TRAP1 inhibits MIC60 ubiquitination to mitigate the injury of cardiomyocytes and protect mitochondria in extracellular acidosis

The mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in mitochondrial metabolic homeostasis

(2020) Abhinav Joshi et al.   BMC BIOLOGY

Different serotypes of AAV vectors and lentivirus meditated tropism in choroid plexus by intracerebroventricular delivery

(2020) Xi Chen et al.   HUMAN GENE THERAPY

MICOS assembly controls mitochondrial inner membrane remodeling and crista junction redistribution to mediate cristae formation

(2020) Till Stephan et al.   EMBO JOURNAL

TRAP1 attenuates H9C2 myocardial cell injury induced by extracellular acidification via the inhibition of MPTP opening

(2020) Lingxiao Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Vitamin D and intestinal homeostasis: Barrier, microbiota, and immune modulation

(2020) Hana. M.A. Fakhoury et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Cellular metabolism and homeostasis in pluripotency regulation

(2020) Kun Liu et al.   Protein & Cell

Cardiac ischemia/reperfusion stress reduces inner mitochondrial membrane protein (mitofilin) levels during early reperfusion

(2020) Nathalie Tombo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Clearance of damaged mitochondria via mitophagy is important to the protective effect of ischemic preconditioning in kidneys

(2019) Man J. Livingston et al.   Autophagy

Targeting acidity in cancer and diabetes

(2019) Robert J. Gillies et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Sam50–Mic19–Mic60 axis determines mitochondrial cristae architecture by mediating mitochondrial outer and inner membrane contact

(2019) Junhui Tang et al.   CELL DEATH AND DIFFERENTIATION

Hsp70- and Hsp90-Mediated Regulation of the Conformation of p53 DNA Binding Domain and p53 Cancer Variants

(2019) Marta Boysen et al.   MOLECULAR CELL

The class 3 PI3K coordinates autophagy and mitochondrial lipid catabolism by controlling nuclear receptor PPARα

(2019) Anton Iershov et al.   Nature Communications

Compromised Mitochondrial Protein Import Acts as a Signal for UPRmt

(2019) Stéphane G. Rolland et al.   Cell Reports

Comparison of Gene Delivery to the Kidney by Adenovirus, Adeno-Associated Virus, and Lentiviral Vectors After Intravenous and Direct Kidney Injections

(2019) Jeffrey D. Rubin et al.   HUMAN GENE THERAPY

Consequences of inner mitochondrial membrane protein misfolding

(2019) Liam P. Coyne et al.   MITOCHONDRION

Iron deficiency impairs contractility of human cardiomyocytes through decreased mitochondrial function

(2018) Martijn F. Hoes et al.   EUROPEAN JOURNAL OF HEART FAILURE

Regulation of Ca 2+ signaling by acute hypoxia and acidosis in rat neonatal cardiomyocytes

(2018) José-Carlos Fernández-Morales et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Clinical use of lentiviral vectors

(2018) Michael C. Milone et al.   LEUKEMIA

A Lethal Channel between the ATP Synthase Monomers

(2018) Salvatore Nesci   TRENDS IN BIOCHEMICAL SCIENCES

Ubiquitin-Dependent Degradation of Mitochondrial Proteins Regulates Energy Metabolism

(2018) Julie Lavie et al.   Cell Reports

Extracellular acidification induces ROS- and mPTP-mediated death in HEK293 cells

(2018) José Teixeira et al.   Redox Biology

PINK1-dependent mitophagy is driven by the UPS and can occur independently of LC3 conversion

(2018) Aleksandar Rakovic et al.   CELL DEATH AND DIFFERENTIATION

Entering the Modern Era of Gene Therapy

(2018) Xavier M. Anguela et al.   Annual Review of Medicine

TRAP1 ameliorates renal tubulointerstitial fibrosis in mice with unilateral ureteral obstruction by protecting renal tubular epithelial cell mitochondria

(2017) Jun-Feng Chen et al.   FASEB JOURNAL

TRAP1 controls cell cycle G2-M transition through the regulation of CDK1 and MAD2 expression/ubiquitination

(2017) Lorenza Sisinni et al.   JOURNAL OF PATHOLOGY

Lactic Acidosis in Sepsis: It’s Not All Anaerobic

(2016) Bandarn Suetrong et al.   CHEST

Mitochondrial contact site and cristae organizing system

(2016) Martin van der Laan et al.   CURRENT OPINION IN CELL BIOLOGY

Extracellular pH regulates autophagy via the AMPK-ULK1 pathway in rat cardiomyocytes

(2016) Liping Zhao et al.   FEBS LETTERS

PKA Regulates PINK1 Stability and Parkin Recruitment to Damaged Mitochondria through Phosphorylation of MIC60

(2016) Shiori Akabane et al.   MOLECULAR CELL

Development of Third-generation Cocal Envelope Producer Cell Lines for Robust Lentiviral Gene Transfer into Hematopoietic Stem Cells and T-cells

(2016) Olivier Humbert et al.   MOLECULAR THERAPY

Protein misfolding in the endoplasmic reticulum as a conduit to human disease

(2016) Miao Wang et al.   NATURE

Mitochondrial Cristae: Where Beauty Meets Functionality

(2016) Sara Cogliati et al.   TRENDS IN BIOCHEMICAL SCIENCES

Mic60/Mitofilin determines MICOS assembly essential for mitochondrial dynamics and mtDNA nucleoid organization

(2015) H Li et al.   CELL DEATH AND DIFFERENTIATION

Double-edged alliance: mitochondrial surveillance by the UPS and autophagy

(2015) André Franz et al.   CURRENT OPINION IN CELL BIOLOGY

Transgenic overexpression of mitofilin attenuates diabetes mellitus-associated cardiac and mitochondria dysfunction

(2015) Dharendra Thapa et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

MICOS coordinates with respiratory complexes and lipids to establish mitochondrial inner membrane architecture

(2015) Jonathan R Friedman et al.   eLife

Tissue acidosis induces neuronal necroptosis via ASIC1a channel independent of its ionic conduction

(2015) Yi-Zhi Wang et al.   eLife

Role of NHE1 in the Cellular Dysfunction of Acute Metabolic Acidosis

(2014) Dongmei Wu et al.   AMERICAN JOURNAL OF NEPHROLOGY

Structural Asymmetry in the Closed State of Mitochondrial Hsp90 (TRAP1) Supports a Two-Step ATP Hydrolysis Mechanism

(2014) Laura A. Lavery et al.   MOLECULAR CELL

Mitochondrial oxidative phosphorylation TRAP(1)ped in tumor cells

(2014) Andrea Rasola et al.   TRENDS IN CELL BIOLOGY

Acidosis overrides oxygen deprivation to maintain mitochondrial function and cell survival

(2014) Mireille Khacho et al.   Nature Communications

Mitochondrial Cristae Shape Determines Respiratory Chain Supercomplexes Assembly and Respiratory Efficiency

(2013) Sara Cogliati et al.   CELL

Characterization of a third generation lentiviral vector pseudotyped with Nipah virus envelope proteins for endothelial cell transduction

(2013) S R Witting et al.   GENE THERAPY

Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysis

(2013) S. Yoshida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interaction of Metabolic and Respiratory Acidosis with α and β-adrenoceptor Stimulation in Rat Myocardium

(2012) Matthieu Biais et al.   ANESTHESIOLOGY

Mitochondria: In Sickness and in Health

(2012) Jodi Nunnari et al.   CELL

Lentiviral vectors and cardiovascular diseases: a genetic tool for manipulating cardiomyocyte differentiation and function

(2012) E Di Pasquale et al.   GENE THERAPY

TRAP1 and the proteasome regulatory particle TBP7/Rpt3 interact in the endoplasmic reticulum and control cellular ubiquitination of specific mitochondrial proteins

(2011) M R Amoroso et al.   CELL DEATH AND DIFFERENTIATION

Body Fluid Dynamics: Back to the Future

(2011) G. Bhave et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mitochondrial Chaperone Trap1 and the Calcium Binding Protein Sorcin Interact and Protect Cells against Apoptosis Induced by Antiblastic Agents

(2010) M. Landriscina et al.   CANCER RESEARCH

Metabolic acidosis: pathophysiology, diagnosis and management

(2010) Jeffrey A. Kraut et al.   Nature Reviews Nephrology