(2015) Zeneng Wang et al.   CELL

Molecular Basis of Cardioprotection: Signal Transduction in Ischemic Pre-, Post-, and Remote Conditioning

(2015) G. Heusch   CIRCULATION RESEARCH

High-level adherence to a Mediterranean diet beneficially impacts the gut microbiota and associated metabolome

(2015) Francesca De Filippis et al.   GUT

Gut Dysbiosis Is Linked to HypertensionNovelty and Significance

(2015) Tao Yang et al.   HYPERTENSION

Evidence for a link between gut microbiota and hypertension in the Dahl rat

(2015) Blair Mell et al.   PHYSIOLOGICAL GENOMICS

Microbiota-Generated Metabolites Promote Metabolic Benefits via Gut-Brain Neural Circuits

(2014) Filipe De Vadder et al.   CELL

Mechanisms of Plaque Formation and Rupture

(2014) Jacob Fog Bentzon et al.   CIRCULATION RESEARCH

Treatment of Dyslipidemia and Cardiovascular Outcomes: The Journey So Far—Is This the End for Statins?

(2014) S Zoungas et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults

(2014) Edward S Chambers et al.   GUT

Fecal microbiota transplantation as therapy for inflammatory bowel disease: A systematic review and meta-analysis

(2014) Ruben J. Colman et al.   Journal of Crohns & Colitis

Intestinal Blood Flow in Patients With Chronic Heart Failure

(2014) Anja Sandek et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Butyrate impairs atherogenesis by reducing plaque inflammation and vulnerability and decreasing NFκB activation

(2014) E.C. Aguilar et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition

(2014) Pamela V. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of butyrate on immune response of a chicken macrophage cell line

(2014) Z.Y. Zhou et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Apocynin suppresses the progression of atherosclerosis in apoE-deficient mice by inactivation of macrophages

(2013) Hiroyuki Kinoshita et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

HDAC9 Knockout Mice Are Protected From Adipose Tissue Dysfunction and Systemic Metabolic Disease During High-Fat Feeding

(2013) T. K. Chatterjee et al.   DIABETES

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

(2013) Nicholas Arpaia et al.   NATURE

Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation

(2013) Jennifer L. Pluznick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dietary fibre intake and risk of cardiovascular disease: systematic review and meta-analysis

(2013) D. E. Threapleton et al.   BMJ-British Medical Journal

Sodium Butyrate Stimulates Expression of Fibroblast Growth Factor 21 in Liver by Inhibition of Histone Deacetylase 3

(2012) H. Li et al.   DIABETES

Atherosclerosis induced by endogenous and exogenous toll-like receptor (TLR)1 or TLR6 agonists

(2012) Linda K. Curtiss et al.   JOURNAL OF LIPID RESEARCH

Gut Microbial Activity, Implications for Health and Disease: The Potential Role of Metabolite Analysis

(2012) Edna. P. Nyangale et al.   JOURNAL OF PROTEOME RESEARCH

The Warburg Effect Dictates the Mechanism of Butyrate-Mediated Histone Acetylation and Cell Proliferation

(2012) Dallas R. Donohoe et al.   MOLECULAR CELL

Significance of Short Chain Fatty Acid Transport by Members of the Monocarboxylate Transporter Family (MCT)

(2012) Ivano Moschen et al.   NEUROCHEMICAL RESEARCH

Short-Chain Fatty Acid Propionate Alleviates Akt2 Knockout-Induced Myocardial Contractile Dysfunction

(2011) Linlin Li et al.   Experimental Diabetes Research

Hemoglobin Directs Macrophage Differentiation and Prevents Foam Cell Formation in Human Atherosclerotic Plaques

(2011) Aloke V. Finn et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Progress and challenges in translating the biology of atherosclerosis

(2011) Peter Libby et al.   NATURE

SCFAs Induce Mouse Neutrophil Chemotaxis through the GPR43 Receptor

(2011) Marco A. R. Vinolo et al.   PLoS One

Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41)

(2011) I. Kimura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Valproic Acid Attenuates Blood–Brain Barrier Disruption in a Rat Model of Transient Focal Cerebral Ischemia: The Roles of HDAC and MMP-9 Inhibition

(2010) Zhifei Wang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Suppressive effect of short-chain fatty acids on production of proinflammatory mediators by neutrophils

(2010) Marco A.R. Vinolo et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Berberine suppresses proinflammatory responses through AMPK activation in macrophages

(2009) Hyun Woo Jeong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Short-chain fatty acids stimulate the migration of neutrophils to inflammatory sites

(2009) Marco A. R. Vinolo et al.   CLINICAL SCIENCE

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

(2009) Kendle M. Maslowski et al.   NATURE

Butyrate and propionate induced activated or non-activated neutrophil apoptosis via HDAC inhibitor activity but without activating GPR-41/GPR-43 pathways

(2009) Michiko Aoyama et al.   NUTRITION

Functional expression of the olfactory signaling system in the kidney

(2009) Jennifer L. Pluznick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Short-chain fatty acids act as antiinflammatory mediatorsby regulating prostaglandin E2 and cytokines

(2009) Mary Ann Cox et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Association of Leukocyte and Neutrophil Counts With Infarct Size, Left Ventricular Function and Outcomes After Percutaneous Coronary Intervention for ST-Elevation Myocardial Infarction

(2008) Stanley Chia et al.   AMERICAN JOURNAL OF CARDIOLOGY

Butyrate and trichostatin A attenuate nuclear factor κB activation and tumor necrosis factor α secretion and increase prostaglandin E2 secretion in human peripheral blood mononuclear cells

(2008) Makoto Usami et al.   NUTRITION RESEARCH

Endotoxin accelerates atherosclerosis independent of complement activation

(2008) Kurt Reifenberg et al.   THROMBOSIS RESEARCH