Review
Oncology
Lei Wang, Xiaowei Qin, Jianmin Liang, Pengfei Ge
Summary: Pyroptosis is a lytic pro-inflammatory type of programmed cell death that has a complex relationship with cancer. It can provide a comfortable environment for tumor proliferation as inflammatory cell death, but excessive activation can also inhibit the development of tumor cells.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Hongyong Huang, Yanmin Weng, Wen Tian, Xian Lin, Jian Chen, Lianxiang Luo
Summary: This review provides an overview of the mechanisms of pyroptosis, the relationship between the gasdermin family and pyroptosis, and the interplay between pyroptosis and anti-tumor immunity. Additionally, the potential implications of pyroptosis in cancer immunotherapy are discussed, along with future research possibilities and a novel approach to tumor treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Lee M. Booty, Clare E. Bryant
Summary: The discovery of pyroptosis and its implications in infection and immunity has provided new insights into host defense against pathogens. However, the regulation of pyroptosis is complex and varies between cell types, stimulation conditions, pathogens, and animal species. Excessive inflammation caused by pyroptosis contributes to the development of sepsis. Understanding the regulation of pyroptotic pathways is crucial for identifying potential therapeutic targets for sepsis.
JOURNAL OF MOLECULAR BIOLOGY
(2022)
Review
Immunology
Claudine S. S. Greenwood, Meghan A. A. Wynosky-Dolfi, Allison M. M. Beal, Lee M. M. Booty
Summary: The discovery of gasdermin D (GSDMD) as the terminal executioner of pyroptosis fills an important gap in our understanding of cell death and highlights the significance of the gasdermin family. GSDMD connects the innate alarm systems to an explosive, inflammatory form of cell death, triggering immunological responses in the local environment.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Ruixuan You, Xinglan He, Zhuotong Zeng, Yi Zhan, Yangfan Xiao, Rong Xiao
Summary: Autoimmune diseases are a group of heterogeneous diseases caused by the destruction of immune tolerance and the production of autoantibodies. Excessive exacerbation of pyroptosis, a form of programmed cell death, plays a crucial role in the development of autoimmune diseases. Inflammasomes act as switches for pyroptosis, and various pyroptosis pathways disrupt immune system homeostasis and promote autoimmunity.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Qiuyun Jiang, Zhigang Zhu, Xinliang Mao
Summary: Inflammasomes serve as a vital component in the innate immune system to defend against disruptions in homeostasis caused by pathogens or host molecules. Comprised of protein complexes, these inflammasomes assemble in the cytosol upon detection of danger signals. Activation of inflammasomes leads to the release of pro-inflammatory cytokines and pyroptotic cell death. Recent studies have highlighted the role of protein post-translational modifications, particularly ubiquitination, in modulating inflammasome activation. Understanding these mechanisms could offer new strategies for targeting diseases associated with the inflammasome pathway.
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2023)
Article
Biochemistry & Molecular Biology
Dhruv Chauhan, Dieter Demon, Lieselotte Vande Walle, Oonagh Paerewijck, Annalisa Zecchin, Leslie Bosseler, Karin Santoni, Remi Planes, Silvia Ribo, Amelie Fossoul, Amanda Goncalves, Hanne Van Gorp, Nina Van Opdenbosch, Filip Van Hauwermeiren, Etienne Meunier, Andy Wullaert, Mohamed Lamkanfi
Summary: This study confirms the presence of multiple canonical inflammasomes in neutrophils and identifies their differential roles in neutrophil immune responses. It provides new insights into the immune mechanisms of neutrophils.
Review
Immunology
Qing Kong, Zhibin Zhang
Summary: Inflammasome-activated pyroptosis (IAP) and cancer-associated pyroptosis (CAP) are both mediated by pore-forming Gasdermin (GSDM) proteins, but they differ in occurrence sites, activating mechanisms, secreting cytokines, and biological outcomes. For cancer treatment, CAP may provoke anti-tumor immunity and present a promising avenue for developing therapeutic interventions to enhance immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Tianyi Liu, Min Hou, Manyu Li, Cheng Qiu, Lin Cheng, Tianyu Zhu, Jinfeng Qu, Lanyu Li
Summary: Ovarian cancer, with its complexity and difficulty in early-stage diagnosis, has the second highest mortality among all gynecological cancers. Pyroptosis, a distinctive form of programmed cell death, has been shown to be connected with various disorders, including ovarian cancer. This review summarizes the major pathways of pyroptosis and its research foundations in ovarian cancer, providing potential insights for the treatment and future research directions.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Madeline J. Churchill, Patrick S. Mitchell, Isabella Rauch
Summary: Pyroptosis is a form of cell death executed by GSDMs proteins, which release cytokines and eliminate pathogen replication to play a role in host defense. Pyroptosis also occurs in barrier epithelia, but requires unique mechanisms to maintain barrier integrity.
JOURNAL OF MOLECULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sebastian A. Hughes, Meng Lin, Ashley Weir, Bing Huang, Liya Xiong, Ngee Kiat Chua, Jiyi Pang, Jascinta P. Santavanond, Rochelle Tixeira, Marcel Doerflinger, Yexuan Deng, Chien-Hsiung Yu, Natasha Silke, Stephanie A. Conos, Daniel Frank, Daniel S. Simpson, James M. Murphy, Kate E. Lawlor, Jaclyn S. Pearson, John Silke, Marc Pellegrini, Marco Herold, Ivan K. H. Poon, Seth L. Masters, Mingsong Li, Qin Tang, Yuxia Zhang, Maryam Rashidi, Lanlan Geng, James E. Vince
Summary: This study reveals that genetic mutations in X-linked inhibitor of apoptosis (XIAP) can lead to cell death-associated inflammatory diseases. The findings show that patients with XIAP deficiency-associated inflammatory bowel disease have increased inflammatory IL-1 beta maturation and cell death-associated caspase-8 and Gasdermin D (GSDMD) processing, which can be reduced by patient treatment.
Review
Biochemistry & Molecular Biology
See Jie Yow, Hui Wen Yeap, Kaiwen W. Chen
Summary: This article summarizes the latest advances in inflammasome, gasdermin, and cell death signaling in neutrophils, and discusses their roles in neutrophil resistance to bacterial infection and inflammatory disorders.
MOLECULAR MICROBIOLOGY
(2022)
Review
Immunology
Marta Slaufova, Tugay Karakaya, Michela Di Filippo, Paulina Hennig, Hans-Dietmar Beer
Summary: Gasdermins are a family of pore-forming proteins that are involved in (auto)inflammatory diseases and cancer. They can form pores, leading to cell death and inflammation, and are closely associated with the functions of keratinocytes and the skin.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Medicine, Research & Experimental
Zuohao Liu, Chunming Wang, Changjun Lin
Summary: Pyroptosis is a recently discovered programmed cell death mode caused by inflammasomes and Gasdermin family proteins. It leads to the release of inflammatory factors and triggers an inflammatory cascade response. Pyroptosis has different morphological features compared to other cell death modes and can be a potential cancer treatment strategy. However, there is still much unknown about its molecular mechanisms in pathogenicity and therapeutics, requiring further research.
Review
Cardiac & Cardiovascular Systems
Xinzhe Chen, Peng-Chao Tian, Kai Wang, Man Wang, Kun Wang
Summary: Cardiovascular disease (CVD) is a common and serious health threat. Different forms of cardiomyocyte death, including apoptosis, necrosis, and pyroptosis, play important roles in the pathogenesis of CVD. Controlling cardiomyocyte pyroptosis holds promise for the treatment of cardiovascular disease.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)