Review
Biochemistry & Molecular Biology
Hongyong Huang, Yanmin Weng, Wen Tian, Xian Lin, Jian Chen, Lianxiang Luo
Summary: This review provides an overview of the mechanisms of pyroptosis, the relationship between the gasdermin family and pyroptosis, and the interplay between pyroptosis and anti-tumor immunity. Additionally, the potential implications of pyroptosis in cancer immunotherapy are discussed, along with future research possibilities and a novel approach to tumor treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Review
Oncology
Xiuxia Lu, Tianhui Guo, Xing Zhang
Summary: Pyroptosis, a new form of programmed cell death, has garnered attention in cancer research. Various stimuli can trigger pyroptosis, but its role in cancer remains unclear with conflicting findings. Despite the uncertainties, pyroptosis may hold potential as a promising anti-cancer therapy.
Article
Biochemistry & Molecular Biology
Sebastian A. Hughes, Meng Lin, Ashley Weir, Bing Huang, Liya Xiong, Ngee Kiat Chua, Jiyi Pang, Jascinta P. Santavanond, Rochelle Tixeira, Marcel Doerflinger, Yexuan Deng, Chien-Hsiung Yu, Natasha Silke, Stephanie A. Conos, Daniel Frank, Daniel S. Simpson, James M. Murphy, Kate E. Lawlor, Jaclyn S. Pearson, John Silke, Marc Pellegrini, Marco Herold, Ivan K. H. Poon, Seth L. Masters, Mingsong Li, Qin Tang, Yuxia Zhang, Maryam Rashidi, Lanlan Geng, James E. Vince
Summary: This study reveals that genetic mutations in X-linked inhibitor of apoptosis (XIAP) can lead to cell death-associated inflammatory diseases. The findings show that patients with XIAP deficiency-associated inflammatory bowel disease have increased inflammatory IL-1 beta maturation and cell death-associated caspase-8 and Gasdermin D (GSDMD) processing, which can be reduced by patient treatment.
Review
Oncology
Tianyi Liu, Min Hou, Manyu Li, Cheng Qiu, Lin Cheng, Tianyu Zhu, Jinfeng Qu, Lanyu Li
Summary: Ovarian cancer, with its complexity and difficulty in early-stage diagnosis, has the second highest mortality among all gynecological cancers. Pyroptosis, a distinctive form of programmed cell death, has been shown to be connected with various disorders, including ovarian cancer. This review summarizes the major pathways of pyroptosis and its research foundations in ovarian cancer, providing potential insights for the treatment and future research directions.
FRONTIERS IN ONCOLOGY
(2022)
Review
Endocrinology & Metabolism
Chen Huang, Jian Li, Chenliang Zhang
Summary: Pyroptosis, a caspase-dependent cell death, plays a complex role in cancer development. It can be both anti-tumor and pro-tumor. Pyroptosis provides potential new targets for cancer treatment and helps optimize the use of existing drugs. Immunotherapy is a hot research direction in the field of cancer treatment.
MOLECULAR METABOLISM
(2022)
Review
Cardiac & Cardiovascular Systems
Xinzhe Chen, Peng-Chao Tian, Kai Wang, Man Wang, Kun Wang
Summary: Cardiovascular disease (CVD) is a common and serious health threat. Different forms of cardiomyocyte death, including apoptosis, necrosis, and pyroptosis, play important roles in the pathogenesis of CVD. Controlling cardiomyocyte pyroptosis holds promise for the treatment of cardiovascular disease.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Immunology
Dengqiang Wu, Yujie Li, Ranxing Xu
Summary: Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease with undefined causes, leading to persistent synovial inflammation and destruction of articular cartilage and bone. Current drugs for RA can relieve joint symptoms, but there are limitations and the need for new mechanisms to prevent and treat RA.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Microbiology
Beatrice I. Herrmann, James P. Grayczyk, Igor E. Brodsky
Summary: The immune system of multicellular organisms defends against harmful microbes. Bacterial infection can influence the formation and activity of inflammasomes, which are responsible for activating cell death pathways and triggering proinflammatory responses. This review examines how bacterial activities impact inflammasomes and the consequences for both the host and pathogen.
ANNUAL REVIEW OF MICROBIOLOGY
(2023)
Review
Immunology
Meini Chen, Rong Rong, Xiaobo Xia
Summary: Pyroptosis is a type of programmed cell death characterized by rapid plasma membrane disruption and release of pro-inflammatory mediators. Recent studies have shown its involvement in various ocular diseases. This review summarizes the role of pyroptosis in common ocular diseases and suggests that targeting pyroptosis signaling pathways could be a potential therapeutic strategy.
JOURNAL OF NEUROINFLAMMATION
(2022)
Review
Biochemistry & Molecular Biology
Skylar S. Wright, Swathy O. Vasudevan, Vijay A. Rathinam
Summary: The noncanonical inflammasome plays important roles in regulating cell death and inflammation by monitoring bacterial lipopolysaccharide in the cytosol. Recent studies have advanced our understanding of the activation mechanism and biological consequences of the noncanonical inflammasome, but there are still remaining gaps to be addressed.
JOURNAL OF MOLECULAR BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ruo-Nan Zhang, Zhi-Jun Sun, Lu Zhang
Summary: Inflammatory bone diseases, including osteoarthritis (OA) and rheumatoid arthritis (RA), cause severe bone damage and bring significant medical costs to patients' families and government agencies. The complexity of osteoimmunology has made it challenging to research these diseases. Understanding the potential mechanisms and finding effective drugs to target inflammatory bone diseases is urgent. Pyroptosis, a necrotic cell death featuring the secretion of pro-inflammatory cytokines, has been identified as a vital component in the etiopathogenesis of these diseases. This review discusses the characteristics and mechanisms of pyroptosis and its clinical significance in inflammatory bone diseases. The current research progress of drugs targeting pyroptosis for enhancing therapeutic efficacy is also summarized, providing new insights for future directions.
Review
Biochemistry & Molecular Biology
Natsuki Morimoto, Tomoya Kono, Masahiro Sakai, Jun-ichi Hikima
Summary: PRRs, including NLRs, play important roles in inducing inflammatory responses through recognizing various patterns. The activation of inflammasome leads to the maturation of proinflammatory cytokines and pyroptosis, which play protective roles against pathogen infection in mammals and teleosts.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Lee M. Booty, Clare E. Bryant
Summary: The discovery of pyroptosis and its implications in infection and immunity has provided new insights into host defense against pathogens. However, the regulation of pyroptosis is complex and varies between cell types, stimulation conditions, pathogens, and animal species. Excessive inflammation caused by pyroptosis contributes to the development of sepsis. Understanding the regulation of pyroptotic pathways is crucial for identifying potential therapeutic targets for sepsis.
JOURNAL OF MOLECULAR BIOLOGY
(2022)
Review
Oncology
Dengqiang Wu, Changhong Wei, Yujie Li, Xuejia Yang, Sufang Zhou
Summary: Pyroptosis, a type of programmed cell death, occurs through the gasdermin protein family and triggers an inflammatory response, showing a close relationship with the development of tumors.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Reid Loveless, Ryan Bloomquist, Yong Teng
Summary: Pyroptosis, a lytic and inflammatory programmed cell death pathway, has shown potential in addressing tumor resistance to apoptosis and the immunosuppressive tumor microenvironment by inducing a robust inflammatory response and marked tumor regression. Gasdermin proteins mediate pyroptosis and facilitate immune cell activation and infiltration, but aberrant pyroptosis may also contribute to tumor progression by upregulating gasdermin proteins in certain cancers. Harnessing pyroptosis as a tool in anticancer strategies shows promise in novel interventions.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Zongqi Wang, Ye Ding, Xuanzhong Wang, Shan Lu, Chongcheng Wang, Chuan He, Lei Wang, Meihua Piao, Guangfan Chi, Yinan Luo, Pengfei Ge
Article
Oncology
Ye Ding, Chuan He, Shan Lu, Xuanzhong Wang, Chongcheng Wang, Lei Wang, Ji Zhang, Meihua Piao, Guangfan Chi, Yinan Luo, Ke Sai, Pengfei Ge
Article
Biochemistry & Molecular Biology
Xuanzhong Wang, Shan Lu, Chuan He, Chongcheng Wang, Lei Wang, Meihua Piao, Guangfan Chi, Yinan Luo, Pengfei Ge
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2019)
Article
Oncology
Mengxin Li, Xuanzhong Wang, Shan Lu, Chuan He, Chongcheng Wang, Lei Wang, Xinyu Wang, Pengfei Ge, Dong Song
Article
Cell Biology
Chongcheng Wang, Chuan He, Shan Lu, Xuanzhong Wang, Lei Wang, Shipeng Liang, Xinyu Wang, Meihua Piao, Jiayue Cui, Guangfan Chi, Pengfei Ge
CELL DEATH & DISEASE
(2020)
Article
Chemistry, Multidisciplinary
Chuan He, Shan Lu, Xuan-zhong Wang, Chong-cheng Wang, Lei Wang, Shi-peng Liang, Tian-fei Luo, Zhen-chuan Wang, Mei-hua Piao, Guang-fan Chi, Peng-fei Ge
Summary: The study demonstrates that FOXO3a attenuates temozolomide-induced DNA double strand breaks in human glioma cells by promoting BNIP3-mediated mitophagy.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Chemistry, Multidisciplinary
Shan Lu, Xuan-zhong Wang, Chuan He, Lei Wang, Shi-peng Liang, Chong-cheng Wang, Chen Li, Tian-fei Luo, Chun-sheng Feng, Zhen-chuan Wang, Guang-fan Chi, Peng-fei Ge
Summary: The study demonstrates that brucine inhibits glioma cell growth and induces ferroptosis by promoting the accumulation of H2O2 and iron via activation of ATF3.
ACTA PHARMACOLOGICA SINICA
(2021)
Review
Pharmacology & Pharmacy
Long Gu, Xueqi Pan, Chongcheng Wang, Lei Wang
Summary: Anesthetics are necessary for cancer surgery, but some of them have been proven to promote the occurrence of certain cancers, leading to adverse effects on patients' lives. Propofol, as an anesthetic, not only has positive effects on immunity, but also has an anticancer effect, making it significant in oncologic surgery.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Oncology
Guangqiang You, Chen Zhou, Lei Wang, Zefeng Liu, He Fang, Xiaoxao Yao, Xuewen Zhang
Summary: The COMMD proteins are involved in various biological activities and have been linked to a wide range of disorders, including hepatitis, ischemia, HIV infection, and cancer. In particular, their role in tumors has been extensively studied, and they can either promote or inhibit different types of cancer. COMMD proteins have an impact on tumor progression, invasion, metastasis, and angiogenesis, and are associated with key signaling pathways and oncogenes.
FRONTIERS IN ONCOLOGY
(2023)
Article
Microbiology
Lei Wang, Zhihao Xie, Guoliang Li, Guangyao Li, Jianmin Liang
Summary: This study used Mendelian randomization to investigate the causal relationship between gut microbiota and ADHD. The results suggest a potential causal link between certain gut bacteria and the risk of developing ADHD, as well as the protective effects of other gut bacteria. This research provides a foundation for understanding the causal relationship between gut microbiota and ADHD.
FRONTIERS IN MICROBIOLOGY
(2023)