A tubulin binding molecule drives differentiation of acute myeloid leukemia cells

CPEB4-Promoted Paclitaxel Resistance in Ovarian Cancer In Vitro Relies on Translational Regulation of CSAG2

(2021) Yaqing Zhang et al.   Frontiers in Pharmacology

Two decades of targeted therapies in acute myeloid leukemia

(2021) David G. J. Cucchi et al.   LEUKEMIA

A Phenotypic Screen Identifies a Compound Series That Induces Differentiation of Acute Myeloid Leukemia Cells In Vitro and Shows Antitumor Effects In Vivo

(2021) Laia Josa-Culleré et al.   JOURNAL OF MEDICINAL CHEMISTRY

JAK2 regulates paclitaxel resistance in triple negative breast cancers

(2021) Jongmin Han et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

A User’s Guide to Novel Therapies for Acute Myeloid Leukemia

(2020) Shyam A. Patel et al.   Clinical Lymphoma Myeloma & Leukemia

Azacitidine and Venetoclax in Previously Untreated Acute Myeloid Leukemia

(2020) Courtney D. DiNardo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Combining experimental strategies for successful target deconvolution

(2020) Isabel V.L. Wilkinson et al.   DRUG DISCOVERY TODAY

Cancer statistics, 2019

(2019) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Targeting FLT3 mutations in AML: review of current knowledge and evidence

(2019) Naval Daver et al.   LEUKEMIA

The R package Rsubread is easier, faster, cheaper and better for alignment and quantification of RNA sequencing reads

(2019) Yang Liao et al.   NUCLEIC ACIDS RESEARCH

Current advances of tubulin inhibitors as dual acting small molecules for cancer therapy

(2019) Kinsie E Arnst et al.   MEDICINAL RESEARCH REVIEWS

Enasidenib, an inhibitor of mutant IDH2 proteins, induces durable remissions in older patients with newly diagnosed acute myeloid leukemia

(2019) Daniel A. Pollyea et al.   LEUKEMIA

The novel dihydroorotate dehydrogenase (DHODH) inhibitor BAY 2402234 triggers differentiation and is effective in the treatment of myeloid malignancies

(2019) Sven Christian et al.   LEUKEMIA

A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis

(2019) Mark F. van Delft et al.   Nature Chemical Biology

Mebendazole for Differentiation Therapy of Acute Myeloid Leukemia Identified by a Lineage Maturation Index

(2019) Yulin Li et al.   Scientific Reports

From genomics to targeted treatment in haematological malignancies: a focus on acute myeloid leukaemia

(2018) Niels Asger Jakobsen et al.   CLINICAL MEDICINE

Safety and preliminary efficacy of venetoclax with decitabine or azacitidine in elderly patients with previously untreated acute myeloid leukaemia: a non-randomised, open-label, phase 1b study

(2018) Courtney D DiNardo et al.   LANCET ONCOLOGY

Chemoproteomics Reveals the Anti-proliferative Potential of Parkinson’s Disease Kinase Inhibitor LRRK2-IN-1 by Targeting PCNA Protein

(2018) Weichao Li et al.   MOLECULAR PHARMACEUTICS

Clonal heterogeneity of acute myeloid leukemia treated with the IDH2 inhibitor enasidenib

(2018) Lynn Quek et al.   NATURE MEDICINE

Durable Remissions with Ivosidenib in IDH1-Mutated Relapsed or Refractory AML

(2018) Courtney D. DiNardo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ivosidenib: First Global Approval

(2018) Sohita Dhillon   DRUGS

Molecular remission and response patterns in patients with mutant-IDH2 acute myeloid leukemia treated with enasidenib

(2018) Eytan M. Stein et al.   BLOOD

The emergence of dihydroorotate dehydrogenase (DHODH) as a therapeutic target in acute myeloid leukemia

(2018) David B. Sykes   EXPERT OPINION ON THERAPEUTIC TARGETS

The PRIDE database and related tools and resources in 2019: improving support for quantification data

(2018) Yasset Perez-Riverol et al.   NUCLEIC ACIDS RESEARCH

Targeting acute myeloid leukemia by drug-induced c-MYB degradation

(2017) V Walf-Vorderwülbecke et al.   LEUKEMIA

Opportunities and challenges in phenotypic drug discovery: an industry perspective

(2017) John G. Moffat et al.   NATURE REVIEWS DRUG DISCOVERY

Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia

(2016) David B. Sykes et al.   CELL

Calcium-Catalyzed Synthesis of Polysubstituted 2-Alkenylfurans from β-Keto Esters Tethered to Propargyl Alcohols

(2016) Sara P. Morcillo et al.   CHEMISTRY-A EUROPEAN JOURNAL

Lineage-specific and single-cell chromatin accessibility charts human hematopoiesis and leukemia evolution

(2016) M Ryan Corces et al.   NATURE GENETICS

The Perseus computational platform for comprehensive analysis of (prote)omics data

(2016) Stefka Tyanova et al.   NATURE METHODS

Genomic Classification and Prognosis in Acute Myeloid Leukemia

(2016) Elli Papaemmanuil et al.   NEW ENGLAND JOURNAL OF MEDICINE

Uses and misuses of the fudge factor in quantitative discovery proteomics

(2016) Quentin Giai Gianetto et al.   PROTEOMICS

Multifunctional Reagents for Quantitative Proteome-Wide Analysis of Protein Modification in Human Cells and Dynamic Profiling of Protein Lipidation During Vertebrate Development

(2015) Malgorzata Broncel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An update of current treatments for adult acute myeloid leukemia

(2015) H. Dombret et al.   BLOOD

DataWarrior: An Open-Source Program For Chemistry Aware Data Visualization And Analysis

(2015) Thomas Sander et al.   Journal of Chemical Information and Modeling

Acute promyelocytic leukemia: where did we start, where are we now and the future

(2015) C C Coombs et al.   Blood Cancer Journal

Design and Synthesis of Minimalist Terminal Alkyne-Containing Diazirine Photo-Crosslinkers and Their Incorporation into Kinase Inhibitors for Cell- and Tissue-Based Proteome Profiling

(2013) Zhengqiu Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Inhibition of Mnk kinase activity by cercosporamide and suppressive effects on acute myeloid leukemia precursors

(2013) J. K. Altman et al.   BLOOD

Cell-Based Proteome Profiling of Potential Dasatinib Targets by Use of Affinity-Based Probes

(2012) Haibin Shi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pretubulysin derived probes as novel tools for monitoring the microtubule network via activity-based protein profiling and fluorescence microscopy

(2012) Jürgen Eirich et al.   Molecular BioSystems

Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia

(2012) Tino Schenk et al.   NATURE MEDICINE

Design and Synthesis of a New Class of Membrane-Permeable Triazaborolopyridinium Fluorescent Probes

(2011) Sudath Hapuarachchige et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Factor H and Factor H-Related Protein 1 Bind to Human Neutrophils via Complement Receptor 3, Mediate Attachment to Candida albicans, and Enhance Neutrophil Antimicrobial Activity

(2009) J. Losse et al.   JOURNAL OF IMMUNOLOGY

Acute promyelocytic leukemia: from highly fatal to highly curable

(2008) Z.-Y. Wang et al.   BLOOD

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY

Curative Strategies in Acute Promyelocytic Leukemia

(2008) M. S. Tallman et al.   Hematology-American Society of Hematology Education Program