Ly6C hi monocytes balance regulatory and cytotoxic CD4 T cell responses to control virus-induced immunopathology

Catch and release: freeing up PD-L1 ameliorates autoimmunity

(2022) Stephanie Grebinoski et al.   NATURE IMMUNOLOGY

COVID-19 and the human innate immune system

(2021) Joachim L. Schultze et al.   CELL

Tumor-specific cytolytic CD4 T cells mediate immunity against human cancer

(2021) Amélie Cachot et al.   Science Advances

Inflammatory Type 2 cDCs Acquire Features of cDC1s and Macrophages to Orchestrate Immunity to Respiratory Virus Infection

(2020) Cedric Bosteels et al.   IMMUNITY

Cytotoxic CD4+ T lymphocytes may induce endothelial cell apoptosis in systemic sclerosis

(2020) Takashi Maehara et al.   JOURNAL OF CLINICAL INVESTIGATION

A gammaherpesvirus licenses CD8 T cells to protect the host from pneumovirus-induced immunopathologies

(2020) Mickaël Dourcy et al.   Mucosal Immunology

Intratumoral CD4+ T Cells Mediate Anti-tumor Cytotoxicity in Human Bladder Cancer

(2020) David Y. Oh et al.   CELL

Placenta-specific 8 limits IFNγ production by CD4 T cells in vitro and promotes establishment of influenza-specific CD8 T cells in vivo

(2020) Chris D. Slade et al.   PLoS One

Cytokine Storm in COVID-19: The Current Evidence and Treatment Strategies

(2020) Yujun Tang et al.   Frontiers in Immunology

Imbalance of Regulatory and Cytotoxic SARS-CoV-2-Reactive CD4+ T Cells in COVID-19

(2020) Benjamin J. Meckiff et al.   CELL

Primary EBV Infection Induces an Acute Wave of Activated Antigen-Specific Cytotoxic CD4+ T Cells

(2019) Benjamin J. Meckiff et al.   JOURNAL OF IMMUNOLOGY

The PD-1/PD-L1 Axis and Virus Infections: A Delicate Balance

(2019) Günther Schönrich et al.   Frontiers in Cellular and Infection Microbiology

Single-cell transcriptomics reveals expansion of cytotoxic CD4 T cells in supercentenarians

(2019) Kosuke Hashimoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-cell transcriptomics of human T cells reveals tissue and activation signatures in health and disease

(2019) Peter A. Szabo et al.   Nature Communications

NicheNet: modeling intercellular communication by linking ligands to target genes

(2019) Robin Browaeys et al.   NATURE METHODS

CXCL9, CXCL10, CXCL11/CXCR3 axis for immune activation – A target for novel cancer therapy

(2018) Ryuma Tokunaga et al.   CANCER TREATMENT REVIEWS

c-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4+ T cells

(2018) Leona Gabryšová et al.   NATURE IMMUNOLOGY

Epstein–Barr Virus and Hemophagocytic Lymphohistiocytosis

(2018) Rebecca A. Marsh   Frontiers in Immunology

Epithelial MHC Class II Expression and Its Role in Antigen Presentation in the Gastrointestinal and Respiratory Tracts

(2018) Jonathan E. Wosen et al.   Frontiers in Immunology

Induction of Autonomous Memory Alveolar Macrophages Requires T Cell Help and Is Critical to Trained Immunity

(2018) Yushi Yao et al.   CELL

Helminth-induced IL-4 expands bystander memory CD8+ T cells for early control of viral infection

(2018) Marion Rolot et al.   Nature Communications

IFNγ-Induced MHC Class II Expression on Islet Endothelial Cells Is an Early Marker of Insulitis but Is Not Required for Diabetogenic CD4+ T Cell Migration

(2018) Nicholas A. Scott et al.   Frontiers in Immunology

Lung Homeostasis: Influence of Age, Microbes, and the Immune System

(2017) Clare M. Lloyd et al.   IMMUNITY

Cytotoxic CD4+ T Cells Drive Multiple Sclerosis Progression

(2017) Liesbet M. Peeters et al.   Frontiers in Immunology

Cytotoxic CD4 T Cells—Friend or Foe during Viral Infection?

(2017) Jennifer A. Juno et al.   Frontiers in Immunology

A Role for Neutrophils in Viral Respiratory Disease

(2017) Jeremy V. Camp et al.   Frontiers in Immunology

Costimulatory and Coinhibitory Receptor Pathways in Infectious Disease

(2016) John Attanasio et al.   IMMUNITY

Inflammatory monocytes and NK cells play a crucial role in DNAM-1–dependent control of cytomegalovirus infection

(2016) Tihana Lenac Rovis et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Fulminant Myocarditis with Combination Immune Checkpoint Blockade

(2016) Douglas B. Johnson et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Differentiation and Protective Function of Cytolytic CD4 T Cells in Influenza Infection

(2016) Deborah M. Brown et al.   Frontiers in Immunology

BubbleGUM: automatic extraction of phenotype molecular signatures and comprehensive visualization of multiple Gene Set Enrichment Analyses

(2015) Lionel Spinelli et al.   BMC GENOMICS

Variation in the Human Immune System Is Largely Driven by Non-Heritable Influences

(2015) Petter Brodin et al.   CELL

The cytokine storm of severe influenza and development of immunomodulatory therapy

(2015) Qiang Liu et al.   Cellular & Molecular Immunology

Bone-Marrow-Resident NK Cells Prime Monocytes for Regulatory Function during Infection

(2015) Michael H. Askenase et al.   IMMUNITY

The Cytokine GM-CSF Drives the Inflammatory Signature of CCR2+ Monocytes and Licenses Autoimmunity

(2015) Andrew L. Croxford et al.   IMMUNITY

Monocytes and infection: Modulator, messenger and effector

(2015) Huizhong Xiong et al.   IMMUNOBIOLOGY

Cytomegalovirus-Specific CD4 T Cells Are Cytolytic and Mediate Vaccine Protection

(2015) Shilpi Verma et al.   JOURNAL OF VIROLOGY

Dengue virus infection elicits highly polarized CX3CR1+cytotoxic CD4+T cells associated with protective immunity

(2015) Daniela Weiskopf et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

circlize implements and enhances circular visualization in R

(2014) Zuguang Gu et al.   BIOINFORMATICS

The Virome in Mammalian Physiology and Disease

(2014) Herbert W. Virgin   CELL

Role of the Microbiota in Immunity and Inflammation

(2014) Yasmine Belkaid et al.   CELL

Gammaherpesviruses and Lymphoproliferative Disorders

(2013) Ethel Cesarman   Annual Review of Pathology-Mechanisms of Disease

MHV68 Latency Modulates the Host Immune Response to Influenza A Virus

(2013) Fumitake Saito et al.   INFLAMMATION

Resident CD11b+Ly6C− Lung Dendritic Cells Are Responsible for Allergic Airway Sensitization to House Dust Mite in Mice

(2013) Claire Mesnil et al.   PLoS One

IFN-α-driven CCL2 production recruits inflammatory monocytes to infection site in mice

(2012) C D Conrady et al.   Mucosal Immunology

Regulation and Functions of the IL-10 Family of Cytokines in Inflammation and Disease

(2011) Wenjun Ouyang et al.   Annual Review of Immunology

Pathogenesis and Host Control of Gammaherpesviruses: Lessons from the Mouse

(2011) Erik Barton et al.   Annual Review of Immunology

Immune modulation during latent herpesvirus infection

(2011) Douglas W. White et al.   IMMUNOLOGICAL REVIEWS

Novel Highly Sensitive IL-10- -Lactamase Reporter Mouse Reveals Cells of the Innate Immune System as a Substantial Source of IL-10 In Vivo

(2011) H. Bouabe et al.   JOURNAL OF IMMUNOLOGY

Autocrine Regulation of Pulmonary Inflammation by Effector T-Cell Derived IL-10 during Infection with Respiratory Syncytial Virus

(2011) Jie Sun et al.   PLoS Pathogens

CD4 T Cells Mediate Killing during Persistent Gammaherpesvirus 68 Infection

(2009) K. A. Stuller et al.   JOURNAL OF VIROLOGY

PD-1 and Its Ligands in Tolerance and Immunity

(2008) Mary E. Keir et al.   Annual Review of Immunology

In vivo imaging of murid herpesvirus-4 infection

(2008) R. Milho et al.   JOURNAL OF GENERAL VIROLOGY

Programmed death 1 ligand signaling regulates the generation of adaptive Foxp3+CD4+ regulatory T cells

(2008) L. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The MHV68 M2 Protein Drives IL-10 Dependent B Cell Proliferation and Differentiation

(2008) Andrea M. Siegel et al.   PLoS Pathogens