Cytoglobin Silencing Promotes Melanoma Malignancy but Sensitizes for Ferroptosis and Pyroptosis Therapy Response

Crosstalk of pyroptosis, ferroptosis, and mitochondrial aldehyde dehydrogenase 2-related mechanisms in sepsis-induced lung injury in a mouse model

(2022) Zhenzhen Cao et al.   Bioengineered

Downregulation of macrophage migration inhibitory factor attenuates NLRP3 inflammasome mediated pyroptosis in sepsis-induced AKI

(2022) Tianlong Li et al.   Cell Death Discovery

Androglobin, a chimeric mammalian globin, is required for male fertility

(2022) Anna Keppner et al.   eLife

Cytoglobin inhibits non-thermal plasma-induced apoptosis in melanoma cells through regulation of the NRF2-mediated antioxidant response

(2022) Joey De Backer et al.   Redox Biology

Androglobin gene expression patterns and FOXJ1-dependent regulation indicate its functional association with ciliogenesis

(2021) Teng Wei Koay et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ferroptosis: mechanisms, biology and role in disease

(2021) Xuejun Jiang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cytoglobin protects cancer cells from apoptosis by regulation of mitochondrial cardiolipin

(2021) Lorna S. Thorne et al.   Scientific Reports

Current Melanoma Treatments: Where Do We Stand?

(2021) Alvaro Moreira et al.   Cancers

Induction of Pyroptosis: A Promising Strategy for Cancer Treatment

(2021) Lei Wang et al.   Frontiers in Oncology

Recent Advances in the Treatment of Melanoma

(2021) Brendan D. Curti et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pyroptosis in Cancer: Friend or Foe?

(2021) Xiuxia Lu et al.   Cancers

Cytoglobin has potent superoxide dismutase function

(2021) Jay L. Zweier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Antioxidative Role of Cytoglobin in Podocytes: Implications for a Role in Chronic Kidney Disease

(2020) Elisa B. Randi et al.   ANTIOXIDANTS & REDOX SIGNALING

LncRNA MEG3 promotes melanoma growth, metastasis and formation through modulating miR-21/E-cadherin axis

(2020) Liangcai Wu et al.   Cancer Cell International

Targeting the MAPK Pathway in KRAS-Driven Tumors

(2020) Matthias Drosten et al.   CANCER CELL

Lessons from the post-genomic era: Globin diversity beyond oxygen binding and transport

(2020) Anna Keppner et al.   Redox Biology

Evolving complexity of MIF signaling

(2019) Stanislovas S. Jankauskas et al.   CELLULAR SIGNALLING

PI3K/Akt/mTOR inhibitors in cancer: At the bench and bedside

(2019) Ali S. Alzahrani   SEMINARS IN CANCER BIOLOGY

Combination of Immunotherapy With Targeted Therapy: Theory and Practice in Metastatic Melanoma

(2019) Chune Yu et al.   Frontiers in Immunology

FSP1 is a glutathione-independent ferroptosis suppressor

(2019) Sebastian Doll et al.   NATURE

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

(2019) Kirill Bersuker et al.   NATURE

Regulation of Nitric Oxide Metabolism and Vascular Tone by Cytoglobin

(2019) Jay L. Zweier et al.   ANTIOXIDANTS & REDOX SIGNALING

Cytoglobin Attenuates Neuroinflammation in Lipopolysaccharide-Activated Primary Preoptic Area Cells via NF-κB Pathway Inhibition

(2019) Bruna R. B. Gomes et al.   Frontiers in Molecular Neuroscience

Cancer statistics, 2018

(2018) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Multi-stage Differentiation Defines Melanoma Subtypes with Differential Vulnerability to Drug-Induced Iron-Dependent Oxidative Stress

(2018) Jennifer Tsoi et al.   CANCER CELL

Lipid Peroxidation Drives Gasdermin D-Mediated Pyroptosis in Lethal Polymicrobial Sepsis

(2018) Rui Kang et al.   Cell Host & Microbe

Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma

(2018) Behrouz Hassannia et al.   JOURNAL OF CLINICAL INVESTIGATION

Strong modulation of nitrite reductase activity of cytoglobin by disulfide bond oxidation: Implications for nitric oxide homeostasis

(2018) Brandon J. Reeder et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Macrophage migration inhibitory factor is required for NLRP3 inflammasome activation

(2018) Tali Lang et al.   Nature Communications

Cytoglobin affects tumorigenesis and the expression of ulcerative colitis-associated genes under chemically induced colitis in mice

(2018) Mohammad Yassin et al.   Scientific Reports

Heme Oxygenase 1 in the Nervous System: Does It Favor Neuronal Cell Survival or Induce Neurodegeneration?

(2018) Mariapaola Nitti et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis 

(2018) Bo Zhou et al.   CELL RESEARCH

A Dual Role of Heme Oxygenase-1 in Cancer Cells

(2018) Shih-Kai Chiang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Putative tumor suppressor cytoglobin promotes aryl hydrocarbon receptor ligand-mediated triple negative breast cancer cell death

(2018) Leah K. Rowland et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The inhibitory effect of MEG3/miR-214/AIFM2 axis on the growth of T-cell lymphoblastic lymphoma

(2017) Fang-Yi Fan et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Recombinant Human Cytoglobin Prevents Atherosclerosis by Regulating Lipid Metabolism and Oxidative Stress

(2017) Lingling Ou et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

Mechanisms and prevention of UV-induced melanoma

(2017) Ashley Sample et al.   PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE

Protective effects of recombinant human cytoglobin against chronic alcohol-induced liver disease in vivo and in vitro

(2017) Jian Wen et al.   Scientific Reports

Cytoglobin Promotes Cardiac Progenitor Cell Survival against Oxidative Stress via the Upregulation of the NFκB/iNOS Signal Pathway and Nitric Oxide Production

(2017) Shuning Zhang et al.   Scientific Reports

The Roles of NRF2 in Modulating Cellular Iron Homeostasis

(2017) Michael John Kerins et al.   ANTIOXIDANTS & REDOX SIGNALING

Peroxidase activation of cytoglobin by anionic phospholipids: Mechanisms and consequences

(2016) Jesús Tejero et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Discovery of cytoglobin and its roles in physiology and pathology of hepatic stellate cells

(2016) Katsutoshi YOSHIZATO et al.   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

DNA hypermethylation analysis in sputum for the diagnosis of lung cancer: training validation set approach

(2015) A J Hubers et al.   BRITISH JOURNAL OF CANCER

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Destruction of a distal hypoxia response element abolishestrans-activation of thePAG1gene mediated by HIF-independent chromatin looping

(2015) Alexandra Schörg et al.   NUCLEIC ACIDS RESEARCH

Heme oxygenase-1 accelerates erastin-induced ferroptotic cell death

(2015) Min-Young Kwon et al.   Oncotarget

The Molecular Signatures Database Hallmark Gene Set Collection

(2015) Arthur Liberzon et al.   Cell Systems

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

A novel distal upstream hypoxia response element regulating oxygen-dependent erythropoietin gene expression

(2014) F. Storti et al.   HAEMATOLOGICA

The GOA database: Gene Ontology annotation updates for 2015

(2014) Rachael P. Huntley et al.   NUCLEIC ACIDS RESEARCH

Melanoma Transition Is Frequently Accompanied by a Loss of Cytoglobin Expression in Melanocytes: A Novel Expression Site of Cytoglobin

(2014) Yoshihiko Fujita et al.   PLoS One

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

(2014) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

Mitochondrial Cardiolipin Is Required for Nlrp3 Inflammasome Activation

(2013) Shankar S. Iyer et al.   IMMUNITY

Cytoglobin modulates myogenic progenitor cell viability and muscle regeneration

(2013) S. Singh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myoglobin and mitochondria: A relationship bound by oxygen and nitric oxide

(2012) Christelle Kamga et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Lipid binding to cytoglobin leads to a change in haem co-ordination: a role for cytoglobin in lipid signalling of oxidative stress

(2011) Brandon J. Reeder et al.   BIOCHEMICAL JOURNAL

Review: Targeting the Hedgehog pathway in cancer

(2010) Sachin Gupta et al.   Therapeutic Advances in Medical Oncology

Cytoglobin is upregulated by tumour hypoxia and silenced by promoter hypermethylation in head and neck cancer

(2009) R J Shaw et al.   BRITISH JOURNAL OF CANCER

A functional heteromeric MIF receptor formed by CD74 and CXCR4

(2009) Verena Schwartz et al.   FEBS LETTERS

Cutting Edge: TNF-  Mediates Sensitization to ATP and Silica via the NLRP3 Inflammasome in the Absence of Microbial Stimulation

(2009) L. Franchi et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Cytoglobin, the Newest Member of the Globin Family, Functions as a Tumor Suppressor Gene

(2008) N. Shivapurkar et al.   CANCER RESEARCH

Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells

(2008) Wan Seok Yang et al.   CHEMISTRY & BIOLOGY